Human Vascular Endothelium from Induced Pluripotent Stem Cells
Contributors: Garcia-Cardena, Guillermo; Suo, Zhigang; Mooney, David
Published: 2013
Language: eng
Description: The vascular endothelium is a dynamic cellular interface that displays a unique phenotypic plasticity. This plasticity is critical for vascular function and when dysregulated is pathogenic in several diseases. The development of new human endothelial genotype-phenotype studies, personalized vascular medicine efforts and cell based regenerative therapies are limited by the unavailability of patient-specific endothelial cells. Induced pluripotent stem cells (iPSC) offer great promise as a new personalized source of endothelium; however, the reproducibility, fidelity and functionality of iPSC-derived endothelial cells remains poorly understood.
Notes: Keywords: endothelium, induced pluripotent stem cells.

Thesis Ph.D. Harvard University 2013