Mouse models for drug discovery
Subtitle: methods and protocols
By: edited by Gabriele Proetzel and Michael V. Wiles
Series: Methods in molecular biology -- 602; Springer protocols; Methods in molecular biology (Clifton, N.J.) -- v. 602.; Springer protocols
Publisher: Humana
Published: 2010
Place of publication: Totowa, N.J
Language: eng
Number of pages: 421
ISBN-13: 9781607610571; 9781607610588
Subjects: Diseases; Transgenic Mice; Drugs; Drug development; Animal models in research; Molecular aspects; Drug Design; Physiological effect; Animal Disease Models; Animal Models; Preclinical Drug Evaluation; Effect of drugs on; Mice; Drug Discovery
Notes: Includes bibliographical references and index.
Table of contents: title: Improving toxicity screening and drug development by using genetically defined strains / Michael F.W. Festing; title: Sophisticated mouse: protecting a precious reagent / Michael V. Wiles, Rob A. Taft; title: Genetically engineered mouse models in drug discovery research / Rosalba Sacca, Sandra J. Engle, Wenning Qin, Jeffrey L. Stock, John D. McNeish; title: Engineering the mouse genome to model human disease for drug discovery / Frank Koentgen, Gabriele Suess, Dieter Naf; title: Profiling of drug action using reporter mice and molecular imaging / Gianpaolo Rando, Andrea Biserni, Paolo Ciana, Adriana Maggi; title: Human FcRn transgenic mice for pharmacokinetic evaluation of therapeutic antibodies / Derry C. Roopenian, Gregory J. Christianson, Thomas J. Sproule; title: Development of novel major histocompatibility complex class I and class II-defecient NOD-SCID IL2R gamma chain knockout mice for modeling human xenogeneic graft-versus-host disease / Steve Pino, Michael A. Brehm, Laurence Covassin-Barberis, Marie King, Bruce Gott, Thomas H. Chase, Jennifer Wagner, Lisa Burzenski, Oded Foreman, Dale L. Greiner, Leonard D. Shultz; title: Bridging mice to men: using HLA transgenic mice to enhance the future prediction and prevention of autoimmune type I diabetes in humans / David V. Serreze, Marijke Niens, John Kulik, Teresa P. DeLorenzo; title: Mouse models of type II diabetes mellitus in drug discovery / Helene Baribault; title: Cholesterol absorption and metabolism / Philip N. Howles; title: Collegen-induced arthritis in mice / Lisette Bevaart, Margriet J. Vervoordeldonk, Paul P. Tak; title: Skin diseases in laboratory mice: approaches to drug tartget identification and efficacy screening / John P. Sundbert, Kathleen A. Sliva, Caroline McPhee, Lloyd E. King; title: Models of metastasis in drug discovery / James E. Talmadge; title: Methods for evaluating effects of an ironotecan + 5-fluorouracil/leucovorin (IFL) regimen in an orthotopic metastatic colorectal cancer model utilizing in vivo bioluminescence imaging / David Surguladze, Philipp Steiner, Marie Prewetz, James R. Tonra; title: CML mouse model in translational research / Cong Peng, Shaoguang Li; title: Mouse models for studying depression-like states and antidepressant drugs / Carisa L. Bergner, Amanda N. Smolinsky, Peter C. Hart, Brett D. Dufour, Rupert J. Egan, Justin L. LaPorte, Allan V. Kaleuff; title: Virus-delivered RNA interference in mouse brain to study addiction-related behaviors / Amy W. Lasek, Nourredine Azouaou; title: Experimental models of anxiety for drug discovery and brain research / Peter C. Hart, Carisa L. Bergner, Amanda N. Smolinsky, Brett D. Dufour, Rupert J. Egan, Justin L. LaPorte, Allan v. Kalueff; title: Mouse models of neurodegenerative diseases: criteria and general methodology / Christopher Janus, Hans Welzl; title: Neuromuscular disease models and analysis / Robert W. Burgess, Gregory A. Cox, Kevin L. Seburn; title: Murine model of cutaneous infection with Streptococcus pyogenes / Eva Medina; title: Murine model of pneumococcal pneumonia / Eva Medina; title: Murine model of polymicrobial septic peritonitis using cecal ligation and puncture (CLP) / Eva Medina.