Autoimmunity
Subtitle: methods and protocols
By: edited by Andras Perl.
Contributors: Perl, Andras.
Series: Methods in molecular medicine -- 102.
Publisher: Humana Press
Published: 2004
Place of publication: Totowa, N.J
Language: eng
Number of pages: 431
Subjects: Autoimmune diseases -- Laboratory manuals; Autoimmunity -- Laboratory manuals
Genres: Laboratory manuals.
Description: A ready-to-use guide for establishing and interrogating human and animal models of autoimmune diseases. Patr I contains methods and protocols to assess immunological and biochemical pathways relevant for disease pathogenesis. Part II contains protocols to establish and assess inflammatory arthritis, SLE, myocarditis, thyroiditis, experimental allergic encephalomyelitis (EAE, IDDM, scleroderma, uveitis, and vitiligo. All methods focus on assessment of genetic, immunological, and biochemical parameters underlying spontaneous or exogenous antigen-induced diseases.
Notes: Includes bibliographical references and index.
Table of contents: title: Pathogenesis and spectrum of autoimmunity / Andras Perl; title: Models of pathogenesis in human autoimmune disorders; title: Mapping the systematic lupus erythematosus susceptibility genes / Swapan K. Nath, John B. Harley, and R. Hal Scofield; title: T cell signaling abnormalities in human systemic lupus erythematosus / Madhusoodana P. Nambiar, Sandeep Krishnan, and George Tsokos; title: TCR chain abnormalities in human systemic lupus erythematosus / Madhusoodana P. Nambiar ... [et al.]; title: Protein kinase A and signal transduction in T lymphocytes : biochemical and molecular methods / Islam U. Khan and Gary M. Kammer; title: Apoptosis and mitochondrial dysfunction in lymphocytes of patients with systemic lupus erythematosus / Andras Perl ... [et al.]; title: Methods for inducing apoptosis / Kathryn M. Roberts, Antony Rosen, and Livia A. Casciola-Rosen; title: Measurement of cytokines in autoimmune disease / Kyriakos A. Kirou, Christina Lee, and Mary K. Crow; title: Evaluation of autoimmunity to transaldolase in multiple sclerosis / Brian Niland and Andras Perl; title: Animal models of autoimmunity; title: Animal models for autoimmune myocarditis and autoimmune thyroiditis / Daniela Ciháková ... [et al.]; title: Animal models of insulin-dependent diabetes mellitus / Edwin Liu ... [et al.]; title: Generation, maintenance, and adoptive transfer of diabetogenic T cell lines/clones from the nonobese diabetic mouse / Martha J. Milton ... [et al.]; title: Experimental use of murine lupus models / Stanford L. Peng; title: The anti-DNA knockin model of systemic autoimmunity induced by the chronic graft-vs-host reaction / Robert Eisenberg and Arpita Choudhury; title: Murine models of lupus induced by hypomethylated T cells / Bruce Richardson, Donna Ray, and Raymond Yung; title: The mouse model of collagen-induced arthritis / David D. Brand, Andrew H. Kang, and Edward F. Rosloniec; title: Proteoglycan aggrecan-induced arthritis: a murine autoimmune model of rheumatoid arthritis / Tibor T. Glant; title: Methods for induction and analysis of mouse models of multiple; title: Sclerosis : experimental autoimmune encephalomyelitis and Theiler's virus-induced demyelinating disease / Kevin G. Fuller ... [et al.]; title: Experimental autoimmune encephalitomyelitis / Praveen Rao and Benjamin M. Segal; title: Animal models of scleroderma / Gabriella Lakos, Shinsuke Takagawa, and John Varga; title: Rodent models of experimental autoimmune uveitis / Rajeev K. Agarwal and Rachel R. Caspi; title: Autoimmune depigmentation following sensitization to melanoma antigens / Arthur A. Hurwitz and Qingyong Ji.