Molecular biology in medicinal chemistry
By: edited by Th. Dingermann, D. Steinhilber and G. Folkers.
Contributors: Dingermann, Theodor.; Steinhilber, Dieter, 1959-; Folkers, Gerd.
Edition: 1. Aufl.
Series: Methods and principles in medicinal chemistry ;; v. 21
Publisher: Wiley-VCH
Published: 2003
Place of publication: Weinheim
Language: eng
Number of pages: 413
Subjects: Molecular biology.; Molecular pharmacology.; Pharmacogenomics.; Genomics.; Chiral drugs.
Description: Explains the identification of molecular targets via cellular assays, reporter genes or transgenic models, as well as surveying recent advances in the synthesis, separation and analysis of drugs. A special section is devoted to molecular genetics methods. Appropriate for pharmaceutical chemists, molecular biologists and medical researchers using molecular methods to study drugs and their action.
Notes: Includes bibliographical references and index.
Table of contents: title: Cellular assays in drug discovery; title: Gene knockout models; title: Reporter gene assay systems for the investigation of GPCRs; title: From the human genome to new drugs: The potential of orphan GPCRs; title: Stereoselective synthesis with the help of recombinant enzymes; title: Nucleic acid drugs; title: Recent trends in enantioseparation of chiral drugs; title: Affinity chromatography; title: NMR-based drug discovery; title: 13C- and 15N-Isotopic labeling of proteins; title: Antibody fragments as crystallization enhancers; title: Pharmacogenetics: the effect of inherited henetic variation on drug disposition and drug response; title: Pharmacogenomics of bioavailability and elimination; title: Toxicogenomics: integration of new molecular biological tools in toxicology.