Insulin-like growth factor I (IGF I) in the red spotted newt, Notophthalmus viridescens: Description of larval limb development; localization of IGF I in larval and adult newt limbs; and effects of IGF I on epimorphic regeneration of an adult newt appendage in vitro.
Published: 2004
Language: eng
Number of pages: 202
ISBN-13: 9780494220764
Subjects: Notophthalmus viridescens.; Insulin-Like Growth Factor I.
Description: This study initiates research into the effects of IGF I on epimorphic appendage regeneration in the adult newt, Notophthalmus viridescens. As regeneration in this animal is often considered a recapitulation of development, the current research compares the expression of IGF I in developing larval forelimbs and regenerating adult forelimbs. To facilitate this comparison, a description of larval forelimb development was undertaken. This thesis is the first comprehensive record staging limb development in N. viridescens. In addition to the morphological descriptions, whole-mount and histological analyses of cellular development were made. This study determined that IGF I is a naturally occurring growth factor in this animal's liver, as observed among many vertebrates. ...
Notes: Thesis (Ph.D.) -- University of Toronto, 2004.

Includes bibliographical references.

Electronic version licesed for access by U. of T. users.