Gene transfer and the ethics of first-in-human research
Subtitle: lost in translation
By: Jonathan Kimmelman
Publisher: Cambridge University Press
Published: 2010
Place of publication: Cambridge, UK; New York
Language: eng
Number of pages: 205
ISBN-13: 9780521690843
Description: "Human gene transfer is widely regarded as one of the most promising technologies for the treatment of a variety of disorders, but it presents practitioners with a variety of difficult ethical questions. Gene Transfer and the Ethics of First-in-Human Research examines the ethical and policy dimensions of testing interventions in human beings for the first time. The book discusses the difficult ethical challenges that arise from attempting to translate laboratory discoveries into clinical applications. These range from which available techniques to use, when to initiate human testing, questions of consent, expectation in public arenas, how to define acceptable risk, and the inclusion of vulnerable or disadvantaged subjects in early phase trials. This book is relevant to ethicists, legal practitioners, policy makers, geneticists and clinicians involved in clinical trials of new medical interventions"--Provided by publisher.
Notes: Includes bibliographical references and index.
Table of contents: title: Introduction: gene transfer lost in translation; title: What is gene transfer?; title: Safety, values, and legitimacy: the protean nature of risk in translational trials; title: Taming uncertainty: risk and gene-transfer clinical research; title: Succor or suckers? Benefit, risk, and the therapeutic misconception; title: Looking backward: a model value for translational trials; title: The chasm: the ethics of initiating first-in-human clinical trials; title: Tropic of cancers: gene transfer in resource-poor settings; title: Great expectations and hard times: expectation management in gene transfer; title: Something in the sight adjusts itself: conclusions.