The effect of barley beta-glucan concentrate on LDL-cholesterol and other risk factors for cardiovascular disease.
Published: 2007
Language: eng
Number of pages: 130
ISBN-13: 9780494273791
Description: Conclusions. These studies suggest that although the beta-glucan concentrate used in these studies may have beneficial hypoglycemic effects when administered in a beverage, long-term intake could not lower LDL-c relative to placebo.Background. beta-glucan, a soluble dietary fibre found in barley, can reduce postprandial glycemia and serum lipids, thereby lowering risk of type 2 diabetes and cardiovascular disease. It is not clear however what amount of beta-glucan is required to significantly improve glycemic response and lipid profile, and further how the mode of administration affects the physiological response. The current thesis examines the dose-dependant effect of a barley beta-glucan concentrate on postprandial glycemia and lipid profile, and whether this affect is dependant on the mode of administration.Results. Study 1 demonstrated a dose-dependant effect of a beta-glucan beverage in attenuating postprandial glycemic response. In study 2, multiple doses of beta-glucan given in bars had no effect compared to control. In study 3, two doses of beta-glucan resulted in no effect on lipid profile.Design. To address these objectives, two double-blinded, acute, crossover randomized clinical trials (RCTs) (study 1 & 2) were conducted in healthy individuals and one long-term doubleblinded, two-centre, parallel RCT (study 3) was conducted in hypercholesterolemic individuals. In study 1 and 2, different doses of beta-glucan were examined using different modes of administration. In study 3, the effect of 6-week intake of different doses beta-glucan was examined.
Notes: Source: Masters Abstracts International, Volume: 45-06, page: 3137.

Thesis (M.Sc.)--University of Toronto, 2007.

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