DNA repair in cancer therapy
Subtitle: molecular targets and clinical applications
By: edited by Mark R. Kelley
Edition: 1st ed.
Publisher: Elsevier/Academic Press
Published: 2012
Place of publication: London; Waltham, MA
Language: eng
Number of pages: 316
ISBN-13: 9780123849991
Subjects: Genetics; Cancer; Neoplasms; Genetic aspects; DNA repair; Treatment; DNA Repair; Drug therapy
Notes: Includes bibliographical references and index.
Table of contents: title: Introduction and overview of current targets: bench to clinic / Mark R. Kelley; title: 2. MGMT a critical DNA repair gene target for chemotherapy resistance / Stanton L. Gerson and Lili Liu; title: 3. Blockade of base excision repair: inhibition of small lesions results in big consequences to cancer cells / Melissa Fishel and Carlo Vascotto; title: 4. PARP inhibitors; title: scientific rationale and clinical development for cancer / Ruth Plummer, Nicola J. Curtin and Yvette Drew; title: 5. Chemotherapy intervention by inhibiting DNA polymerases for therapeutic intervention / Anthony J. Berdis; title: 6. Targeting the nucleotide excision repair pathway for therapeutic applications / John Turchi and Stephan M. Patrick; title: 7. Homologous recombination and ATM/ATR targets / Henning Willers, Lee Zou and Heike N. Pfaffle; title: 8. DNA double strand break repair by nonhomologous end joining and its clinical relevance / Michael Weinfeld and Susan Lees-Miller; title: 9. Defective MMR-c-Abl-p73-GADD45alpha expression in cancer chemoresistance / David Boothman and Long Shan Li; title: 10. DNA repair signaling targets / Susan Ashwell; title: 11. Redox regulation of DNA repair and therapeutic / Millie M. Georgiadis; title: 12. Personalized cancer medicine: DNA repair alterations is a promising predictive marker in cancer / Srinivasan Madhusudan; title: 13. The role of DNA damage and repair in neurotoxicity caused by cancer therapies / Michael R. Vasko; title: 14. Future directions with DNA repair inhibitors / Mark R. Kelley.