Amiloride-sensitive sodium channels
Subtitle: physilogy and functional diversity
By: edited by Dale J. Benos
Series: Current topics in membranes -- v. 47
Publisher: Academic Press
Published: 1999
Place of publication: San Diego
Language: eng
Format: [electronic resource] :
Number of pages: 384
ISBN-13: 9780080585185
Subjects: Life Sciences; Cell Biology; Amiloride; Sodium Channels; SCIENCE; Sodium channels; Cellules e pithe liales; Cell membranes; Ionenkanalen; Natrium; Canaux a   sodium; Physiology
Description: Sodium reabsorbing epithelia play a major role in whole-body sodium homeostasis. Some examples of sodium regulating tissues include kidney, colon, lung, and sweat ducts. Sodium transport across these membranes is a two-step process: entry through an amiloride-sensitive sodium channel and exit via the ouabain-sensitive sodium/potassium ATPase. The sodium entry channels are the rate-limiting determinant for transport and are regulated by several different hormones. The sodium channels also play a significant role in a number of disease states, like hypertension, edema, drug-induced hyperkalemia,
Notes: Includes bibliographical references and index.

Description based on print version record.
Table of contents: title: Chapter 4. Cell-Specific Expression of ENaC and Its Regulation by Aldosterone and Vasopressin in Kidney and ColonChapter 5. Regulation of ENaC by Interacting Proteins and by Ubiquitination; Chapter 6. Role of G Proteins in the Regulation of Apical Membrane Sodium Permeability by Aldosterone in Epithelia; Chapter 7. The Role of Posttranslational Modifications of Proteins in the Cellular Mechanism of Action of Aldosterone; Chapter 8. Regulation of Amiloride-Sensitive Na+