Statistical Methodology for Sequence Analysis
Contributors: Lange, Christoph; Laird, Nan; King, Gary
Published: 2012
Language: eng
Description: Rare disease variants are receiving increasing importance in the past few years as the potential cause for many complex diseases, after the common disease variants failed to explain a large part of the missing heritability. With the advancement in sequencing techniques as well as computational capabilities, statistical methodology for analyzing rare variants is now a hot topic, especially in case-control association studies.
Notes: Keywords: Bayesian Modeling, Common Variants, Genetic Association, Rare variants, Statistical Methodology.

Thesis Ph.D. Harvard University 2012