Genetically engineered mice for cancer research
Subtitle: design, analysis, pathways, validation and pre-clinical testing
By: Jeffrey E. Green, Thomas Ried, editors
Publisher: Springer Verlag
Published: 2012
Place of publication: New York
Language: eng
Number of pages: 632
ISBN-13: 9780387698038
Subjects: Mice as laboratory animals; Transgenic mice; Animal models; Cancer; Mice; Genetic engineering
Notes: Includes bibliographical references and index.
Table of contents: title: Overview of designing genetically engineered mouse (GEM) models; title: Use of Cre-loxP technology and inducible systems to generate mouse models of cancer; title: Using recombineering technology to create genetically engineered mouse models; title: Insertional mutagenesis for generating mouse models of cancer; title: RCAS/TVA somatic gene transfer method in modeling human cancer; title: Target-selected ENU mutagenesis to develop cancer models in the rat; title: Tumor pathology of genetically engineered mice: genomic pathology; title: Genomic DNA copy number alterations in mouse cancer models and human cancer; title: Characterization of chromosomal translocations in mouse models of hematological malignancies using spectral karyotyping, FISH, and immunocytochemistry; title: Expression profiling of mouse models of human cancer: model categorization and guidance for preclinical testing; title: Imaging mouse models of human cancer; title: Identifying mammary epithelial stem and progenitor cells; title: Differentiation programs in development and cancer; title: Roles of p53 and pRB tumor suppressor networks in human cancer: insight from studies in the engineered mouse; title: Mouse models for colorectal cancer; title: Src family tyrosine kinases: implications for mammary tumor progression; title: Maspin and suppresion of tumor metastasis; title: Epigenetic mouse models; title: Modeling transforming growth factor-ss signalling in cancer; title: Modeling stromal-epithelial interactions; title: Utilizing mouse models of human cancer for assessing immune modulation of cancer development; title: Transplanted tumor models for preclinical drug testing and the potential benefit of genetically engineered mouse models; title: Development and use of genetically tractable preclinical mouse models; title: Animal models for breast cancer prevention research; title: Oncogene addiction: mouse models and clinical relevance for molecularly targeted therapies; title: Mouse models in preclinical drug development: applications to CNS models; title: Mouse models of human cancer: role in preclinical testing and personalized medicine; title: Mighty, bow how useful? The emerging role of genetically engineered mice in cancer drug discovery and development.