The effects of vanadium on bone quality in rat models of diabetes and postmenopausal osteoporosis.
Published: 2005
Language: eng
Number of pages: 168
Description: Vanadium-based drugs lower glucose by enhancing insulin's effects. Oral vanadium drugs are being tested for diabetes treatment. Vanadium accumulates in bone, though its effects on bone are unknown. The purpose of this study was to determine if incorporated vanadium affects the quality of bones in normal, diabetic and osteoporotic rats. Sham-operated, streptozotocin-induced diabetic or ovariectomized rats were treated with bis(ethylmaltolato)oxovanadium(IV) (BEOV), a vanadium-based anti-diabetic drug. Bone mechanical, mineral and remodeling parameters were examined. In normal rats, BEOV increased bone formation, bone vanadium content, mineralization and cortical toughness. In diabetic rats, BEOV improved diabetes-induced decreases in mechanical properties, mineralization and crystal length by improving the diabetic state, but also increased bone formation and bone vanadium content. In osteoporotic rats, BEOV increased bone vanadium content, but did not affect other bone quality parameters. These results suggest that BEOV has direct actions on bone cells and bone mineral in normal and diabetic bone.
Notes: Source: Masters Abstracts International, Volume: 44-01, page: 0430.

Thesis (M.A.Sc.)--University of Toronto, 2005.

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