Overexpression and Knockout of Cytokines in Transgenic Mice (Current Cytokines)
Edition: 1st edition
Publisher: Academic Press
Published: January 15, 1994
Language: eng
Format: Hardcover
Number of pages: 191
ISBN-13: 9780123784506
Subjects: Animal physiology; Biochemical immunology; Genetic engineering; Immunogenetics; Medical / Nursing; Medical; Immunology; Science / Zoology
First sentence: Interleukin-1 (IL-1) has an enormous range of reported biological activities from effects on the hematopoietic system to the reproductive system and the central nervous system (Durum and Oppenheim, 1989), an observation which provokes a number of fundamental biological questions.
Description: Cytokines are a steadily growing family of molecules which play a major role in intercellular communication. Key questions for the cytokine researcher today include 'which cytokines are involved in the pathophysiology of a disease or immune response', 'when do these cytokines function' and 'which of their many activities are relevant in vivo'.

The intricate ways in which they act, often with the exhibition of pleiotropic or synergistic effects, make the study of cytokine biology complicated, and the results potentially ambiguous using conventional systems. As a consequence, many investigators are now utilizing the powerful tools of transgenic technology to address some of these questions.

Written by the leading authorities in the field, this book describes the achievements realized so far, and clearly demonstrates the feasibility of using this approach to study the expression of this group of biologically important substances.