Botulinum neurotoxins
By: Andreas Rummel, Thomas Binz, editors
Series: Current topics in microbiology and immunology -- v.364; Current topics in microbiology and immunology -- 364.
Publisher: Springer
Published: 2013
Place of publication: Heidelberg; New York
Language: eng
Number of pages: 321
ISBN-13: 9783642335693; 9783642335709
Subjects: Botulinum toxin; Therapeutic use; Type A Botulinum Toxins; Pharmacology; Neuromuscular Agents; Botulinum toxin -- Therapeutic use; Botulinum Toxins -- therapeutic use; Toxines botuliniques; Emploi en thérapeutique
Description: The extremely potent substance botulinum neurotoxin (BoNT) has attracted much interest in diverse fields. Originally identified as cause for the rare but deadly disease botulism, military and terrorist intended to misuse this sophisticated molecule as biological weapon. This caused its classification as select agent category A by the Centers for Diseases Control and Prevention and the listing in the Biological and Toxin Weapons Convention. Later, the civilian use of BoNT as long acting peripheral muscle relaxant has turned this molecule into an indispensable pharmaceutical world wide with annual revenues >$1.5 billion--
Notes: Includes bibliographical references and index.
Table of contents: title: Genetic diversity within Clostridium botulinum serotypes, botulinum neurotoxin gene clusters and toxin subtypes  -- Karen K. Hill and Theresa J. Smith; title: Assembly and function of the botulinum neurotoxin progenitor complex  -- Shenyan Gu and Rongsheng Jin; title: Uptake of botulinum neurotoxin in the intestine  -- Yukako Fujinage, Yo Sugawara and Takuhiro Matsumura; title: Double receptor anchorage of botulinum neurotoxins accounts for their exquisite neurospecificity  -- Andreas Rummel; title: The elusive compass of clostridial neurotoxins : Deciding when and where to go?  -- Kinga Bercsenyi, Francesco Giribaldi and Giampietro Schiavo; title: Synchronized chaperone function of botulinum neurotoxin domains mediates light chain translocation into neurons  -- Audrey Fischer; title: Clostridial neurotoxin light chains : Devices for SNARE cleavage mediated blockade of neurotransmission  -- Thomas Binz; title: Synaptic vesicle proteins : Targets and routes for botulinum neurotoxins  -- Gudrun Ahnert-Hilger, Agnieszka Münster-Wandowski and Markus Höltje; title: Persistence of botulinum neurotoxin inactivation of nerve function  -- Charles B. Shoemaker and George A. Oyler; title: Structure-based drug discovery for botulinum neurotoxins  -- Subramanyam Swaminathan; title: Complexity of botulinum neurotoxins : Challenges for detection technology  -- Martin B. Dorner ... [et al.]; title: Progress in cell based assays for botulinum neurotoxin detection  -- Sabine Pellett; title: Transforming the domain structure of botulinum neurotoxins into novel therapeutics  -- John Chaddock; title: Botulinum toxin : Application, safety, and limitations -- Hans Bigalke.