Epithelial anion transport in health and disease
Subtitle: the role of the SLC26 transporters family.
Series: Novartis Foundation Symposium -- 273
Publisher: John Wiley & Sons
Published: 2006
Place of publication: Chichester, U.K
Language: eng
Number of pages: 273
ISBN-13: 9780470016244
Subjects: Epithelial cells -- Congresses; Carrier proteins -- Congresses; Ion channels -- Congresses
Genres: Congresses.
Description: This book includes chapters on the transport of other molecules by the SLC26 family, including oxalate in the kidney and sugars in cochlear hair cells amongst others. It also describes recent discoveries that most SLC26 transporters bind to scaffold proteins and that they all contain a conserved domain predicted to participate in protein-protein interactions. These suggest the SLC26 transporters exist in complexes with other Cl- and HCO3- transporters, and possibly other regulatory proteins. This book explores the functional role of these interactions, leading to better understanding of transepithelial fluid and electrolyte secretion and the diseases associated with it.
Notes: Includes bibliographical references and index.