Integrated strategies for drug discovery using mass spectrometry
By: [edited by] Mike S. Lee.
Contributors: Lee, Mike S., 1960-
Publisher: Wiley-Interscience
Published: 2005
Place of publication: Hoboken, N.J
Language: eng
Number of pages: 550
Subjects: Mass spectrometry.; Drugs -- Analysis.; High throughput screening (Drug development); Drug Design.; Pharmaceutical Preparations -- analysis.; Chromatography, Liquid -- methods.; Pharmacokinetics.; Spectrum Analysis, Mass -- methods.
Notes: Includes bibliographical references and index.
Table of contents: title: Miniaturized formats for efficient liquid chromatography mass spectrometry-based proteomics and therapeutic development / Gary A. Valaskovic and Neil Kelleher; title: Mass-spectrometry-based drug screening assays for early phases in drug discovery / Marshall M. Siegel; title: ESI-FTICR as a high throughput drug discovery platform / Kristin A. Sannes-Lowery ... [et al.]; title: Mass spectrometry-based proteomic approaches for disease diagnosis and biomarker discovery / Thomas P. Conrads ... [et al.]; title: Metabonomic applications in toxicity screening and disease diagnosis / John P. Shockcor and Elaine Holmes; title: The central role of mass spectrometry in natural products discovery / Jeffrey R. Gilbert ... [et al.]; title: Application of mass spectrometry to compound library generation, analysis, and management / Xueheng Cheng and Jill Hochlowski; title: A combinatorial process for drug discovery / David S. Wagner ... [et al.]; title: Application of technological advances in biotransformation studies / Carmen L. Fernández-Metzler, Raju Subramanian and Richard C. King; title: Applications of mass spectrometry for the characterization of reactive metabolites of drugs in discovery / Jim Wang ... [et al.]; title: Advances in high throughput quantitative drug discovery bioanalysis / Bradley L. Ackermann, Michael J. Berna and Anthony T. Murphy; title: New strategies for the implementation and support of bioanalysis in a drug metabolism environment / Walter A. Korfmacher; title: An integrated LC-MS strategy for preclinical candidate optimization / Jonathan L. Josephs and Mark Sanders; title: New approaches for method development and purification in lead optimization / Yining Zhao and David J. Semin; title: High throughput metabolic and physicochemical property analysis / Edward H. Kerns and Li Di; title: Organ perfusion and mass spectrometry / C. Gerald Curtis ... [et al.]; title: Sample preparation for drug discovery bioanalysis / David A. Wells; title: Automation / John D. Laycock and Thomas Hartmann.