The Enzymes
Subtitle: Structure and control
Edition: 3rd ed.
Publisher: Elsevier
Published: 1970
Place of publication: Oxford
Language: eng
Format: [electronic resource] :
Number of pages: 577
ISBN-13: 9780080865782
Subjects: Enzymes
Notes: Description based upon print version of record.

The Enzymes.
Table of contents: title: Front Cover; The Enzymes Structure and Control, Volume I; Copyright Page; Contents; List of Contributors; Preface; Contents of Other Volumes; Chapter 1. X-Ray Crystallography and Enzyme Structure; I. Introduction; II. Enzyme Crystals; III. X-Ray Diffraction and Principles of Protein Structure Analysis; IV. X-Ray Diffraction Studies of Globular Macromolecules; V. Summary and Conclusions; Glossary of Symbols; Chapter 2. Chemical Modification by Active-Site-Directed Reagents; I. Nature of Affnnity Labeling and Its Relationship to Chemical Modification in General; title: II. Modification of Serine Proteases by Active-Site-Directed ReagentsIII. Active Center Labeling of Other Enzymes by Directed Reagents; IV. Particular Usefulness of Active-Site-Directed Reagents; V. Conclusions; Chapter 3. Chemical Modification as a Probe of Structure and Function; I. Introduction; II. Principles of Chemical Modification; III. Methodology; IV. Modification as a Probe of Structure; V. Modification as a Probe of Function; VI. Other Uses of Chemical Modification; VII. Discussions of Specific Enzymes; VIII. Conclusions; Chapter 4. Multienzyme Complexes; I. Introduction; title: II. a-Ketoacid Dehydrogenase ComplexesIll. Fatty Acid Synthetases; IV. Multienzyme Complexes in the Biosynthesis of Aromatic Amino Acids; V. Biological Significance of Multienzyme Complexes; Chapter 5. Genetic Probes of Enzyme Structure; I. Introduction; II. Genes and Mutations; III. Specific Examples of Mutationally Altered Proteins; IV. Amino Acid Analogs; V. Advantages and Limitations of Mutants; Chapter 6. Evolution of Enzymes; I. General Considerations-Evolutionary and Structure-Function Relationships in Proteins; II. Some Principles from the Study of Cytochrome c; title: III. Expressions of Genetic Phenomena in Protein StructureIV. Expression of Evolutionary Factors in Protein Structure; Chapter 7. The Molecular Basis for Enzyme Regulation; I. Introduction; II. Qualitative Features of Molecular Models; III. Quantitative Molecular Parameters for Regulatory Proteins; IV. Diagnostic Tests; V. Molecular Properties of Allosteric Proteins; VI. Conclusions; VII. Glossary; Chapter 8. Mechanisms of Enzyme Regulation in Metabolism; I. Introduction; II. Principles of Metabolic Regulation; III. Regulation of Balance between Metabolic Functions; title: IV. Feedback Regulation of Multifunctional PathwaysChapter 9. Enzvmes as Control Elements in Metu bolic Regulation; I. Introduction; II. Analogy between Metabolic and Electronic Systems; III. Physiological Function and Design Requirements; IV. Summary; Author Index; Subject Index