Genetics of complex human diseases
By: edited by Ammar Al-Chalabi, Laura Almasy.
Contributors: Al-Chalabi, Ammar; Almasy, Laura.
Publisher: Cold Spring Harbor Laboratory Press
Published: 2010
Place of publication: Cold Spring Harbor, N.Y
Language: eng
Number of pages: 220
ISBN-13: 9780879698829; 9780879698836
Subjects: Medical genetics
Description: Many human diseases including Alzheimer's disease, schizophrenia, cancer, and cardiovascular disease have complex genetics that require sophisticated analysis. Tools that geneticists use to find disease genes with the genetic concepts and statistical theories that underpin these research approaches. Topics covered include basic genetics and Mendelian inheritance, statistical methods, genetic epidemiology, linkage studies, transmission disequilibrium test analysis, variance components analysis, genome-wide association studies, copy-number variation, methods for high-throughput genotyping, the complexity of RNA editing, and genetic computer programs. The book's chapters, written by leading investigators in the field, blend practical information and reviews of each topic, providing both the how and the why of complex disease analysis.