The Design of Synthetic Inhibitors of Thrombin (Advances in Experimental Medicine and Biology)
Contributors: Goran Claeson (Editor); Michael F. Scully (Editor); Vijay V. Kakkar (Editor); John Deadman (Editor)
Edition: 1 edition
Publisher: Springer
Published: January 31, 1994
Language: eng
Format: Hardcover
Number of pages: 256
ISBN-13: 9780306445934
Subjects: Physiology; Pharmacological Product Development; Medical; Medical / Nursing; Science/Mathematics; Life Sciences - Biochemistry; Pharmacology; Medical / Pharmacology; Science : Life Sciences - Biochemistry; Antithrombins; Congresses; Drug Design; Thrombin; antagonists & inhibitors
Description: Papers presented at a meeting held at the Thrombosis Research Institute in London, July 1991, to consider all aspects of the design of thrombin inhibitors. Among the topics: molecular basis for the inhibition of thrombin by hirudin; new peptide boronic acid inhibitors of thrombin; synthetic thrombin inhibitors as anticoagulants--pharmacological aspects; substrate-related phosphonopeptides as thrombin inhibitors; and the synthesis and anticoagulant activity of novel peptidylfluoroalkanes.