Rhythmic and synchronous firing of thalamic bursting cells in awake patients.
Published: 2004
Language: eng
Number of pages: 132
Description: Thalamic cells fire in tonic and burst mode. The burst mode is recorded when the T-type Ca2+ channels are de-inactivated as a consequence of membrane potential hyperpolarization. Succeeding depolarization causes the low-threshold Ca2+ spike (LTS). Usually observed during slow wave sleep, recently the LTS has been reported in awake patients, and associated with neurological disorders where it should be rhythmic and synchronized. The aim of the present studies was to investigate the rhythmicity and the synchronization among pair of bursting thalamic cells. 212 neurons were recorded in the anterior, medial and lateral thalamus of patients suffering from chronic pain, essential tremor, Parkinson's disease, and epilepsy. 34% of the cells were rhythmic, and 4% of the pairs showed coherent activity. The low incidence of rhythmic and synchronous firing fails to strongly support the hypothesis of synchronous activity among pairs of bursting cells in the thalamus of patients with neurological diseases during wakefulness.
Notes: Adviser: Jonathan Dostrovsky.

Thesis (M.Sc.)--University of Toronto, 2004.

Electronic version licensed for access by U. of T. users.

Source: Masters Abstracts International, Volume: 42-06, page: 2082.

MICR copy on microfiche (2 microfiches).