Role of SAP102 in NMDA receptor-mediated neurotoxicity.
Published: 2005
Language: eng
Number of pages: 117
Description: TAT-NR2B9c is a peptide containing the C-terminal PDZ binding domain from the NR2 subunit can prevent excitotoxicity and is neuroprotective during ischemic damage (Aarts, M. et al., 2002). The peptide may disrupt the interaction between Postsynaptic Density Protein -95 (PSD95) and the NMDA receptor (NMDAR), thereby uncoupling NO production from NMDAR activation. An increased production of nitric oxide (NO) is thought to underlie the excitotoxicity associated with NMDAR activation. This research has identified Synapse Associated Protein-102 (SAP102), a member of the PSD95 protein family, as a key NR2B interacting protein. The knock down cultures of SAP102 showed neuroprotective effects during NMDA toxicity assays, suggesting that the protein may be involved in NMDA receptor-mediated excitotoxic signaling pathway. Furthermore, the knock down cultures contained unchanged NO production level during excitotoxicity, supporting the notion that SAP102 does not bind to nNOS and thus does not result in increased amount of NO.
Notes: Source: Masters Abstracts International, Volume: 44-02, page: 0769.

Thesis (M.Sc.)--University of Toronto, 2005.

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