Structural virology
By: edited by Mavis Agbandje-McKenna and Robert McKenna
Contributors: Royal Society of Chemistry (Great Britain)
Series: RSC biomolecular sciences -- no. 21; RSC biomolecular sciences -- no. 21.
Publisher: RSC Publishing
Published: 2011
Place of publication: Cambridge
Language: eng
Number of pages: 371
ISBN-13: 9780854041718
Subjects: Molecular virology; Virus Physiological Phenomena; Nucleocapsid Proteins; Viruses; Morphology; Ultrastructure
Description: "Structural Virology covers a wide range of topics and is split into three sections. The first discusses the vast biophysical methodologies used in structural virology, including sample production and purification, confocal microscopy, mass spectrometry, negative-stain and cryo-electron microscopy, X-ray crystallography and nuclear magnetic resonance spectroscopy. The second discusses the role of virus capsid protein structures in determining the functional roles required for receptor recognition, cellular entry, capsid assembly, genome packaging and mechanisms of host immune system evasion. The last section discusses therapeutic strategies based on virus protein structures, including the design of antiviral drugs and the development of viral capsids as vehicles for foreign gene delivery"--From publisher's description.
Notes: Includes bibliographical references and index.
Table of contents: title: Production and purification of viruses for structural studies / Brittney L. Gurda and Mavis Agbandje-McKenna; title: Microscopic analysis of viral cell binding, entry and infection in live cells / Colin R. Parrish; title: Probing viral capsids in solution / Brian Bothner and Jonathan K. Hilmer; title: Three-dimensional structures of pleiomorphic viruses from cryo-electron tomography / Alasdair C. Steven, Giovanni Cardone, Carmen Butan, Dennis C. Winkler and J. Bernard Heymann; title: Structure determination of icosahedral viruses imaged by cryo-electron microscopy / Robert S. Sinkovits and Timothy S. Baker; title: X-ray crystallography of virus capsids / Lakshmanan Govindasamy, Mavis Agbandje-McKenna and Robert McKenna; title: Structural studies of viral proteins : x-ray crystallography / John Domsic and Robert McKenna; title: Solution NMR spectroscopy in characterizing structure, dynamics and intermolecular interactions of retroviral structural proteins / Kang Chen and Nico Tjandra; title: Evolution of viral capsid structures : the three domains of life / Reza Khayat and John E. Johnson; title: Mechanisms of icosahedral virus assembly / Adam Zlotnick and Bentley S. Fane; title: Mechanisms of genome packaging / Mark Oram and Lindsay W. Black; title: Attachment and entry : receptor recognition in viral pathogenesis / Damian C. Ekiert and Ian A. Wilson; title: Attachment and entry : viral cell fusion / Rachel M. Schowalter, Everett C. Smith and Rebecca Ellis Dutch; title: Structural studies on antibody-virus complexes / Thomas J. Smith; title: Development of anti-HIV drugs / Roxana M. Coman and Robert McKenna; title: Design of capsid-binding antiviral agents against human rhinoviruses / Chuan Xiao, Mark A. McKinlay and Michael G. Rossmann; title: Viral vectors for gene delivery / David J. Dismuka, Steven J. Gray, Matthew L. Hirsch, Richard Samulski and Nicholas Muzyczka.