In vitro toxicology systems
By: edited by Anna Bal-Price, European Union Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM), Systems Toxicology Unit, Institute for Health and Consumer Protection, Joint Research Centre, European Commision, Ispra (VA), Italy, Paul Jennings, Division of Physiology, Department of Physiology and Medical Physics, Innsbruck Medical University, Innsbruck, Austria
Series: Methods in pharmacology and toxicology; Springer protocols; Methods in pharmacology and toxicology; Springer protocols (Series)
Publisher: Humana Press
Published: 2014
Place of publication: New York, NY
Language: eng
Number of pages: 583
ISBN-13: 9781493905201; 9781493905218
Copyright date: 2014
Subjects: Alternative toxicity testing; Toxicity Tests; Laboratory Manuals; Animal Testing Alternatives
Description: In Vitro Toxicology Systems brings together important issues and considerations needed in order to develop a workable, reliable, integrated testing strategy for the replacement of animals in toxicity testing regimes. This thorough volume includes sections on in vitro models for systemic organ toxicity, neurotoxicity, sensory organs, immunotoxicity and reproductive toxicity and addresses how stem cells may be used going forward. The book also tackles difficult areas of toxicology such as carcinogenicity and nanotoxicology, with additional chapters dedicated to kinetics, metabolism, and in vitro in vivo extrapolation. The book also addresses biological processes such as stress response pathways and mechanistic biomarkers and how these can be uncovered and measured using high content approaches. Reliable and authoritative, In Vitro Toxicology Systems will be of benefit not only to students, scientists, and regulators working in the field of chemical safety assessment but also to a wider scientific audience.--
Notes: Includes bibliographical references and index.
Table of contents: title: Machine generated contents note: pt. I Introduction; title: 1.The Past, Present, and Future of Chemical Risk Assessment / Alice Limonciel; title: pt. II Systemic Organ Toxicity; title: 2.In Vitro Systems for Hepatotoxicity Testing / Patricio Godoy; title: 3.In Vitro Methods for Cardiotoxicity Testing / Agapios Sachinidis; title: 4.Renal Cell Culture / Gerhard Gstraunthaler; title: 5.Cellular Models for In Vitro Lung Toxicology / Oliver H. Wittekindt; title: pt. III Neurotoxicity; title: 6.In Vitro Developmental Neurotoxicity Testing: Relevant Models and Endpoints / Helena T. Hogberg; title: 7.Blood; title: Brain Barrier In Vitro Models and Their Applications in Toxicology / Maxime Culot; title: pt. IV Sensory Organ Models; title: 8.Ocular Toxicity / Valerie Zuang; title: 9.In Vitro Models for Ototoxic Research / Michael G. Leitner; title: pt. V Other Organs and Aspects; title: 10.Dermal Toxicity: Skin Sensitization / Silvia Casati; title: 11.Immunotoxicity / Thomas Hartung; title: 12.Reproductive Toxicity / Cesare Galli