Comparative toxicology of hypolipidaemic fibrates
By: Mary J. Tucker and Terry C. Orton.
Contributors: Orton, Terry C.
Publisher: Taylor & Francis
Published: 1995
Place of publication: London; Bristol, PA
Language: eng
Number of pages: 101
Subjects: Antilipemic Agents -- toxicity.; Clofibrate -- toxicity.; Clofenapate -- toxicity.; Clofibrate -- Toxicology.; Methylclofenapate -- Toxicology.; Clobuzarit -- Toxicology.; Hypolipemia -- Chemotherapy.; Peroxisomes.; Enzyme induction.; Xenobiotics -- Metabolism.; Drugs -- Metabolism.; Biochemical toxicology.
Description: Drug toxicology data are generally confidential due to their commercial value and consequently very little data are published in the scientific literature. This book therefore provides a unique opportunity to follow the detailed toxicology programmes for three drugs with information on how and when decisions were made to investigate key findings and to terminate development. Hypolipidaemic fibrates are a class of drugs developed for the treatment of lipid disorders in man. Toxicology studies have linked them with peroxisome proliferation and, in turn, liver cancer in rodents. This book provides a detailed record of regulatory studies carried out by ICI (now Zeneca) Pharmaceuticals on three fibrates, namely, clofibrate, methylclofenapate and clobuzarit. Comparative Toxicology of Hypolipidaemic Fibrates constitutes a comprehensive database on the long-term, acute and chronic toxicity of these compounds. Toxicologists will find details of the design of toxicity, teratogenicity and oncogenicity tests. Salient results of chemical pathology, pharmacokinetics and tissue pathology are presented, together with the predictions arising from these studies. Unique data in the book include 7-year studies and hepatotoxicity tests in many species.
Notes: Includes bibliographical references (p. 93-95) and index.