Biologic foundations for skeletal tissue engineering
By: Ericka M. Bueno, Julie Glowacki
Contributors: Glowacki, Julie
Series: Synthesis lectures on tissue engineering -- # 7
Publisher: Morgan & Claypool
Published: 2011
Place of publication: San Rafael, Calif. (1537 Fourth Street, San Rafael, CA 94901 USA)
Language: eng
Format: [electronic resource] /
ISBN-13: 9781608451739; 9781608451722
Subjects: Tissue Engineering; Bone Regeneration; Cartilage; Tissue engineering; Regeneration; Bone regeneration
Other titles: Synthesis digital library of engineering and computer science.
Description: Tissue engineering research for bone and joint applications entails multidisciplinary teams bringing together the needed expertise in anatomy, biology, biochemistry, pathophysiology, materials science, biomechanics, fluidics, and clinical and veterinary orthopedics. It is the goal of this volume to provide students and investigators who are entering this exciting area with an understanding of the biologic foundations necessary to appreciate the problems in bone and cartilage that may benefit from innovative tissue engineering approaches. This volume includes state-of-the-art information about bone and cartilage physiology at the levels of cell and molecular biology, tissue structure, developmental processes, their metabolic and structural functions, responses to injury, mechanisms of post-natal healing and graft incorporation, the many congenital and acquired disorders, effects of aging, and current clinical standards of care. It reviews the strengths and limitations of various experimental animal models, sources of cells, composition and design of scaffolds, activities of growth factors and genes to enhance histogenesis, and the need for new materials in the context of cell-based and cell-free tissue engineering. These building blocks constitute the dynamic environments in which innovative approaches are needed for addressing debilitating disorders of the skeleton. It is likely that a single tactic will not be sufficient for different applications because of variations in the systemic and local environments. The realizations that tissue regeneration is complex and dynamic underscore the continuing need for innovative multidisciplinary investigations, with an eye to simple and safe therapies for disabled patients.
Notes: Part of: Synthesis digital library of engineering and computer science.

Series from website.

Includes bibliographical references (p. 127-208).

Abstract freely available; full-text restricted to subscribers or individual document purchasers.

Also available in print.

Mode of access: World Wide Web.

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Table of contents: title: 1. Introduction; title: 2. Structure and function of bone and cartilage tissue; title: Bone; title: Structure; title: Function; title: Mechanical properties; title: Articular cartilage; title: Structure; title: Function; title: Mechanical properties; title: 3. Development; title: Intramembranous bone formation; title: Endochondral bone formation; title: Articular cartilage; title: 4. Responses to injury and grafting; title: Bone; title: Microfractures; title: Bone fractures; title: Fracture healing; title: Distraction osteogenesis; title: Comparison of post-natal fracture healing and skeletal embryogenesis; title: Bone grafts, implants, and bone substitute materials; title: Cartilage; title: 5. Clinical applications for skeletal tissue engineering; title: Disorders in bone; title: Focal deficiencies; title: Systemic disorders of bone; title: Cartilage; title: Osteoarthritis; title: Rheumatoid arthritis; title: Osteochondritis dissecans; title: Temporomandibular joint (TMJ) disorders; title: 6. Animal models; title: Bone; title: Biocompatibility; title: Osteocompatibility; title: Bone substitutes; title: Clinical relevance; title: Cartilage; title: 7. Tissue engineering principles for bone and cartilage; title: Bone; title: Scaffolds; title: Bioactive factors; title: Cells; title: In vitro studies; title: In vivo studies; title: Cartilage; title: Scaffolds; title: Bioactive factors; title: Cells; title: In vitro studies; title: In vivo studies; title: 8. Perspectives; title: References; title: Authors' biographies.