Involvement of the anterior cingulate cortex in remote conditioned taste aversion memory recall.
Published: 2006
Language: eng
Number of pages: 117
ISBN-13: 9780494213674
Description: We studied time-dependent reorganization of neuronal circuitry underlying permanent memory storage by examining the involvement of the anterior cingulate cortex (ACC) in remote memory recall of conditioned taste aversion (CTA) in mice. Results showed that a 0.30M lithium chloride (LiCl) injection produced a stronger CTA memory and reduced locomotor activity more rapidly in mice than a 0.15M LiCl injection. We then showed that reversible inactivation of the ACC by lidocaine, a sodium charnel blocker, temporarily blocked remote (30 day old) but rot recent (1 day old) CTA memory in mice trained with 0.15M or 0.30M LiCl. Furthermore, intra-ACC infusion of CNQX (5mM), an AMPA receptor antagonist, reduced Fos expression within the ACC, but infusion of CNQX (5mM or 15mM) had no effect on remote CTA memory recall. Thus, ACC's involvement in remote CTA memory recall may be mediated by non-AMPA-dependent transmission.
Notes: Source: Masters Abstracts International, Volume: 45-03, page: 1395.

Thesis (M.Sc.)--University of Toronto, 2006.

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