Analytical Method Development by Liquid Chromatography
Subtitle: Development and Validation of Analytical Methods for the Assay of Selected Drugs in Pharmaceutical Dosage forms and Biological fluids
Publisher: LAP Lambert Academic Publishing
Published: 2011-10-25
Place of publication: Germany
Language: eng
Format: Paperback
Number of pages: 352
ISBN-13: 9783844328691
Description: Analytical methods development and validation play important roles in the discovery, development, and manufacture of pharmaceuticals. The current good manufacturing practice (cGMP) and Food Drug Administration (FDA) Guidelines insist for adoption of sound methods of analysis with greater sensitivity and reproducibility. This thesis describes analytical methods developed for drug determination in pharmaceutical dosage forms and biological matrixes including Chromatography (RP-HPLC) and Hyphenated Techniques (LC-MS/MS). Methods have been developed for separation and quantification of selected drugs from categories like Antihypertensive, Antihyperlipidemic, Skeletal Muscle Relaxant, Non-Steroidal Anti-inflammatory Drug (NSAID), Antibiotic, Anticonvulsant, Antiviral, and Analeptic.