Drug stereochemistry
Subtitle: analytical methods and pharmacology
By: edited by Krzysztof Jozwiak, W. John Lough, Irving W. Wainer
Edition: 3rd ed.
Series: Drugs and the pharmaceutical science series -- 211; Drugs and the pharmaceutical sciences -- v. 211.
Publisher: Informa Healthcare
Published: 2012
Place of publication: New York
Language: eng
Number of pages: 322
ISBN-13: 9781420092387
Subjects: Molecular Conformation; Stereoisomerism; Methods; Pharmaceutical Chemistry
Description: "Updated to reflect modern advances in the techniques and methodology of drug stereochemistry, the Third Edition comprehensively presents all aspects of chiral drugs from scientific, academic, governmental, industrial, and clinical points of view. This stand-alone text covers the lifespan of stereochemistry, from its early history, including an overview of terms and concepts, to the current drug development process, legal and regulatory issues, and the new stereoisomeric drugs. New topics in the Third Edition include: The use of enzymes in the synthesis and resolution of enantiometrically pure compounds in drug discovery; How stereochemistry impacts decisions made in the Absorption, Distribution, Metabolism, Excretion, and Toxicity (ADMET) stages of drug discovery; A chapter on pharmacokinetics and pharmacodynamics that discusses the issues faced during the final stages of the drug development process; The impact of International Conference on Harmonisation on the use of single isomer drugs; Racemic switches; The concept of molecular chiral recognition and how it affects the separation and behavior of stereochemically pure drugs; A chapter on the legal perspectives of patent issues surrounding racemic switches and the marketing of single enantiomer switches"--Provided by publisher.
Notes: Includes bibliographical references and index.