The effects of dioxin on mandibular incisor socket healing in a rat model.
Published: 2005
Language: eng
Number of pages: 85
Description: Introduction. It has been suggested that aryl hydrocarbons (Ah), found in cigarette smoke might be linked to poor wound healing in bone.Conclusions. Dioxin did not alter bone wound healing in this model. This may be related to the fact that dioxin does not seem to interfere with function of fully differentiated osteoblasts.Purpose. To determine if dioxin affects osseous wound healing.Method. A rat incisor tooth extraction model was used. Female Sprague-Dawley rats were assigned randomly into three treatment groups (control, 0.25 ug/kg dioxin, 1.0 ug/kg dioxin). They were given a total of 8 intraperitoneal injections biweekly starting the day before incisor extraction. The animals were sacrificed at 28 days. Analysis of socket bone fill was determined in a blinded fashion using a bone histomorphometry program.Results. Wound closure was unaffected by treatment with dioxin, all extraction site wounds healing at the same rate.
Notes: Source: Masters Abstracts International, Volume: 44-02, page: 0807.

Thesis (M.Sc.)--University of Toronto, 2005.

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