The neurology of AIDS
By: edited by Howard E. Gendelman ... [et al.].
Edition: 3rd ed.
Publisher: Oxford University Press; Oxford University Press, USA
Published: 2012
Place of publication: Oxford
Language: eng
Number of pages: 1115
ISBN-13: 9780195399349
Subjects: Etiology; Central Nervous System Diseases; Neurology; AIDS (Disease); Complications; Neurologic Manifestations; Acquired Immunodeficiency Syndrome
Description: Neurological complications of progressive HIV-1 infection remain a common cause of morbidity even during widespread use of antiretroviral therapy (ART). Long-term resistance to ART, drug compliance, untoward drug side effects, a myriad of opportunistic infection, depression and other psychiatric disease manifestations, concomitant drug abuse, neuropathies, and an inability to clear viral reservoirs, explain, in large measure, disease progression and immune deterioration. These are associated with a number of psychiatric, muscle, nerve, infectious, as well as cognitive, behavioral, and motor disturbances seen in infected people. Fully updated from the previous two editions and replete with color images, The Neurology of AIDS, Third Edition covers each of these neurological complications and more with a focus on molecular and viral disease processes, cellular factors influencing viral replication therapeutic challenges, and the changing epidemiological patterns of disease. From basic science to clinical care, to epidemiological disease patters, this book is the only complete textbook available on AIDS neurology and the only one comprehensive enough to stand alone in each segment of study in brain disorders affected by the human immunodeficiency virus. It is an resource for students, resident physicians, practicing physicians, and for researchers and experts in the HIV/AIDS field.
Notes: Includes bibliographical references and index.
Table of contents: title: HIV-1 biology and immunology; title: Innate and cellular immunity and neurogenesis; title: Blood brain barrier and HIV CNS entry; title: Cellular and viral neurotoxicity and abused drugs; title: Animal models; title: Personal perspectives in living with HIV/AIDS; title: Clinical and pathologic manifestations of disease; title: Pathogenesis of co-morbid conditions; title: Diagnostics and biomarkers; title: Children and adolescents; title: Antiretroviral and adjunctive therapies; title: Psychiatry and psychobiology.