The risk of postpartum haemorrhage (PPH) with selective serotonin reuptake inhibitors (SSRIs) and other antidepressants.
Published: 2006
Language: eng
Number of pages: 104
ISBN-13: 9780494213612
Description: Objective. To determine if PPH was associated with third trimester antidepressant exposure, particularly SSRIs. Methods. This population-based nested case-control study of Ontario women with government-funded prescription coverage identified case patients who experienced PPH and randomly selected matched controls (1:10) from the same cohort. Hospitalisation records and prescription claims data were linked to ascertain outcomes and exposures for the study period (January 1999-March 2005). Results. There were 2.460 cases of PPH and 23.943 matched controls. Adjusted odds ratios for the association between PPH and exposure to SSRIs and non-SSRIs within 90 days prior to index were 1.30 (95% confidence interval 0.98-1.72) and 1.12 (95% confidence interval 0.62-2.01), respectively. Conclusions. Results were not consistent with a significantly increased risk of PPH in association with antidepressant exposure. Findings are applicable in risk-benefit assessments and are of public health importance given the prevalence of antenatal depression and the need to consider appropriate treatment strategies.
Notes: Source: Masters Abstracts International, Volume: 45-03, page: 1470.

Thesis (M.Sc.)--University of Toronto, 2006.

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