Protein Structure Prediction (Methods in Molecular Biology)
Contributors: Mohammed Zaki (Editor); Chris Bystroff (Editor)
Edition: 2nd ed. edition
Publisher: Humana Press
Published: September 12, 2007
Language: eng
Format: Hardcover
Number of pages: 337
ISBN-13: 9781588297525
Subjects: Proteins; Science; Science/Mathematics; Life Sciences - Biochemistry; Life Sciences - Biology - Molecular Biology; Computational methods; Data-driven comparative modeling; Protein folding; Protein interaction; Science / Biochemistry; Structure alignment
Description: This book covers elements of both the data-driven comparative modeling approach to structure prediction and also recent attempts to simulate folding using explicit or simplified models. Despite the unsolved mystery of how a protein folds, advances are being made in predicting the interactions of proteins with other molecules, such as small ligands, nucleic acids or other proteins. Also rapidly advancing are the methods for solving the inverse folding problem, the problem of finding a sequence to fit a structure. This book focuses on the various computational methods for prediction, their successes and their limitations, from the perspective of their most well known practitioners.