Where proteins go to die
Subtitle: Elucidating the physiological and therapeutic significance of the Clp protease complex in Mycobacterium tuberculosis
Contributors: Rubin, Eric J.; Wirth, Dyann; Fortune, Sarah; Duraisingh, Manoj; Ehrt, Sabine
Published: 2012
Language: eng
Description: Microbiologists have long focused on transcription as a main source of physiological regulation in bacterial adaptation. However, the time scale on which certain cellular responses must be coordinated dictates that a more rapid system be in place to deal with sudden environmental stresses. In eukaryotes, understanding the proteasome and ubiquitin-tagging has led to an appreciation for protein turnover as a mechanism for rapid adaptation.
Notes: Keywords: beta-lactones, Clp, Mycobacteria, protease, Tuberculosis.

Thesis Ph.D. Harvard University 2012