Role of Neto proteins in hippocampus dependent learning and memory.
Published: 2006
Language: eng
Number of pages: 97
ISBN-13: 9780494214480
Description: Neto 1 and Neto 2 are neural-specific proteins with largely overlapping regions of expression in the hippocampus (Ng et al., 2006 submitted). The immunoprecipitation studies demonstrated direct interaction of Neto 1 protein with N-methyl-D-aspartate receptors (NMDAR). NMDA receptors are of vital importance for hippocampus-dependent learning and memory and long term potentiation (LTP). LTP measured at the Schaffer collateral-CA1 was impaired in Neto 1 -/- hippocampal slices. Ng et al., (2006, submitted). Present study demonstrated that Neto 1-/- mice were impaired in hippocampus-dependent contrary to Neto 2-/- mice that showed normal learning in hippocampus dependent tests. It is possible that presence of Neto 1 protein may compensate for the absence of Neto 2 protein, since loss of both Neto 1 and Neto 2 protein in Neto 1-/-2-/- mice resulted in severe deficits in spatial learning which were improved with modulator of the AMPA receptor, CX-546. Thus, Neto proteins serve a role in hippocampus-dependent learning and memory.
Notes: Source: Masters Abstracts International, Volume: 45-03, page: 1396.

Thesis (M.Sc.)--University of Toronto, 2006.

Electronic version licensed for access by U. of T. users.

ROBARTS MICROTEXT copy on microfiche.