Localization of maternal HSP83 mRNA to the posterior pole of the Drosophilia embryo.
Published: 2005
Language: eng
Number of pages: 129
Description: RNA localization is an important means of post-transcriptional control in eukaryotic organisms. In the early Drosophila embryo, generalized degradation in the bulk cytoplasm coupled with local protection from degradation at the posterior localizes Hsp83 mRNA to the posterior pole. Degradation-protection is mediated by cis-acting elements: (i) those that target the transcript for degradation; and (ii) those that target it for protection in an intracellular region. This thesis describes the cis-acting requirements of Hsp83 mRNA protection at the posterior of the unfertilized egg. Ultimately this work should lead to identification of the trans-acting factors that interact with this cis-element and the elucidiation of the molecular mechanism of transcript protection. Finally, the protection element characterized in this study may eventually help us define a consensus protection element that can then be used to identify other transcripts localized by degradation-protection.
Notes: Source: Masters Abstracts International, Volume: 44-02, page: 0763.

Thesis (M.Sc.)--University of Toronto, 2005.

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