Statistical methods for dynamic treatment regimes
Subtitle: reinforcement learning, causal inference, and personalized medicine
By: Bibhas Chakraborty, Erica E.M. Moodie
Contributors: Moodie, Erica E. M., author
Series: Statistics for biology and health; Statistics for biology and health
Publisher: Springer
Published: 2013
Place of publication: New York, NY
Language: eng
Number of pages: 204
ISBN-13: 9781461474272; 9781461474289
Copyright date: 2013
Subjects: Medical statistics; Medical records; Data processing; Statistics as Topic; Methods; Statistical Data Interpretation; Evidence-Based Medicine; Longitudinal Studies; Statistical Models
Description: Presents statistical methods developed to address questions of estimation and inference for dynamic treatment regimes, a branch of personalized medicine. These methods are demonstrated with their conceptual underpinnings and illustration through analysis of real and simulated data, and their application to the practice of personalized medicine, which emphasizes the systematic use of individual patient information to optimize patient health care. Provides an overview of methodology and results gathered from journals, proceedings, and technical reports with the goal of orienting researchers to the field. Readers need familiarity with elementary calculus, linear algebra, and basic large-sample theory to use this text. Throughout the text, authors direct readers to available code or packages in different statistical languages to facilitate implementation. In cases where code does not already exist, the authors provide analytic approaches in sufficient detail that any researcher with knowledge of statistical programming could implement the methods from scratch. Applicable to a wide range of researchers, including statisticians, epidemiologists, medical researchers, and machine learning researchers interested in medical applications, as well as advanced graduate students in statistics and biostatistics --
Notes: Includes bibliographical references (pages 185-201) and index.
Table of contents: title: Introduction; title: The data : observational studies and sequentially randomized trials; title: Statistical reinforcement learning; title: Semi-parametric estimation of optimal DTRs by modeling contrasts of conditional mean outcomes; title: Estimation of optimal DTRs by directly modeling regimes; title: G-computation: parametric estimation of optimal DTRs; title: Estimation DTRs for alternative outcome types; title: Inference and non-regularity; title: Additional considerations and final thoughts.