The effects of recurrent restraint stress on counterregulation to subsequent stressors of restraint and hypoglycemia in diabetes.
Published: 2006
Language: eng
Number of pages: 151
ISBN-13: 9780494163917
Description: Our laboratory has shown impaired stress responsiveness, and defective hypoglycemic counterregulation following recurrent hypoglycemia, in diabetic rats. Presently, we investigate the effect of recurrent neurogenic stress on subsequent counterregulation to similar (homotypic, restraint) and different (heterotypic, hypoglycemia) stressors in non-diabetic and streptozotocin-diabetic rats. Naive control and recurrently restraint-stressed non-diabetic and diabetic rats were subjected to hypoglycemia and restraint, and counterregulatory hormones responses were measured. Diabetes resulted in impaired ACTH and corticosterone responses to restraint but enhanced ACTH, corticosterone, and epinephrine to responses hypoglycemia. Furthermore, diabetic rats showed hierarchy of hypoglycemic counterregulation. Rats showed similar glucagon habituation to homotypic stress, and epinephrine response in recurrently stressed diabetic rats was abolished. Moreover, heterotypic corticosterone and glucagon potentiation was lost in diabetic rats. These experiments show for the first time that recurrent neurogenic stress exerts divergent changes in diabetic stress counterregulation. These findings may have implications for daily stress management in diabetic patients.
Notes: Source: Masters Abstracts International, Volume: 44-06, page: 2719.

Thesis (M.Sc.)--University of Toronto, 2006.

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