Rhesus macaque KIR recognition of MHC class I molecules
Subtitle: Ligand identification and modulation of interaction by SIV peptides
Contributors: Evans, David T.; Gabuzda, Dana; Williams, Kenneth; Allen, Todd; Le Gall, Sylvie
Published: 2014
Language: eng
Description: Natural killer (NK) cells can kill virus-infected cells without prior antigenic exposure, and are therefore important for controlling viral replication prior to the onset of adaptive immune responses. Primate NK cells express activating and inhibitory killer-cell immunoglobulin-like receptors (KIRs) that bind to specific major histocompatibility complex (MHC) class I molecules. The importance of KIR interactions with MHC class I in human immunodeficiency virus (HIV) pathogenesis is demonstrated by the association of select KIR and MHC class I genotypes with delayed progression to acquired immunodeficiency syndrome (AIDS).
Notes: Keywords: KIR, MHC class I, NK cell, Rhesus macaque, SIV.

Thesis Ph.D. Harvard University 2014