The role of TRP channels in auditory transduction and amplification in Drosophila
Contributors: Corey, David; Eatock, Ruth A.; Garrity, Paul; Holt, Jeffrey
Published: 2012
Language: eng
Description: Auditory receptor cells rely on force-gated channels to transform sound stimuli into neural activity. These primary auditory neurons form the first stage of the neural circuits that support a host of higher-order functions, such as the localization of sound or the comprehension of speech. The mechanisms of sound transduction, as well as higher-order processes such as acoustic communication during courtship, can be studied in the fruit fly Drosophila melangogaster, a model organism with a suite of powerful genetic tools. However, this work is hampered by incomplete knowledge of the components of the Drosophila auditory system and a lack of high resolution techniques for investigating their function.
Notes: Keywords: auditory, drosophila, electrophysiology, transduction, trp.

Thesis Ph.D. Harvard University 2012