Characterization of the endoplasmic reticulum stress response in bipolar-I disorder.
Published: 2006
Language: eng
Number of pages: 120
ISBN-13: 9780494213537
Description: Considerable evidence suggests dysregulation in intracellular calcium signaling and endoplasmic reticulum (ER) function plays a role in the pathophysiology of bipolar disorder (BD). Perturbed intracellular Ca2+ dynamics can result in misfolded and unfolded protein accumulation in the ER lumen, activating a rescuing pathway named the ER stress response. We examined whether ER stress response is altered in BD-I patients and the relationship with basal intracellular Ca2+ levels in B lymphoblast cell lines (BLCLs) from BD-I patients.ER stress induction of XBP1, CHOP, and GRP78 was determined by real time quantitative PCR in BLCLs from BD-I patients with high basal calcium levels ([Ca2+]B) compared to those with normal [Ca 2+]B, and controls. Compared with controls, XBP1 and CHOP, but not GRP78, induction was significantly louver in BD-I patients, all independent of [Ca2+]B levels. The results suggest that ER stress response disturbances occur in BD-I disorder, irrespective of altered intracellular Ca2+ dynamics.
Notes: Source: Masters Abstracts International, Volume: 45-03, page: 1474.

Thesis (M.Sc.)--University of Toronto, 2006.

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