Investigation of the mechanism and specificity of D-Ala-D-Ala ligases in bacterial cell wall biosynthesis and the VanA (D-Ala-D-Lac ligase) and VanC2 (D-Ala-D-Ser ligase) variants that underlie vancomycin resistance
By: a thesis presented by Vicki Lynn Healy
Published: 2000
Language: eng
Number of pages: 123
Subjects: Bacterial cell walls; Bacterial genetics; Vancomycin resistance; Cellular signal transduction
Notes: Thesis (Ph. D., Division of Medical Sciences (Biological Chemistry and and Molecular Pharmacology))--Harvard University, 2000.

Includes bibliographical references.
Table of contents: title: Includes two offprints :; title: Active-site mutants of the VanC2 D-alanyl-D-serine ligase, characteristic of one vancomycin-resistant bacterial phenotype, revert towards wild-type D-alanyl-D-alanine ligases  -- Vicki L. Healy, Il-Seon Park and Christopher T. Walsh -- (Chemistry & biology, v.5, April 1998, pp.197-207); title: Determinants for differential effects on D-Ala-D-Lactate vs D-Ala-D-Ala formation by the VanA ligase from vancomycin-resistant enterococci-- (Biochemistry, v.38, October 1999, pp.14006-14022)