High frequency ultrasound for monitoring changes in liver tissue during preservation.
Published: 2005
Language: eng
Number of pages: 85
Description: To examine the effects of liver ischemia at different temperatures livers from Wistar rats were surgically excised, immersed in phosphate buffer saline and stored at 4 and 20&deg;C for 24h. To mimic organ preservation, livers were excised, flushed with University of Wisconsin (UW) solution and stored at 4&deg;C for 24h. Preservation injury was simulated by either not flushing livers with UW solution or, before scanning, allowing livers to reach room temperature. Ultrasound images and corresponding radio-frequency data were collected over the ischemic period.In this study I use high frequency ultrasound integrated backscatter (HFUIB) to assess liver damage in experimental models of liver ischemia.No significant increase in HFUIB (&sim;2.5dBr) was measured for the livers prepared using standard preservation conditions. For all other ischemia models, HFUIB increased by 4--9 dBr, demonstrating kinetics dependent on storage conditions. The results provide a potential framework for using high frequency ultrasound imaging to non-invasively assess liver preservation injury.
Notes: Source: Masters Abstracts International, Volume: 44-01, page: 0275.

Thesis (M.Sc.)--University of Toronto, 2005.

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