Oral bisphosphonates for treatment of sublesional osteoporosis after spinal cord injury: A retrospective cohort study.
Published: 2007
Language: eng
Number of pages: 227
ISBN-13: 9780494273418
Description: This retrospective analytic cohort study compared the proportion of bisphosphonate users versus nonusers with a 5% clinically important increase in bone mineral density (CII in BMD) of the total hip region from baseline over a minimum 18 month period among subjects with spinal cord injury (SCI) and sublesional osteoporosis. Eligible SCI subjects (n = 64) were identified from two rehabilitation centres in Ontario with a total hip BMD T-score of &le;-1.5 and two hip BMD measures &ge;18 months apart. BMD measures were obtained via chart abstraction. Bisphosphonate exposure was self reported. Users (n = 42) were defined by &ge;60% adherence. There was no difference in the proportion of users 35.7% (15/42) versus nonusers 31.5% (8/22) with a CII in BMD of the total hip (Fisher's Exact test, df = 1, p = 0.58). A median 36 months exposure did not predict a CII in BMD of the total hip region.
Notes: Source: Masters Abstracts International, Volume: 45-06, page: 3119.

Thesis (M.Sc.)--University of Toronto, 2007.

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