Exploring genetic redundancy and uniqueness in Arabidopsis  using a bioinformatics approach.
Published: 2006
Language: eng
Number of pages: 84
ISBN-13: 9780494211670
Description: Genetic redundancy is a common phenomenon in Arabidopsis thaliana and is thought to be responsible for the lack of phenotype in a majority of single loss-of-function mutants. The availability of large-scale public gene expression data sets, enabled bioinformatics approaches to be used to study this concept. During this study, a database, the Botany Array Resource (BAR) was set up for the collection and management of Arabidopsis  expression data along with data mining tools for their meaningful exploration. A list of 'redundant' genes was generated using BAR. From this list two pairs of genes were selected for biological validation. In this study, we show absence of redundancy at the phenotypic level for our so-called redundant gene pairs. Finally, we introduce a novel tool that using gene expression data can help in investigating genetic redundancy and uniqueness at the expression level and help guide hypothesis generation. This tool is available at  http://bbc.botany.utoronto.ca/agurr.
Notes: Source: Masters Abstracts International, Volume: 45-03, page: 1351.

Thesis (M.Sc.)--University of Toronto, 2006.

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