Genetic manipulation of receptor expression and function
By: edited by Domenico Accili
Contributors: Accili, Domenico
Series: Receptor biochemistry and methodology; Receptor biochemistry and methodology (Unnumbered)
Publisher: Wiley-Liss
Published: 2000
Place of publication: New York
Language: eng
Number of pages: 240
Subjects: Cell receptors; Genetic engineering; Gene targeting; Cell receptors -- Research -- Methodology
Notes: Includes bibliographical references and index
Table of contents: title: Ch. 1. Transgenic rescue of mutant phenotypes using large DNA fragments; title: Ch. 2. Behavioral characterization of transgenic and knockout mice; title: Ch. 3. Genetic analysis of receptor phenotypes; title: Ch. 4. Immortalization of cell lines from transgenic and knockout mice by viral transformation; title: Ch. 5. The VP16-dependent binary system for inducible gene expression in transgenic mice; title: Ch. 6. Gene-targeting strategies in the analysis of alcohol and anesthetic mechanisms; title: Ch. 7. In vivo functions of the c-Met gene:(HGF/SF receptor); title: Ch. 8. Tissue-specific knockouts of insulin receptor tyrosine kinase; title: Ch. 9. Targeted dominant negative mutations; title: Ch. 10. Toxin-mediated targeted cell ablation in vivo; title: Ch. 11. Antisense RNA-mediated inhibition of gene expression; title: Ch. 12. Delivery of antisense oligonucleotides to the brain to analyze receptor function