Component-Based Syntheses of Trioxacarcins
Contributors: Myers, Andrew G.; Jacobsen, Eric N.; Shair, Matthew D.
Published: 2014
Language: eng
Description: The trioxacarcins are structurally complex, highly oxygenated bacterial isolates that potently inhibit the growth of human cancer cells in culture as a consequence of their ability to alkylate guanosine residues of duplex DNA. This dissertation presents a component-based synthetic route to the trioxacarcin structural class, broadly defined, which resulted in fully synthetic routes to trioxacarcin A (1), DC-45-A1 (10), and a diverse collection of analogs.
Notes: Keywords: analog, antiproliferative, DC-45-A1, glycosylation, synthesis, trioxacarcin.

Thesis Ph.D. Harvard University 2014