Multichain immune recognition receptor signaling
Subtitle: from spatiotemporal organization to human disease
By: edited by Alexander B. Sigalov.
Contributors: Sigalov, Alexander B.
Series: Advances in experimental medicine and biology -- v. 640
Publisher: Springer Science+Business Media; Landes Bioscience
Published: 2008
Place of publication: New York; Austin, Tex
Language: eng
Number of pages: 357
ISBN-13: 9780387097886
Subjects: Immune recognition; T cells -- Receptors; Killer cells; Cellular signal transduction; Cell receptors; Receptors, Immunologic; Models, Immunological; Signal Transduction
Description: The central idea of this book is to show that the structural similarity of the MIRRs determines the general principles underlying MIRR-mediated transmembrane signaling mechanisms and furthermore, provides the basis for existing and future therapeutic strategies targeting MIRRs. This book intends to assemble reviews on the progress in defining and controlling the spatiotemporal organization of key events in immune cell activation. Improved understanding of MIRR-mediated signaling has a number of potential practical applications, from the rational design of drugs and vaccines to the engineering of cells for biotechnological purposes. In Section 1, spatial organization and physiological function of the MIRR family members such as T cell receptor (TCR), B cell receptor (BCR), Fc receptors, natural killer (NK) cell receptors, and platelet glycoprotein VI (GPVI) will be reviewed. Section 2 will focus on current models of MIRR-triggering and highlight modern technologies to visualiz.
Notes: Includes bibliographical references and index.
Table of contents: title: T-cell receptor / Jose M. Rojo, Raquel Bello. and Pilar Portoløs; title: B-cell receptor / Randall J. Brezski and John G. Monroe; title: FC receptors / Maree S. Powell and P. Mark Hogarth; title: Natural killer cell receptors / Roberto Biassoni; title: Platelet glycoprotein vi / Stephanie M. Jung and Masaaki Moroi; title: Clustering models / Wolfgang W.A. Schamel and Michael Reth; title: Segregation models / Elaine P. Dopfer ... [et al.]; title: Kinetic proofreading model / Byron Goldstein ... [et al.]; title: Serial triggering model / Jacob Rachmilewitz; title: Conformational model / Ruth M. Risueøo, Angel R. Ortiz, and Balbino Alarcøn; title: Permissive geometry model / Susana Minguet and Wolfgang W.A. Schamel; title: Signaling chain homooligomerization (SCHOOL) model / Alexander B. Sigalov; title: Visualization of cell-cell interactioncontacts : synapses and kinapses / Michael L. Dustin; title: Visualization of protein interactions in living cells / Tomasz Zal; title: Immunogenicity in peptide immunotherapy : from self/nonself to similar/dissimilar sequences / Darja Kanduc; title: Therapeutic application of transmembrane T and natural killer cell receptor peptides / Nicholas Manolios ... [et al.]; title: FC receptor targeting in the treatment of allergy, autoimmune diseases, and cancer / Akira Nakamura, Tomohiro Kubo, and Toshiyuki Takai; title: Therapeutic blockade of T-cell antigen receptor signal transduction and costimulation in autoimmune disease / Joseph R. Podojil, Danielle M. Turley, and Stephen D. Miller; title: MHC and MHC-like molecules structural perspectives on the design of molecular vaccines / Vasso Apostolopoulos, Eliada Lazoura, and Minmin Yu; title: SCHOOL model and new targeting strategies / Alexander B. Sigalov; title: Immune receptor signaling, aging, and autoimmunity / Anis Larbi, Tamas Føløp, and Graham Pawelec; title: Viral pathogenesis, modulation of immune receptor signaling, and treatment / Walter M. Kim and Alexander B. Sigalov.