Antisense drug technology
Subtitle: principles, strategies, and applications
By: editor Stanley T. Crooke.
Contributors: Crooke, Stanley T.
Edition: 2nd ed.
Publisher: Taylor & Francis; CRC Press
Published: 2006
Place of publication: Boca Raton
Language: eng
Number of pages: 825
ISBN-13: 9780849387968
Subjects: Antisense nucleic acids -- Therapeutic use; Oligonucleotides, Antisense -- therapeutic use
Description: This second edition continues to offer answers to challenging questions while looking ahead to the future of antisense drugs, covering the fundamentals of oligonucleotide-based therapeutics and hybridization-based drugs as well as therapeutic applications for cardiovascular purposes, metabolic diseases, and cancer.
Notes: Includes bibliographical references and index.
Table of contents: title: Mechanisms of antisense drug action, an introduction / Stanley T. Crooke ... [et al.]; title: The RNase h mechanism / Walt Lima, Hongjiang Wu, Stanley T. Crooke; title: Small RNA silencing pathways / Alla Sigova, Phillip Zamore; title: Splice switching sligonucleotides as potential therapeutics / Peter Sazani, Maria A. Graziewicz, Ryszard Kole; title: Basic principles of antisense drug discovery / Susan M. Freier, Andrew T. Watt; title: The medicinal chemistry of oligonucleotides / Eric E. Swayze, Balkrishen Bhat; title: Basic principles of the pharmacokinetics of antisense oligonucleotide drugs / Arthur A. Levin, Rosie Z. Yu, Richard S. Geary; title: Routes and formulations for delivery of antisense oligonucleotides / Gregory E. Hardee, Lloyd G. Tillman, Richard S. Geary; title: Liposomal formulations for nucleic acid delivery / Ian MacLachlan; title: Pharmacological properties of 2'-O-methoxyethyl modified oligonucleotides / C. Frank Bennett; title: Pharmacokinetic/pharmacodynamic properties of phosphorothioate 2'-O-(2-methoxyethyl) modified antisense oligonucleotides in animals and man / Richard S. Geary ... [et al.]; title: Toxicologic properties of 2'-methoxyethyl chimeric antisense inhibitors in animals and man / Scott P. Henry ... [et al.]; title: An overview of the clinical safety experience of first and second generation antisense oligonucleotides / T. Jesse Kwoh; title: Manufacturing and analytical processes / Daniel C. Capaldi, Anthony N. Scozzari; title: Harnessing RNA interference pathways for therapeutics utilizing chemistry: chemically modified siRNAs, drug delivery systems and antagomirs / Muthiah Manoharan; title: Discovery and development of RNAi therapeutics / Antonin R. deFougerolles, John M. Maraganore; title: Optimization of second generation antisense drugs: going beyond generation 2.0 / Brett P. Monia ... [et al.]; title: Modulating gene function with peptide nucleic acids (PNA) / Peter E. Nielsen; title: Locked nucleic acid / Troels Koch, Henrik Ørum; title: Morpholinos / Patrick L. Iversen; title: Potential therapeutic applications of antisense oligonucleotides in ophthalmology / Lisa R. Grillone, Scott P. Henry; title: Cardiovascular therapeutic applications / Rosanne M. Crooke, Brenda F. Baker, Mark K. Wedel; title: Developing antisense drugs for metabolic diseases: a novel therapeutic approach / Sanjay Bhanot; title: Inflammatory diseases / Susan A. Gregory, James G. Karras; title: Antisense oligonucleotides for the treatment of cancer / Boris A. Hadaschik, Martin E. Gleave; title: Targeting neurological disorders with antisense oligonucleotides / Richard A. Smith, Timothy M. Miller; title: Mechanisms and therapeutic applications of immune modulatory oligodeoxynucleotide and oligoribonucleotide ligands for toll-like receptors / Jörg Vollmer, Arthur M. Krieg.