Immunobiology and pathogenesis of persistent virus infections
By: edited by Brian W.J. Mahy and Richard W. Compans.
Contributors: Mahy, B. W. J.; Compans, Richard W.
Publisher: Harwood Academic
Published: 1996
Place of publication: Amsterdam, The Netherlands
Language: eng
Number of pages: 258
Subjects: Virus diseases -- Immunological aspects.; Virus Diseases -- immunology.; Viruses -- pathogenicity.
Description: Virus persistence is little understood, but is a critically important aspect of numerous diseases, including viral hepatitis, AIDS, and herpes virus infections. Many of these persistent viruses may lie dormant in the human body, but may be reactivated in response to some stimulus; this fact is especially important when the human host is receiving immunosuppressive therapy - for example, following transplant surgery - or is otherwise immunocompromised, as in AIDS patients. Immunobiology and Pathogenesis of Persistent Virus Infections distills state-of-the-art research in the area of persistent virus infections. A distinguished group of contributing virologists explore the mechanisms by which various viruses, including HIV-1, herpes, measles, retroviruses, hepatitis, and lentiviruses, persist within the human host. The book considers viral persistence on three separate levels: persistence within the cell; persistence within the human individual; and persistence within the human population. Genetic changes associated with virus persistence are reviewed, and intervention strategies are discussed.
Notes: Includes bibliographical references and index.
Table of contents: title: Mechanisms of CD4+ T cell depletion in human immunodeficiency virus type 1 infection / J. Steven McDougal; title: Latency and activation of lentiviruses : studies of visna virus in monocytes and macrophages / Janice E. Clements, Lucy M. Carruth, and Susan Gdovin; title: Comparative epidemiology of human retroviruses / William A. Blattner; title: Viral protein targets of the immune response to varicella-zoster virus (VZV) / Ann M. Arvin; title: Pathogenic aspects of measles virus infections / Sibylle Schneider-Schaulies ... [et al.]; title: Interactions of measles virus and the immune system / Diane E. Griffin, Brian J. Ward, and Lisa M. Esolen; title: Persistence of measles in a vaccinated population / William J. Bellini; title: Mechanisms of hepatitis B virus (HBV) persistence and associated disease / William S. Robinson; title: Interaction of hepatitis B virus with hepatocytes / Wolfram H. Gerlich and Xuanyong Lu; title: Viral hemorrhagic fevers : persistent problems, persistent in reservoirs / C.J. Peters and James W. LeDuc; title: Anti-viral CDS+ cytotoxic T cell memory / Lisa L. Lau and Rofi Ahmed.