Lab-on-a-chip
Subtitle: techniques, circuits, and biomedical applications
By: Yehya H. Ghallab, Wael Badawy
Contributors: Badawy, Wael
Series: Integrated microsystems series; Artech House integrated microsystems series
Publisher: Artech House
Published: 2010
Place of publication: Boston
Language: eng
Number of pages: 220
ISBN-13: 9781596934184
Subjects: Microelectromechanical systems; Chemical laboratories; Biomedical engineering; Electronic equipment
Notes: Includes bibliographic references and index.
Table of contents: title: 1. Introduction to Lab-on-a-Chip; title: 1.1. History; title: 1.2. Parts and Components of Lab-on-a-Chip; title: 1.2.1. Electric and Magnetic Actuators; title: 1.2.2. Electrical Sensors; title: 1.2.3. Thermal Sensors; title: 1.2.4. Optical Sensors; title: 1.2.5. Microfluidic Chambers; title: 1.3. Applications of Lab-on-a-Chip; title: 1.4. Advantages and Disadvantages of Lab-on-a-Chip; title: References; title: 2. Cell Structure, Properties, and Models; title: 2.1. Cell Structure; title: 2.1.1. Prokaryotic Cells; title: 2.1.2. Eukaryotic Cells; title: 2.1.3. Cell Components; title: 2.2. Electromechanics of Particles; title: 2.2.1. Single-Layer Model; title: 2.2.2. Double-Layer Model; title: 2.3. Electrogenic Cells; title: 2.3.1. Neurons; title: 2.3.2. Gated Ion Channels; title: 2.3.3. Action Potential; title: References; title: 3. Cell Manipulator Fields; title: 3.1. Electric Field; title: 3.1.1. Uniform Electric Field (Electrophoresis); title: 3.1.2. Nonuniform Electric Field (Dielectrophoresis); title: 3.2. Magnetic Field; title: 3.2.1. Nonuniform Magnetic Field (Magnetophoresis); title: 3.2.2. Magnetophoresis Force (MAP Force); title: References; title: 4. Metal-Oxide Semiconductor (MOS) Technology Fundamentals; title: 4.1. Semiconductor Properties; title: 4.2. Intrinsic Semiconductors; title: 4.3. Extrinsic Semiconductor; title: 4.3.1. N-Type Doping; title: 4.3.2. P-Type Doping; title: 4.4. MOS Device Physics; title: 4.5. MOS Characteristics; title: 4.5.1. Modes of Operation; title: 4.6. Complementary Metal-Oxide Semiconductor (CMOS) Device; title: 4.6.1. Advantages of CMOS Technology; title: References; title: 5. Sensing Techniques for Lab-on-a-Chip; title: 5.1. Optical Technique; title: 5.2. Fluorescent Labeling Technique; title: 5.3. Impedance Sensing Technique; title: 5.4. Magnetic Field Sensing Technique; title: 5.5. CMOS AC Electrokinetic Microparticle Analysis System; title: 5.5.1. Bioanalysis Platform; title: 5.5.2. Experimental Tests; title: References; title: 6. CMOS-Based Lab-on-a-Chip; title: 6.1. PCB Lab-on-a-Chip for Micro-Organism Detection and Characterization; title: 6.2. Actuation; title: 6.3. Impedance Sensing; title: 6.4. CMOS Lab-on-a-Chip for Micro-Organism Detection and Manipulation; title: 6.5. CMOS Lab-on-a-Chip for Neuronal Activity Detection; title: 6.6. CMOS Lab-on-a-Chip for Cytometry Applications; title: 6.7. Flip-Chip Integration; title: References; title: 7. CMOS Electric-Field-Based Lab-on-a-Chip for Cell Characterization and Detection; title: 7.1. Design Flow; title: 7.2. Actuation; title: 7.3. Electrostatic Simulation; title: 7.4. Sensing; title: 7.5. The Electric Field Sensitive Field Effect Transistor (eFET); title: 7.6. The Differential Electric Field Sensitive Field Effect Transistor (DeFET); title: 7.7. DeFET Theory of Operation; title: 7.8. Modeling the DeFET; title: 7.8.1. A Simple DC Model; title: 7.8.2. SPICE DC Equivalent Circuit; title: 7.8.3. AC Equivalent Circuit; title: 7.9. The Effect of the DeFET on the Applied Electric Field Profile; title: References; title: 8. Prototyping and Experimental Analysis; title: 8.1. Testing the DeFET; title: 8.1.1. The DC Response; title: 8.1.2. The AC (Frequency) Response; title: 8.1.3. Other Features of the DeFET; title: 8.2. Noise Analysis; title: 8.2.1. Noise Sources; title: 8.2.2. Noise Measurements; title: 8.3. The Effect of Temperature and Light on DeFET Performance; title: 8.4. Testing the Electric Field Imager; title: 8.4.1. The Response of the Imager Under Different Environments; title: 8.4.2. Testing the Imager with Biocells; title: 8.5. Packaging the Lab-on-a-Chip; title: References; title: 9. Readout Circuits for Lab-on-a-Chip; title: 9.1. Current-Mode Circuits; title: 9.2. Operational Floating Current Conveyor (OFCC); title: 9.2.1. A Simple Model; title: 9.2.2. OFCC with Feedback; title: 9.3. Current-Mode Instrumentation Amplifier; title: 9.3.1. Current-Mode Instrumentation Amplifier (CMIA) Based on CCII; title: 9.3.2. Current-Mode Instrumentation Amplifier Based on OFCC; title: 9.4. Experimental and Simulation Results of the Proposed CMIA; title: 9.4.1. The Differential Gain Measurements; title: 9.4.2. Common-Mode Rejection Ratio Measurements; title: 9.4.3. Other Features of the Proposed CMIA; title: 9.4.4. Noise Results; title: 9.5. Comparison Between Different CMIAs; title: 9.6. Testing the Readout Circuit with the Electric Field Based Lab-on-a-Chip; title: References; title: 10. Current-Mode Wheatstone Bridge for Lab-on-a-Chip Applications; title: 10.1. Introduction; title: 10.2. CMWB Based on Operational Floating Current Conveyor; title: 10.3. A Linearization Technique Based on an Operational Floating Current Conveyor; title: 10.4. Experimental and Simulation Results; title: 10.4.1. The Differential Measurements; title: 10.4.2. Common-Mode Measurements; title: 10.5. Discussion; title: References; title: 11. Current-Mode Readout Circuits for the pH Sensor; title: 11.1. Introduction; title: 11.2. Differential ISFET-Based pH Sensor; title: 11.2.1. ISFET-Based pH Sensor; title: 11.2.2. Differential ISFET Sensor; title: 11.3. pH Readout Circuit Based on an Operational Floating Current Conveyor; title: 11.3.1. Simulation Results; title: 11.4. pH Readout Circuit Using Only Two Operational Floating Current Conveyors; title: 11.4.1. Simulation Results; title: References.