ALTERNATIVE SPLICING REGULATION IN PROGRAMMED CELL DEATH AND NEUROLOGICAL DISORDERS
Subtitle: A SYSTEMS BIOLOGY APPROACH
Contributors: Silver, Pamela A.; Mitchison, Timothy J.; Gray, Jesse; Szostak, Jack W.; Churchman, Stirling
Published: 2013
Language: eng
Description: Alternative splicing (AS) is a major source of biological diversity and a crucial determinant of cell fate and identity. Characterizing the role of AS regulatory networks in physiological and pathological processes remains challenging. The work presented here addresses this challenge using systems biology analyses of AS regulatory networks in programmed cell death and neurological disorders.
Notes: Keywords: apoptosis, neurological disorders, PQBP1, RNA alternative splicing, RNA-seq analysis, synthetic memory circuit.

Thesis Ph.D. Harvard University 2013