Effect of exercise in women with polycystic ovary syndrome (PCOS)
Subtitle: a randomized controlled trial of diet and exercise compared with diet alone.
Published: 2004
Language: eng
Number of pages: 184
Description: Background. PCOS affects 6% of reproductive aged women. It results in oligo/anovulation, hyperandrogenism, dyslipidemia, diabetes mellitus, and may increase risk of hypertension, endometrial cancer and coronary artery disease. Insulin resistance plays a critical role in PCOS. This randomized controlled trial was conducted to determine whether moderately intense exercise, combined with diet, is better than diet alone to improve ovulatory rates and other outcomes in women with PCOS.Interpretation. Exercise combined with diet may improve ovulatory and menstrual rates among women with PCOS. The main limitation of this trial was drop-out; however, the risk of harm with exercise is very low and therefore it should be offered as a non-pharmacologic alternative for women of reproductive age with PCOS.Results. Eighty-two women were randomized, 40 to the diet and exercise group and 42 to the diet only group. The two groups were similar at baseline. Primary outcome data were available on 38 women in the exercise group and 40 women in the control group. Secondary outcome data at 6 and 12 months were available on 26 and 21 women in the exercise group, and 27 and 28 women in the control group, respectively. There were trends favouring the exercise group for ovulation (RR [90%CI] = 1.71 [0.97, 2.41], p(1-tailed) = 0.056) and menses (RR [98%CI] = 1.36 [0.98, 1.83], p(1-tailed) = 0.014). No differences were seen in measures of insulin resistance, hyperandrogenemia, cardiovascular disease risk factors and SF-36 scores. There were trends favouring the exercise group for LH/FSH ratio (P = 0.036), Feniman-Gallwey hirsutism score (p = 0.018) and change in sleep at 6 months (p = 0.026). There was a trend towards lower BMI in the control group (p = 0.049). There were differences favouring the exercise group for percent body fat by skin folds (p = 0.010) and change in relationship satisfaction at 6 months (p = 0.001) and 12 months (p = 0.0025).Methods. Women with PCOS were randomly assigned to receive diet and exercise (exercise) or diet alone (control) for 12 months. The primary outcome was the ovulatory rate over 12 months. Secondary outcomes were other symptoms of PCOS and cardiovascular disease risk factors. The planned sample size was 80 women. Analysis was by intention-to-treat.
Notes: Adviser:  Mary E. Hannah.

Thesis (Ph.D.)--University of Toronto, 2004.

Electronic version licensed for access by U. of T. users.

Source: Dissertation Abstracts International, Volume: 65-10, Section: B, page: 5085.