DNA DAMAGE CONTROLLING SYSTEMS IN MITOCHONDRIA
Publisher: Nai Prakashan
Published: 2021
Place of publication: Kathmandu, Nepal
Format: Paperback
Number of pages: 155
Copyright date: 2021
First sentence: Mitochondria are essential double membrane organelles within a cell that harbor their own genetic material, the mitochondrial DNA (mtDNA), which encodes indispensable protein components of the electron transport chain (ETC) and oxidative phosphorylation (OXPHOS).
Table of contents: title: 1 SNAPSHOT; title: 2 INTRODUCTION; title: 3 MITOCHONDRIAL DNA STRUCTURE, TOPOLOGY, AND ORGANIZATION; title: 3.1 Budding Yeast Mitochondrial DNA; title: 3.2 Budding Yeast Mitochondrial Nucleoid; title: 3.3 Human Mitochondrial DNA; title: 3.4 Human Mitochondrial Nucleoid; title: 4 MITOCHONDRIAL DNA DAMAGE; title: 4.1 Mitochondrial DNA Damage by Reactive Oxygen Species; title: 4.2 Mitochondrial DNA Damage by Ionizing Radiation; title: 4.3 Mitochondrial DNA Damage by Chemotherapeutic Agents; title: 5 MITOCHONDRIAL DNA REPAIR; title: 5.1 Types of Mitochondrial DNA Repair; title: 5.1.1 Direct Repair/Direct Reversal; title: 5.1.1.1 Photolyases; title: 5.1.1.2 O6-MethylguanineDNAMethyltransferase; title: 5.1.1.3 AlkB Homologs; title: 5.1.1.3 AlkB Homologs; title: 5.1.2 Base Excision Repair; title: 5.1.3 Nucleotide Excision Repair; title: 5.1.4 Mismatch Repair; title: 5.1.5 Double-Strand Break Repair; title: 5.1.5.1 Double-Strand Break Repair in Mammalian Mitochondria; title: 5.1.5.1.1 Homologous Recombination; title: 5.1.5.1.2 Classical Non-Homologous End Joining; title: 5.1.5.1.3 Microhomology-Mediated End Joining; title: 5.1.5.2 Double-Strand Break Repair in Yeast Mitochondria; title: 6 MITOCHONDRIAL DNA DEGRADATION; title: 7 SANITATION OF PREMUTAGENIC FREE NUCLEOTIDES; title: 8 TRANSLESION SYNTHESIS; title: 8.1 DNA Polymerase Gamma; title: 8.2 PrimPol; title: 8.3 DNA Polymerase Zeta; title: 8.4 DNA Polymerase Theta; title: ABBREVIATIONS; title: REFERENCES