Beyond thalidomide
Subtitle: birth defects explained
By: Janet McCredie
Publisher: Royal Society of Medicine Press
Published: 2007
Place of publication: London; Ashland, OH
Language: eng
Number of pages: 418
ISBN-13: 9781853157417
Subjects: Abnormalities, Drug-Induced; Congenital Limb Deformities; Chemically induced; Thalidomide; Adverse effects; Human Abnormalities; Side effects
Description: How do birth defects happen? Why does thalidomide mutilate the embryo? In this challenging text the author takes a new approach to the resulting disordered anatomy and demonstrates that the skeletal defects seen are inconsistent with primary bone disease, but indicate primary damage to the embryonic sensory nerves--neural crest injury. This book will be of interest to those involved with birth defects.
Notes: Includes bibliographical references and index.
Table of contents: title: The thalidomide epidemic; title: Pharmacology of thalidomide: interaction with the human embryo; title: Animal studies; title: Thalidomide polyneuropathy; title: Clinical radiology; title: Terminology, classification and the rejection of authority; title: The pattern of the disease: first radiological analysis (Sydney); title: Verification of the disease pattern: second radiological analysis (London); title: Congenital reductions of the radius; title: Congenital dislocation; title: Congenital synostosis; title: The hypothesis of neural crest injury; title: The neural crest; title: Neurotrophism; title: Nerve in limb bud; title: Regeneration and embryogenesis; title: Neural crest ablation and limb morphogenesis; title: Thalidomide deformities and their nerve supply: first morphometirc study in rabbits; title: Thalidomide deformities and their nerve supply: second morphometric study in rabbits; title: The sensory nerve supply of bone; title: The sclerotomes; title: Sclerotome aplasia/subtraction; title: Sclerotome aplasia/subtraction in 203 cases; title: Radial/tibial dysmelia: limb reductions typical of thalidomide; title: Associated internal malformations and their embryology; title: Neurotomes and multiple malformation syndromes; title: Hands and feet in thalidomide embryopathy: histology and sclerotomes in the digits; title: Other disorders of similar sclerotomes; title: Segmental and truncal neuorpathies in sclerotomes not affected by thalidomide; title: Review of actions of thalidomide; title: Conclusion: beyond thalidomide.