Pharmacokinetics
Publisher: Bookboon
Published: 2013
ISBN-13: 9788740300901
Table of contents: title: ADME and Pharmacokinetics; title: ADME – Absorption Distribution, Metabolism and Excretion; title: Pharmacokinetics; title: Absorption: Absorption rate constant, Bioavailability and Salt factor; title: Passive diffusion and other mechanisms by which drugs may cross biological membranes; title: Rate of drug absorption and the Absorption rate constant (Ka); title: Bioavailability; title: Salt factor; title: Distribution: Compartments and Volume of Distribution; title: The rate of distribution and compartments; title: One compartment model; title: Two compartment model; title: The extent of distribution; title: Volume of distribution; title: Using the volume of distribution to calculate dose size; title: Practice calculations; title: Elimination: Elimination rate constant, half-life and clearance; title: Elimination rate constant and half-life; title: Clearance; title: Practice calculations; title: Single intravenous bolus injection into one compartment; title: Concentration versus time graph; title: Relationship between time and concentration; title: Area Under the Curve (AUC); title: Practice calculations; title: Appendix 1; title: Appendix 2; title: Analysis of experimental data from a bolus i.v; title: injection into one compartment; title: Analysis of clinical trials data; title: Analysis of data arising in a clinical setting; title: Practice calculations; title: Appendix 1; title: Appendix 2; title: Single intravenous bolus injection into two compartments; title: The model to be considered; title: Drug concentrations in blood and the rest of the first compartment; title: Determining how many compartments a drug occupies; title: Drug concentration in the second compartment; title: Two compartment systems and therapeutic drug monitoring for digoxin; title: Constant intravenous infusion; title: The model to be considered; title: Concentration versus time curve during infusion; title: Relationship between rate of infusion and concentration at steady state; title: Loading doses; title: The accumulation period; title: Practice questions; title: Appendix; title: Extravascular administration; title: The situation to be considered; title: Concentration versus time curve; title: Changing the rate of absorption; title: Cmax and Tmax; title: Determination of bioavailability for extravascular doses; title: Trapezoidal rule – A practical method to measure AUC; title: Practice question; title: Appendix; title: Multiple dosing; title: Pharmacokinetic accumulation and steady state; title: Multiple extravascular doses; title: Concentrations at steady state; title: Loading dose; title: Accumulation stage; title: Extent of fluctuation in drug concentrations; title: Practice questions; title: Appendix; title: Non-linear pharmacokinetics; title: Considering drug metabolism as an enzyme catalysed reaction; title: Exceptions to linearity; title: Effect of non-linearity on the relationship between dose and drug concentration; title: Clinical significance of non-linear kinetics; title: Non-linear kinetics and drug development; title: Non-compartmental pharmacokinetics; title: The case for non-compartmental methods; title: Calculation methods; title: More complex situations; title: Computerized analysis of pharmacokinetic data; title: Least squares fitting; title: Practice question; title: Creatinine clearance; title: Clearance of creatinine and various drugs; title: Digoxin dosing; title: Practice questions; title: Pharmacokinetic symbols and equations; title: Symbols; title: Cockcroft and Gault equations; title: Additional material available from the internet; title: Answers to practice questions