Cell Fate Decisions in Early Embryonic Development
Contributors: McMahon, Andrew P.; Dulac, Catherine; Sanes, Joshua R.; Meissner, Alexander; Liu, Xiaole S.
Published: 2013
Language: eng
Description: The basis of developmental biology lies in the idea of when and how cells decide to divide or to differentiate. Previous studies have established several signaling pathways that determine cell fate decisions, including Notch, Wingless, Hedgehog, Bone morphogenetic protein, and Fibroblast growth factor. Signaling converges on transcriptional factors that regulate gene expression. In mouse embryonic stem cells, I explored how pluripotency and differentiation are regulated through opposing actions of beta-catenin-mediated canonical Wnt signaling, and the mechanisms underlying Sonic hedgehog signaling in generating progenitor cells in the ventral neural tube.
Notes: Keywords: ChIP-seq, embryonic development, embryonic stem cell, gene regulatory network, neural tube, signaling pathway.

Thesis Ph.D. Harvard University 2013