Structure-based drug discovery
By: edited by Leslie W. Tari
Series: Methods in molecular biology -- 841; Springer protocols; Methods in molecular biology (Clifton, N.J.) -- v. 841.; Springer protocols
Publisher: Humana Press/Springer
Published: 2012
Place of publication: New York
Language: eng
Number of pages: 385
ISBN-13: 9781617795190; 9781617795206
Subjects: Methods; Computational Biology; Drugs; Laboratory manuals; Molecular Conformation; Design; Drug Discovery; Laboratory Manuals
Notes: Includes bibliographical references and index.
Table of contents: title: The utility of structural biology in drug discovery  -- Leslie W. Tari; title: Genetic construct design and recombinant protein expression for structural biology  -- Suzanne C. Edavettal, Michael J. Hunter, and Ronald V. Swanson; title: Purification of proteins for crystallographic applications  -- Daniel C. Bensen; title: Protein crystallization for structure-based drug design  -- Isaac D. Hoffman; title: X-ray sources and high-throughput data collection methods  -- Gyorgy Snell; title: The use of molecular graphics in structure-based drug design  -- Paul Emsley and Judit É. Debreczeni; title: Crystallographic fragment screening  -- John Badger; title: The role of enzymology in a structure-based drug discovery program : bacterial DNA gyrase  -- Mark L. Cunningham; title: Leveraging structural information for the discovery of new drugs : computational methods  -- Toan B. Nguyen, Sergio E. Wong, and Felice C. Lightstone; title: Chemical informatics : using molecular shape descriptors in structure-based drug design  -- Andy Jennings; title: Accounting for solvent in structure-based drug design  -- Leslie W. Tari; title: Structure-based drug design on membrane protein targets : human integral membrane protein 5-lipoxygenase-activating protein  -- Andrew D. Ferguson; title: Application of SBDD to the discovery of new antibacterial drugs  -- John Finn; title: Leveraging SBDD in protein therapeutic development : antibody engineering  -- Gary L. Gilliland ... [et al.]; title: A medicinal chemistry perspective on structure-based drug design and development -- Shawn P. Maddaford.