Therapeutic applications of quadruplex nucleic acids
By: Stephen Neidle
Edition: 1st ed.
Publisher: Elsevier/Academic Press
Published: 2012
Place of publication: London; Waltham, MA
Language: eng
Number of pages: 196
ISBN-13: 9780123751386
Subjects: G-Quadruplexes; Pharmacology; Quadruplex nucleic acids; Neoplasms; Telomere; Drug therapy; Therapeutic use; Chemistry; Antineoplastic Agents; Nucleic Acid Conformation
Description: "Therapeutic applications of quadruplex nucleic acids provides a single comprehensive survey that describes and assesses recent advances in quadruplex therapeutics and targeting strategies. It also covers the underlying fundamentals of such topics as quadruplex structure, small-molecule recognition, biological roles of genomic quadruplexes, and quadruplex informatics"--P. [4] of cover.
Notes: Includes bibliographical references and index.
Table of contents: title: Introduction: quadruplexes and their biology; title: DNA and RNA quadruplex structures; title: The structures of human telomeric DNA quadruplexes; title: Telomeric quadruplex ligands I: anthraquinones and acridines; title: Telomeric quadruplex ligands II: polycyclic and non-fused ring compounds; title: The biology and pharmacology of telomeric quadruplex ligands; title: Genomic quadruplexes as therapeutic targets; title: RNA quadruplexes; title: Design principles for quadruplex-binding small molecules; title: The determination of quadruplex structures.