Biofilm eradication and prevention
Subtitle: a pharmaceutical approach to medical device infections
By: Tamilvanan Shunmugaperumal
Publisher: Wiley
Published: 2010
Place of publication: Hoboken, N.J
Language: eng
Number of pages: 423
ISBN-13: 9780470479964
Subjects: Biofilms; Drug Carriers; Sterilization; Microbiology; Prosthesis-Related Infections; Medical instruments and apparatus; Prostheses and Implants; Prevention & control; Therapeutic use; Anti-Infective Agents
Description: "Biofilm Eradication and Preventions presents the basics of biofilm formation on medical devices, diseases related to this formation, and approaches pharmaceutical researchers need to take to limit this problem. Split into three parts, the first deals with the development and characterization of biofilm on the surfaces of implanted or inserted medical devices. Questions as to why biofilms form over medical device surfaces and what triggers biofilm formation are addressed. In the second section, the author discusses biofilm-mediated chronic infections occurred in various organs (eyes, mouth, wounds) and pharmaceutical and drug delivery knowledge gained from research in these area. The third part explores pharmaceutical approaches like lipid-and polymer-based drug delivery carriers for eradicating biofilm on device-related infections. In addition, this section also explores the topic of novel small molecule (like iron and its complexes/metal chelators) and a quorum-sensing inhibitors to control medical biofilm formation"--Provided by publisher.
Notes: Includes bibliographical references and index.
Table of contents: title: (Publisher-supplied data) Chapter 1. Introduction and Overview of Biofilm   Chapter 2. Rationale for biofilm eradication from modern medical devices     Chapter 3. Pathogenesis of device-related nosocomial infections     Chapter 4. Biofilm resistance/tolerance to conventional antimicrobial agents     Chapter 5. Analytical techniques useful to study biofilm Chapter 6. Biofilm-related infections in ophthalmology   Chapter 7. Biofilm-related infections in oral cavity     Chapter 8. Implications of biofilm formation in chronic wound and in cystic fibrosis   Chapter 9. Strategies for prevention of device-related nosocomial infections Chapter 10. Liposomes as drug delivery carriers to biofilms Chapter 11. Polymer-based antimicrobial delivery carriers.