Neonatal and childhood cerebral sinovenous thrombosis: Recanalization rates and outcomes.
Published: 2006
Language: eng
Number of pages: 159
ISBN-13: 9780494213223
Description: Background. Safety of anticoagulants (ACTs), recanalization rate and effect of recanalization on clinical outcome in childhood cerebral sinovenous thrombosis (CSVT) have not been well studied. Methods. Consecutive children (birth-18years) with radiographically confirmed CSVT from January 1992-January 2005 were studied. Clinical features, treatment (based on standardized institutional protocols), radiographic data at presentation, and follow-up were analyzed. Predictors of recanalization and clinical outcome were selected a priori for statistical analysis. Results. One hundred forty-five children had CSVT. Bleeding complications occurred in only six percent of the ninety-seven treated patients. Maximum recanalization rates were achieved by three-months after diagnosis in neonates and by six-months in non-neonates. Younger age at CSVT (p=0.0004) and non-occlusive initial CSVT (p=0.032) independently predicted better recanalization. Older age at CSVT (p=0.0003), extent of recanalization (p=0.0016) & length of follow-up period (p=0.0183) independently predicted better clinical outcome.  Conclusions. ACTs are safe in childhood CSVT. Neonates recanalize faster than older children. Extent of recanalization predicts clinical outcome. Clinical outcome is better in older children than in neonates.
Notes: Source: Masters Abstracts International, Volume: 45-03, page: 1453.

Thesis (M.Sc.)--University of Toronto, 2006.

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