Development of novel ionic biodegradable polymer resins for use in temporary bone fracture fixation
By: by Liu Yang.
Published: 2006
Language: eng
Number of pages: 323
ISBN-13: 9780494157442
Description: Swelling for the synthesized polymers increased with increasing ionic content. In vitro biodegradation studies using either cholesterol esterase (CE) or U 937 cells (a macrophage-like cell line) demonstrated surface erosion and significant release of polymer components, confirming biodegradability.A new oligomeric methacrylate monomer based on polycarbonate was synthesized. It was utilized to make ionic biodegradable polymers containing ionic function to promote adhesion to biodegradable calcium polyphosphate (CPP) in the form of interpenetrating phase composites (IPC).The ionic groups enhanced the interfacial bonding of the ionic polymers to the CPP and increased the bending strength and modulus of the as made IPCs. The biodegradation studies showed that the mechanical properties of IPC made of ionic polymers dropped dramatically upon incubation in phosphate buffer and CE solutions. Swelling of the polymers, formation of microvoids and loss of interfacial bonding were three major mechanisms responsible for the decrease in mechanical properties of IPCs.
Notes: Source: Dissertation Abstracts International, Volume: 67-06, Section: B, page: 3275.

Thesis (Ph.D.)--University of Toronto, 2006.

Includes bibliographic references.

Electronic version licensed for access by U. of T. users.