Preclinical drug development
By: edited by Mark C. Rogge, David R. Taft.
Contributors: Rogge, Mark C.; Taft, David R.
Edition: 2nd ed.
Series: Drugs and the pharmaceutical sciences -- 187; Drugs and the pharmaceutical sciences -- v. 187.
Publisher: Informa Healthcare
Published: 2010
Place of publication: New York
Language: eng
Number of pages: 359
ISBN-13: 9781420084726
Subjects: Drug development; Drug Evaluation, Preclinical -- methods; Drug Industry -- methods
Notes: Includes bibliographical references and index.
Table of contents: title: The scope of preclinical drug development : an introduction and framework / Mark C. Rogge; title: Lead molecule selection : pharmaceutical profiling and toxicity assessments / P.L. Bullock; title: Interspecies differences in physiology and pharmacology : extrapolating preclinical data to human populations / M.N. Martinez; title: Pharmacokinetics/ADME of small molecules / A.D. Ajavon and David R. Taft; title: Pharmacokinetics/ADME of large molecules / R. Braeckman; title: Preclinical pharmacokinetic-pharmacodynamic modeling and simulation in drug development / P.L. Bonate and P. Vicini; title: Formulation and production strategies for enhancing bioavailability of poorly absorbed drugs / A.B. Watts and R.O. Williams III; title: Transporters involved in drug disposition, toxicity, and efficacy / C.Q. Xia and G.T. Miwa; title: Toxicity evaluations, ICH guidelines, and current practice / J.L. Larson; title: Application of pathology in safety assessment / Robert A. Ettlin and David E. Prentice; title: Utilizing the preclinical database to support clinical drug development / H. Lee.