LATCA: A library of biologically active small molecules for plant chemical genomics.
Published: 2007
Language: eng
Number of pages: 110
ISBN-13: 9780494272817
Description: Chemical genomics utilizes small molecules to alter the functions of specific target genes/proteins. To promote its use in plant research, I assembled a chemical library enriched with plant bioactive compounds, which is named  Library of AcTive  Compounds in Arabidopsis (LATCA). The chemicals were selected with an etiolated hypocotyl growth inhibition assay using three chemical libraries which identified &sim;1100 chemicals. The collection is complemented with an additional 900 chemicals. In total LATCA contains 2080 compounds, &sim;300 are known bioactive chemicals. As a new approach to classifying chemical effects, I developed a phenotype based clustering scheme. The chemicals are also clustered according to their structural similarities. In addition, potencies of the chemicals were assessed with dose curve analysis. These three datasets together enable analyses of structure-activity relationships of well defined phenotypic clusters. The LATCA collection provides integrated datasets with which future studies and other chemical genomic screens can systematically build upon.
Notes: Source: Masters Abstracts International, Volume: 45-06, page: 3031.

Thesis (M.Sc.)--University of Toronto, 2007.

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