Homeostasis of Adipose Tissue Macrophages
By: Ethan Edwin
Publisher: [publisher not identified]
Published: 2020
Place of publication: [New York, N.Y.?]
Language: eng
Description: Adipose tissue macrophages are a heterogeneous component of adipose tissue with poorly defined ontogeny. I test the hypothesis that macrophage populations in murine adipose have distinct ontogenies that determine their functions. In Aim 1, I identify resident and recruited adipose macrophage populations using three complementary cell-tracking techniques. In Aim 2, I characterize the transcriptomes of resident and recruited adipose macrophages. In Aim 3, I increase the expression of either a macrophage recruitment factor or a macrophage growth factor in adipose. Overall, I conclude that there are distinct populations of resident and recruited macrophages in adipose and that macrophage ontogeny is an important factor that determines phenotype.
Notes: Department: Nutritional and Metabolic Biology.

Thesis advisor: Anthony W. Ferrante.

Thesis (Ph.D.)--Columbia University, 2020.