Cognitive Control of Emotional Information in Schizophrenia
Subtitle: Understanding the Mechanisms of Social Functioning Impairments
Contributors: Hooker, Christine I.; Hooley, Jill; McNally, Richard; Alvarez, George
Published: 2013
Language: eng
Description: Social functioning impairments are a core, debilitating, and treatment refractory feature of schizophrenia. The mechanisms contributing to these impairments are unknown. Cognitive control mechanisms, mediated by the lateral prefrontal cortex (LPFC), are known to influence response to interpersonal stressors in healthy individuals, thus impairments in these processes may contribute to social deficits. Deficits in cognitive control and lateral prefrontal abnormalities are well-documented in schizophrenia, but the relationship between these deficits and social interactions has received limited attention in the literature. The current dissertation presents a systematic examination of the contribution of the behavioral and neural mechanisms of cognitive control to social functioning impairments in schizophrenia. Three papers are presented.
Notes: Keywords: cognitive control, experience sampling, fMRI, schizophrenia, social cognition, social functioning.

Thesis Ph.D. Harvard University 2013