Evaluation of Enzyme Inhibitors in Drug Discovery
Subtitle: A Guide for Medicinal Chemists and Pharmacologists (Methods of Biochemical Analysis)
Publisher: Wiley-Interscience
Published: March 28, 2005
Language: eng
Number of pages: 296
ISBN-13: 9780471686965
First sentence: Medicine in the twenty-first century has largely become a molecular science in which drug molecules are directed toward specific macromolecular targets whose bioactivity is pathogenic or at least associated with disease.
Description: "This publication provides readers with a thorough understanding of enzyme-inhibitor evaluation to assist them in their efforts to discover and optimize novel drug therapies. Key topics such as competitive, noncompetitive, and uncompetitive inhibition, slow binding, tight binding, and the use of Hill coefficients to study reaction stoichiometry are all presented. Examples of key concepts are presented with an emphasis on clinical relevance and practical applications."--Jacket.