Blood transfusion and colorectal cancer in the leukoreduction era: Outcomes and appropriateness.
Published: 2006
Language: eng
Number of pages: 121
ISBN-13: 9780494213131
Description: We assessed the relationship between transfusion and colorectal cancer (CRC) outcomes, as well as the appropriateness of perioperative transfusion, in patients who had curative resections for colorectal adenocarcinoma between Sept. 1999 and Dec. 2002 at a tertiary centre. Patients were followed until Dec. 2005 to estimate overall survival (OS) and disease-free survival (DFS). Transfusion appropriateness was assessed using hospital guidelines. Among 301 patients, 29.9% were transfused. OS was shorter in transfused patients (3-yr OS: 68.9 vs. 91.3%, log rank p&lt;0.0001) while no differences were observed in DFS. The adjusted hazards of transfusion on OS was 2.5 (95% CI: 1.37-2.56). Among 268 transfusion events, 31.0% were inappropriate. Intra-operative transfusions (adjusted OR: 0.21, 95% CI: 0.05-0.98) and transfusions in non-bleeding patients (adjusted OR: 3.15, 95% CI: 1.01-9.81) were independently associated with inappropriate transfusion. Further study to improve the safety of transfusion medicine in this population is warranted.
Notes: Source: Masters Abstracts International, Volume: 45-03, page: 1451.

Thesis (M.Sc.)--University of Toronto, 2006.

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