The proteomic landscape of human disease
Subtitle: construction and evaluation of networks associated to complex traits
Contributors: Daly, Mark J.; Hirschhorn, Joel; Regev, Aviv; Stranger, Barbara; Kraft, Peter
Published: 2012
Language: eng
Description: Genetic mapping of complex traits has been successful over the last decade, with over 2,000 regions in the genome associated to disease. Yet, the translation of these findings into a better understanding of disease biology is not straightforward. The true promise of human genetics lies in its ability to explain disease etiology, and the need to translate genetic findings into a better understanding of biological processes is of great relevance to the community. We hypothesized that integrating genetics and protein-protein interaction (PPI) networks would shed light on the relationship among genes associated to complex traits, ultimately to help guide understanding of disease biology.
Notes: Keywords: genetics, GWAS, network, protein-protein interaction, proteomics, sequencing.

Thesis Ph.D. Harvard University 2012