I. Engaging Cationic Intermediates in Asymmetric Catalysis
Subtitle: Enantioselective Reactions of Carbenium Ions and N,N-Dialkyliminium Ions II. Enantioselective Catalysis of the Cope-Type Hydroamination by H-Bond Donors
Contributors: Jacobsen, Eric N.; Balskus, Emily P.; Ritter, Tobias
Published: 2013
Language: eng
Description: The research described here explores the ability of dual H-bond donor catalysts to induce asymmetry in a variety of synthetically useful transformations that proceed via diverse reactive intermediates. In Chapters 1-3, we investigate ureas and thioureas as anion-binding catalysts for asymmetric reactions that proceeed via cationic intermediates with little precedent as electrophiles in asymmetric catalysis. Chapter 4 details our application of H-bond donor catalysis to the Cope-type hydroamination.
Notes: Keywords: Catalysis, Hydroamination, Hydrogen-Bonding.

Thesis Ph.D. Harvard University 2013