Statistical issues in drug development
By: Stephen Senn.
Edition: 2nd ed.
Series: Statistics in practice
Publisher: John Wiley & Sons
Published: 2007
Place of publication: Chichester, England; Hoboken, NJ
Language: eng
Number of pages: 498
ISBN-13: 9780470018774
Subjects: Drug development -- Statistical methods.; Clinical Trials as Topic.; Drug Design.; Statistics as Topic -- methods.
Notes: Includes bibliographical references and index.
Table of contents: title: A brief and superficial history of statistics for drug developers; title: Design and interpretation of clinical trials as seen by a statistician; title: Probability, Bayes, P-values, tests of hypotheses, and confidence intervals; title: The work of the pharmaceutical statistician; title: Allocating treatments to patients in clinical trials; title: Baselines and covariate information; title: The measurement of treatment effects; title: Demographic subgroups : representation and analysis; title: Multiplicity; title: Intention to treat, missing data and related matters; title: One-sided and two-sided tests and other issues to do with significance and P-values; title: Determining the sample size; title: Multicentre trials; title: Active control equivalence studies; title: Meta-analysis; title: Cross-over trials; title: n-of-1 trials; title: Sequential trials; title: Dose-finding; title: Concerning pharmacokinetics and pharmacodynamics; title: Bioequivalence studies; title: Safety data, harms, drug monitoring, and pharmaco-epidemiology; title: Pharmaco-economics and portfolio management; title: Concerning pharmacogenetics, pharmacogenomics, and related matters.