The prevalence of thiamin deficiency in hospitalized patients with congestive heart failure.
Published: 2004
Language: eng
Number of pages: 183
Description: This study determined the prevalence of thiamin deficiency (TD) in a cross-section of hospitalized congestive heart failure (CHF) patients and investigated factors that may contribute to its development. Erythrocyte TPP concentrations, using high performance liquid chromatography, were measured in 100 CHF patients, and compared to 50 controls (C). TD was significantly more prevalent in CHF patients (33%) compared to C (12%) (p = 0.007). TD was related to pre-admission spironolactone use (p = 0.046), non-use of thiamin-containing supplements (p = 0.046), and preserved renal function (p = 0.046). TD tended to be associated with worsened CHF (p = 0.13), malnutrition (p = 0.16), decreased appetite (p = 0.13), and inadequate thiamin intake (p = 0.18). Urine thiamin (mug/g creatinine) was a significant positive predictor of thiamin status using multiple regression analysis (p = 0.03). A significant proportion of hospitalized CHF patients were TD. Studies of thiamin supplementation in CHF patients are warranted. Larger trials are needed to substantiate the risk factors for TD.
Notes: Adviser:  Pauline Darling.

Thesis (M.Sc.)--University of Toronto, 2004.

Electronic version licensed for access by U. of T. users.

Source: Masters Abstracts International, Volume: 42-06, page: 2170.

MICR copy on microfiche (2 microfiches).