Stem cell-based strategies to enhance muscle regeneration through extrinsic and intrinsic regulators
Contributors: Wagers, Amy J.; Schier, Alex; Francis, Nicole; Hochedlinger, Konrad
Published: 2012
Language: eng
Description: Skeletal muscle has a remarkable capacity for regeneration, mediated by muscle stem cells that can self-renew or differentiate to form the mature myofibers of the tissue. Several human diseases are characterized by a loss of function and strength in skeletal muscle, with impairments in the ability to regenerate and consequent decreases in quality of life and increases in mortality.
Notes: Keywords: Induced pluripotent stem cells, satellite cells, Skeletal muscle, Stem cells.

Thesis Ph.D. Harvard University 2012