Computational systems biology of cancer
By: authors, Emmanuel Barillot ... [et al.].
Series: Chapman & Hall/CRC mathematical and computational biology series; Chapman & Hall/CRC mathematical and computational biology series (Unnumbered)
Publisher: Taylor & Francis
Published: 2013
Place of publication: Boca Raton, FL
Language: eng
Number of pages: 461
ISBN-13: 9781439831441
Subjects: Neoplasms; Therapy; Methods; Computational Biology
Description: The future of cancer research and the development of new therapeutic strategies rely on our ability to convert biological and clinical questions into mathematical models--integrating our knowledge of tumour progression mechanisms with the tsunami of information brought by high-throughput technologies such as microarrays and next-generation sequencing. Offering promising insights on how to defeat cancer, the emerging field of systems biology captures the complexity of biological phenomena using mathematical and computational tools.
Notes: Includes bibliographical references and index.
Table of contents: title: Introduction : why systems biology of cancer?; title: Basic principles of the molecular biology of cancer; title: Experimental high-throughput technologies for cancer research; title: Bioinformatics tools and standards for systems biology; title: Exploring the diversity of cancers; title: Prognosis and prediction : towards individualised treatments; title: Mathematical modelling applied to cancer cell biology; title: Mathematical modelling of cancer hallmarks; title: Cancer robustness : facts and hypotheses; title: Cancer robustness : mathematical foundations; title: Finding new cancer targets.