Childhood leukemias
By: edited by Ching-Hon Pui
Edition: 3rd ed.
Publisher: Cambridge University Press
Published: 2012
Place of publication: Cambridge
Language: eng
ISBN-13: 9780521196611
Subjects: Leukemia; Child
Description: "In the five years since publication of the second edition of Childhood Leukemias, new insights into the molecular and cellular biology of cancers in general, and of the leukemias in particular, have catalyzed exciting advances in diagnostic methods, strategies of risk assessment and the development of targeted and other novel forms of treatment. Encouraged by this progress, and the enthusiastic responses of readers of the previous edition, I willingly accepted the invitation to develop a third edition of this successful book. The rapid growth in our understanding of the biology of childhood leukemias and the accelerating pace of innovations in diagnostic and therapeutic approaches presented a considerable challenge during revision of the second edition. As you will notice, each chapter has been extensively modified or rewritten to accommodate the most recent information and references. Although structured to emphasize emerging themes in leukemia pathobiology and treatment, the reworked book still seeks to maintain a balance between fundamental pathophysiology and practical approaches to patient management, a standard that was central to the success of our earlier editions.Three chapters are entirely new. One deals with the epigenetics of leukemia, a topic that hasmoved rapidly to the fore of leukemia research.The discovery that aberrant epigenetic changes often cooperate with DNA sequence alterations in the initiation and progression of cancer, and that such changes are potentially reversible, has already led to clinical trials of therapies based on key epigenetic findings"--Provided by publisher.
Notes: Includes bibliographical references and index.
Table of contents: title: Machine generated contents note: Preface; Part I. History and General Issues:; title: History of leukemia Paul Gaynon, Toska Zomorodian and Donald Pinkel; title: Diagnosis and classification Mihaela Onciu and Ching-Hon Pui; title: Epidemiology and etiology Logan Spector, Bridget Charbonneau and Leslie L. Robison; Part II. Cell Biology and Pathobiology; title: Immunophenotyping Fred G. Behm; title: Immunoglobulin and T-cell receptor gene rearrangements Jacques J. M. van Dongen and Anton W. Langerak; title: Cytogenetics of acute leukemias Susana C. Raimondi; title: Molecular genetics of acute lymphoblastic leukemias Charles Mullighan; title: Molecular genetics of acute myeloid leukemia Tanja A. Gruber and James R. Downing; title: Epigenetics of leukemias William Stevenson and Guillermo Garcia-Manero; title: Genetics and cellular drug resistance in acute leukemia / Monique L. den Boer and Rob Pieters; title: Heritable predispositions to childhood hematologic malignancies / Doan Le, Kevin Shannon and Beverly J. Lange; Part III. Evaluation and Treatment; title: Pharmacokinetic, pharmacodynamic, and pharmacogenetic considerations / Stephen W. Paugh, Mary V. Relling and Williams E. Evans; title: Acute lymphoblastic leukemia Ching-Hon Pui; title: Relapsed acute lymphoblastic leukemia / Günter Henze and Arend von Stackelberg; title: B-cell acute lymphoblastic leukemia and Burkitt lymphoma / John T. Sandlund and Mihaela Onciu; title: Acute myeloid leukemia / Jeffrey E. Rubnitz, Hiroto Inaba and Raul Ribeiro; title: Relapsed acute myeloid leukemia Ursula Creutzig; title: Myelodysplastic syndromes / Henrik Hasle; title: Chronic myeloproliferative disorders / Charlotte M. Niemeyer and Franco Locatelli; title: Leukemias in patients with Down syndrome / Jeffrey W. Taub, April Sorrell and James A. Whitlock; title: Treatment of adolescents and young adults with acute lymphoblastic leukemia / James Nachman; title: Hematopoietic stem cell and natural killer cell transplantation / Wing Leung and Michael A. Pulsipher; title: Treatment in the underprivileged countries / Raul Ribeiro, Scott C. Howard and Ching-Hon Pui; title: Antibody-targeted therapy Alan S. Wayne; title: Adoptive cellular immunotherapy / Hyoung Jin Kang, Cliona M. Rooney and Helen Heslop; title: Gene therapy: methods and applications / Ulrike Gerdemann, Martin Pule; and Malcolm K. Brenner; title: Development therapeutics / Sima Jeha; title: Minimal residual disease / Dario Campana, Andrea Biondi and Jacques J. M. van Dongen; Part IV. Complications and Supportive Care; title: Acute complications / Scott C. Howard, Raul Ribeiro and Ching-Hon Pui; title: Late complications after leukemia therapy / Melissa Hudson; title: Therapy-related leukemias / Carolyn A. Felix; title: Infectious complications / Hana Hakim and Patricia M. Flynn; title: Hematologic supportive care / Fariba Navid and Victor M. Santana; title: Pain management / Doralina L. Anghelescu and Roland Kaddoum; title: Psychosocial issues / Sean Phipps, Vida L. Tyc, Heather Conklin and Kevin Krull; title: Nursing care / Jami S. Gattuso, Martha May and Michele Pritchard; Index.