An introduction to statistics in early phase trials
By: Steven Julious, David Machin, Say-Beng Tan.
Contributors: Machin, David, 1939-; Tan, Say-Beng.
Publisher: John Wiley
Published: 2010
Place of publication: Chichester, West Sussex; Hoboken, NJ
Language: eng
ISBN-13: 9780470059852
Subjects: Drugs -- Testing -- Statistical methods; Clinical trials -- Statistical methods; Clinical Trials, Phase I as Topic -- methods; Biometry -- methods; Clinical Trials, Phase II as Topic -- methods; Models, Statistical; Statistics as Topic -- methods
Notes: Includes bibliographical references and index.
Table of contents: title: Early phase trials; title: Introduction to pharmacokinetics; title: Sample size calculations for clinical trials; title: Crossover trial basics; title: Multiperiod crossover trials; title: First time into man; title: Bayesian and frequentist methods; title: First-time-into-new-population studies; title: Bioequivalence studies; title: Other phase I trials; title: Phase II trials : general issues; title: Dose/response studies; title: Phase II trials with toxic therapies; title: Interpreting and applying early phase trial results; title: Go/no-go criteria.