Inhibitors to Coagulation Factors (Advances in Experimental Medicine and Biology)
Contributors: Louis M. Aledort (Editor); Leon W. Hoyer (Editor); Jeanne M. Lusher (Editor); Howard M. Reisner (Editor); Gilbert C. White II (Editor)
Edition: 1 edition
Publisher: Springer
Published: February 29, 1996
Language: eng
Format: Hardcover
Number of pages: 324
ISBN-13: 9780306451966
Subjects: Immunology; Mammals; Medical Hematology; Medical; Medical / Nursing; Science/Mathematics; Life Sciences - Genetics & Genomics; Physiology; Medical / Immunology; Hematology; Antagonists; Blood coagulation factors; Complications; Congresses; Hemophilia
First sentence: Ultimately, understanding how inhibitors to coagulation factors develop will require precise knowledge of the structural epitopes in these factors that are recognized by components of the immune system.
Description: The proceeding papers investigate the integration of modern concepts of immunology and hematology toward the design of potential new therapies for the prevention or elimination of antibodies to F.VIII and F.IX. The current research anticipates gene therapy for hemophilias and the implications of inhibitors in such a course of treatment. Papers include discussions on: the molecular and antigenic structure of factors VIII and IX and von Willebrand factor, the human immune response molecular basis, genetic variation and the immune response, inhibitor treatment, coagulation tolerance, and panel discussions.