Design and analysis of non-inferiority trials
By: Mark D. Rothmann, Brian L. Wiens, Ivan S.F. Chan
Contributors: Wiens, Brian L.; Chan, Ivan S. F.
Series: Chapman & Hall/CRC biostatistics series; Chapman & Hall/CRC biostatistics series
Publisher: Chapman & Hall/CRC
Published: 2011
Place of publication: Boca Raton
Language: eng
ISBN-13: 9781584888048
Subjects: Research Design; Experimental Therapeutics; Experimental design; Testing; Drugs; Investigational Therapies; Clinical Trials as Topic
Description: "The increased use of non-inferiority analysis has been accompanied by a proliferation of research on the design and analysis of non-inferiority studies. Design and Analysis of Non-Inferiority Trials brings together this body of research and confronts the issues involved in the design of a non-inferiority trial. Using examples from real clinical trials, the book discusses general and regulatory issues and illustrates how they affect analysis. Each chapter begins with a non-technical introduction, so the subject is easily understood by those without prior knowledge of non-inferiority clinical trials. The book also provides detailed mathematical approaches along with their mathematical properties"--Provided by publisher.
Notes: Includes bibliographical references and index.