Cancer on trial
Subtitle: oncology as a new style of practice
By: Peter Keating and Alberto Cambrosio
Contributors: Cambrosio, Alberto, 1950-
Publisher: The University of Chicago Press
Published: 2012
Place of publication: Chicago; London
Language: eng
Number of pages: 456
ISBN-13: 9780226428918
Subjects: Oncology; Cancer; Research
Description: This title charts the emergence of a clinical field - medical oncology - for which experimental protocols have become routinized as a form of normal practice.
Notes: Includes bibliographical references and index.
Table of contents: title: From "nonentity" to global network: the rise of a new style of biomedical practice; title: An early career in clinical oncology; title: About this book; title: A capsule history of cancer clinical trials; title: Cancer clinical trials as a new style of practice; title: The protocol; title: Before there were trials; title: Cancer hospitals and cancer institutes; title: Diagnosing cancer; title: Treating cancer; title: Prognosticating cancer; title: Testing therapies; title: The emergence of clinical cancer research (1955-66); title: A landmark clinical trial; title: Curing leukemia: the vamp trial; title: A collective undertaking; title: The elements of innovation; title: What about the patients?; title: The collective turn: cooperative groups as epistemic organizations; title: Assembling the US cooperative system; title: Screening for drugs: from mice to humans; title: Tinkering with the cooperative group structure; title: Meanwhile in Europe; title: Clinical trial statistics; title: What is a random sample?; title: What is statistical significance?; title: Statisticians, statistics, and early cooperative clinical trials; title: Statisticians at the NIH; title: Statisticians in Paris; title: Fabricating the tools of the trade; title: Controversial methods; title: The emergence of the phase system; title: Criticism and the redefinition of clinical cancer trials as an autonomous form of research; title: Clinical cancer research under fire; title: The reorganization of screening and clinical trials in the United States; title: Surgery and radiotherapy in the cooperative groups; title: An avalanche of numbers from the new style of practice (1965-89); title: A web of trials; title: Breast cancer and its trials; title: The lessons of the breast cancer trials; title: The emergence of combination chemotherapy; title: The multiple meanings of breast cancer trials; title: Statisticians, data centers, and the organization of large-scale clinical trials; title: Centers of calculation: us statisticians and the data center; title: The mechanics of data production; title: Meanwhile in Europe, take two; title: Back in the USA: group statisticians and NCI statisticians; title: Insiders' dissent: the randomization debate; title: A relational space of substances and regimens; title: The clinical evaluation of substances; title: Screening substances: the animal screen; title: Procuring compounds; title: Oncopolitics? reshaping collaborative research; title: Centralization or coordination? the European debate; title: Clinical trials as clinical research: the US debate; title: Oncology in the community; title: Targeted therapy, targeted trials (1990-2006); title: Second interlude: molecular biology and oncogenes; title: The rise of molecular biology; title: Cancer and molecular biology: 1960-80; title: The clinical isolation of human oncogenes; title: Oncogenes and oncoproteins since 1982; title: Magic bullets? the Gleevec trials; title: Molecular biology and targeted substances; title: The trials of a targeted therapy; title: Where did Gleevec come from?; title: Monitoring data, managing risks; title: A medical oncologist and his patients; title: Patients and activists; title: Targeted therapy and clinical cancer research; title: Introduction: molecular biology and translational research; title: Molecular biology and the US cooperative groups; title: The reorganization of the drug discovery process and the transformation of the NCI screen; title: Clinical trials in a targeted age; title: More oncopolitics; title: Looking back and looking forward; title: The observational alternative to clinical cancer trials; title: Comparative effectiveness and clinical trials.