Preclinical drug development
By: edited by Mark Rogge, David R. Taft.
Contributors: Rogge, Mark C.; Taft, David R.
Edition: 2nd ed.
Series: Drugs and the pharmaceutical sciences -- 187; Drugs and the pharmaceutical sciences -- v. 187.
Publisher: Informa Healthcare
Published: 2009
Place of publication: New York
Language: eng
ISBN-13: 9781420084726
Subjects: Drug development; Drug Evaluation, Preclinical -- methods; Drug Industry -- methods
Notes: Includes bibliographical references and index.
Table of contents: title: The scope of preclinical drug development : an introduction and framework / Mark C. Rogge; title: Lead molecule selection : pharmaceutical and toxicity assessments / Peter Bullock; title: Interspecies differences in physiology and pharmacology : extrapolating preclinical data to human populations / Marilyn N. Martinez; title: Pharmacokinetics/ADME of small molecules / David Taft and Lawrence Gan; title: Pharmacokinetics/ADME of large molecules / Rene Braeckman and Mark Rogge; title: Preclinical pharmacokinetic-pharmacodynamic modeling and simulation in drug development / Paolo Vicini and Peter L. Bonate; title: Formulation and route of administration influencing drug permeability and absorption / Lynn Van Kampen; title: Assessment of pharmacokinetics and drug activity : isolated organ systems and the membrane transporter family / Kevin R. Sweeney; title: Toxicity evaluations : ICH guidelines and current practice / Jeffrey L. Larson; title: Application of pathology in safety assessment / Robert A. Ettlin and David E. Prentice; title: Utilizing the preclinical database to support clinical drug development / Howard Lee.