Multiscale modeling of cancer
Subtitle: an integrated experimental and mathematical modeling approach
By: Vittorio Cristini, John Lowengrub
Contributors: Lowengrub, John
Publisher: Cambridge University Press
Published: 2010
Place of publication: Cambridge
Language: eng
Number of pages: 298
ISBN-13: 9780521884426
Description: "Mathematical modeling, analysis and simulation are set to play crucial roles in explaining tumor behavior, and the uncontrolled growth of cancer cells over multiple time and spatial scales. This book, the first to integrate state-of-the-art numerical techniques with experimental data, provides an in-depth assessment of tumor cell modeling at multiple scales. The first part of the text presents a detailed biological background with an examination of single-phase and multi-phase continuum tumor modeling, discrete cell modeling, and hybrid continuum-discrete modeling. In the final two chapters, the authors guide the reader through problem-based illustrations and case studies of brain and breast cancer, to demonstrate the future potential of modeling in cancer research. This book has wide interdisciplinary appeal and is a valuable resource for mathematical biologists, biomedical engineers and clinical cancer research communities wishing to understand this emerging field"--Provided by publisher.
Notes: Includes bibliographical references and index.
Table of contents: title: Machine generated contents note: Part I. Theory: 1. Introduction; 2. Biological background; 3. Continuum tumor modeling: single phase; 4. Analysis and calibration of single-phase continuum tumor models; 5. Continuum tumor modeling: multiphase; 6. Discrete cell modeling; 7. Hybrid continuum-discrete models; 8. Numerical schemes; Part II. Applications: 9. Continuum tumor modeling: a multidisciplinary approach; 10. Agent-based cell modeling: application to breast cancer.