Studies on Application of Silyl Groups in Ring-Closing Metathesis Reactions and Fragment-Based Probe Discovery
Contributors: Schreiber, Stuart L.; Kahne, Daniel; Ritter, Tobias
Published: 2012
Language: eng
Description: In efforts to search for tool compounds that are capable of probing normal and disease-associated biological processes, both quality and identity of the screening collection are very important. Towards this goal, diversity-oriented synthesis (DOS) has been explored for a decade, which aims to populate the chemical space with diverse sets of small molecules distinct from the traditional ones obtained via combinatorial chemistry.
Notes: Keywords: diversity-oriented synthesis, fragment-based drug discovery, macrocycle, ring-closing metathesis, stereoselective, vinylsiloxane.

Thesis Ph.D. Harvard University 2012