Small-molecule probes to explore cancer
Contributors: Schreiber, Stuart L.; Kahne, Daniel; Saghatelian, Alan
Published: 2014
Language: eng
Description: Small molecules play important roles in therapeutics and drug discovery. Significant progress has been made by the chemical biology community to discover small-molecule probes to explore biological processes and to treat disease. This thesis describes both the discovery of novel probes for the Hedgehog (Hh) pathway and the application of small molecules in identifying cancer dependencies.
Notes: Keywords: cancer, cancer dependencies, hedgehog signaling, small-molecule probes.

Thesis Ph.D. Harvard University 2014