Is there a common antipsychotic pathway for neuronal gene expression in vitro?
Published: 2006
Language: eng
Number of pages: 102
ISBN-13: 9780494213469
Description: Antipsychotics are the primary medications for schizophrenia. It is hypothesized that all antipsychotics act through a common molecular pathway. To test this hypothesis, the effect on gene expression of two antipsychotics, haloperidol and aripiprazole, was investigated by DNA microarray technology using the NT2 cell fine in vitro. Eighty-one genes were identified to be upregulated in response to both haloperidol and aripiprazole, whereas 61 genes exhibited downregulation in the presence of these drugs. Interestingly, a subset of these genes included COMT and UBE2B, which localize to chromosome regions previously shown to be linked to schizophrenia. In addition, our studies indicate for the first time a number of novel genes, including AREG, KCTD16 and UPB1, that exhibit an altered expression in the presence of these antipsychotics. The discovery of novel genes implicated in the pathways of psychosis may serve as potential targets for the development of new antipsychotics.
Notes: Source: Masters Abstracts International, Volume: 45-03, page: 1472.

Thesis (M.Sc.)--University of Toronto, 2006.

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