Mechanistic studies of SecY-mediated protein translocation in intact Escherichia coli cells
Contributors: Rapoport, Tom A.; Beckwith, Jonathan; Salic, Adrian; Wickner, William; Moazed, Danesh
Published: 2012
Language: eng
Description: During the synthesis of secretory and membrane proteins, polypeptides move through a universally conserved protein-conducting channel, formed by the Sec61/SecY complex that is located in the eukaryotic endoplasmic reticulum membrane or the prokaryotic plasma membrane. The channel operates in two different modes depending on its binding partners. In co-translational translocation, a pathway found in all organisms, the channel associates with a translating ribosome. In post-translational translocation, the channel cooperates with either the Sec62-Sec63 complex in eukaryotes or the SecA ATPase in bacteria.
Notes: Keywords: Protein-conducting channel, Protein translocation, Sec61, Secretion, SecY.

Thesis Ph.D. Harvard University 2012