CONTROLLED HYPEROXYGENATION AND ENDOTRACHEAL SUCTIONING IN HEAD-INJURED ADULTS.
Contributors: Case Western Reserve University.
Published: 1989
Number of pages: 280
Subjects: Health Sciences, Nursing.
Description: The specific aim of this study was to identify the effects of three lung hyperinflation volumes, given before endotracheal suctioning, on the cerebrovascular status of head-injured adults. Two research questions were generated. (1) What are the effects of three controlled lung hyperinflation (LH) volumes, given before endotracranial suctioning (ETS), upon mean arterial pressure (MAP), mean intracranial pressure (MICP), cerebral perfusion pressure (CPP), heart rate (HR), and arterial oxygen saturation levels (SaO2) in adults with a severe closed head injury (CHI)? (2) Which of the three controlled lung hyperinflation volumes produced the least changes in MAP, MICP, CPP (calculated value), HR, and SaO2 in adults with a severe closed head injury.

Results of a repeated-measures analysis of variance (Rh-ANOVA) for significant mean differences from baseline for each dependent variable indicated the following. Lung hyperinflation volumes were not significant for any of the dependent variables (p $>$.05). Sequence effects were significant statistically for all the dependent variables (p $<$.05). Treatment effects were significant for MAP, MICP, HR, and SaO2 (p $<$.05). Volume and sequence interaction effects were significant for HR and SaO2 (P $<$.05).

Post-hoc analysis indicated that MAP was elevated significantly above baseline for 150 seconds after the LH/ETS protocol (p $<$.05). MICP remained elevated significantly for 90 seconds (p $<$.05). CPP remained elevated significantly from baseline for 30 seconds (p $<$.05). SaO2 did not differ significantly from baseline at any time-point after the protocol. HR was elevatedignificantly above baseline at 0, 0, and 60 seconds postprotocol (p $<$.05).

A descriptive analysis of group and individual responses revealed that LH did not protect the majority of the subjects from deleterious changes in MAP and MICP. However, CPP, HR, and SaO2 remained within specified parameters for the majority of subjects during and after the protocol.

The findings support the need for analysis of group and individual responses to experimental protocols since mean values may not reflect changes that are deleterious to an individual. The findings also support the need for additional studies to identify LH volumes that protect subjects from deleterious changes in MAP, MICP, CPP, HR, and SaO2 during ETS. Implications for nursing practice are discussed. (Abstract shortened with permission of author.).
Notes: Source: Dissertation Abstracts International, Volume: 50-10, Section: B, page: 4451.

Thesis (PH.D.)--CASE WESTERN RESERVE UNIVERSITY (HEALTH SCIENCES), 1989.

School code: 0499.