A Role for PVRL4-driven Cell-Cell Interactions in Tumorigenesis
Contributors: Elledge, Stephen J.; Polyak, Kornelia; Brown, Myles; Gaudet, Suzanne; Kuperwasser, Charlotte
Published: 2013
Language: eng
Description: Deciphering genetic determinants of tumorigenesis is the greatest challenge and promise of the present-day era of biomedical research. As extensive tumor genome characterization efforts of the past decade had revealed, tumor genomes harbor multiple point mutations and gene copy number alterations. This exquisite complexity brings forth the challenge of distinguishing numerous incidental alterations from those that are functionally relevant to tumorigenesis. During the past decade, functional genetic screens have shown their utility in identifying genetic changes that functionally contribute to tumor-specific hallmarks and thus hold a great potential for identifying promising new targets for the rational design of successful anticancer therapies.
Notes: Keywords: anchorage independence, cancer, genetic screens, oncogene, transformation.

Thesis Ph.D. Harvard University 2013