Polycystin-1 and bone mechanotransduction
Contributors: Olsen, Bjorn R.; Hauschka, Peter; Warman, Matthew; Reichenberger, Ernst
Published: 2012
Language: eng
Description: Bone mechanotransduction is a fundamental process underlying the remarkable ability of bones to perceive surrounding physical cues and adapt their mass, structure and overall strength to their mechanical environment. Therefore, it is central to many aspects of bone biology and disease. The key to a mechanistic understanding of this process lies in better knowledge of critical signaling molecules that relay the mechanical information inside bone cells. In this thesis, we investigate the role of polycystin-1 (PC1), a proposed fluid flow sensor in kidney epithelial cells, in transducing mechanical signals in bone cells.
Notes: Keywords: bone, loading, mechanotransduction, polycystin-1, shear, shockwave.

Thesis Ph.D. Harvard University 2012