Tight junctions in cancer metastasis
By: Tracey A. Martin, Wen G. Jiang, editors
Series: Cancer metastasis - biology and treatment -- v. 19; Cancer metastasis -- v. 19.
Publisher: Springer
Published: 2013
Place of publication: Dordrecht; New York
Language: eng
Number of pages: 313
ISBN-13: 9789400760271; 9789400760288
Subjects: Metastasis; Neoplasm Metastasis; Tight Junctions
Description: There has been a dramatic increase in knowledge of tight junctions in the past decade. The molecular structure of tight junctions, cellular functions and the pathophysiological roles of tight junctions are becoming clear. Of the most important functions, the role of the cellular structure in cancer spread and drug delivery are increasingly realised. It is now clear that there are fundamental changes to tight junctions during the process of cancer development. Tight junctions are also critical to the metastatic process of cancer cells. The cellular structure is also crucial in drug therapies, namely, the permeability and bioavailability of the drugs, penetration of barriers such as the blood brain barrier. This current volume aims to summarise the current knowledge of tight junctions, their role in cancer and cancer metastasis and is of interest to scientists and clinicians.
Notes: Includes bibliographical references and index.
Table of contents: title: Molecular aspects of tight junctions  -- Elaine A. McSherry, Mark B. Owens, and Ann M. Hopkins; title: Distribution of tight junctions and junctional proteins in the human body  -- Anna-Maria Tokes ... [et al.]; title: Methods to study tight junctions  -- Maria Isabel Larre, Catalina Flores-Maldonado, and Marcelino Cereijido; title: Enhanced vascular permeability in solid tumors : a promise for anticancer nanomedicine  -- Sebastien Taurin and Khaled Greish; title: Tight junctions, junctional adhesion molecules (JAMs), and the blood brain barrier  -- Klaus Ebnet ... [et al.]; title: Tight junctions in human urinary bladder cancer  -- Tracey A. Martin ... [et al.]; title: Tight junctions in colorectal cancer  -- Frederic Hollande and Marina Papin; title: Tight junctions in breast cancer : multifaceted players in tumorigenesis and progression  -- Yvonne Myal and Anne A.A. Blachard; title: Regulation of tight junctions for therapeutic advantages  -- Lorenza Gonzalez-Mariscal, Monica Diaz-Coranguez, and Miguel Quiros; title: VEGF-mediated effects on brain microvascular endothelial tight junctions and transmigration of breast cancer cells across the blood-brain barrier  -- Shalom Avraham ... [et al.]; title: Claudin-5 and cancer metastasis  -- Claudia Malheiros Coutinho-Camillo, Silvia Vanessa Lourenco, and Fernando Augusto Soares; title: Signaling pathways regulating endothelial cell-cell junctions as a barrier to tumor cell metastasis  -- Shigetomo Fukuhara and Naoki Mochizuki; title: ROCK signalling pathway and tight junctions -- Jane Lane, Tracey A. Martin, and Wen G. Jiang.