Differential modulation of intracellular calcium responses in B lymphoblasts by mood stabilizers: Relevance to the molecular therapeutics of bipolar disorder.
Published: 2006
Language: eng
Number of pages: 171
ISBN-13: 9780494213513
Description: Chronic ex vivo treatment with lithium and valproate attenuates stimulated intracellular calcium (Ca2+) responses in B lymphoblast cell lines (BLCLs) from BD-I patients and healthy controls (13Cs). The main objective of this study was to determine whether modification of intracellular Ca2+ abnormalities is a common target of other clinically efficacious mood stabilizers, in particular, lamotrigine. To address this question, the effects of acute and chronic ex vivo treatment of BLCLs from BD-I patients and HCs with therapeutically relevant concentrations of lithium, lamotrigine, or respective vehicles on G-protein-coupled receptor (GPCR)-operated (lysophosphatidic acid [LPA]-stimulated) and capacitance-mediated (thapsigargin [TG]-induced) Ca2+ mobilization were examined. Chronic treatment with lithium modulated receptor-operated Ca2+ flux in BLCLs. In contrast, neither acute nor chronic treatment with lamotrigine affected Ca2+ responses in this cell model. The differential effects of lithium as compared with lamotrigine on Ca2+ homeostasis may reflect the distinctive clinical profiles of these mood stabilizers.
Notes: Source: Masters Abstracts International, Volume: 45-03, page: 1474.

Thesis (M.Sc.)--University of Toronto, 2006.

Electronic version licensed for access by U. of T. users.

ROBARTS MICROTEXT copy on microfiche.