Nonviral Vectors for Gene Therapy, Part 2, Volume 54, Second Edition (Advances in Genetics)
Contributors: Leaf Huang (Editor); Mien-Chie Hung (Editor); Ernst Wagner (Editor)
Edition: 2 edition
Publisher: Academic Press
Published: June 15, 2005
Language: eng
Format: Hardcover
Number of pages: 400
ISBN-13: 9780120176540
Subjects: Medical genetics; Medical / Nursing; Medical; Biotechnology; Genetics; Life Sciences - Genetics & Genomics; Science / Genetics; Gene therapy; Genetic transformation; Genetic vectors
First sentence: As with studies involving viral transduction, the delivery of naked nucleic acids can be broken down into several transport steps, including (1) transport of nuclei acids from the site of injection to the liver, (2) exit of nucleic acids out of the liver vessel lumen into contact with hepatocytes, (3) uptake by hepatocytes, (4) entry into the cytoplasm, and (5) entry into the nucleus.