The role of pigmentation and oncogenic BRAF in melanoma
Contributors: Fisher, David E.; Haigis, Kevin; Weinberg, Robert; Sicinski, Peter; Bardeesy, Nabeel
Published: 2012
Language: eng
Description: BRAF(V600E), the most commonly mutated oncogene in melanoma, is found in about half of patients. By hyperactivating the MAPK pathway, this mutation promotes cell growth and proliferation. Melanocytic BRAF(V600E) alone, however, is insufficient to cause melanoma and rather promotes the development of benign nevi (moles).
Notes: Keywords: BRAF, MC1R, Melanoma, Pigmentation, Redhead, UV-independent.

Thesis Ph.D. Harvard University 2012