Characterization of the transformation and signal transduction properties of TEL/JAK2 fusion proteins associated with human leukemias
By: a thesis presented by Julie Carolyn Frantsve
Published: 2002
Language: eng
Number of pages: 264
Subjects: Leukemia; Genetic aspects; Cellular signal transduction
Notes: Thesis (Ph. D., Division of Medical Sciences (Genetics))--Harvard University, 2002.

Includes bibliographical references (leaves 195-264).
Table of contents: title: Includes three offprints :; title: Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myelo- and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion genes -- (EMBO journal, v.17:18, 1998, pp. 5321-5333); title: Stat5 is essential for the myelo- and lymphoproliferative disease induced by TEL/JAK2 -- (Molecular cell, v.6, September 2000, pp. 693-704); title: Socs-1 inhibits TEL-JAK2-mediated transformation of hematopoietic cells through inhibition of JAK2 kinase activity and induction of proteasome-mediated degradation-- (Molecular and cellular biology, v.21:10, May 2001, pp. 3547-3557)