Obesity is not associated with non-alcoholic fatty liver disease (NAFLD) in HIV-positive gay males.
Published: 2006
Language: eng
Number of pages: 137
ISBN-13: 9780494213445
Description: Background. Although obesity and metabolic syndrome (MS) are associated with non-alcoholic-fatty liver disease (NAFLD) in the general population, it is unclear whether a similar association is found in HIV-associated NAFLD. Objective. To determine if obesity and MS-related parameters are similar in HIV(+)-NAFLD males and HIV(-) NAFLD males. Methods. Anthropometry, diet, exercise, and MS parameters were assessed in eighteen HIV(+) and fourteen HIV(-) age-matched male patients with ultrasound-proven NAFLD. Results. Waist circumference was significantly lower in HIV(+) than HIV(-), 93.1+/-1.7 versus 99.9+/-3.0 cm, respectively. Body mass index and fat mass % were lower whereas arm muscle area was higher in HIV(+). Insulin resistance (IR) parameters and the distribution of simple steatosis versus steatohepatitis were similar in both groups. Conclusion. The results suggest that in HIV(+)-male patients, NAFLD is not associated with obesity related to MS. Other factors such as chronic infection and HIV medications may contribute to IR and metabolic abnormalities.
Notes: Source: Masters Abstracts International, Volume: 45-03, page: 1467.

Thesis (M.Sc.)--University of Toronto, 2006.

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