Fluorine and health
Subtitle: molecular imaging, biomedical materials and pharmaceuticals
By: edited by Alain Tressaud, Günter Haufe
Contributors: ScienceDirect (Online service)
Edition: 1st ed.
Publisher: Elsevier Science
Published: 2008
Place of publication: Amsterdam; Boston
Language: eng
Format: [electronic resource] :
ISBN-13: 9780444530868
Subjects: Biomedical materials; Diagnostic imaging; Pharmacology; Health aspects; Metabolism; Physiological effect; Biomedical and Dental Materials; Pharmaceutical chemistry; Fluorine Radioisotopes; Toxicity; Pharmaceutical Chemistry; Fluorine
Description: Fluorine and Health presents a critical multidisciplinary overview on the contribution of fluorinated compounds to resolve the important global issue of medicinal monitoring and health care. The involved subjects are organized in three thematic parts devoted to Molecular Imaging, Biomedical Materials and Pharmaceuticals. Initially the key-position of partially fluorinated low molecular weight compounds labelled either with the natural 19F-isotope for Magnetic Resonance Imaging (MRI) or labelled with the radioactive [18F]-isotope for Positron Emission Tomography (PET) is highlighted. Both non-invasive methods belong to the most challenging in vivo imaging techniques in oncology, neurology and in cardiology for the diagnosis of diseases having the highest mortality in the industrialized countries. The manifold facets of fluorinated biomaterials range from inorganic ceramics to perfluorinated organic molecules.^

Liquid perfluorocarbons are suitable for oxygen transport and as potential respiratory gas carriers, while fluorinated polymers are connected to the pathology of blood vessels. Another important issue concerns the application of highly fluorinated liquids in ophthalmology. Moreover, fluorine is an essential trace element in bone mineral, dentine and tooth enamel and is applied for the prophylaxis and treatment of dental caries. The various origins of human exposure to fluoride species is detailed to promote a better understanding of the effect of fluoride species on living organisms. Medicinally relevant fluorinated molecules and their interactions with native proteins are the main focus of the third part. New molecules fluorinated in strategic position are crucial for the development of pharmaceuticals with desired action and optimal pharmacological profile. Among the hundreds of marketed active drug components there are more than 150 fluorinated compounds.^

The chapters will illustrate how the presence of fluorine atoms alters properties of bioactive compounds at various biochemical steps, and possibly facilitate its emergence as pharmaceuticals. Finally the synthetic potential of a fluorinase, the first C-F bond forming enzyme, is summarized. - New approach of topics involving chemistry, biology and medicinal techniques - Transdisciplinar papers on fluoride products - Importance of fluoride products in health - Updated data on specific topics.
Notes: Includes bibliographical references and index.

Electronic reproduction. Amsterdam : Elsevier Science & Technology, 2008. Mode of access: World Wide Web. System requirements: Web browser. Title from title screen (viewed on Nov. 14, 2008). Access may be restricted to users at subscribing institutions.
Table of contents: title: PART I: MOLECULAR IMAGING; title: 1. Fluorine-18 Chemistry for Molecular Imaging with Positron Emission Tomography; title: Fr&eacute;d&eacute;ric Doll&eacute;, Dirk Roeda, Bertrand Kuhnast, and Marie-Claire Lasne; title: 2. Application of 18F-PET Imaging for the Study of Alzheimer's Disease; title: Kjell N&aring;gren and Juha O. Rinne; title: 3. 18F-Labeled PET-Tracers for Cardiological Imaging; title: Klaus Kopka, Stefan Wagner, Michael Sch̃fers, Andreas Faust, Otmar Schober, and G&uuml;nter Haufe; title: 4. [18F]-Labeled PET and PET/CT Compounds in Oncology; title: Ken Herrmann and Bernd Joachim Krause; title: 5. Non-Invasive Physiology and Pharmacology Using 19F Magnetic Resonance; title: Jian-Xin Yu, Weina Cui, Dawen Zhao, and Ralph P. Mason; title: PART II: BIOMEDICAL MATERIALS; title: 6. Fluoride-Based Bioceramics; title: Christian Rey, Chrisẗle Combes, Christophe Drouet, and Hocine Sfihi; title: 7. Fluoride in Dentistry and Dental Restoratives; title: John W. Nicholson and Beata Czarnecka; title: ^; title: 8. Fluorinated Biomaterials for Cardiovascular Surgery; title: Charles Baquey, Marie-Christine Durrieu, and Robert G. Guidoin; title: 9. Fluorinated Molecules in Eye Surgery: Experimental and Clinical Benefit of a Heavy Silicone Oil Oxane Hdʼ (Mixture of Silicone Oil and RMN3 Fluorine Olefin) in the Treatment of Retinal Detachment; title: I. Rico-Lattes, J. C. Quintyn, V. Pagot-Mathis, X. Benouaich, and A. Mathis; title: 10. Biocompatibility of Highly Fluorinated Liquids Used in Ophthalmic Surgery; title: Dirk-Henning Menz and Joachim H. Dresp; title: 11. Perfluorochemical-Based Oxygen Therapeutics, Contrast Agents, and Beyond; title: Marie Pierre Krafft and Jean G. Riess; title: 12. Exposure of Humans to Fluorine and Its Assessment; title: Maja Ponikvar; title: PART III: PHARMACEUTICALS; title: 13. Biological Impacts of Fluorination: Pharmaceuticals Based on Natural Products; title: Jean-Pierre B&eacute;gu&eacute; and Dani&egrave;le Bonnet-Delpon; title: 14. Synthesis and Pharmacological Properties of Fluorinated Prostanoids; title: ^; title: ^^; title: Yasushi Matsumura; title: 15. Synthesis and Biochemical Evaluation of Fluorinated Monoamine Oxidase Inhibitors; title: Kenneth L. Kirk, Shinichi Yoshida, and G&uuml;nter Haufe; title: 16. Fluoroolefin Dipeptide Isosteres: Structure, Syntheses, and Applications; title: John T. Welch; title: 17. Molecular Interactions of Fluorinated Amino Acids in a Native Polypeptide Environment; title: Mario Salwiczek, Christian J̃ckel, and Beate Koksch; title: 18. Biological Fluorination in Streptomyces cattleya: The Fluorinase; title: Hai Deng, Fang-Lu Huang, James H. Naismith, David O&prime;Hagan, Jonathan B. Spencer, and Xiaofeng Zhu.; title: ^^