Impedimetric biosensors for medical applications
Subtitle: current progress and challenges
By: Jo V. Rushworth, Natalie A. Hirst, Jack A. Goode, Douglas J. Pike, Asif Ahmed, Paul A. Millner
Contributors: Hirst, Natalie A., author; Goode, Jack A., author; Pike, Douglas J., author; Ahmed, Asif, 1979- author; Millner, Paul, author
Series: Biomedical & nanomedical technologies; Biomedical & nanomedical technologies
Publisher: ASME Press; Momentum Press
Published: 2013
Place of publication: New York, NY
Language: eng
Number of pages: 70
ISBN-13: 9780791860243; 9781606506370
Subjects: Biosensors; Impedance spectroscopy; Biosensing Techniques; Dielectric Spectroscopy
Description: In this monograph, the authors discuss the current progress in the medical application of impedimetric biosensors, along with the key challenges in the field. First, a general overview of biosensor development, structure and function is presented, followed by a detailed discussion of impedimetric biosensors and the principles of electrochemical impedance spectroscopy. Next, the current state-of-the art in terms of the science and technology underpinning impedance-based biosensors is reviewed in detail. The layer- by-layer construction of impedimetric sensors is described, including the design of electrodes, their nano-modification, transducer surface functionalisation and the attachment of different bioreceptors. The current challenges of translating lab-based biosensor platforms into commercially-available devices that function with real patient samples at the POC are presented; this includes a consideration of systems integration, microfluidics and biosensor regeneration. The final section of this monograph describes case studies of successful impedance-based biosensors for the detection of a range of analytes from small molecules up to whole microorganisms. Finally, the authors put forward future perspectives for the clinical applications of impedimetric biosensors. --
Notes: Includes bibliographical references (pages 57-70).
Table of contents: title: 2. Biosensors; title: 2.1 Brief history of biosensor development; title: 2.2 Applications of biosensors; title: 2.3 Biosensor architecture, an overview; title: 2.4 Biorecognition element; title: 2.5 Transducer element; title: 2.6 Summary; title: 3. Electrochemical impedance spectroscopy; title: 3.1 Brief history of the development of impedimetric biosensors; title: 3.2 An overview of impedance; title: 3.3 Principles of impedimetric sensing; title: 3.4 Presenting and analysing impedance data; title: 4. Fabrication of impedimetric biosensors; title: 4.1 Electrode design and materials; title: 4.2 Bioreceptor tethering to transducer surfaces; title: 5. Commercializing impedimetric biosensors: from laboratory to field; title: 5.1 Components of a point-of-care diagnostic device; title: 5.2 From research to point-of-care; title: 5.3 Sample delivery & processing; title: 5.4 Sensor regeneration; title: 5.5 Barriers to commercialisation; title: 6. Case studies of impedimetric biosensors for medical applications; title: 6.1 Whole cells and pathogenic microorganisms; title: 6.2 Protein and peptide biomarkers of disease; title: 6.3 Small molecules; title: 8. Author biographies; title: References.