Mitochondrial inheritance and cell cycle regulation in Saccharomyces cerevisiae
By: David Garry Crider
Publisher: [publisher not identified]
Published: 2012
Place of publication: [New York, N.Y.?]
Language: eng
Description: Movement and positional control of mitochondria and other organelles are coordinated with cell cycle progression in the budding yeast, Saccharomyces cerevisiae. Recent studies have revealed a checkpoint that inhibits cytokinesis when there are severe defects in mitochondrial inheritance. An established checkpoint signaling pathway, the mitotic exit network (MEN), participates in this process. Here, we describe mitochondrial motility during inheritance in budding yeast, emerging evidence for mitochondrial quality control during inheritance, and organelle inheritance checkpoints for mitochondria and other organelles.
Notes: Department: Pathobiology and Molecular Medicine.

Thesis advisor: Liza A. Pon.

Thesis (Ph.D.)--Columbia University, 2012.