Discovering Bioactive Peptides and Characterizing the Molecular Pathways that Control Their Activity
Contributors: Saghatelian, Alan; Liu, David; Hunter, Craig; Leschziner, Andres
Published: 2012
Language: eng
Description: Bioactive peptides constitute a major class of signaling molecules in animals and have been shown to play a role in diverse physiological processes, including hypertension, appetite and sleep. As a result, knowing the identity of these molecules and understanding the mechanisms by which they are regulated has basic and medical significance. In this dissertation, I describe the development and application of novel methods for discovering bioactive peptides and the molecular pathways that control their activity.
Notes: Keywords: bioactive peptide, mass spectrometry, peptidomics, short open reading frame, spinal cord, substance P.

Thesis Ph.D. Harvard University 2012