Glucocorticoids regulate kisspeptin neurons during stress and contribute to infertility and obesity in leptin-deficient mice
Contributors: Saper, Clifford B.; Seminara, Stephanie B.; Carlezon, William A.; De Vries, Geert J.
Published: 2012
Language: eng
Description: Stressors generate adaptive responses, including transient suppression of reproductive function. Natural selection depends on successful reproduction, but inhibition of reproduction to survive famine or escape predation allows animals to survive to reproduce at a later time. The cellular locations and mechanisms responsible for inhibiting and reactivating the reproductive axis during and after stress, respectively, are not well understood.
Notes: Keywords: Glucocorticoid, Kisspeptin, Leptin, Obesity, Reproduction, Stress.

Thesis Ph.D. Harvard University 2012