Prostate cancer
Subtitle: biochemistry, molecular biology and genetics
By: Donald J. Tindall, editor
Series: Protein reviews -- 16; Protein reviews -- 16.
Publisher: Springer
Published: 2013
Place of publication: New York
Language: eng
Number of pages: 522
ISBN-13: 9781461468271
Copyright date: 2013
Subjects: Prostate; Cancer
Description: Prostate cancer is the most frequently diagnosed non-cutaneous malignancy in men, and the second leading cause of male cancer-related mortality in the United States.  The last decade has seen unprecedented progress in the detection, prognosis, treatment and prevention of prostate cancer. These advances have been driven largely by an increased understanding of the underlying biochemistry, molecular biology and genetics of the disease. New cell and animal models have been developed that recapitulate the natural progression of prostate cancer. New technologies have allowed scientists to view in detail the genomic, proteomic, metabolomics and other –omic universe of cancer cells and tissues. This has resulted in a greater understanding of the pathophysiology of the disease.
Notes: Includes bibliographical references and index.
Table of contents: title: Cell biology. Stem cells in the normal and malignant prostate / Norman J. Maitland; title: Role of reactive stroma in prostate cancer / Rebeca San Martin, David R. Rowley; title: The role of cholesterol in prostate cancer / Keith R. Solomon, Kristine Pelton, Michael R. Freeman; title: Genetics. PTEN in prostate cancer / Marcus A. Ruscetti, Hong Wu; title: ETS fusion genes in prostate cancer / J. Chad Brenner, Arul M. Chinnaiyan, Scott A. Tomlins; title: Cell signaling. Signaling mechanisms of Vav3, a guanine nucleotide exchange factor and androgen receptor coactivator, in physiology and prostate cancer progression / Leah S. Lyons, Kerry L. Burnstein; title: Transforming growth factor-beta in prostate cancer / David Danielpour; title: The p38 MAPK pathway in prostate cancer / Daniel Djakiew; title: NF-kappaB2/p52 in prostate cancer / Nagalakshmi Nadiminty, Ramakumar Tummala, Yezi Zhu; title: The functional role of DAB2IP, a homeostatic factor, in prostate cancer / Eun-Jin Yun, Kaijie Wu, Yuh-Shyan Tsai; title: Tyrosine kinases in prostate cancer / Yun Qiu, Dhanraj Deshmukh; title: Human prostatic acid phosphatase in prostate carcinogenesis / Sakthivel Muniyan, Yu-Wei Chou, Shou-Qiang Ou-Yang; title: Hormonal. Truncated androgen receptor splice variants in prostate cancer / Peter E. Lonergan, Donald J. Tindall; title: Biology and clinical relevance of estrogen receptors in prostate cancer / Shuk-Mei Ho, Pheruza Tarapore, Ming-Tsung Lee, and Yuet-Kin Leung; title: Vitamin D and prostate cancer / Jung-Sun Kim, Justin M. Roberts, Nancy L. Weigel; title: HDAC6 regulation of androgen signaling in prostate cancer / Junkui Ai, Zhou Wang; title: Beyond the cell cycle : implications of D-type cyclin deregulation in prostate cancer / Michael A. Augello, William F. Ostrander Jr., Karen E. Knudsen; title: Cell death. Role of par-4 in prostate cancer / Nidhi Shukla, Nikhil K. Hebbar, Vivek M. Rangnekar; title: Autophagy and prostate cancer therapeutics / Hsing-Jien Kung, Chun Changou, Hao G. Nguyen, Joy C. Yang, Christopher P. Evans, Richard J. Bold, and Frank Chuang.