The pyrabactins: Small molecule agonists of the abscisic acid signaling pathway.
Published: 2006
Language: eng
Number of pages: 87
ISBN-13: 9780494211571
Description: A chemical genetic screen in etiolated Arabidopsis  seedlings resulted in the identification of the Pyrabactins (for pyridyl aba activation). Structure-activity analysis revealed the nitrogen in the pyridyl moiety to be important for inhibitory effects of the Pyrabactins on germination and hypocotyl cell expansion. Since many known germination inhibitors affect the GA or ABA pathways, we tested the hypothesis that the Pyrabactins may act through these pathways using mutants. Results suggest that Pyrabactin A activates the ABA signaling. Microarray experiments show that Pyrabactin A is an agonist of the seed-specific ABA pathway. A genetic approach was undertaken to identify mutants resistant to Pyrabactin A. Map-based cloning has been initiated for one of the Pyrabactin A resistant mutants,  pyr1. Genetic analysis of pyr1 suggests that resistance is a dominant Mendelian trait. Results from this thesis provide the basis for developing the Pyrabactins as a tool to further delineate the ABA signaling pathway.
Notes: Source: Masters Abstracts International, Volume: 45-03, page: 1385.

Thesis (M.Sc.)--University of Toronto, 2006.

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