Stochastic models for cell signaling and toxic effects on cells
By: D.P. Gaver, P.A. Jacobs, R.L. Carpenter, T.K. Narayanan
Contributors: Jacobs, Patricia A.; Carpenter, Robert L.; Narayanan, Tandore K.; Naval Postgraduate School (U.S.). Dept. of Operations Research
Publisher: Naval Postgraduate School; Available from National Technical Information Service
Published: 1994
Place of publication: Monterey, Calif; Springfield, Va
Language: eng
Number of pages: 67
Subjects: STOCHASTIC PROCESSES; TOXINS AND ANTITOXINS; CELLS(BIOLOGY)
Other titles: NPS-OR-94-016.
Description: This paper presents generic models for the effect of a chemical toxin on cells forming the tissue      of an organ. The models are illustrative, not specific to organ or toxin. Interactive response of      within-tissue toxin and cells is modeled: cell capability to modify (metabolize or bind) toxin is      represented, as is the alteration of that capability by toxin presence. Both processes are      represented in the context of simple versions of the cell cyde. Toxin-cell interaction is explicitly      represented in terms of inter-cell chemical signaling that encourages replacement or repair of      cells. The impact of cell death by apoptosis and necrosis is represented in terms of      within-tissue toxin concentration. The model is explicitly stochastic, representing inter-cell and      toxin input and within-organ concentration in terms of diffusion approximations. Explicit      mathematical discussion is given of dose-response function behavior at low doses.
Notes: Cover title.

"NPS-OR-94-016."

"December 1994."

AD A290 605.

Includes bibliographical references (p. 58-59).

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