The Role of N6-methyladenosine RNA Methylation in the Regulation of Hematopoietic Stem Cells
By: Heather Lee
Publisher: [publisher not identified]
Published: 2020
Place of publication: [New York, N.Y.?]
Language: eng
Description: Hematopoietic stem cells (HSCs) give rise to all blood cells and are characterized by their ability for life-long self-renewal and multilineage differentiation. HSC function is regulated by complex cell-intrinsic and -extrinsic pathways, but these regulatory mechanisms are not completely understood. Recent work has demonstrated that the epitranscriptional modification N6-methyladenosine (m6A) has important roles in the regulation of many physiologic and pathologic processes in various cell types, but it was previously unknown if and how m6A may regulate adult HSC function. In this work, I uncover the role for m6A in HSC regulation, both cell-intrinsically in regulating HSC differentiation and cell–extrinsically by regulating the formation the HSC bone marrow niche.
Notes: Department: Cellular, Molecular and Biomedical Studies.

Thesis advisor: Lei Ding.

Thesis (Ph.D.)--Columbia University, 2020.