Molecular evolution of new and old mammalian kallikrein gene families.
Published: 2005
Language: eng
Number of pages: 129
Description: Kallikrein gene families have been identified previously in three mammalian species, and individual genes found in many more. This study presents the in silico identification of kallikrein gene families in the recently-sequenced genomes of four additional mammalian species, the chimpanzee, the dog, the pig, and the opossum. Also reported here is the phylogenetic analysis of kallikrein genes and proteins from all seven mammalian families, which clarified the evolutionary relationship between these genes. The chimpanzee was found to contain 15 kallikreins and the canine genome 14, with no orthologue to human KLK3. The pig genome contained 13 genes, lacking homologues to KLK2 and  KLK3, and in the opossum genome 11 kallikreins, orthologous to human  KLK5 through KLK15, were discovered. Common ancestry was proposed for KLK4, KLK5 and KLK14, for  KLK9, KLK11 and KLK15, for KLK10 and KLK12, for KLK6 and KLK13, and for KLK8 and the classical kallikreins (KLK1, KLK2 and KLK3).
Notes: Source: Masters Abstracts International, Volume: 44-02, page: 0753.

Thesis (M.Sc.)--University of Toronto, 2005.

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