Assessing ocular toxicology in laboratory animals
By: Andrea B. Weir, Margaret Collins, editors
Series: Molecular and integrative toxicology; Molecular and integrative toxicology
Publisher: Humana Press (some color)
Published: 2013
Place of publication: New York
Language: eng
Number of pages: 319
ISBN-13: 9781627031639; 9781627031646
Subjects: Ocular toxicology; Veterinary ophthalmology; Tumors in animals; Laboratory animals; Toxicity Tests; Methods; Eye; Anatomy & histology; Pathology; Eye Diseases; Chemically induced; Animal Models
Description: Ocular toxicity is routinely assessed in toxicology studies conducted for regulatory purposes.  Ocular anatomy and physiology and the assessment of ocular toxicity itself can be challenging to scientists involved in the safety assessment of pharmaceuticals, pesticides and other agents. Anatomical and physiological differences between species can impact the nature of ocular effects observed following intended or unintended exposure of ocular tissues to xenobiotics. Ocular Toxicity in Laboratory Animals provides a concise reference addressing ocular anatomy and physiology across species that will enhance the design and interpretation of toxicology studies conducted for regulatory purposes.  The book provides an overview of routine and advanced techniques that are used to assess ocular toxicity including slit lamp biomicroscopy, indirect ophthalmoscopy, electrophysiology and imaging methods for the anterior and posterior segments of the eye. Additionally, the book defines the regulatory expectations for pharmaceuticals intended to treat ocular diseases and for other non-pharmaceutical regulated chemicals. With contributions from experts in the field, Ocular Toxicity in Laboratory Animals is an authoritative, accessible guide for toxicologists and other scientists involved in conducting toxicology studies for regulatory purposes and/or reviewing data from such studies.
Notes: Includes bibliographical references and index.
Table of contents: title: Comparative Ocular Anatomy in Commonly Used Laboratory Animals  -- Mark Vézina; title: Assessment of Ocular Toxicity Potential: Basic Theory and Techniques  -- Robert J. Munger; title: Emerging Imaging Technologies for Assessing Ocular Toxicity in Laboratory Animals  -- T. Michael Nork; title: Emerging Electrophysiological Technologies for Assessing Ocular Toxicity in Laboratory Animals  -- James N. Ver Hoeve; title: Toxicologic Pathology of the Eye: Histologic Preparation and Alterations of the Anterior Segment  -- Kenneth A. Schafer; title: Toxicologic Pathology of the Eye: Alterations of the Lens and Posterior Segment  -- Kenneth A. Schafer; title: Nonclinical Regulatory Aspects for Ophthalmic Drugs  -- Andrea B. Weir; title: Ocular Toxicity Regulatory Considerations for Nondrug Food and Drug Administration (FDA) Products and the Environmental Protection Agency (EPA) -- Christopher Bartlett.