Microarray technology and cancer gene profiling
By: edited by Simone Mocellin.
Contributors: Mocellin, Simone.
Series: Advances in experimental medicine and biology -- v. 593
Publisher: Kluwer Academic/Plenum Publishers; Landes Bioscience/Eurekah.com
Published: 2007
Place of publication: New York, N.Y; Austin, Tex
Language: eng
Number of pages: 159
ISBN-13: 9780387399775
Subjects: Oncogenes; DNA microarrays; Neoplasms -- genetics; Gene Expression Profiling -- methods; Microarray Analysis -- methods
Description: Cancer is a heterogeneous disease in most respects, including its cellularity, different genetic alterations and diverse clinical behaviors. Traditional molecular analyses are reductionist, assessing only one or a few genes at a time, thus working with a biologic model too specific and limited to confront a process whose clinical outcome is likely to be governed by the combined influence of many genes. The potential of functional genomics is enormous, because for each experiment, thousands of relevant observations can be made simultaneously. In the present book, written by leading experts in each field, the technical features characterizing this powerful laboratory tool are discussed, and the applications so far described in the field of oncology are reviewed.
Notes: Includes bibliographical references and index.
Table of contents: title: Manufacturing of microarrays; title: Technological platforms for microarray gene expression profiling; title: Principles of gene microarray data analysis; title: Gaining weights ... and feeling good about it!; title: Complementary techniques; title: Microarrays for cancer diagnosis and classification; title: Gene profiling for the prediction of tumor response to treatment: the case of immunotherapy; title: Identification of molecular determinants of tumor sensitivity and resistance to anticancer drugs; title: SNP and mutation analysis; title: Cancer development and progression; title: Gene expression profiling in malignant lymphomas; title: Tumor immunology.