Protein-protein complexes
Subtitle: analysis, modeling and drug design
By: edited by Martin Zacharias
Publisher: Imperial College Press; Distributed by World Scientific Pub.; World Scientific Publishing Co Pte Ltd
Published: 2010
Place of publication: London; Hackensack, NJ
Language: eng
Number of pages: 390
ISBN-13: 9781848163386; 9781848163393
Subjects: Protein Interaction Mapping; Protein Conformation; Protein Binding; Protein-protein interactions; Chemistry; Multiprotein Complexes
Description: Given the immense progress achieved in elucidating protein-protein complex structures and in the field of protein interaction modeling, there is great demand for a book that gives interested researchers/students a comprehensive overview of the field. This book does just that. It focuses on what can be learned about protein-protein interactions from the analysis of protein-protein complex structures and interfaces. What are the driving forces for protein-protein association? How can we extract the mechanism of specific recognition from studying protein-protein interfaces? How can this knowledge be used to predict and design protein-protein interactions (interaction regions and complex structures)? How can we influence protein-protein interactions by mutagenesis and small-molecule drugs or peptide mimetics?

The book consists of 13 review chapters, written by experts, on the characterization of protein-protein interfaces, structure determination of protein complexes, theory of protein-protein binding, prediction of interfaces and prediction of protein-protein complex structures. It serves as a bridge between analyzing protein-protein complexes and the prediction and design of interactions. --Book Jacket.
Notes: Includes bibliographical references and index.