EFFECT OF POSITIONING ON VENOUS OXYGEN SATURATION IN THE CRITICALLY ILL PATIENT WITH A LOW EJECTION FRACTION.
Contributors: University of California, Los Angeles.
Published: 1993
Number of pages: 179
Subjects: Health Sciences, Nursing.; Health Sciences, Medicine and Surgery.; Biology, Animal Physiology.
Description: Critically ill patients with a low ejection fraction may be vulnerable to decreased mixed venous oxygen saturation resulting from position change. The purposes of this study were the following: (1) to describe the effects of changes in positioning on mixed venous oxygen saturation (SvO$\sb2)$ in the critically ill patient whose cardiopulmonary function is severely compromised by a low ejection fraction; (2) to describe the contribution of variables of oxygen delivery and oxygen consumption to the variance in SvO$\sb2$ in the critically ill patient with a low ejection fraction; (3) to identify the relationship between SvO$\sb2$ and cardiac output (CO) in the critically ill patient with a low ejection fraction. An experimental two-group repeated measures design was used in 42 critically ill patients with an ejection fraction, $<$30% (mean = 19.5%). Patients were assigned randomly to one of two position sequences: supine, right lateral, left lateral or supine, left lateral, right lateral. Data on SvO$\sb2$ were collected at baseline, each minute after position change for 5 minutes and at 15 and 25 minutes. Repeated measures multivariate analysis of variance revealed a difference in SvO$\sb2$ among the 3 positions across time $(<$.0001), with the greatest differences occurring within the first 4 minutes and in the left lateral position. Stepwise multiple regression showed that VO$\sb2$ accounted for a greater proportion of the variance in SvO$\sb2$ with position change than did DO$\sb2,$ 54% (p = 0.001) versus 31% (p = 0.001). The correlation between SvO$\sb2$ and CO was r = 0.54 (p = 0.0002). For subjects not on vasoactive medications (n = 28), the correlation was r = 0.52 (p = 0.004), while for those on vasoactive medication (n = 14), the correlation was r = 0.57 (p = 0.03).

In conclusion, changes in SvO$\sb2$ occur with positioning in critically ill patients with a low ejection fraction. These change s are transient and are the result of changes in oxygen consumption rather than changes in oxygen delivery. The moderate correlation between SvO$\sb2$ and CO suggests that SvO$\sb2$ should not replace CO measurement for clinical decision-making in critically ill patients with a low ejection fraction. Similar correlations in the vasoactive medication group and the no-vasoactive medication group suggest that even with pharmacological support these patients experience changes in SvO$\sb2$ which may not be reflected in concomitant changes in CO.
Notes: Source: Dissertation Abstracts International, Volume: 54-11, Section: B, page: 5602.

Thesis (D.N.SC.)--UNIVERSITY OF CALIFORNIA, LOS ANGELES, 1993.

School code: 0031.