Advances in mitochondrial medicine
By: Roberto Scatena, Patrizia Bottoni, Bruno Giardina, editors
Series: Advances in experimental medicine and biology -- v. 942; Advances in experimental medicine and biology -- v. 942.
Publisher: Springer Verlag
Published: 2012
Place of publication: Dordrecht; New York
Language: eng
Number of pages: 461
ISBN-13: 9789400728684
Subjects: Mitochondrial pathology; Mitochondrial Diseases; Effect of drugs on; Cells; Mitochondria; Physiology
Description: Mitochondria are far more than the powerhouse of the cell as they have classically been described. In fact, mitochondria biological activities have progressively expanded to include not only various bioenergetic processes but also important biosynthetic pathways, calcium homeostasis and thermogenesis, cell death by apoptosis, several different signal transduction pathways mainly related to redox control of gene expression and so on. This functional and structural complexity may undergo important derangements so to justify the definition of mitochondrial medicine, which should include all the clinical consequences of congenital or acquired mitochondrial dysfunctions. There are actually a growing number of studies which assign a significant pathogenic role to damaged mitochondria in different diseases: ischemia/reperfusion injury, neurodegenerative diseases, cancer with its dramatic sequelae (i.e, metastasis), metabolic syndrome, hyperlipidemias, just to mention a few of the most important pathologies. In this context, a further aspect that should not be disregarded is the interaction of pharmacological agents with mitochondria, not only in regard of the toxicological aspects but, above all, of the potential therapeutic applications. In fact, it is interesting to note that, while the properties of different so-called mitoxicants are well-known, the subtle linkages between drugs and mitochondria is still in need of a real pharmacological and therapeutic control at the clinical level. This lack of consideration can often lead to an underestimation of unwanted toxic effects but also of desirable therapeutic activities. A reevaluation of the potential clinical role of mitochondria could give a new light on some yet obscure aspects of human pathophysiology.
Notes: Includes bibliographical references and index.
Table of contents: title: Physiology and structure of mitochondria.; title: The oxidative phosphorylation system in mammalian mitochondria  -- Sergio Papa ... [et al.]; title: Physiology and pathophysiology of mitochondrial DNA  -- Hongzhi Li ... [et al.]; title: Mitochondrial Ca²⁺ as a key regulator of mitochondrial activities  -- Tito Calì, Denis Ottolini, and Marisa Brini; title: Mitochondria and nitric oxide : chemistry and pathophysiology  -- Paolo Sarti ... [et al.]; title: Mitochondria and reactive oxygen species : which role in physiology and pathology?  -- Giorgio Lenaz; title: Uncoupling proteins : molecular, functional, regulatory, physiological, and pathological aspects  -- Francis E. Sluse; title: The mitochondrial pathways of apoptosis -- Jérome Estaquier ... [et al.].; title: Mitochondria and disease.; title: Inherited mitochondrial disorders  -- Josef Finsterer; title: Role of mitochondrial function in insulin resistance  -- Myrte Brands, Arthur J. Verhoeven, and Mireille J. Serlie; title: Mitochondria and diabetes : an intriguing pathogenetic role  -- Philip Newsholme, Celine Gaudel, and Maurico Krause; title: Mitochondria and heart disease  -- Elinor J. Griffiths; title: Mitochondria in neurodegeneration  -- Lezi E and Russell H. Swerdlow; title: Mitochondria and cancer : a growing role in apoptosis, cancer cell metabolism, and dedifferentiation -- Roberto Scatena.; title: Mitochondria, aging, and pharmacotoxicological aspects.; title: Mitochondria and aging  -- Hsin-Chen Lee and Yau-Huei Wei; title: Mitochondria and drugs  -- Roberto Scatena; title: Iatrogenic mitochondriopathies : a recent lesson from nucleoside/nucleotide reverse transcriptase inhibitors  -- George P.H. Leung; title: Dysfunction of mitochondrial respiratory chain complex I in neurological disorders : genetics and pathogenetic mechanisms  -- Vittoria Petruzzella ... [et al.]; title: Anthracyclines and mitochondria -- Alvaro Mordente ... [et al.].; title: Applications of mitochondrial science.; title: Mitochondrial proteomic approaches for new potential diagnostic and prognostic biomarkers in cancer  -- Patrizia Bottoni ... [et al.]; title: Mitochondria in anthropology and forensic medicine -- Tomasz Grzybowski and Urszula Rogalla.