Biological - Mathematical Modeling of Chronic Toxicity
Contributors: MIAMI UNIV FLA DEPT OF ANESTHESIOLOGY
Publisher: Defense Technical Information Center
Published: 1975
Place of publication: Ft. Belvoir
Language: eng
Number of pages: 131
Subjects: Partial pressure; Exponential functions; Gas chromatography; Perfusion; Inhalation; Vapors; Mathematical models; Chemical properties; Compartments; Excretion; Toxicology; Distribution; Toxicity; Dogs; Methylenes; Numerical Mathematics; Humans; Solubility; Metabolism; Blood gases; Concentration(Chemistry); Blood analysis; Pharmacokinetics; Exposure(Physiology); Physiology; Rhesus monkeys
Description: Physiological parameters for rhesus monkey and beagle dog (collected from literature) were tested in inhalation experiments with Forane. (Since Forane does not undergo biotransformation, its uptake and distribution depend solely on physiologocal parameters and solubility). Forane and methylene chloride were used to demonstrate species differences in vapor solubility in tissues of man, rhesus monkeys, beagle dogs, and Wistar rats. The experiments were performed to determine the metabolic coefficients of methylene chloride in monkey and dog. Published data was used to determine the coefficients of methylene chloride in man. These coefficients were used to model chronic exposures.
Notes: APPROVED FOR PUBLIC RELEASE