The hERG cardial potassium channel
Subtitle: structure, function, and long QT syndrome
By: [editors, Derek J. Chadwick, James Goode].
Contributors: Chadwick, Derek.; Goode, Jamie.; Novartis Foundation.
Series: Novartis Foundation symposium -- 266
Publisher: J. Wiley
Published: 2005
Place of publication: New York
Language: eng
Number of pages: 297
Subjects: Potassium channels -- Congresses.; Long QT syndrome -- Congresses.; Heart -- Physiology -- Congresses.; Heart -- Pathophysiology -- Congresses.
Genres: Congresses.
Description: This book draws together contributions from basic, pharmaceutical and clinical sciences and regulatory authority perspectives aimed at a better understanding of the structure and function of hERG, the molecular basis for compound binding and preferred preclinical test systems. Topics include hERG channel gating, regulation of functional expression, pharmacological properties of hERG/IKr channels, drug-induced long QT syndrome and preclinical evaluation and regulatory recommendations for assessing QT prolongation risks.
Notes: Based on a symposium.

Includes bibliographical references and indexes.