Immunobiology of bacterial CpG-DNA
By: H. Wagner (ed.).
Contributors: Wagner, H. 1941-
Series: Current topics in microbiology and immunology -- 247.
Publisher: Springer
Published: 2000
Place of publication: Berlin; New York
Language: eng
Number of pages: 260
Subjects: Cellular immunity.; Immune response.; T cells.
Description: Bacterial CpG-DNA sequences not only serve for genetic information but act as "danger" signal to alert immune cells such as macrophages & dendritic cells. CpG-DNA directly causes activation of these members of the innate immune system yielding in up-regulation of co-stimulatory molecules & pro-inflammatory cytokines. As such they act as "natural" adjuvants to promote protective Th1 polarized T cell immune responses. This book is the first comprehensive review of the data emerging in this field.
Notes: Includes bibliographical references and index.