The impact of bupropion on cue-reactivity and the subjective effects of smoking in ad-lib smokers.
Published: 2006
Language: eng
Number of pages: 111
ISBN-13: 9780494213551
Description: Bupropion is a first-line pharmacotherapy for smoking cessation, but its mechanisms of action are unclear. The effect of bupropion on the smokers' biased reactivity towards smoking-related cues and the influence of bupropion on the subjective effects of smoking were investigated. In a parallel, double-blind study, bupropion (300mg/day) or placebo was randomly assigned for six weeks to 32 daily smokers who did not intend to quit. Outcome measures were collected in biweekly experimental sessions and daily in a diary, under ad-lib smoking condition. Bupropion did not selectively attenuate reactivity towards smoking-related words or visual cues, nor did it influence the subjective effects of smoking. Bupropion-treated subjects showed a reduction in serum cotinine from pre to post treatment, but reported no change in the number of cigarettes smoked daily. These findings do not support reduction in cue-reactivity or attenuation of the subjective effects of smoking as potential mechanisms of action of bupropion.
Notes: Source: Masters Abstracts International, Volume: 45-03, page: 1473.

Thesis (M.Sc.)--University of Toronto, 2006.

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