Advances in medicinal chemistry
By: editors, Bruce E. Maryanoff, Allen B. Reitz
Publisher: Jai Press
Published: 1999
Place of publication: Stamford, Conn
Language: eng
Format: [electronic resource] /
ISBN-13: 9780080526379
Subjects: Drug Guides; Nursing; Pharmacology; MEDICAL; Pharmaceutical chemistry; Pharmacy
Description: Volume 4 of Advances in Medicinal Chemistry is comprised of six chapters on a wide range of topics in medicinal chemistry, including molecular modeling, structure-based drug design, organic synthesis, peptide conformational analysis, biological assessment, structure-activity correlation, and lead optimization. Chapter 1 presents an account about amino acid-based peptide mimetics corresponding to b-turn, loop, helical motifs in proteins as a probe of ligand-receptor and ligand-enzyme molecular interactions. Chapter 2 addresses new facets of the medicinal chemistry of the important anticancer dr.
Notes: Title from PDF title page (viewed July 22, 2008).
Table of contents: title: CHAPTER 5. A THEORETICAL MODEL OF THE HUMAN THROMBIN RECEPTOR (PAR-1), THE FIRST KNOWN PROTEASE-ACTIVATED G-PROTEIN-COUPLED RECEPTORCHAPTER 6. FARNESYL TRANSFERASE INHIBITORS: DESIGN OF A NEW CLASS OF CANCER CHEMOTHERAPEUTIC AGENTS; INDEX;