Wall shear stress and intimal thickening in the right coronary artery.
Published: 2004
Language: eng
Number of pages: 89
Description: Low wall shear stress has been implicated in atherogenesis throughout the arterial tree including the right coronary artery. The objectives of this study were to explicitly test the hypothesis that a correlation exists between atherogenesis and wall shear stress in the right coronary artery, and to determine if it is important to include the effect of branch outflows when assessing this correlation. Post-mortem histological measurements of intimal thickness were compared to wall shear stresses calculated from computational flow modeling in four human right coronary arteries. We found no consistent correlation between intimal thickness and wall shear stress, and also found that ignoring branch flow effects can lead to the observation of a spurious correlation. These findings suggest that wall shear stress does not play a dominant role in the localization of atherogenesis in the human right coronary artery.
Notes: Adviser:  C. Ross Ethier.

Thesis (M.A.Sc.)--University of Toronto, 2004.

Electronic version licensed for access by U. of T. users.

Source: Masters Abstracts International, Volume: 42-06, page: 2083.

MICR copy on microfiche (2 microfiches).