Synthesis of annulated pyrazoles via a tandem alkylation/direct arylation sequence.
Published: 2006
Language: eng
Number of pages: 134
ISBN-13: 9780494210406
Description: The following thesis describes the palladium-catalyzed, norbornene mediated tandem alkylation/direct arylation of pyrazole substrates to form polycyclic annulated compounds. The reaction involves the alkylation of activated aryl groups followed by arylation of the pyrazole nucleus in a one-pot procedure. The mechanism for such transformations is described as a C-H functionalization of the unactivated pyrazole moiety; a previously undescribed event for this heterocycle. Such a methodology circumvents prior activation of the azole and provides a novel route for the functionalization of the core unit. We have shown that a variety of substitution patterns on both the pyrazole moiety and the arene are tolerated in the reaction and a large number of annulated pyrazoles easily produced.
Notes: Source: Masters Abstracts International, Volume: 45-03, page: 1499.

Thesis (M.Sc.)--University of Toronto, 2006.

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