Directed differentiation of mouse embryonic stem cells into neocortical output neurons
Contributors: Macklis, Jeffrey D.; Ma, Qiufu; Dymecki, Susan M.; Young-Pearse, Tracy L.; Nedivi, Elly
Published: 2013
Language: eng
Description: During development of the neocortex, many diverse projection neuron subtypes are generated under regulation of cell-extrinsic and cell-intrinsic controls. One broad projection neuron class, corticofugal projection neurons (CFuPN), is the primary output neuron population of the neocortex. CFuPN axons innervate sub-cortical targets including thalamus, striatum, brainstem, and spinal cord.
Notes: Keywords: Corticofugal projection neurons, Corticospinal motor neurons, Directed Differentiation, Embryonic stem cells, Neocortex, Synthetic modified RNA.

Thesis Ph.D. Harvard University 2013