Regulation of Synapse Development by Activity Dependent Transcription in Inhibitory Neurons
Contributors: Greenberg, Michael E.; Chen, Chinfei; Hensch, Takao; Fishell, Gordon
Published: 2013
Language: eng
Description: Neuronal activity and subsequent calcium influx activates a signaling cascade that causes transcription factors in the nucleus to rapidly induce an early-response program of gene expression. This early-response program is composed of transcriptional regulators that in turn induce transcription of late-response genes, which are enriched for regulators of synaptic development and plasticity that act locally at the synapse.
Notes: Keywords: Activity, Inhibition, Npas4, somatostatin, synapse development.

Thesis Ph.D. Harvard University 2013