Comparative toxicogenomics
By: edited by Christer Hogstrand and Peter Kille
Contributors: ScienceDirect (Online service)
Edition: 1st ed.
Series: Advances in experimental biology
Publisher: Elsevier
Published: 2008
Place of publication: Amsterdam; Boston
Language: eng
Format: [electronic resource] /
ISBN-13: 9780444532749
Subjects: Genetic toxicology
Description: Toxicogenomics analyses the activity of a particular toxin or chemical substance on living tissue based upon a profiling of its known effects on genetic material. Toxicogenomics is important because it may enhance understanding of mechanisms of toxicity, cellular defence systems, and drug action. If this technique is proven to work, it could be used in a similar way for toxicology and toxin-determination to DNA-testing in the forensic identification of individuals. Comparative Toxicogenomics provides a timely overview of current achievements and future areas of development including a review of some of the first really fruitful studies made in this area. * Provides a review of some of the first really fruitful studies made in this area. * Covers different organisms ranging from humans to model species and environmental sentinels so researchers can see how this technique has been used across different organisms and compare the results of each. * The chapters transect research interests from identification of toxic action to environmental monitoring providing a broad view of the area increasing its attractiveness to researchers working in a variety of specialties.
Notes: Includes bibliographical references and indexes.

Electronic reproduction. Amsterdam : Elsevier Science & Technology, 2008. Mode of access: World Wide Web. System requirements: Web browser. Title from title screen (viewed on Nov. 14, 2008). Access may be restricted to users at subscribing institutions.
Table of contents: title: Joseph R. Shaw, Dartmouth College: 'Daphnia Toxicogenomics'; title: Professor Joseph Lunec and Dr. Eugene Halligan, King's College London: 'Human Toxicogenomics'; title: Jake Bundy and Jeremy Nicholson, Imperial College: "Metabolomics and Toxicogenomics"; title: Chris Vulpe, University of California, Berkely: "Model Organisms of Environmental Toxicogenomics (Ecotoxicological model species - Daphnia, fathead minnow and zebrafish)"; title: David Spurgeon, CEH Monks Wood: "Non-model organism Toxicogenomics or Earthworm Toxicogenomics"; title: Charles Tyler, Exeter: "Application of Toxicogenomics for study of endocrine disruption in fish"; title: Jason Snape, Astra-Zeneca Brixham Enviornmental Laboratories: "Microbial Toxicogenomics"; title: Jonathan Freedman, NIEHS: "Comparative Toxicogenomics".