Genetic analysis of complex diseases
By: [edited by] Jonathan L. Haines, Margaret Pericak-Vance.
Contributors: Haines, Jonathan L., 1957-; Pericak-Vance, Margaret Ann.
Edition: 2nd ed.
Publisher: Wiley-Liss
Published: 2006
Place of publication: New York, NY
Language: eng
Number of pages: 485
Subjects: Genetic disorders -- Molecular diagnosis; Gene mapping -- Technique; Genetic Diseases, Inborn -- genetics; Chromosome Mapping; Genetic Markers; Genotype
Other titles: Approaches to gene mapping in complex human diseases.
Description: Provides a comprehensive introduction to the various strategies, designs, and methods of analysis for the study of human genetic disease. It offers a broad-based understanding of the problems and solutions based on successful applications in the design and execution of gene mapping projects. Chapters present clear and easily referenced overviews of the broad range of considerations involved in genetic analysis of human genetic disease, including design, sampling, data collection, linkage and association studies, and social, legal, and ethical issues. Incorporating all new discussion questions and practical examples within each chapter, the book significantly updates treatment of bioinformatics, multiple comparisons, sample size requirements, parametric linkage analysis, case-control and family based approaches, and genomic screening. It covers new methods for analysis of gene-gene and gene-environmental interactions, and features a complete rewrite of the chapter on determining genetic components of disease.
Notes: Includes bibliographical references and index.
Rev. ed. of: Approaches to gene mapping in complex human diseases. Wiley, c1998.