Current topics in membranes
Subtitle: Mechanosensitive Ion Channels : Part A.
Contributors: Benos, Dale J.; Hamill, Owen P.
Series: Current Topics in Membranes -- v.58; Current topics in membranes
Publisher: Elsevier
Published: 2007
Place of publication: Burlington
Language: eng
Format: [electronic resource] :
Number of pages: 444
ISBN-13: 9780080488639
Subjects: Mechanoreceptors; Membrane proteins; Ion Channel Gating; Membrane Potentials; Cell Membrane; Active Biological transport; Cellular Mechanotransduction; Ion channels
Description: Membranes are essential cellular organelles. They not only define cells and other organelles, but also are critical in the cell function by selectively regulating the passage of molecules by acting as a matrix for other signaling molecules, and as conduits of information transfer between the external environment and the cell interior. This series was originally added in 1970 and has since provided a systematic, comprehensive, and rigorous approach to specific topics relevant to the study of cellular membranes. Each volume is a guest edited compendium of membrane biology. This series has been a.
Notes: Description based upon print version of record.

IV. Experimental Results on Flexoelectricity in Biomembranes
Table of contents: title: Front Cover; Mechanosensitive Ion Channels, Part A; Copyright Page; Contents; Contributors; Foreword; Previous Volumes in Series; Chapter 1: Structures of the Prokaryotic Mechanosensitive Channels MscL and MscS; I. Overview; II. Introduction; III. Conductances of MscL and MscS: General Considerations; IV. Structure Determination of MscL and MscS; A. General Considerations in Membrane Protein Crystallography; B. Crystallographic Analysis of MscL and MscS; V. MscL and MscS Structures; VI. The Permeation Pathway in MscL and MscS; VII. Disulfide Bond Formation in MscL; VIII. Concluding Remarks; title: AcknowledgmentsReferences; Chapter 2: 3.5 Billion Years of Mechanosensory Transduction: Structure and Function of Mechanosensitive Channels in Prokaryotes; I. Overview; II. Introduction; III. Discovery, Mechanism, and Structure of MS Channels in Prokaryotes; A. Historical Perspective; B. Conductance, Selectivity, and Activation by Membrane Tension of Bacterial MS Channels; C. Cloning of MscL and MscS of E. coli; D. Molecular Identification of MS Channels in Archaea; E. Molecular Structure of Prokaryotic MS Channels; F. Bilayer Mechanism and Gating by Mechanical Force; title: G. Spectroscopic StudiesH. Structural Models of Gating in MscL and MscS; IV. Pharmacology of Prokaryotic MS Channels; V. Families of Prokaryotic MS Channels; A. MscL Family; B. MscS Family; VI. Early Origins of Mechanosensory Transduction; A. Physiological Function of MS Channels in Prokaryotic Cells; B. Function of MscS-Like Channels in Mechanosensory Transduction in Plants; VII. Concluding Remarks; Acknowledgments; References; Chapter 3: Activation of Mechanosensitive Ion Channels by Forces Transmitted Through Integrins and the Cytoskeleton; I. Overview; II. Introduction; title: III. Conventional Views of MS Channel GatingIV. Tensegrity-Based Cellular Mechanotransduction; V. Force Transmission Through Integrins in Living Cells; VI. Potential Linkages Between Integrins and MS Ion Channels; VII. Conclusions and Future Implications; References; Chapter 4: Thermodynamics of Mechanosensitivity; I. Overview; II. Introduction; A. General Equations; III. Area Sensitivity; A. Line Tension and Area Sensitivity; B. Direct Observations of the Effect of Line Tension and Shape Transformation; IV. Shape Sensitivity; A. Experimental Observation of Shape Sensitivity; title: V. Length Sensitivity and Switch Between Stretch-Activation and Stretch-Inactivation ModesA. Channel Activation by LPLs; B. Other Parameters Regulating Switch Between Stretch-Activation and Inactivation Modes; VI. Thermodynamic Approach and Detailed Mechanical Models of MS Channels; A. Detailed Mechanical Models; VII. Conclusions; References; Chapter 5: Flexoelectricity and Mechanotransduction; I. Overview; II. Introduction; III. Flexoelectricity, Membrane Curvature, and Polarization; A. Flexoelectricity and Membrane Lipids; B. Flexoelectricity and Membrane Proteins