HALOFUGINONE
Subtitle: A STORY OF HOW TARGET IDENTIFICATION OF AN ANCIENT CHINESE MEDICINE AND MULTI-STEP EVOLUTION INFORMS MALARIA DRUG DISCOVERY
Contributors: Wirth, Dyann F.; Gray, Nathanael; Garraway, Levi; Duraisingh, Manoj; Winzeler, Elizabeth
Published: 2014
Language: eng
Description: Malaria is a treatable communicable disease yet remains a common cause of death and disease especially among pregnant women and children. Most of malaria's worldwide burden disproportionately lies in Southeast Asia and Sub-Saharan Africa. Western medicine's 100+ year history of combating Plasmodium falciparum has taught us that the global population of malaria parasites has a unique and dangerous ability to rapidly evolve and spread drug resistance. Recently it was documented that resistance to the first-line antimalarial artemisinin may be developing in Southeast Asia.
Notes: Keywords: drug resistance, evolution, halofuginone, malaria, non-genetic adaptation, tRNA synthetase.

Thesis Ph.D. Harvard University 2014