Hair cortisol as a biomarker of systemic cortisol status in humans.
Published: 2006
Language: eng
Number of pages: 113
ISBN-13: 9780494213520
Description: While further investigation in larger sample populations is required, these results corroborate that hair cortisol levels are a reflection of systemic cortisol concentrations.The purpose of this study was to evaluate the utility of cortisol measurement in hair using a commercial salivary cortisol ELISA and to study the use of hair cortisol levels as a biological marker of Systemic cortisol exposure.Precision, extraction and recovery studied in the assay evaluation were within analytical method guidelines. As expected, hair cortisol levels did not correlate with salivary, plasma or 24-hour urinary Cortisol in the non-obese and healthy subjects combined. Hair cortisol was stable with age, but positively correlated to systolic BP (r=0.283; P=0.033) and weight (r=0.271; P=0.041). The reference range generated in 39 healthy controls was 17.7-153.2 pg/mg of hair (median=46.1 pg/mg). Compared to healthy controls, hair cortisol levels were not significantly different in obese subjects but were significantly higher in chronic pain subjects (P&lt;0.001).
Notes: Source: Masters Abstracts International, Volume: 45-03, page: 1474.

Thesis (M.Sc.)--University of Toronto, 2006.

Electronic version licensed for access by U. of T. users.

ROBARTS MICROTEXT copy on microfiche.