Patterns of molecular evolution and epistasis on a genomic and genic scale
Contributors: Hartl, Daniel L.; Extavour, Cassandra G.; Hoekstra, Hopi E.; Pringle, Anne
Published: 2013
Language: eng
Description: Epistasis describes non-additive interactions which affect gene expression and phenotype. It can happen on multiple levels, including on a genomic level with interactions between genes or even chromosomes affecting global patterns of gene expression. It can also happen within a gene itself, with epistatic interactions between amino acids affecting gene expression and resultant phenotypes. I present three studies in two organisms to study this phenomenon on a global-genomic scale, and also on a local-genic scale.
Notes: Keywords: drug resistance, epistasis, heterochromatin, malaria, Y chromosome.

Thesis Ph.D. Harvard University 2013