Immunotoxicology strategies for pharmaceutical safety assessment
By: [edited by] Danuta J. Herzyk, Jeanine L. Bussiere.
Contributors: Herzyk, Danuta J.; Bussiere, Jeanine L.
Publisher: John Wiley & Sons
Published: 2008
Place of publication: Hoboken, N.J
Language: eng
ISBN-13: 9780470122389
Subjects: Immunotoxicology; Immune system -- Effect of drugs on; Toxicity testing; Drugs -- Toxicology; Drug Toxicity -- immunology; Drug Design; Drug Evaluation -- methods; Immune System -- drug effects; Immunotoxins -- adverse effects; Risk Assessment
Notes: Includes bibliographical references and index.
Table of contents: title: Introduction to immunotoxicology / Jack H. Dean; title: Current regulatory expectations for immunotoxicity evaluation of pharmaceuticals / Kenneth L. Hastings; title: Clinical pathology as crucial insight into immunotoxicity testing / Ellen Evans; title: Histomorphology of the immune system : a basic step in assessing immunotoxicity / Patrick Haley; title: Need for specialized immunotoxicity tests / Kazuchi Nakamura; title: Specific drug-induced immunotoxicity : immune-mediated hemolytic anemia / Raj Krishnaraj; title: T-cell dependent antibody response tests / Joseph R. Picotti; title: Natural killer cell assay and other innate immunity tests / Lisa Plitnick; title: Cellular immune response in delayed hypersensitivity test / Karen Price; title: Evaluation of drug effects on immune cell phenotypes / Laurie Iciek; title: Functional cellular responses and cytokine profiles / Elizabeth R. Gore; title: Application of flow cytometry in drug development / Padma Narayanan, Nianyu Li, and Peter J. Bugelski; title: Animal models of host resistance / Gary R. Burleson and Florence G. Burleson; title: Approaches to evaluation of autoimmunity / Danuta J. Herzyk; title: Differentiation between desired immunomodulation and potential immunotoxicity / Jeanine L. Bussiere and Barbara Mounho; title: Relevant immune tests across different species and surrogate models / Jeanine L. Bussiere; title: Anti-drug antibody responses in preclinical studies and their implications / Barbara Mounho; title: Pharmacological immunogenicity and adverse responses to vaccines / Mary Kate Hart, Mark Bolanowski, and Robert V. House; title: Immunotoxicological concerns for vaccines and adjuvants / Catherine Kaplanski ... [et al.]; title: Systemic hypersensitivity / Raymond Pieters; title: Nonclinical models to assess respiratory hypersensitivity potential / Curtis C. Maier; title: Developmental immunotoxicity in rodents / Rodney R. Dietert and Leigh Ann Burns-Naas; title: Developmental immunotoxicity in non-human primates / Pauline L. Martin and Eberhard Buse; title: Alternative animal models for immunomodulation and immunotoxicity / Peter J. Bugelski; title: Animal models for preclinical comparative immunogenicity testing / Daniel Wierda; title: T-cell epitopes and minimization of immunogenicity / Harald Kropshoffer and Thomas Singer; title: Bridging immunotoxicology to clinical drug development / Ian Gourley and Jacques Descotes.