Conditional mutagenesis
Subtitle: an approach to disease models
By: contributors: A. Abuin ... [et al.] ; editors: Robert Feil and Daniel Metzger.
Contributors: Abuin, A.; Feil, Robert.; Metzger, Daniel.
Series: Handbook of experimental pharmacology -- v. 178
Publisher: Springer
Published: 2007
Place of publication: Berlin; New York
Language: eng
Number of pages: 529
ISBN-13: 9783540351085
Subjects: Mutagenesis -- genetics.; Disease Models, Animal.; Mice, Transgenic -- genetics.; Mutagenesis.; Diseases -- Animal models.; Mice -- Genetics.; Genomes.
Notes: Includes bibliographical references and index.
Table of contents: title: Conditional somatic mutagenesis in the mouse using site-specific recombinases; title: Cre/loxP-mediated chromosome engineering of the mouse genome; title: Tetracycline-controlled genetic switches; title: Novel gene switches; title: Improved embryonic stem cell technologies; title: Gene trap mutagenesis; title: RNA interference in mice; title: Viral vectors: a wide range of choices and high levels of service; title: Conditional mutagenesis by cell-permeable proteins: potential, limitations and prospects; title: Analysis of mouse development with conditional mutagenesis; title: Conditional mouse models of cancer; title: Conditional mutagenesis reveals immunological functions of widely expressed genes: activation thresholds, homeostatic mechanisms and disease models; title: Conditional transgenesis and recombination to study the molecular mechanisms of brain plasticity and memory; title: A novel conditional knockout strategy applied to serotonin receptors; title: Conditional mouse models for Friedreich Ataxia, a neurodegenerative disorder associating cardiomyopathy; title: Animal models in cardiovascular diseases: new insights from conditional models; title: Conditional animal models for the study of lipid metabolism and lipid disorders; title: Conditional mouse models to study developmental and pathophysiological gene function in muscle; title: Analysis of calcuim channels by conditional mutagenesis; title: Conditional mutagenesis of G-protein coupled receptors and G-proteins; title: Contribution of targeted conditional somatic mutagenesis to deciphering retinoid X receptor functions and to generating mouse models of human diseases.