Development and characterization of a novel animal model of diet-induced insulin resistant diabetes and metabolic dyslipidemia: Mechanistic interactions between dietary fructose, fat and cholesterol, and the possible role of liver X receptor in the induction of metabolic syndrome.
Published: 2006
Language: eng
Number of pages: 185
ISBN-13: 9780494161524
Description: The underlying mechanisms of the metabolic syndrome are poorly understood. To further explore these mechanisms, a diet-induced hamster model was studied using the FFC diet (40% fructose, 30% fat, 0.25% cholesterol) over a period of 2 to 20 weeks. Results indicated evidence of hepatic steatosis, elevations in plasma triglyceride (TG), cholesterol, very low density lipoprotein (VLDL)-TG, and increased levels of apolipoprotein B-100 (apoB). Metabolic studies showed alterations in both newly synthesized lipids and lipoprotein metabolism. Hepatic gene expression showed elevations of lipogenic enzymes, and evidence of hepatic insulin resistance.The nuclear receptor LXR is known to be involved in the regulation of signaling and lipid pathways found to be altered in the FFC diet study; a second study was performed to examine LXRalpha-induced changes using the specific LXR agonist, TO901317. LXR activation was found to stimulate lipogenesis, increase newly synthesized apoB-containing lipoprotein particles, and cause a dysregulation of insulin signaling.
Notes: Source: Masters Abstracts International, Volume: 44-06, page: 2773.

Thesis (M.Sc.)--University of Toronto, 2006.

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