Medical scientist virologist pharmacologist Fangruida New crown virus pneumonia research masterpiece: The Great Plague of Humans in the World in the 21st Century---New Coronavirus Pneumonia compiled by Lisa. Laros 2020v.3.5
Subtitle: Fangruida New Coronavirus Pneumonia Research and Prevention Classic-Century Collector's Edition 2020v.3.5
Edition: Fangruida New Coronavirus Pneumonia Research and Prevention Classic-Century Collector's Edition 2020v.3.5
Publisher: Internet
Published: 2020
Place of publication: USA
Language: eng
Copyright date: 3/7/2020
Description: Lisa. Laros:Medical scientist virologist pharmacologist Fangruida New crown virus pneumonia research masterpiece: The Great Plague of Humans in the World in the 21st Century---New Coronavirus Pneumonia
compiled by Lisa. Laros 2020v.3.5
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Fangruida New Coronavirus Pneumonia Research and Prevention Classic-Century Collector's Edition 2020v.3.5
Notes: Fangruida New Coronavirus Pneumonia Research and Prevention Classic-Century Collector's Edition 2020v.3.5
Table of contents: title: Fangruida: ↈ ♣ Top 10 drugs of the new coronavirus pneumonia（Davis）2020v3.0; title: ...————————————————————————————————————; title: The cumulative number of confirmed cases of new coronary pneumonia in the world exceeded 9.08 million, reaching 9.87078 million cases and 471.396 deaths. The number of confirmed cases in the United States reached 2.36 million 593 cases, and there were 122.281 deaths. Statistics from worldometers show that there are 18 countries with more than 100,000 confirmed cases of new pneumonia worldwide, namely the United States, Brazil, Russia, Spain, United Kingdom, India, Italy, Peru, Germany, Iran, Turkey, France, Chile, Mexico, Saudi Arabia, Pakistan, Bangladesh, Canada. There are 7 countries with more than 10,000 deaths, namely the United States, Brazil, Spain, the United Kingdom, Italy, France and Mexico.; title: The World Health Organization WHO announced on the 21st local time that the number of newly confirmed cases in the world's new crown reached a single-day high, with more than 183,000 new cases in 24 hours and more than 4,700 deaths; there were 8.7 million diagnosed cases worldwide and more than 460,000 deaths. From various countries and regions, the number of new cases in the United States and Brazil accounted for half of the total number of new cases on the same day.; title: . New coronavirus pneumonia rages across the world and becomes a global plague. The number of patients and deaths are shocking. The time is long. The range is wide. The transmission coefficient and infection coefficient are difficult to effectively treat.; title: For a long time, it has been up to half a year, and there has not been a decline; title: . It has a major impact on global politics, economy, culture, education, sports, religion, etc., with losses of up to one trillion dollars. If mankind fails to respond effectively to suppression, major disasters will occur worldwide, and the consequences and consequences will be unimaginable. Although group immunization makes sense, it is too costly and deserves reflection and discussion. Therefore, it is very important to use effective drugs and vaccines to prevent and treat symptomatic diseases. Before new special drugs and vaccines are developed, it is especially necessary to respond to effective drugs and try to reduce morbidity and mortality.; title: ....................................................................................; title: A; title: Many people believe that the new coronavirus pneumonia has no specific drugs and no vaccine,; title: and it is an incurable disease. Many industry experts share this view. This kind of cognition and; title: viewpoint must say that it is not wrong. However, there are not only high mortality data in clinical; title: practice, but also a relatively high cure rate. In addition to the patient's condition, medical; title: technology and other reasons, various effective drugs have played a major role, of course,; title: including ventilators, artificial lungs, tube cutting and other rescue medical methods and; title: technologies. According to clinical data, 85% to 93% of patients mainly rely on various medicines; title: to cure, including critically ill late rescue. Most patients are mainly treated with various medicines,; title: especially mild patients and ordinary infected patients. This fully proves the important role of; title: drug control. For critically ill patients, the use of ventilator, artificial lung, intubation, etc. and; title: comprehensive treatment of medical treatment is about 15% -25%. Of course, the cases in; title: different countries in the world are different. Difference or contrast. It is calculated based on the; title: cure rate and average value of the total cases worldwide. Therefore, the significance and clinical; title: effectiveness of various drug treatments cannot be underestimated. This is the most obvious; title: truth, obvious. If you ignore or ignore the important role of drugs, where does the cure rate; title: come from? Where do the large-scale recovery rates, such as sheltered hospitals, come from?; title: What is a magic medicine? What is a new special medicine? Nowadays, we can only look for the; title: wonderful things from the existing effective medicines. If you just wait for new special medicines; title: and new vaccines to come out, the mortality rate will be as high as 56% -92.5%, which is even; title: common knowledge for even three-year-olds. Time is life, time is money, time is price, time is; title: victory or defeat. Even if the isolation such as the closure of the city is effective again, the final; title: victory over the disease mainly requires the completion of various effective drugs. Only when the; title: chemical substances enter the human body will it have a curative effect. (Intubation, ventilator,; title: artificial lung, etc. undoubtedly play an irreplaceable role for drugs, and the two complement; title: each other). Global shutdown for one minute, the economic loss is 300-800 billion US dollars; the; title: United States will die one patient in 26-35 minutes (average count).; title: A; title: A; title: A; title: ,; title: Antivirus The drug of choice is; title: Ribavirin (triazole ribonucleoside, Virazole). [Mechanism of action] is a broad-spectrum antiviral; title: drug, which may inhibit phosphocreatinine dehydrogenase, prevent guanine nucleotides from; title: being synthesized and prevent viral nucleic acids synthesis. It is effective against influenza viruses; title: (type A and B), DNA and RNA viruses, but has no obvious effect on hepatitis B virus; it has; title: preventive and therapeutic effects on viral pneumonia, hepatitis A, herpes, and measles, but; title: clinical evaluations are mixed.; title: Amantadine hydrochloride Rimantadine Hydioch1oride antiviral drugs; title: 】 Polyinosinic Polycytidylic Acid; title: Interferons [Mechanism of Action] This product is a class of antiviral glycoproteins produced by; title: vertebrate cells after other infections caused by viral infection. It is used for the treatment oradjuvant treatment of viral infections, such as viral keratitis, hepatitis, influenza, etc., and; title: malignant tumors.; title: Amantadini Hydrochloridum; title: Aulenuridine Holpin, Brivudine, Audenyl Deoxyuridine, Aufuridine; title: Hydroxymethyl acyclovir ganciclovir; title: Redoxivir azithromycin chloroquine phosphate and so on.; title: A; title: 3 ribavirin; title: 4 Amantadine hydrochloride; title: 5 acyclovir; title: 6 Deoxyacyclic guanosine desciclovir 7 Polyinosinic acid; title: 8 interferon; title: 9 Amantadine hydrochloride; title: 10 Briwood; title: 11 Virus Spirit; title: 12 Adenosine arabinoside 13 Zidovudine; title: 14 dideoxythymidine; title: 15 ganciclovir; title: 16 iodine herpes net; title: 17 telbivudine; title: 18.Dexamethasone For the treatment of severe new coronary pneumonia, British doctors found the effect and effectiveness of dexamethasone. The common side effects of dexamethasone in the treatment of other diseases include anxiety, difficulty sleeping, weight gain, and fluid retention.; title: Less common side effects include eye discomfort, blurred vision, and bleeding.; title: However, patients with new coronavirus only need to use a relatively small amount of medicine to follow the doctor's advice, so side effects should be limited.; title: A; title: ██ Immunopharmaceuticals First choice drug protein powder, thymus pentageptide, thymus; title: peptide, and injections to improve immunity, such as human albumin, lentinan, etc.; title: A; title: ███ Antipneumonia Drugs The first choice for viral pneumonia. The commonly used drugs; title: used to be beneficial to bevirin, but now oseltamivir can also be taken by mouth.; title: For bacterial infections, we usually use various penicillin drugs and cephalosporin drugs.; title: For mycoplasmal pneumonia infections, usually azithromycin, or erythromycin, roxithromycin,; title: etc.; title: A; title: A; title: █████ * Anti-bacteria Anti-bacterial drugs mainly include chemical synthesis: (1) quinones; title: (2) sulfonamides. Antibiotics: (1) Penicillins (2) Chloramphenicol (3) Macrolides (4) Tetracyclines; title: drug*************************************************; title: █ █ █ █ █; title: First choice drug against; title: respiratory infections; title: ███████ due to drug protease inhibits recombinant hepatitis B vaccine (various other; title: recombinant vaccines); title: Recombinant Erythropoietin; title: Interleukin; title: Antagonist; title: A; title: A█████████ compound drug preferred drug bio-missile-virus target tracking bio-virus; title: missile-compound drug; title: ████████████ Pneumonia vaccine The drug of first choice Pneumonia vaccine is; title: a very mature vaccine. The first population is patients with chronic underlying diseases.; title: Especially suffering from congenital heart disease, congestive heart failure, cardiomyopathy, and; title: chronic lung disease, especially chronic obstructive pulmonary disease, pulmonary edema; title: asthma, chronic liver disease, cirrhosis and diabetic cochlear implant, cerebrospinal fluid leakage,; title: etc. Diseases are all people who need pneumonia vaccine.; title: The second population is functional or anatomical asplenium.; title: Chain cell disease and other hemoglobin diseases, congenital or acquired asplenia, splenic; title: dysfunction, splenectomy patients are also pneumonia vaccination groups.; title: The third type of population is those with impaired immune function.; title: If there is congenital or acquired immunodeficiency, or hIv infection or chronic renal failure; title: nephrotic syndrome, systemic malignant tumor, bone marrow transplantation and the need for; title: immunosuppressive drugs, long-term treatment with sebaceous hormones, and radiotherapy; title: and chemotherapy Patients also need to be vaccinated against pneumonia.; title: In addition to the pneumonia vaccines for the three groups above, in fact, infants, young children,; title: elderly people, and patients with alcoholism and smoking are also at high risk of pneumonia.; title: They should also be vaccinated according to their physical conditions.; title: The pneumonia vaccine is not a newly developed vaccine for the new coronavirus pneumonia.; title: Pneumonia combined vaccine, pneumonia combined vaccine is vaccination PC v7; title: Pneumonia polysaccharide vaccine, 23-valent polysaccharide vaccine is also known as; title: pneumonia polysaccharide vaccine. This vaccine can cover 23 serotypes that can cause; title: pneumonia. In life, about 90% of pneumonia are caused by these 23 Caused by various serotypes.; title: And this pneumonia polysaccharide vaccine can play a good role in preventing pneumonia. At; title: present, it has been applied in many regions, and the vaccination protection rate can generally; title: reach 92%, which is very safe. The persistence of the drug effect is also very strong.; title: A; title: It also has a certain preventive effect on the prevention of new coronavirus pneumonia.; title: ██████████████ auxiliary medicine; title: █████████████████ plant medicine; title: A; title: ……… the first choice and screening of drugs, mainly for the diagnosis and treatment of new; title: coronavirus pneumonia, (with underlying diseases not included, comprehensive treatment based; title: on the patient's condition and individual differences, including the treatment of critical illness.); title: The clinical application should be based on the human system It is suitable for flexible application.; title: Pay attention to drugs and various adverse reactions, effective and safe, dosage, and follow the; title: doctor's advice. It should be more cautious for critically ill patients such as elderly and weak; title: patients.; title: ………………………………………; title: The latest number of global outbreaks, relevant sources of information on the website.; title: A total of 1694954 cases, 102607 deaths, and 376102 cases were cured. There were more than; title: 98,000 newly diagnosed cases outside China, with a cumulative total of 1.61 million cases; the; title: number of new deaths exceeded 7097 cases, with a cumulative total of more than 99,000 cases.A; title: According to the epidemic data released by Johns Hopkins University in the United States, as of; title: 9:30 on April 11, Beijing time, a total of 499,252 cases have been diagnosed in the United States; title: and a total of 18,637 deaths.; title: A; title: 147577 cases diagnosed in Italy; title: On the 10th local time, the Italian Civil Protection Department said that Italy had 3951 new cases; title: of newly diagnosed coronary pneumonia with a total of 147577 diagnoses; 570 new deaths and a; title: total of 18849 deaths.; title: A; title: A total of 157,022 cases have been diagnosed in Spain; title: The official website of the Spanish Ministry of Health reported on the 10th that in the past 24; title: hours, the country has added 4,576 new cases of new coronary pneumonia, with a total of; title: 157,022 cases diagnosed. There were 605 new deaths and a total of 15,843 deaths. Another; title: 55,668 people have recovered.; title: A total of 68,192 cases were diagnosed in Iran. The government plans to implement the "Smart; title: Alienation Plan"; title: Iran ’s Ministry of Health announced the latest data on the new coronavirus epidemic on the; title: 10th. As of noon on that day, Iran had 1972 newly diagnosed cases, with a total of 68192; title: confirmed cases, including 4232 deaths, 35465 cases cured, and 3969 cases in critical condition.; title: According to real-time data from Johns Hopkins University, Germany has accumulatively; title: diagnosed 122,171 cases of new coronary pneumonia, 2767 deaths, and cured 53,913 people.; title: A; title: A total of 125,930 cases were diagnosed in France, and only 50 people were diagnosed on the; title: only active aircraft carrier.; title: According to real-time statistical data from Johns Hopkins University in the United States, the; title: number of confirmed cases of new coronary pneumonia in France increased to 125,931, with a; title: total of 13,215 deaths and 25,195 people recovering.; title: A; title: 73,758 cases diagnosed in the UK; title: According to the report of the British Ministry of Health and Social Security on the 10th, there; title: were 5706 new cases of newly diagnosed coronary pneumonia in the UK, and a total of 73,758; title: cases were diagnosed. There were 980 new deaths and a total of 8958 deaths.; title: A; title: A total of 47,029 cases were diagnosed in Turkey, intended to repair patients admitted to; title: abandoned military hospitals; title: According to real-time statistical data from Johns Hopkins University in the United States, the; title: number of confirmed cases of new pneumonia in Turkey increased to 47,029, with a total of; title: 1,006 deaths and 2,423 people recovering.; title: A; title: A total of 22,059 cases were diagnosed in Canada, the official prediction of the new crown; title: epidemic or the death of 10,000 people; title: According to real-time statistics from Johns Hopkins University in the United States, the number; title: of confirmed cases of new coronary pneumonia in Canada increased to 22,148, with a total of570 deaths and 5,892 people recovering.; title: The new Crown Epidemiological Model released by the Canadian government recently shows; title: that even according to the median value of the most ideal situation, 2.5% of the country ’s; title: population, that is, about 934,000 people may be infected with the new crown virus, and about; title: 11,000 people will die.; title: A total of 6134 cases were diagnosed in Japan.; title: According to the Japan Broadcasting Association, as of 11 p.m. local time, 589 new cases of new; title: coronary pneumonia were diagnosed in Japan, with a total of 119 deaths and a total of 6134; title: confirmed diagnoses. Among them, there were 189 newly confirmed cases in Tokyo. Currently,; title: 1,705 cases have been diagnosed in Tokyo.; title: A; title: A; title: In addition to Italy, Spain, France, Germany, and the United Kingdom, 26667 cases were; title: diagnosed in Belgium; 24551 cases were diagnosed in Switzerland and Liechtenstein; 23249 cases; title: were diagnosed in the Netherlands; 15472 cases were diagnosed in Portugal; 9685 cases were; title: diagnosed in Sweden; 6314 cases were diagnosed in Norway;; title: 10408 cases were diagnosed in Israel; 4346 cases were diagnosed in Malaysia; 4695 cases were; title: diagnosed in Pakistan; 2473 cases were diagnosed in Thailand; 3651 cases were diagnosed in; title: Saudi Arabia; 7598 cases were diagnosed in India; 2108 cases were diagnosed in Singapore; 1279; title: cases were diagnosed in Iraq; 993 cases were confirmed in Kuwait; 257 cases were confirmed in; title: Vietnam.; title: 6215 cases were diagnosed in Australia; 1283 cases were diagnosed in New Zealand.; title: There were 19638 cases in Brazil, 5897 cases in Peru and 171 cases in Venezuela.; title: (Source: Johns Hopkins University data, World Health Organization, bbc, Wikipedia, encyclopedia; title: website, etc.); title: Fangruid–Research on New Coronary Pneumonia and Emergency Treatment and Prevention of Outbreak (2020v.30 Global Edition) Luska; title: Fang Ruida New Crown Virus Pneumonia and Viral Biomissile Target Tracking Focus; title: The pandemic virus pneumonia pandemic, in addition to infection and virus contact transmission, is invisible transmission, the spread and spread of hidden patients with no obvious symptoms and no history of direct contact. Bacterial pneumonia, severe respiratory infectious disease pneumonia, viral pneumonia and other respiratory infections, pulmonary inflammation and other cross-infection cause each other. It is also one of the important causes of infection for a large number of patients. The transmission and harm of the virus must not be underestimated. This situation has appeared in Italy, France, Germany, Iran, South Korea, Switzerland, the United States, China and other countries and regions. Direct transmission, indirect transmission, and invisible transmission. The former is guarded against by people, such as closing the city, masks, and taking body temperature. The latter is often ignored by people. Therefore, many infections appear. Direct contact and direct transmission are the main, indirect transmission, invisible contact, and invisible patients, but the latter’s harmful occult potential should not be underestimated. New coronavirus pneumonia and pneumococcal pneumonia are different and concealed. Its strong spread is beyond the expectation of the world. Even professional doctors and disease control virus experts are sometimes misled by these specificities of new coronavirus. It even appeared infected by a virus. Therefore, the population and key populations in the affected areas should take or inject some immune drugs, antiviral drugs, anti-infectious diseases drugs, anti-pneumonia drugs, pneumonia vaccines, anti-respiratory infection drugs, plant drugs, compound drugs, gene drugs, etc. in a timely manner. It is very important to prevent the epidemic and prevent the spread of infection. Whether with or without symptoms, whether the test is negative or positive, whether or not the fever is high, etc., such prevention and control should be carried out in advance. It can play a major role in preventing epidemics and achieve the tracking of viral biological missiles. The purpose of the target.; title: Billions of people around the world have entered the war of epidemic prevention and epidemic prevention. After China, Europe has become the worst-hit area in the world, with more than 150,000 infected people, followed by the United States, Iran, and other countries. The epidemic is still spreading and developing. Case. The total number of patients in the world has exceeded 300,000 people, which is quite terrible, and the death rate continues to increase. It can be seen that the power of neocoronavirus pneumonia and the spread of infection far exceed people’s imagination. The virulence of new crown virus pneumonia, the speed of transmission, and the ability of the virus to spread are rare pandemics in human history. It is very important to isolate the city, wear a mask, take a temperature measurement, and isolate the virus from spreading. However, this alone does not completely fight the disease. What is more important and urgent for New Coronavirus pneumonia is to take antiviral anti-infective anti-pneumonia and immune drugs including pneumonia vaccine in advance. This can greatly reduce transmission and infection, especially in epidemic areas and vulnerable populations. Otherwise, the epidemic will expand, the number of patients will increase, and deaths will increase.; title: World-renowned medical scientist, pharmacologist, and virological research expert Fangruida; title: Professor Fang Ruida’s monograph on new coronavirus pneumonia is available in different versions. The latest version is mainly used here. Including the online version and mobile phone reading version, to meet the urgent needs and references of the vast number of netizens and netizens, medical workers in various countries and health institutions in various countries, pharmaceutical manufacturers, governments and organizations in the world, etc. . Defects, to be correAzithromycin oxytetracycline chloroquine phosphate and pneumonia drugs, immune drugs, gene drugs, antiviral drugs, plant drugs, antibacterial drugs, influenza drugs, etc. Reasonable use and coordination of other drugs, combined use, the main drug Secondary medicines should be used flexibly according to the specific conditions of the patient’s body. Clinical attention to individual differences, whether there are other basic diseases, drug resistance, whether there are complications and adverse reactions, etc., age, family history, history of infectious diseases, individual differences, etc., use medication as appropriate, supplemented by other treatments, especially It is a critically ill patient and the elderly and the disabled. The main medicine and auxiliary medicine should be divided into major, minor and coordination to prevent adverse reactions and other side effects of the medicine. Intensify treatment, reduce mortality, and reduce the probability of morbidity and mild to severe development. Of course, due to the specific treatment of people, due to the severity of the disease, and other specific treatments, we cannot be rigid. These drugs can also be used and taken in advance in the majority of epidemic areas and severely affected areas, especially for susceptible people, the elderly, the sick, and the disabled. Of course, they can also be used for immunization, anti-virus, anti-infection, anti-infective, or injection, regardless of infection , Whether the test is negative or not, whether or not fever and high fever. This will play an important role in epidemic prevention and epidemic prevention, and will achieve the isolation and blockade of viral pneumonia infection and infection. This is also an important prevention and control method in addition to dry mouths. This will greatly reduce the probability of morbidity and death from infection.; title: cted at the time of reprint or paper publication. Please note. (Editor’s Note); title: New coronavirus pneumonia; title: Fang Ruida: nouvelle cible pour le suivi de la pneumonie et de la biomasse virale du virus de la couronne; title: La pandémie de pneumonie à virus pandémique, en plus de la transmission par contact infectieux et viral, est une transmission invisible, la propagation et la propagation de patients cachés sans symptômes évidents et sans antécédents de contact direct. La pneumonie bactérienne, la pneumonie infectieuse respiratoire grave, la pneumonie virale et d’autres infections respiratoires, l’inflammation pulmonaire et d’autres infections croisées se causent mutuellement. C’est également l’une des principales causes d’infection pour un grand nombre de patients. La transmission et les dommages du virus ne doivent pas être sous-estimés. Cette situation est apparue en Italie, en France, en Allemagne, en Iran, en Corée du Sud, en Suisse, aux États-Unis, en Chine et dans d’autres pays et régions. Transmission directe, transmission indirecte et transmission invisible. Le premier est protégé contre les gens, comme la fermeture de la ville, les masques et la prise de température corporelle. Ce dernier est souvent ignoré par les gens. Par conséquent, de nombreuses infections apparaissent. Le contact direct et la transmission directe sont les principaux, la transmission indirecte, le contact invisible et les patients invisibles, mais le potentiel occulte néfaste de ces derniers ne doit pas être sous-estimé. La nouvelle pneumonie à coronavirus et la pneumonie à pneumocoque sont différentes et cachées. Sa forte diffusion dépasse les attentes du monde. Même les médecins professionnels et les experts en virus de contrôle des maladies sont parfois induits en erreur par ces spécificités du nouveau coronavirus. Il est même apparu infecté par un virus. Par conséquent, la population et les populations clés dans les zones touchées devraient prendre ou injecter des médicaments immunitaires, des médicaments antiviraux, des médicaments anti-maladies infectieuses, des médicaments anti-pneumonie, des vaccins contre la pneumonie, des médicaments anti-infections respiratoires, des médicaments végétaux, des médicaments composés, des médicaments génétiques , etc. en temps opportun. Il est très important de prévenir l’épidémie et de prévenir la propagation de l’infection. Que ce soit avec ou sans symptômes, que le test soit négatif ou positif, que la fièvre soit élevée ou non, une telle prévention et un tel contrôle doivent être effectués à l’avance. Il peut jouer un rôle majeur dans la prévention des épidémies et réaliser le suivi des missiles biologiques viraux. Le but de la cible.; title: Fangruida, scientifique médicale de renommée mondiale, pharmacologue et experte en recherche virologique; title: La monographie du professeur Fang Ruida sur la nouvelle pneumonie à coronavirus est disponible en différentes versions. La dernière version est principalement utilisée ici. Y compris la version en ligne et la version de lecture de téléphone mobile, pour répondre aux besoins urgents et aux références du grand nombre d’internautes et d’internautes, de travailleurs médicaux dans divers pays et d’établissements de santé dans divers pays, de fabricants de produits pharmaceutiques, de gouvernements et d’organisations dans le monde, etc. . Défectuosités, à être correAzithromycine oxytétracycline chloroquine phosphate et médicaments contre la pneumonie, médicaments immunitaires, médicaments génétiques, médicaments antiviraux, médicaments végétaux, médicaments antibactériens, médicaments antigrippaux, etc. utilisé avec souplesse en fonction des conditions spécifiques du corps du patient. Attention clinique aux différences individuelles, s’il existe d’autres maladies de base, la résistance aux médicaments, s’il y a des complications et des effets indésirables, etc., l’âge, les antécédents familiaux, les antécédents de maladies infectieuses, les différences individuelles, etc., utiliser des médicaments le cas échéant, complété par autres traitements, en particulier Il s’agit d’un patient gravement malade et des personnes âgées et handicapées. Le médicament principal et le médicament auxiliaire doivent être divisés en principaux, mineurs et coordination pour prévenir les effets indésirables et autres effets secondaires du médicament. Intensifiez le traitement, réduisez la mortalité et réduisez la probabilité de morbidité et de développement léger à sévère. Bien sûr, en raison du traitement spécifique des personnes, en raison de la gravité de la maladie et d’autres traitements spécifiques, nous ne pouvons pas être rigides. Ces médicaments peuvent également être utilisés et pris à l’avance dans la majorité des zones épidémiques et des zones gravement touchées, en particulier pour les personnes sensibles, les personnes âgées, les malades et les handicapés. Bien sûr, ils peuvent également être utilisés pour l’immunisation, l’antivirus, l’anti-infection, l’anti-infectieux ou l’injection, indépendamment de l’infection, que le test soit négatif ou non, qu’il y ait ou non de la fièvre et une forte fièvre. Cela jouera un rôle important dans la prévention des épidémies et la prévention des épidémies, et permettra d’isoler et de bloquer l’infection et l’infection par pneumonie virale. C’est également une méthode de prévention et de contrôle importante en plus de la bouche sèche. Cela réduira considérablement la probabilité de morbidité et de décès par infection.; title: au moment de la réimpression ou de la publication sur papier. Notez s’il vous plaît. (Note de l’éditeur); title: Nouvelle pneumonie à coronavirus; title: Fuoco di inseguimento dell’obiettivo del biomissile virale di polmonite del virus di Fang Ruida e del nuovo; title: La pandemia di polmonite da virus pandemico, oltre all’infezione e alla trasmissione del contatto virale, è la trasmissione invisibile, la diffusione e la diffusione di pazienti nascosti senza sintomi evidenti e nessuna storia di contatto diretto. Polmonite batterica, polmonite respiratoria grave, polmonite virale e altre infezioni respiratorie, infiammazione polmonare e altre infezioni crociate si causano a vicenda. È anche una delle cause importanti dell’infezione per un gran numero di pazienti. La trasmissione e il danno del virus non devono essere sottovalutati. Questa situazione è apparsa in Italia, Francia, Germania, Iran, Corea del Sud, Svizzera, Stati Uniti, Cina e altri paesi e regioni. Trasmissione diretta, trasmissione indiretta e trasmissione invisibile. Il primo è protetto dalle persone, come la chiusura della città, le maschere e la temperatura corporea. Quest’ultimo è spesso ignorato dalle persone. Pertanto, compaiono molte infezioni. Il contatto diretto e la trasmissione diretta sono i principali, la trasmissione indiretta, il contatto invisibile e i pazienti invisibili, ma il potenziale occulto nocivo di quest’ultimo non deve essere sottovalutato. La polmonite da nuovo coronavirus e la polmonite da pneumococco sono diverse e nascoste. La sua forte diffusione va oltre le aspettative del mondo. Anche i medici professionisti e gli esperti di virus per il controllo delle malattie sono talvolta fuorviati da queste specificità del nuovo coronavirus. Sembrava persino infetto da un virus. Pertanto, la popolazione e le popolazioni chiave nelle aree interessate dovrebbero assumere o iniettare alcuni farmaci immunitari, farmaci antivirali, farmaci per malattie infettive, farmaci anti-polmonite, vaccini contro la polmonite, farmaci anti-respiratori, farmaci vegetali, farmaci composti, farmaci genici , ecc. in modo tempestivo. È molto importante prevenire l’epidemia e prevenire la diffusione dell’infezione. Sia con o senza sintomi, se il test è negativo o positivo, se la febbre è alta o meno, tale prevenzione e controllo dovrebbero essere effettuati in anticipo. Può svolgere un ruolo importante nella prevenzione delle epidemie e nel tracciare i missili biologici virali. Lo scopo del bersaglio.; title: Scienziato medico di fama mondiale, farmacologo ed esperto di ricerca virologica Fangruida; title: La monografia del professor Fang Ruida sulla nuova polmonite da coronavirus è disponibile in diverse versioni. L’ultima versione è utilizzata principalmente qui. Inclusa la versione online e la versione di lettura del telefono cellulare, per soddisfare le urgenti esigenze e riferimenti del vasto numero di netizen e netizen, operatori sanitari in vari paesi e istituzioni sanitarie in vari paesi, produttori farmaceutici, governi e organizzazioni nel mondo, ecc. . Difetti, per essere corretti Azitromicina ossitetraciclina clorochina fosfato e farmaci polmonite, farmaci immunitari, farmaci genetici, farmaci antivirali, farmaci vegetali, farmaci antibatterici, farmaci influenzali, ecc. Uso ragionevole e coordinamento di altri farmaci, uso combinato, il farmaco principale I farmaci secondari dovrebbero essere utilizzato in modo flessibile in base alle condizioni specifiche del corpo del paziente. L’attenzione clinica alle differenze individuali, se ci sono altre malattie di base, resistenza ai farmaci, se ci sono complicazioni e reazioni avverse, ecc., Età, storia familiare, storia di malattie infettive, differenze individuali, ecc., Usare i farmaci come appropriato, integrato da altri trattamenti, in particolare si tratta di un paziente gravemente malato e di anziani e disabili. La medicina principale e la medicina ausiliaria devono essere suddivise in principali, minori e di coordinamento per prevenire reazioni avverse e altri effetti collaterali del medicinale. Intensificare il trattamento, ridurre la mortalità e ridurre la probabilità di morbilità e sviluppo da lieve a grave. Naturalmente, a causa del trattamento specifico delle persone, a causa della gravità della malattia e di altri trattamenti specifici, non possiamo essere rigidi. Questi farmaci possono anche essere utilizzati e assunti in anticipo nella maggior parte delle aree epidemiche e delle aree gravemente colpite, in particolare per le persone sensibili, gli anziani, i malati e i disabili. Naturalmente, possono anche essere utilizzati per immunizzazione, anti-virus, anti-infezione, anti-infettiva o iniezione, indipendentemente dall’infezione, indipendentemente dal fatto che il test sia negativo o meno, indipendentemente dalla febbre e dalla febbre alta. Ciò svolgerà un ruolo importante nella prevenzione dell’epidemia e nella prevenzione dell’epidemia e raggiungerà l’isolamento e il blocco dell’infezione e dell’infezione da polmonite virale. Questo è anche un importante metodo di prevenzione e controllo oltre alla secchezza delle fauci. Ciò ridurrà notevolmente la probabilità di morbilità e morte per infezione.; title: citato al momento della ristampa o pubblicazione su carta. Notare che. (Nota dell’editore); title: Nuova polmonite da coronavirus; title: Fang Ruida New Crown Virus Lungenentzündung und virale biomissile Target Tracking Focus; title: Die Pandemie-Virus-Pneumonie-Pandemie ist neben der Infektion und der Übertragung von Viruskontakten eine unsichtbare Übertragung, die Ausbreitung und Ausbreitung versteckter Patienten ohne offensichtliche Symptome und ohne direkten Kontakt in der Vorgeschichte. Bakterielle Lungenentzündung, schwere Infektionskrankheit der Atemwege, virale Lungenentzündung und andere Infektionen der Atemwege, Lungenentzündung und andere Kreuzinfektionen verursachen sich gegenseitig. Es ist auch eine der wichtigsten Infektionsursachen für eine große Anzahl von Patienten. Die Übertragung und der Schaden des Virus dürfen nicht unterschätzt werden. Diese Situation ist in Italien, Frankreich, Deutschland, Iran, Südkorea, der Schweiz, den Vereinigten Staaten, China und anderen Ländern und Regionen aufgetreten. Direkte Übertragung, indirekte Übertragung und unsichtbare Übertragung. Ersteres wird von Menschen wie der Schließung der Stadt, Masken und Körpertemperatur geschützt. Letzteres wird von Menschen oft ignoriert. Daher treten viele Infektionen auf. Direkter Kontakt und direkte Übertragung sind die Haupt-, indirekte Übertragung, unsichtbarer Kontakt und unsichtbare Patienten, aber das schädliche okkulte Potenzial des letzteren sollte nicht unterschätzt werden. Neue Coronavirus-Pneumonie und Pneumokokken-Pneumonie sind unterschiedlich und verborgen. Seine starke Verbreitung übertrifft die Erwartungen der Welt. Selbst professionelle Ärzte und Experten für Krankheitsbekämpfungsviren werden manchmal durch diese Besonderheiten des neuen Coronavirus in die Irre geführt. Es schien sogar von einem Virus infiziert zu sein. Daher sollten die Bevölkerung und die Schlüsselpopulationen in den betroffenen Gebieten einige Immunmedikamente, antivirale Medikamente, Medikamente gegen Infektionskrankheiten, Medikamente gegen Lungenentzündung, Impfstoffe gegen Lungenentzündung, Medikamente gegen Atemwegsinfektionen, pflanzliche Medikamente, zusammengesetzte Medikamente und Genmedikamente einnehmen oder injizieren usw. rechtzeitig. Es ist sehr wichtig, die Epidemie und die Ausbreitung von Infektionen zu verhindern. Ob mit oder ohne Symptome, ob der Test negativ oder positiv ist, ob das Fieber hoch ist oder nicht usw. Eine solche Prävention und Kontrolle sollte im Voraus durchgeführt werden. Es kann eine wichtige Rolle bei der Verhinderung von Epidemien und der Verfolgung viraler biologischer Raketen spielen. Der Zweck des Ziels.; title: Weltbekannter medizinischer Wissenschaftler, Pharmakologe und virologischer Forschungsexperte Fangruida; title: Die Monographie von Professor Fang Ruida über die neue Coronavirus-Pneumonie ist in verschiedenen Versionen erhältlich. Hier wird hauptsächlich die neueste Version verwendet. Einschließlich der Online-Version und der Handy-Leseversion, um den dringenden Bedürfnissen und Referenzen der großen Anzahl von Internetnutzern und Internetnutzern, Medizinern in verschiedenen Ländern und Gesundheitseinrichtungen in verschiedenen Ländern, Pharmaherstellern, Regierungen und Organisationen in der Welt usw. gerecht zu werden. . Defekte, um zu korrigierenAzithromycin Oxytetracyclin Chloroquinphosphat und Lungenentzündung Medikamente, Immunmedikamente, Genmedikamente, antivirale Medikamente, pflanzliche Medikamente, antibakterielle Medikamente, Influenza-Medikamente usw. Angemessene Verwendung und Koordination anderer Medikamente, kombinierte Verwendung, das Hauptarzneimittel Sekundärmedikamente sollten sein flexibel entsprechend den spezifischen Bedingungen des Körpers des Patienten verwendet. Klinische Aufmerksamkeit für individuelle Unterschiede, ob es andere Grunderkrankungen gibt, Arzneimittelresistenz, ob es Komplikationen und Nebenwirkungen gibt usw., Alter, Familienanamnese, Vorgeschichte von Infektionskrankheiten, individuelle Unterschiede usw., verwenden Sie gegebenenfalls Medikamente, ergänzt durch andere Behandlungen, insbesondere Es handelt sich um einen schwerkranken Patienten sowie ältere und behinderte Menschen. Das Hauptarzneimittel und das Hilfsarzneimittel sollten in Haupt-, Neben- und Koordinationsmedikamente unterteilt werden, um Nebenwirkungen und andere Nebenwirkungen des Arzneimittels zu vermeiden. Intensivieren Sie die Behandlung, senken Sie die Mortalität und verringern Sie die Wahrscheinlichkeit von Morbidität und leichter bis schwerer Entwicklung. Natürlich können wir aufgrund der spezifischen Behandlung von Menschen, der Schwere der Krankheit und anderer spezifischer Behandlungen nicht starr sein. Diese Medikamente können auch in den meisten Epidemiegebieten und stark betroffenen Gebieten, insbesondere für anfällige Menschen, ältere Menschen, Kranke und Behinderte, verwendet und im Voraus eingenommen werden. Natürlich können sie auch zur Immunisierung, Antivirus-, Infektions-, Infektions- oder Injektionsbehandlung verwendet werden, unabhängig von der Infektion. Ob der Test negativ ist oder nicht, ob Fieber und hohes Fieber. Dies wird eine wichtige Rolle bei der Prävention von Epidemien und Epidemien spielen und die Isolierung und Blockade von Infektionen und Infektionen mit viralen Lungenentzündungen erreichen. Dies ist neben trockenem Mund auch eine wichtige Präventions- und Kontrollmethode. Dies wird die Wahrscheinlichkeit von Morbidität und Tod durch Infektion erheblich verringern.; title: Zum Zeitpunkt des Nachdrucks oder der Veröffentlichung in Papierform. Bitte beachten Sie. (Anmerkung der Redaktion); title: Neue Coronavirus-Pneumonie; title: Fang Ruida Nueva corona Virus de la neumonía y Viral Biomissile Target Tracking Focus; title: La pandemia de neumonía por el virus de la pandemia, además de la infección y la transmisión por contacto del virus, es la transmisión invisible, la propagación y propagación de pacientes ocultos sin síntomas obvios y sin antecedentes de contacto directo. La neumonía bacteriana, la enfermedad infecciosa respiratoria grave, la neumonía, la neumonía viral y otras infecciones respiratorias, la inflamación pulmonar y otras infecciones cruzadas se causan entre sí. También es una de las causas importantes de infección para una gran cantidad de pacientes. La transmisión y el daño del virus no deben subestimarse. Esta situación ha aparecido en Italia, Francia, Alemania, Irán, Corea del Sur, Suiza, Estados Unidos, China y otros países y regiones. Transmisión directa, transmisión indirecta y transmisión invisible. El primero está protegido contra personas, como cerrar la ciudad, máscaras y tomar la temperatura corporal. Este último es a menudo ignorado por la gente. Por lo tanto, aparecen muchas infecciones. El contacto directo y la transmisión directa son los principales, la transmisión indirecta, el contacto invisible y los pacientes invisibles, pero no debe subestimarse el potencial oculto dañino de este último. La nueva neumonía por coronavirus y la neumonía neumocócica son diferentes y están ocultas. Su fuerte difusión está más allá de las expectativas del mundo. Incluso los médicos profesionales y los expertos en virus de control de enfermedades a veces se confunden con estas especificidades del nuevo coronavirus. Incluso apareció infectado por un virus. Por lo tanto, la población y las poblaciones clave en las áreas afectadas deben tomar o inyectarse algunos medicamentos inmunes, medicamentos antivirales, medicamentos contra enfermedades infecciosas, medicamentos contra la neumonía, vacunas contra la neumonía, medicamentos contra la infección respiratoria, medicamentos vegetales, medicamentos compuestos, medicamentos genéticos. , etc. de manera oportuna. Es muy importante prevenir la epidemia y prevenir la propagación de la infección. Ya sea con o sin síntomas, si la prueba es negativa o positiva, si la fiebre es alta o no, etc., dicha prevención y control deben llevarse a cabo con anticipación. Puede desempeñar un papel importante en la prevención de epidemias y lograr el seguimiento de misiles biológicos virales. El propósito del objetivo.; title: Fangruida, científico médico, farmacólogo y experto en investigación virológica de renombre mundial.; title: La monografía del profesor Fang Ruida sobre la nueva neumonía por coronavirus está disponible en diferentes versiones. La última versión se usa principalmente aquí. Incluyendo la versión en línea y la versión de lectura de teléfonos móviles, para satisfacer las necesidades urgentes y referencias de la gran cantidad de internautas y cibernautas, trabajadores médicos en varios países e instituciones de salud en varios países, fabricantes farmacéuticos, gobiernos y organizaciones en el mundo, etc. . Defectos, para ser correctosAzitromicina oxitetraciclina fosfato de cloroquina y medicamentos para la neumonía, medicamentos inmunes, medicamentos genéticos, medicamentos antivirales, medicamentos vegetales, medicamentos antibacterianos, medicamentos contra la influenza, etc. Uso razonable y coordinación de otros medicamentos, uso combinado, el medicamento principal Los medicamentos secundarios deben ser Se utiliza de forma flexible de acuerdo con las condiciones específicas del cuerpo del paciente. Atención clínica a las diferencias individuales, si hay otras enfermedades básicas, resistencia a los medicamentos, si hay complicaciones y reacciones adversas, etc., edad, antecedentes familiares, antecedentes de enfermedades infecciosas, diferencias individuales, etc., use medicamentos según corresponda, complementados con Otros tratamientos, especialmente Es un paciente crítico y los ancianos y discapacitados. La medicina principal y la medicina auxiliar deben dividirse en mayor, menor y coordinación para prevenir reacciones adversas y otros efectos secundarios de la medicina. Intensifique el tratamiento, reduzca la mortalidad y reduzca la probabilidad de morbilidad y desarrollo leve a severo. Por supuesto, debido al tratamiento específico de las personas, debido a la gravedad de la enfermedad y otros tratamientos específicos, no podemos ser rígidos. Estos medicamentos también se pueden usar y tomar con anticipación en la mayoría de las áreas epidémicas y áreas severamente afectadas, especialmente para personas susceptibles, ancianos, enfermos y discapacitados. Por supuesto, también pueden usarse para inmunización, antivirus, antiinfecciosos, antiinfecciosos o inyectables, independientemente de la infección, ya sea que la prueba sea negativa o no, ya sea fiebre o fiebre alta. Esto jugará un papel importante en la prevención de epidemias y la prevención de epidemias, y logrará el aislamiento y bloqueo de la infección y la infección por neumonía viral. Este también es un método importante de prevención y control además de la boca seca. Esto reducirá en gran medida la probabilidad de morbilidad y muerte por infección.; title: cted en el momento de la reimpresión o publicación en papel. Tenga en cuenta. (Nota del editor); title: Nueva neumonía por coronavirus; title: Fangruida: Integration of 10 major drugs for clinical application of drugs for effective treatment of new and new coronavirus pneumonia and redundant design of drugs for clinical application–“Virus bio-missile”, “Coronavirus pneumonia (respiratory severe pneumonia infectious disease) alphabetic bio-missile”; title: Fangruida: New crown virus pneumonia swept the world, with more than 300,000 worldwide epidemics, deaths approaching 20,000, pre-control prevention first; title: Billions of people around the world have entered the war on epidemic prevention and resistance. Following China, Europe has become the worst-hit area in the world, with more than 150,000 people infected. Italy, France, Spain, Germany, etc., followed by the United States, Iran and other countries. The epidemic is still spreading, and cases have also occurred in Africa and Australia. The total number of patients in the world has exceeded 300,000 people, which is quite terrible, and the death rate continues to increase. It can be seen that the power of neocoronavirus pneumonia and the spread of infection far exceed people’s imagination. The virulence of new crown virus pneumonia, the speed of transmission, and the ability of the virus to spread are rare pandemics in human history. It is very important to isolate the city, wear a mask, take a temperature measurement, and isolate the virus from spreading. However, this alone does not completely fight the disease. What is more important and urgent for New Coronavirus pneumonia is to take antiviral anti-infective anti-pneumonia and immune drugs including pneumonia vaccine in advance. This can greatly reduce transmission and infection, especially in epidemic areas and vulnerable populations. Otherwise, the epidemic will expand, the number of patients will increase, and deaths will increase. Especially in large and medium-sized cities, which are densely populated and easy to spread and infect, they should take precautions instead of medical treatment after the fact.; title: **************************************; title: March 15, 2020 (Carstensen, J. M. Munich); title: ————————————————————————————————————————; title: Key words; title: New Coronavirus Severe Pneumonia, White Pneumonia Pneumonia Integration of 10 Drugs and Drug Redundant Design Technology Compound Drugs Chemical Drug Structure Modification and Pure Plant Drugs; title: The occult sexual transmission of the new coronavirus pneumonia virus is easily ignored. Therefore, countries in the affected areas should generally adopt various air defense measures, antiviral drugs, immune drugs, pneumonia vaccines, pneumonia drugs, plant drugs, compound drugs, gene drugs, etc These drugs should be taken among key populations susceptible to the population, regardless of whether the test is negative, and whether or not they are in close contact or suspected cases. These drugs will also constitute viral biological missiles, which have a great effect on immunity and anti-virus and anti-infection, especially in key epidemic areas, which is of great significance.; title: ●● Neocoronavirus pneumonia actually has the characteristics and considerable commonalities of coronary pneumonia (Sars et al.), Severe pneumonia, white lung disease pneumonia, and epidemic infectious infection pneumonia, and their respective specificities. It is a new virus pneumonia and an extension of traditional infectious severe pneumonia. This fully demonstrates the evolution and genetic variation of the natural biological world, including microorganisms and animals, and humans.; title: ●● Studies on the pathogenesis and pathogenicity of new coronaviruses (including various virus inhibitors) and the development of effective and efficient fast-acting drugs; title: ●● The new type of coronavirus pneumonia is not incurable. It does not exceed AIDS cancer. Most patients can recover and recover to health. Vulnerable populations and critically ill patients have higher mortality rates.; title: ●● Coronavirus pneumonia and coronavirus are not unfamiliar to humans. They are a large-scale epidemic of common and susceptible diseases in animals and humans. Such infectious diseases are easily ignored and misjudged by humans, and they are most likely to cause large areas Quick start and spread. The coronavirus will exist in the biological nature for a long time. Its occult, rapid, repetitive, and variability will not easily and completely withdraw from the human, animal and plant world.; title: ●● The severity of the patient’s illness and individual differences and other factors vary in the use of clinical treatment drugs, which need to be tailored to local conditions, tailored to people, and treated according to disease. Biochemical and compound drugs, pure plant drugs, and vaccines are the key to symptomatic prevention and treatment.; title: ●● New coronavirus pathogens and animal viruses are absolutely closely related. Animal coronavirus is the same as animal coronavirus pneumonia and zoonotic virus pneumonia, with considerable analogy. Although the pathogenic host is difficult to find out for a while, there is not much objection from animals.; title: ●● Effective and efficient treatment and treatment of new coronavirus pneumonia << 5 + 2 medical plan >>, << 7 + 3 medical plan >> 10 new drugs for clinical application of new and new coronavirus pneumonia Integration and redundant technical solutions, first of all, in the absence of specific drugs and vaccines, medical scientists, pharmacologists, pathologists, infectious disease scientists, virologists and clinicians and nurses need to work together Integrated technology and redundant technology of drugs to treat the life and health of patients with new type of coronavirus pneumonia.; title: ◎Neocoronavirus pneumonia poses a great threat to human beings. It has a strong vitality and a strong and widespread spread. In particular, its occult, recalcitrant, and rapid nature shows that the spread of this new virus has spread beyond Sars, the Middle East Respiratory Syndrome, and Ebola virus. The lung is the most important respiratory organ for animals and humans and has other functions and functions. Respiratory tract infections and transmission can easily cause large-scale population infections to spread. This is the same as coronavirus in animal pneumonia animals. Groups of infections cause rapid deaths in groups. Neocoronavirus pneumonia exists in susceptible populations, as well as in young and middle-aged patients. There are also some specific cases of family genetic history of infection history with no obvious symptoms and no obvious contact history. Such cases occur in Asia, Europe, America, and Africa. This requires people to be more alert and to take effective precautions against invisible patients (including invisible patients and transmission). The great plague of the century, a worldwide infectious disease, swept the world, more than 160 countries and regions, and nearly 6-7 billion people. In just a few months, it poses a major hazard to all mankind worldwide. According to incomplete estimates and calculations, the number of infected people can reach 300,000 to 400,000, the number of deaths can reach 1-3 million or more, and the epidemic can take up to six months or more to completely subside and end. Direct economic losses and indirect economic losses will reach 3.9 trillion to 5.8 trillion US dollars, which will account for 25% -37.8% of the world’s total output value, and world GDP will fall by several percentage points. The persistence and repetitive variability of this disease must not be underestimated. Otherwise, human society will pay a higher price and enter the “end of the world virus.” Of course, we don’t have to be stubborn all day long and can’t do anything about it. Only scientific and rational wisdom can meet and face the threatening virus disease demons, which will eventually defeat them completely. Viral biological missiles and other advanced and effective medical technologies are powerful weapons to defeat viral disease.; title: ◎”Virus bio-missile”, “Coronavirus pneumonia (respiratory severe pneumonia infectious disease) alphabetic bio-missile” (biochemical drug modification and improvement + plant refined substance = trace element inhibitor), leading drugs, auxiliary drugs, immune drugs and other scientific and reasonable Combination, applied to the clinic, suitable for viral pneumonia virus infection. English abbreviation “VBM” “CPPAbM >>; title: ********************************************; title: A natural active drug with antiviral activity and targeting property-poison crown anti-inhibition complex. This type of conjugate introduces natural active drugs into antiviral medicinal chemistry through chemical grafting, and is physically mixed with a ligand-phytoside purified product with targeted delivery ability to form a natural active drug-targeting complex. Self-assembled nano-micelles are characterized by: 1) the ability to target delivery, improve virus suppression and fire suppression, reduce adverse reactions, and increase patient tolerance; 2) the hydrophobic core formed by hydrophobic groups can physically encapsulate resistance Viral drugs can significantly improve the compatibility and use of antiviral and antiviral drugs; 3) Through chemical coupling and physical encapsulation of antiviral drugs, the effects of combined antiviral and antiviral treatments can be achieved and toxic side effects can be reduced. 4) The preparation method of the compound drug invention is simple, and the raw materials are firstly chemical structure modification-chemical intermediates-natural plant purification and purification-chemical medium-chemical combination-physical mixing, chemical European Union and physical mixing-specific trace elements, easy to operate, The yield is high, the cost is low, the application is wide, and it is easy to realize industrialization. 5) It is widely used in anti-virus, virus suppression, virus inactivation, and bacteriotoxicity, etc. Indications: Coronavirus infection, bacterial virus erosion, respiratory infectious disease pneumonia, general viral disease suppression, immunity enhancement Pneumonia, pulmonary respiratory infections, etc. 6) Prevention and treatment of chemical conjugate compound reactions, trace element configuration can produce chemical antagonism and chemical reaction resistance, strengthen drug targeting functions, form biological missiles, and avoid side effects such as drug dispersion. 7) This drug is an antiviral-toxic crown inhibitory compound, which also has obvious curative effects and significant effects on animals. Trade name “Poison Crown Anti-Inhibitory Spirit”. Oral medication, tablets, and liquids are generally divided into compound tablets and split tablets.; title: 1.; title: “Virus Biological Missile”, “Coronavirus pneumococcal biological missile” mainly uses biochemical virus drug modification and chemical structure modification, chemical intermediates and plant virus antagonists, trace element inhibition and other compounds, including chemical purification, physical coating Target tracking, shunting, etc. are mainly used to resist the virus from eroding the respiratory tract and key lung tissues and suppressing them. Trace elements can enhance the immune effect and are widely used in viral infections and bacterial viral pneumonia. (A) Biochemical drugs (B) Compound drugs (C) Plant drugs.; title: (1) Combination of main and auxiliary drugs (2) Combination of biochemical and compound drugs, plant drugs, (3) Reasonable and effective combination of antiviral drugs and immune drugs, gene drugs, pneumonia drugs, and other physical treatments (for general new models) Coronary pneumonia patients with mild disease, such as ordinary patients, can effectively compare to 65.8-95.9%. Due to different epidemics, different degrees of danger, individual differences between races and patients, medical resources and technical means and other differences Difference) Technical means such as surgery; title: (4) Including cpu ventilator, artificial lung, intubation, etc. Especially for critical populations (5) screening and rational application of coronavirus pneumonia drugs for animals; title: , Toxic and side effects, compatibility taboos, clinical application risk assessment, etc., should be scientifically and rationally used according to the specific situation of the epidemic situation, patient and so on.; title: A mature high-end medical technology, an advanced cutting-edge medical solution, a new type of drugs and vaccines and perfect applications are essential for the treatment and rescue of patients and critically ill patients, especially the large-scale acute epidemic of infectious plagues worldwide At the moment when the earth appeared overwhelmingly, the world was generally caught off guard by sincerity and panic. The scientific spirit, rigorous and realistic, was especially important. This is true for a large number of medical doctors and nurses in the countries affected by the epidemic. Many people are eager to develop new drugs and special-effect drugs, and develop new vaccines to fight the plague. The mood is understandable, but, without waiting, one life will be lost in one minute. It is urgent that China, Italy, Iran, South Korea, Japan, the United States and other epidemic areas Countries and regions. Therefore, the effective and efficient treatment of new coronavirus pneumonia in the clinical application of << 5 + 2 medical plan >>, << 7 + 3 medical plan >> is the only correct first choice. Empty talk and fantasies will not help. Race against time to rescue and save the lives of more infected people worldwide is of great significance and far exceeds the Nobel Prize in Medicine and the Nobel Peace Prize for 1,000 times and 10,000 times. At the critical moment when the highly dangerous new type of coronavirus pneumonia sneaked on all human beings in the world, there was no savior to save and save mankind in the world, only the great mankind himself, especially the warriors who were in charge regardless of life and death.; title: The total number of confirmed cases of new crown pneumonia in the world has exceeded 150,000. The World Health Organization said on the 15th that the total number of confirmed cases of new crown pneumonia worldwide has exceeded 150,000. At present, the number of confirmed cases of new coronary pneumonia outside China has increased to 143, and the number of new cases per day in many countries has exceeded a thousand.; title: (Quoted from network resources, etc.) As of the writing of this article, new coronavirus pneumonia has swept over a dozen countries around the world, Asia Europe America Oceania Africa, almost all over the world, except for Antarctica Arctic It is estimated that the total number of cases can reach 200,000 to 300,000. Suspected patients or close contacts isolate the observers by several million to tens of millions, and the death can reach more than 10,000 to 20,000. It should directly go to the lives and health and safety of nearly 8 billion people worldwide. The focus is on countries and regions such as Asia, Europe, Wuhan, Japan, South Korea, Italy, Iran, and whether the epidemic is repeated. It will take months or six months for the epidemic to end. It is still under analysis and follow-up observation. Eurasia is a severely affected area.; title: << 5 + 2 medical plan >> << 7 + 3 medical plan >> is a basic treatment plan. The clinical application needs to be flexible and applied according to the specific situation such as epidemic situation, ethnicity, individual patient differences, etc., and is not rigid. These treatments are effective and are practical for general patients, which can greatly reduce deaths, greatly reduce the transfer of mild patients to critically ill patients, and can save more lives, including high-risk groups such as the elderly, the weak and the disabled.; title: Coronaviruses are systematically classified as Coronaviridae (Coronaviridae). Coronavirus is a positive-stranded single-stranded RNA virus with an envelope of about 80-120 nm in diameter. Its genetic material is the largest of all RNA viruses and only infects humans, mice, pigs, cats, dogs, and poultry. vertebrate. A variant of coronavirus is the pathogen that causes atypical pneumonia and belongs to the RNA virus. Coronavirus was first isolated from chickens in 1937. The diameter of the virus particles is 60-200nm, with an average diameter of 100nm. It is spherical or oval and has polymorphism. The virus has an envelope, and there are spinous processes on the envelope. The entire virus looks like a corona, and the spinous processes of different coronaviruses are significantly different. Tubular inclusions are sometimes seen in coronavirus-infected cells.; title: In the medical field, three points of medicine and seven points of medicine. This shows that drugs are vital to the health of human life and often play a decisive role.; title: Coronavirus particles are irregular in shape and have a diameter of about 60-220nm. Viral particles are enveloped by fatty membranes, and there are three glycoproteins on the membrane surface: spike glycoproteins; small envelope glycoproteins; membrane glycoproteins are responsible for the transmembrane transport of nutrients, the emergence of new virus buds, and the formation of virus envelopes). A few species also have hemagglutinin glycoproteins. Coronavirus’s nucleic acid is non-segment single-stranded (+) RNA with a length of 27-31kd. It is the longest RNA nucleic acid strand in RNA viruses and has important structural characteristics unique to positive-strand RNA: that is, the 5 ‘end of the RNA strand is methylated. Hat “, with a PolyA” tail “structure at the 3 ‘end. This structure is very similar to eukaryotic mRNA, and is also an important structural role for its genomic RNA itself to play the role of a translation template, eliminating the RNA-DNA-RNA transcription process. Coronavirus has a very high recombination rate between RNA and RNA, and the virus mutates due to this high recombination rate. After recombination, the RNA sequence has changed, and the amino acid sequence encoded by the nucleic acid has also changed. The protein composed of amino acids has changed accordingly, which has caused its antigenicity to change. As a result of changes in antigenicity, the original vaccine failed and immunity failed.; title: Viral RNA polymerase, which is required for RNA virus replication, does not exist in the coronavirus mature particles. After entering the host cell, it directly uses viral genomic RNA as a translation template to express viral RNA polymerase. This enzyme is then used to complete the transcription and synthesis of the negative-strand subgenomic RNA, the synthesis of various structural protein mRNAs, and the replication of viral genomic RNA. There is no post-transcriptional modification and shearing process for the synthesis of mature mRNA of each structural protein of coronavirus, but directly through RNA polymerase and some transcription factors, using a “discontinuous transcription” mechanism to recognize specific transcriptional regulatory sequences Selectively transcribe from the negative-sense RNA one-time all the components that make up a mature mRNA. After the replication of structural proteins and genomic RNA is completed, new coronavirus particles will be assembled at the host’s endoplasmic reticulum and secreted outside the cell through the Golgi apparatus to complete its life cycle.; title: Coronavirus is one of the main pathogens of the common cold in adults. It can cause upper respiratory tract infections in children and spread to the lower respiratory tract. The incubation period for coronavirus infection is usually 2 to 5 days, with an average of 3 days. Typical coronavirus infections have cold symptoms such as runny nose and discomfort. Different types of viruses have different pathogenicity and cause different clinical manifestations. The symptoms caused by OC43 strain are generally more severe than those of 229E virus. Coronavirus infections have been reported to cause fever, chills, and vomiting. The course of disease is usually about 1 week, the clinical course is mild, and there are no sequelae.; title: Coronavirus can also cause acute gastroenteritis in infants and newborns. The main symptoms are watery stools, fever, and vomiting. More than 10 times a day, bloody stools can occur in severe cases.; title: Coronavirus infections have been reported in the literature to produce the following clinical symptoms:; title: 1) Respiratory infections, including severe acute respiratory syndrome (SARS);; title: 2) Intestinal infections (occasional infants);; title: 3) Neurological symptoms (rarely).; title: Coronavirus is excreted through respiratory secretions, and is transmitted through oral fluid, air injection, and contact. Clinically, most coronaviruses cause mild and self-healing diseases, but a few may have neurological complications.; title: Coronavirus infections are extremely common around the world.; title: So far, about 15 different coronavirus strains have been found that can infect a variety of mammals and birds, and some can cause disease in humans.; title: Human diseases caused by coronavirus are mainly respiratory infections (including severe acute respiratory syndrome, SARS). The virus is sensitive to temperature and grows well at 33 ° C, but it is suppressed at 35 ° C. Because of this characteristic, winter and early spring are the epidemic seasons of the virus disease. Coronavirus is one of the main pathogens of the common cold in adults.; title: The growth of the virus is mostly in epithelial cells. It can also infect the liver, kidneys, heart, and eyes. It can also grow in other cell types (such as macrophages). At present, there is no suitable animal model for human coronavirus to be used for research (animal model of human disease) refers to animals with simulated performance of human diseases established in various medical scientific research. Animal disease models are mainly used in experimental physiology , Experimental pathology and experimental therapeutics (including the screening of new drugs), so the coronary disease — nasal mucosal cells can only be isolated after organ culture. It is also difficult to use the above materials for the propagation of viruses.; title: There are dozens of diseases related to pneumonia. The probability of cross-infection of viruses and bacteria is about 45% in young children and 15% in adults [-39%. Cross-infection of pneumonia in coronavirus can reach 65.79%- -97.44%, including cross-infection of respiratory infectious diseases, severe pneumonia, white lung disease, influenza and other cross-infection. The process of pneumonia usually begins with an upper respiratory tract infection response before transferring the infection to the lower respiratory tract. In addition to the inflammation of the lung tissue, the symptoms of pneumonia also cause the consolidation of the lungs, that is, the alveoli are filled with fluid, which in turn blocks blood oxygenation. Fever, chills, and fatigue are common pathological conditions in bacterial pneumonia. The neutrophils, bacteria, and intercellular fluids around the blood vessels will flood the alveoli, which is why the lungs will appear lumpy under X-rays. About 450 million people worldwide (7% of the global population) suffer from pneumonia each year, and about 4 million people die each year. In addition, lung diseases such as lung cancer and tuberculosis kill more than tens of millions. Human respiratory system and tissues, lung inflammation is the most easily attacked by viruses and bacteria, as is animal viral pneumonia and bacterial pneumonia. Sars, the Middle East Respiratory Syndrome, the African Ebola virus and this new coronavirus pneumonia from time to time are evidence of this. This shows that the probability of frequent viral pneumonia and bacterial pneumonia. Most of the severe pneumonias are caused by single infection or cross-infection with coronavirus and bacterial virus. Coronavirus pneumonia is extremely harmful, and currently there are no effective treatment drugs and related vaccines in clinical treatment.; title: Coronavirus serotypes and antigenic variability are unknown. Coronaviruses can have repeated infections, indicating that they have multiple serotypes (at least four are known) and have antigenic variations, and their immunity is difficult. There are currently no specific preventive and therapeutic drugs.; title: Coronavirus is excreted through respiratory secretions, transmitted through oral fluid, sneeze, and contact, and transmitted through air droplets. The infection peaks in autumn, winter, and early spring. The virus is sensitive to heat. Ultraviolet rays, Lysol water, 0.1% peroxyacetic acid, and 1% keliaolin can kill the virus in a short time.; title: There is specific prevention for its prevention, that is, targeted preventive measures (the development of vaccines and vaccines is possible, but it takes a long time to solve the problem of virus reproduction is its problem) and non-specific preventive measures (that is, prevention of spring respiratory infections) Measures, such as wearing a mask, keeping warm, washing hands, ventilating, avoiding excessive fatigue and contact with patients, and going to public places with fewer people, etc.). Electron microscope observations revealed that the envelopes of these viruses have spinous processes that resemble corona, so it is proposed to name these viruses as coronaviruses.; title: Coronaviruses were first isolated from chickens in 1937. In 1965, the first human coronavirus was isolated. It was named “Coronavirus” because it can be observed under the electron microscope that there are obvious stick-like particle protrusions on its outer membrane, making its shape look like the crown of medieval European emperors.; title: In 1975, the Coronavirus Division was officially named by the Viral Naming Committee. According to the serological characteristics of the virus and the differences in nucleotide sequences, the Coronaviridae family is currently divided into two genera, Coronavirus and Cyclovirus. The representative strain of the Coronavirus family is Avianinfectiousbronchitis virus (IBV).; title: The severe acute respiratory syndrome (SevereAcuteRespiratory Syndrome, SARS, SARS) that raged around the world from the winter of 2002 to the spring of 2003 is one of the coronaviridae, a coronavirus genus.; title: In 1953, American molecular biologist James Watson and British physicist Francis Crick proposed a famous model of DNA double helix structure based on X-ray diffraction analysis performed by Wilkins and Franklin. Further explanation is that the gene carrier is DNA. Further research proves that a gene is a segment of a DNA molecule. Every gene; title: Gene mutations and many diseases are involved, such as oncogenes and tumor suppressor genes involved in tumorigenesis.; title: From a chromosomal perspective there are; title: Missing; title: 2. Repeat; title: 3. inverted; title: 4.Translocation; title: By function; title: Loss of function mutation; title: 2. Submorphic mutation; title: 3. Supermorphic mutation; title: 4. Mutation to gain function; title: Classification by mutation principle; title: Point mutation; title: 2. Silent mutation; title: 3. missense mutation; title: 4. Frameshift mutation; title: 5. Nonsense mutation; title: (1) The basic unit of genes is deoxynucleotides.; title: (2) The sequence of deoxynucleotides in genes is called genetic information.; title: (3) The diversity of the sequence of deoxynucleotides in genes determines the diversity of genes.; title: Pathological study of Sars, Ebra and new coronavirus: “Tissue organs lung immune organs other organs SARS [9-10, 12, 15] pulmonary edema, pulmonary consolidation, pulmonary hemorrhage, diffuse exudative alveoli Injury: early desquamative alveolitis and exudative lesions, extensive hyaline membrane formation in advanced stages, accompanied by severe inflammation and necrosis, partial alveolar epithelial hyperplasia and fusion, and part of the cell cytoplasm containing eosinophilic virus inclusions, There are a large number of mononuclear macrophages in the alveolar cavity, and CD68 is positive for immunohistochemical staining. The lungs in the recovery period showed organic pneumonia. Electron microscopy showed that alveolar type Ⅱ epithelial cells and monocyte macrophages were actively growing in the alveolar cavity. Clusters of virus particles. Spleen and lymph node hyperemia and hemorrhage, spleen atrophy, and large spleen tissue necrosis; lymph node vessels are highly dilated, lymph nodules disappear, and tissue sheet necrosis; mononuclear macrophage hyperplasia in lymph sinus; focal necrosis of other lymph tissue Etc. Multi-organ microangitis, focal necrosis of parenchymal organ tissues, inhibition of bone marrow granulocyte system and megakaryocyte system. MERS [20-21] Diffuse exudative alveolar damage, alveolar septal destruction and expansion, type II alveolar epithelial cell proliferation and shedding, large sheet edema fluid with bleeding and fibrin exudation, transparent membrane formation, partial alveolar septum and alveolar cavity are seen in varying amounts Mononuclear-macrophages and multinucleated giant cells with bronchial epithelial shedding and mild to moderate lymphocyte infiltration under the bronchial mucosa. Dense circular viruses with dense spike-like structures are seen in lung cells and macrophages under electron microscopy. In each lymph node, there were reduced lymphoid follicles, multi-vesicular proliferation of polymorphic immunoblasts and reactive lymphocytes, and a large number of immunoblasts and reactive lymphocytes in the spleen. Multi-organ microvasculitis, lymphocytic infiltration, local Necrotic inflammatory foci. COVID-19 [28-29] Early pulmonary edema, protein exudation, thickening of interstitial lung, multinucleated giant cells and macrophage infiltration in the alveolar cavity, etc., but the formation of transparent membranes is not obvious. End stage Diffuse alveolar injury in both lungs with fibrous mucus-like exudate, pulmonary edema, shedding of alveolar epithelial cells, formation of clear membranes, and lymphocytic interstitial inflammation Cell infiltration, large nuclear, amphiphilic granular cytoplasm, and prominent nucleoli are characterized by viral cell changes. Multinucleated giant cells are seen in the alveoli. Still lacking. There is a small amount of inflammatory infiltration of a few monocytes in the myocardial stroma.; title: (Recited from “Review and Prospect of the Pathological Features of Coronavirus Pneumonia Wang Huijun, Du Sihao, Yue Xia, Chen Chuanxiang” (Forensic Identification Center, School of Law, Southern Medical University, Guangzhou 510515, China)); title: After the outbreak of the new coronavirus, scientists around the world are testing the clinical response of different drugs in order to find the right drug as soon as possible.; title: There is currently no specific medicine against the virus, and clinical treatments are generally used to help patients improve their immunity and maintain body function. In view of the fact that it takes several years for new drugs to develop from mass production, if existing drugs are used, time can be greatly saved. Therefore, the drugs currently used to treat patients with new types of coronavirus in countries around the world are mainly those that have been developed or marketed. It is unrealistic to try to develop special-effect drugs at a rapid speed. Therefore, drugs related to the suppression of new coronavirus pneumonia have become Internet celebrities and hot searches. Scientists around the world are racing, fighting for time, and fighting against illness. The vaccine development is proof. However, the most scientific and effective methods are drug screening and the improvement and modification of the chemical structure of existing drugs, as well as biochemical drugs, compound drugs, plant drugs, gene drugs, etc. targeted at targets, the development of biological missiles and viral missiles, etc. Efficient, reliable and fast applied in clinical.; title: Vaccines, monoclonal antibodies, oligonucleotide therapies, peptides, interferon therapies, and small molecule drugs. A number of “potentially effective drugs” against neocrown virus have surfaced, including anti-HIV drugs lopinavir / ritonavir, anti-Ebola drug radsivir, anti-flu drugs fapivir, abi Dole, and chloroquine phosphate; title: “Virus bio-missile”, “Coronavirus pneumonia (respiratory severe pneumonia infectious disease) alphabetic bio-missile” (biochemical drug modification and improvement + plant refined substance = trace element inhibitor; title: “Virus bio-missile”, “Coronavirus pneumonia (respiratory severe pneumonia infectious disease) alphabetic bio-missile” (biochemical drug modification and improvement + plant refined substance = trace element inhibitor), leading drugs, auxiliary drugs, immune drugs and other scientific and reasonable Combination, applied to the clinic, suitable for viral pneumonia virus infection. English abbreviation “VBM” “CPPAbM >>; title: Enhances and suppresses the function of various immune-active cells.; title: Control and repair major bio-amplification systems.; title: Utilizes, regulates, and inhibits immune factors such as lymphokines released by T cells and antibodies synthesized by B cells.; title: Feline infectious peritonitis (FIP) is one of the important causes of cat death.; title: 2.; title: The wells of the microtiter plate are coated with purified coronavirus antigen. Protein A from Staphylococcusaureus Staphylococcusaureus combines with HRP to form a complex. Serum or plasma samples are incubated with protein A enzyme markers in the wells of the microplate. If FCoV antibodies are present in the cat sample, the antibodies will bind to the antigen in the well and then to the protein A enzyme label. The excess enzyme-labeled protein A was washed away and a chromogenic substrate was added. A clear blue color indicates the presence of FCoV antibodies, and no color change indicates no FCoV antibodies. The kit has high specificity and sensitivity, simple operation, and the results can be known within 30 minutes. The kit includes positive quality control and negative quality control. Just by comparing the color with the negative quality control with the naked eye, you can accurately determine the presence of FCoV antibodies in the sample.; title: Under the microscope, most bacterial viruses are found to be different from animal and plant viruses in that they have a complex morphology of head and tail structures. According to the tail, it can be divided into three types: long, short and retractable tail sheath. There are two types of icosahedral bacterial viruses without tails. One type has 1 nodule on each of the 12 horns. The appearance is mulberry-like, and the other type does not have this structure. A small number of bacterial viruses are filaments or equiaxed polyhedrons of 760 × 6 to 1950 × 6 nanometers, with spikes or brush-like spikes at the top of each corner.; title: The head of the bacterial virus in a composite form is a three-dimensional symmetrical polyhedron, which is generally 50 to 60 nanometers in diameter and some is more than 130 nanometers. The structure of this type of bacterial virus is more complicated.; title: Bacterial viruses are mainly composed of nucleic acids and proteins. A few bacterial viruses contain small amounts of non-nucleic acid sugars or lipids. The protein mainly forms the head shell, tail and accessories of the bacterial virus shell or complex. The protein portion is antigenic. Therefore, injecting it into animals can produce specific antibodies, and the neutralizing antibodies can prevent the bacterial virus from adsorbing on the outer wall of the bacteria, thereby preventing the infection from occurring, but without inactivating the bacterial virus. Different bacterial viruses can be distinguished based on antigen specificity.; title: Nucleic acids make up the genome of a bacterial virus. Bacterial viruses contain only one type of nucleic acid, either DNA or RNA, or double-stranded or single-stranded, or linear or circular. Most bacterial viruses contain dsDNA. Bacterial viruses have the same DNA as other organisms, and are made by polymerizing nucleotides. Most bacterial virus DNA is the same as normal DNA and contains 4 bases-adenine (A), guanine (G), thymine (T), cytosine (C), and complies with Watson-Crick’s A = T, G≡C base pairing principle.; title: The screening and development of new coronavirus drugs and other viral pneumonia medical drugs is the cutting-edge of major medical research in the world, which is comparable to the difficult treatment of cancer and AIDS. New coronal disease pneumonia (respiratory viral infectious disease pneumonia) drugs, including pathopharmacology and virological research on the mechanism of virus suppression and inactivation, require a lot of scientific and experimental research, including animal virology, animal coronavirus pneumonia Research and experimental research are very important.; title: Bacterial viruses can exist in three states with different structures and functions: ① mature infectious or free phages outside the bacterial cell; ② vegetative or growing phages inside the bacterial cell; ③ prophages formed by integration on the bacterial cell chromosome . Free bacterial virus encounters sensitive host bacteria, and infection occurs under appropriate conditions. The bacterial virus first adsorbs to the bacteria. The tailed bacteria virus attaches its tail wire to a certain receiving point on the surface of the bacteria. Due to the tail wire bending, The tail needle and the tail plate are fixed to the bacteria. Subsequently, the bacterial virus tail sheath contracts, and the exposed tail shaft penetrates into the outer wall of the bacteria. The DNA is injected into the bacteria through the tail shaft, leaving the protein shell outside the bacteria. Male-specific bacterial viruses are adsorbed on the flagella of bacteria, and nucleic acids may be injected through this.; title: After the bacterial virus DNA is injected into the bacteria, it enters a nutritional state and multiplies. For example, after T even phage infection, E. coli itself immediately stops the synthesis of DNA and protein, and receives the genetic information of the bacterial virus, and synthesizes the products required by the bacterial virus. Within 1 minute after infection, some mRNA (messenger ribonucleic acid) molecules of the bacterial virus are synthesized, and then various proteins encoded by the early genes of the bacterial virus are synthesized, most of which are related to the synthesis of bacterial virus DNA and its precursors.; title: As for the bacterial viruses of RNA and ssDNA, each has its own unique replication process, and the progeny of the linear phage can be released without lysing the host bacteria.; title: After the phage DNA is injected into the host bacteria, it enters the trophic state and completes the bacterial virus proliferation cycle. This type of bacterial virus is called a virulent phage. There is also a type of bacterial virus that does not choose the above-mentioned proliferation pathway after infection with bacteria, but integrates its DNA into the bacterial chromosome and becomes a prephage state.; title: Pegasin, allicin, cationic antimicrobial peptides, miRNA antagonists, miRNA agonists, tannin plate (purification), etc. can all play a role in the development of new drugs, including the biochemical drug compound drug “virus” Biological Missiles >> << Coronavirus Pneumonia (Severe Respiratory Infectious Disease Biological Son-Missile Missile).; title: Lysogenic bacteria have the potential to produce bacterial viruses and immunity to related bacterial viruses, sometimes accompanied by changes in other traits. Called lysogenic conversion. It is now known that the different traits of many fungi are affected by lysogenicity. For example, the production of toxins by diphtheria is due to the structural genes of toxin proteins in their prephages; the production of certain hemolysins of Staphylococcus aureus is related to lysogenicity; the structure of antigens such as Salmonella and Shigella is also related to lysogenic .; title: If the prophage excised from the chromosome of the lysogenic bacteria fails to enter the trophic state in the cell and thus fails to proliferate, the host bacteria will continue to survive and reproduce, so the derived strain will lose the prophage and lysogenicity. , Called a retreatment strain. Some traits changed by lysogenization will also be restored with lysogenic retreatment.; title: When the prophage in a lysogenic bacteria leaves the host chromosome and proliferates for some known (e.g., induced) or unknown (spontaneous) reason, a small number of bacterial virus genomes carry genes from neighboring hosts, and when they infect When a strain is introduced, the host gene can be introduced and recombined to show the characteristics of the gene.; title: 3.; title: Pulmonary angiography includes selective and non-selective; title: Bullosa refers to the increased pressure in the alveolar cavity caused by various reasons. After the alveolar wall ruptures, they fuse with each other. The air-containing cysts formed in the lung tissue are classified into congenital and acquired. Congenital is more common in children, mainly due to congenital bronchial dysplasia, mucosal folds are valvular, and cartilage dysplasia, which results in valve action. Acquired in adults and elderly patients, often with chronic bronchitis, emphysema, chronic obstructive pulmonary disease, old tuberculosis and other basic diseases. Patients may experience symptoms of chest tightness and shortness of breath. If the bullae are infected, cough, sputum, fever, and chills may occur, and cyanosis of the lips may occur in severe cases. A small number of patients with bullae have symptoms of hemoptysis and chest pain. The chest CT examination can be used to determine the size and location of the bullae.; title: Pulmonary fibrosis is medically called pulmonary interstitial fibrosis. It is caused by various reasons for the large amount of deposition of cellulose and fibrous scars in the interstitial lung, causing breathing difficulties, often coughing, white phlegm, and shortness of breath after activities. Pulmonary fibrosis can be light or severe. If mild fibrosis is treated with drugs, some patients can be reversed. For example, the commonly used drugs are N-acetylcysteine ​​and nidanib. Severe pulmonary fibrosis is indeed more difficult to treat.; title: White lung generally refers to the performance of severe pneumonia under x-ray examination, and the lungs are named after a large white. Generally predicts that 90% of the lungs are infiltrated by inflammation. White lung disease is a disease with a high mortality rate in severe pneumonia. White lung generally refers to the performance of severe pneumonia under X-ray examination, and the lungs are named after a large white. The formation of white lung usually indicates that the lungs are infiltrated by inflammation.; title: The development of modern science and technology is particularly important for the research and development of medicine. Drug design software [schrodinger] all manual; title: Discovery Studio molecular simulation drug design software; title: Automatic Tailoring and Transplanting (AutoT & T v2.0) software LUDI, Leapfrog, GROW, SPROU, etc., LUDI is the most commonly used. Therefore, viral biological missiles and coronavirus pneumonia (respiratory severe infectious pneumonia) biological daughter missiles can be efficiently researched using computer software, simulation, chemical structure modification, intermediate improvement, phytochemical purification, trace elements and other chemical drugs. The design, development, and other complex tasks of gene medicine, compound medicine, plant medicine, etc., including some simulation experiments, animal model tests, etc., in order to shorten the research and development cycle, reduce drug development costs, and further enter commercialization.; title: Ground-glass changes in the lungs are mainly due to a decrease in air content in the alveoli, a relatively increase in the number of cells, a thickening of the alveolar space, and a partial filling of the airways on weekends. Ground-glass changes are just a description of medical imaging. Many reasons can cause ground-glass changes, such as inflammatory lesions, focal fibrosis, atypical adenoma-like hyperplasia, and alveolar hemorrhage. The type of ground-glass nodules in the lung. Typical ground-glass nodules change to solid nodules of the lung, and the edges of normal internal structures are clear.; title: The causes of “white lung disease” are often caused by infections, including bacterial infections, viral infections, and atypical pathogenic infections. When bacteria or viruses are infected, they can cause the exudation of inflammatory substances, pulmonary interstitial congestion and edema, etc., leading to decreased lung function. The development of “white lung disease” is often very rapid, causing diffuse lesions of both lungs in a short period of time. In addition to infectious factors, interstitial pneumonia and radiation pneumonitis can also cause “white lung disease”. Secondly, drug damage factors can also cause “white lung”, the most common being pulmonary fibrosis caused by paraquat poisoning.; title: “White lung disease” symptoms; title: The most important symptom of “white lung disease” is hypoxia, and the symptoms of hypoxia cannot be easily improved by inhaling oxygen. Due to diffuse lesions of the lungs, lung function is severely impaired, and patients will have severe symptoms of hypoxia, such as chest tightness, asthma, Symptoms such as dyspnea and respiratory distress may cause cough; patients often experience respiratory failure and symptoms such as coma. In the first treatment of white lung disease, a ventilator should be used to relieve the patient’s hypoxic symptoms. White lung disease often develops rapidly. If no timely and effective treatment is available, if the patient’s hypoxic symptoms are not corrected in time, it will be due to respiratory failure in a short time. Death, followed by actively looking for the cause and treatment of the cause.; title: Severe pneumonia, only the lungs, is very serious and can be infected by viruses, bacteria, and fungi. Viruses and bacteria are common. Severe pneumonia, obvious breathing difficulties, high fever and so on. Severe pneumonia is mainly caused by poor immunity and strong invasion of pathogens, which can cause severe pneumonia in a short time. Double lung white lung; title: ① Respiratory frequency ≥ 30 beats / min; ② Hypoxia, oxygenation index of blood gas analysis is less than 250; ③ Multiple lung lobe infiltration; ④ Psychological consciousness is unclear; ⑤ Hypernitrosemia, urea nitrogen is greater than 20; ⑥ WBC count is less than 4.0 × 10∧9 / L; ⑦Platelet count is less than 10.0 × 10∧9 / L; ⑧Low body temperature (T <36 ℃); 低 Low blood pressure, which requires fluid or booster resuscitation.; title: There are many types of pneumonia, including respiratory infections such as bacterial and viral pneumonia Sars, etc. The differential diagnosis is complex. Coronavirus pneumonia often has the same clinical manifestations and is easy to miss and misdiagnose. It is most likely to cause infection and spread of the disease without Found by a doctor. Sars, Middle East Respiratory Syndrome, Ebola virus, Viral pneumonia, Bacterial pneumonia, White lung disease, Severe pneumonia, etc. are often intertwined. At the same time, there are great similarities and similar symptoms. Pathological reports and clinical test reports There are also many similarities between the index and the value, which makes it more difficult to diagnose and treat new coronavirus pneumonia and prevent and prevent it. Neocoronavirus pneumonia actually has the characteristics and considerable commonalities and respective specificities of coronary pneumonia (Sars et al.), Severe pneumonia, white lung disease pneumonia, and epidemic infectious infection pneumonia. A large number of cases were compared and verified with each other, and the true appearance of the new coronavirus was undoubtedly exposed. Therefore, the reason why the 2019 new type of coronary disease pneumonia rages around the world and sweeps the world, its dangerous spread of infectious and lethality is quite stubborn and dangerous, and it has no choice but to wait. Human lung structure is very important. It is the most important physiological organ and tissue structure of human beings. It is also an important place for erosion and infection by various bacterial viruses. Especially susceptible people in winter and spring are extremely likely to occur and spread, especially for animals. Contact spread.; title: Viral infection is currently the main infectious disease in the world, accounting for more than 3/4 of the infectious disease species. Due to the application of a large number of antibiotics, non-viral infections have been effectively controlled, but viral infections have become increasingly prominent. With the development of virology and molecular biology in recent years, a deeper understanding of the specific enzymes of viral replication, the viral replication cycle, and the mechanism of action of antiviral drugs has promoted the research on antiviral drugs, including anti-herpes virus drugs. rapid development.; title: The viral host of the new coronavirus pneumonia is undoubtedly derived from animals. Natural hosts or intermediate hosts are possible. Wild animals and other domestic animals cannot be excluded. Of course, the former is the main one. As for specific screening or viral gene sequences Comparative research requires a lot of meticulous work. What are the minor differences in the coronaviruses that occur in different countries? A large number of comparative studies are also needed, especially the genomic sequences, which will help the research to achieve breakthroughs. Hundreds of thousands of cases worldwide and more than 10,000 deaths require in-depth research to reach consensus on the generation and prevalence of coronavirus pneumonia.; title: Because of its characteristics, bacterial viruses have become the object of research in various aspects such as the replication, transcription, recombination of nucleic acids (DNA and RNA), the regulation and control of gene expression, and the relationship between viruses and hosts, promoting virology and molecular biology. The development of genetics. As a carrier of genes, it has also become a useful tool in the research of genetic engineering. Bacterial viruses rely on specific lytic action to classify pathogenic bacteria into different types with extreme fineness, which is extremely useful for tracking the source of infection in bacterial diseases epidemiology. In clinical medicine, bacterial viruses have been tried to treat certain bacterial infections. Anti-tumor drugs can be screened and carcinogens checked for the induction of lysobacteria. Bacterial virus contamination may cause great damage to the fermentation industry (such as food industry, antibiotic industry, etc.); title: Loss, so preventing and controlling this pollution is also an important task.; title: 4.; title: Pharmacology is the biology of drugs, including the mechanism of action of drugs, the receptors of drugs in the body, the strength and time course of drug-receptor binding. The intensity and time course of the biological effect.; title: Some bacterial viruses, such as Pseudomonas aeruginosa phage, can treat related diseases. Burn patients are susceptible to infection with Pseudomonas aeruginosa, which can cause purulent infections, and it is not easy to control. Scientists using Pseudomonas aeruginosa phage can effectively treat the purulent sensation of burn patients. Because P. aeruginosa phage is a bacterial virus, it lives and reproduces in P. aeruginosa, making P. aeruginosa unable to live.; title: The virus has no cell structure, only the outer shell of the protein and the internal genetic material. The virus cannot live independently and can only parasitize in other organisms. According to the different hosts of virus parasites, we divide viruses into plant viruses, animal viruses and bacterial viruses. Bacterial viruses are also called phages. Viruses that are specifically parasitic in plant cells are called plant viruses, such as tobacco mosaic virus; viruses that are parasitic in animal and human cells are called animal viruses, such as HIV, avian influenza virus, etc .; viruses that are specifically parasitic in bacteria are called bacterial viruses (Also called phage), such as E. coli phage.; title: So the answer is: plant virus; animal virus; phage; protein; genetic material; title: Viruses are the smallest of pathogenic microorganisms. They multiply in cells. The core of the virus is ribonucleic acid (RNA) or deoxyribonucleic acid (DNA). The outer shell is a protein and does not have a cellular structure. The virus is parasitic in the host cell and relies on the host cell’s metabolic system for proliferation and replication. Viral nucleic acids and proteins are synthesized under the control of genetic information provided by viral genes, and then assembled into mature infectious virions in the cytoplasm, released from cells in various ways and infecting other cells. Most viruses lack an enzyme system and cannot live on their own. They must rely on the host ’s enzyme system to reproduce (replicate) themselves. Viral nucleic acids are sometimes integrated in cells and cannot be easily eliminated. Therefore, the development of antiviral drugs is slow.; title: Viral diseases are the main infectious diseases of human beings. Viruses can invade different tissues and organs and infect cells to cause diseases. Common diseases caused by viruses are:; title: ① Epidemic diseases: influenza, common cold, measles, mumps, polio, infectious hepatitis, polio;; title: ② Chronic sensibility: Hepatitis B, AIDS; title: ③ Latent infection: herpes keratitis, STD herpes virus and tumors: some tumors.; title: The antiviral drugs are: ribavirin emandelamide, acyclovir, dexicyclovir, polyamycin, interferon, amantadine, aureneuridine, arasine, azidothymidine, dideoxythymidine, ganciclovir, and herceptin; title: Ribavirin; title: Ribavirin (ribovirin, Virazole); title: Amantadine hydrochloride; title: Acyclovir; title: Deoxycyclovir desiclovir; title: Deoxycyclovir desiclovir, deoxyaprovir, 6-Deoxyacyclovir, BW-51U.; title: The mechanism of action is the same as that of acyclovir. This product is an acyclovir prodrug, which is well absorbed orally and used in combination with a-interferon to inhibit all HBV markers during treatment. See Aprowe for the rest. Polyinosinic acid; title: Interferon; title: Interferons; title: Amantadine hydrochloride; title: Amantadini Hydrochloridum; title: Briwood; title: Orenuridine, Hurpin, Brilludine, Aethoxyuridine, Afuridine; title: Virus Spirit; title: Zidovudine; title: Azidothymidine Azidodeoxythymidine, Zidovudine, Azidothymidne, Retrovir, AZT.; title: It is mainly used to treat AIDS. Patients with complications (pneumocystis carinii or other infections) should be treated with other symptomatic drugs.; title: Dideoxythymidine; title: Ganciclovir; title: Iodoglycosides; title: Telbivudine; title: Such as prednisone, methylprednisone; calcineurin inhibitors, such as cyclosporine, tacrolimus, etc .; antiproliferative / antimetabolites, such as sirolimus, azathioprine, methotrexate , Cyclophosphamide, etc .; antibodies, anti-lymphocyte globulin, molimumab, baliximab, etc. In addition, Tripterygium glycosides are often used in the treatment of autoimmune diseases. Among them, calcineurin inhibitors are currently the most effective immunosuppressive drugs in clinical practice.; title: ——————————————————————————————————; title: .Selection and Confirmation of Drug Targets and Biomarkers; title: In the early days, people had limited knowledge of the target of drug action, and often only knew that it worked, but didn’t know how to work. For example, for a century, people have known that aspirin has antipyretic, anti-inflammatory, analgesic, antithrombotic, and even anticancer effects. It was not until 1971 that the British John R. Vane published a paper in the journal Nature that clarified the mechanism of action of Aspirin to inhibit prostaglandin synthesis, and was awarded the Nobel Prize in Physiology and Medicine in 1982. The research progress of modern biomedicine and the establishment of human gene maps allow humans to understand the mechanism of disease more accurately, and provide a clear direction and specific targets for the development of new drugs.; title: Identification of lead compounds; title: Once the target for drug action is selected, the medicinal chemist (first must find a compound that has an effect on the target. This compound can be derived from natural products; or it can be a compound designed and synthesized by computer simulation based on the spatial structure of the target; It can also be found according to literature reports or previous research projects. For example, a certain type of compound has pharmacological activity or side effects on the target, etc. Viagra, a drug used to treat erectile dysfunction, was developed from its side effects. At present we commonly The method is to track the drug development of a target by foreign R & D institutions,; title: Study of structure-activity relationship and screening of active compounds; title: A large number of new compounds are designed and synthesized around the lead compounds, and the structure-activity relationship analysis of the synthesized compound activity data and the compound structure is used to further effectively guide the subsequent optimization and modification of the compound structure in order to obtain more active compounds.; title: Selection of candidate; title: Through structure-activity relationship studies, several rounds of optimization have been performed to select all the best compounds that meet the basic biological activity.; title: Pre-clinic toxicology studies; title: After the candidate drug is determined, the new drug research and development enters the development stage. The goal of the first stage of drug development is to complete preclinical toxicology research and submit an application for “experimental new drug” to the drug regulatory department. New drug development requires multidisciplinary collaborations, such as process chemistry, toxicology, pharmacology, pharmacokinetics, formulations, etc. In addition, all majors require the support of analytical chemistry.; title: .Chemistry, Manufacturing and Control; title: The first step in the development of new drugs is Process R & D, which is a process of continuous improvement and improvement. The first batch of APIs provided is mainly used for toxicology research (100-1000g), the faster the better, the cost is not a major consideration. Therefore, as long as the pharmacological route can achieve toxicological batch synthesis, the process research and development department will adopt it. However, as the project progresses, the technology department will design a new synthesis route as needed, and develop a reasonable production process to meet the needs of Phase I-III clinical drug use and commercialization. Similarly, the preparation department will first give the simplest form. Drug, complete toxicology research, and then continue to complete the formulation process research to develop a commercial preparation process.; title: B Pharmacokinetics (PK); title: To understand the absorption, distribution, metabolism, and excretion of drugs in animals, these data can guide clinical studies in the form of administration (oral, inhalation, injection), frequency and dose.; title: C Safety Pharmacology; title: Prove that the compound is biologically active against a specific target disease, and evaluate the effects of the drug beyond its efficacy, such as possible side effects, especially the cardiovascular, respiratory, and central nervous system effects.; title: D. Toxicological research; title: There are many types of toxicology studies, including acute toxicity, subacute toxicity, chronic toxicity, reproductive toxicity, carcinogenicity, and mutagenicity. In order to accelerate the early verification of the effectiveness of new drugs, especially for some anticancer drugs, some time-consuming and expensive toxicology experiments (such as carcinogenicity and reproductive toxicity) are allowed to be carried out at the clinical trial stage.; title: E preparation development; title: Formulation development is an important part of drug development. Design and manufacture of compound drugs or pure botanical drugs. Chemical structure modification, superposition and recombination, and avoiding mutual chemical reactions of drugs are particularly critical. The specific drugs for anti-coronary pneumonia include biochemical drugs, vaccines, gene drugs, etc. The chemical structure of the compound drug is more complicated than the former, and the subsequent engineering amount of design, experiment, and manufacture is still large.; title: 5.; title: << 5 + 2 medical plan >>, << 7 + 3 medical plan >> for clinical application of effective and efficient treatment of new coronavirus pneumonia; title: 1 Antiviral drugs The main drugs are suitable for patients with severe or severe illness. Antiviral drugs are only a kind of virus inhibitors.; title: The principle of antiviral effect lies in:; title: First, it can prevent the virus from adsorbing to host cells, such as gamma globulin.; title: Second, prevent viruses from entering host cells, such as amantadine.; title: Third, inhibit the replication of viral nucleic acids, thereby inhibiting the reproduction of viruses, such as acyclovir, ganciclovir, valacyclovir, lamivudine, adefovir, and so on.; title: Fourth, it can inhibit the synthesis of viral proteins, such as indinavir and ritonavir.; title: Fifth, it can induce host cells to produce an antiviral protein and inhibit the proliferation of many viruses, such as interferon.; title: Sixth, interfere with the release of viruses from host cells, such as oseltamivir.; title: Clinically used drugs for herpes virus infection include acyclovir, valacyclovir, famciclovir, and adenosine arabinoside. Drugs used for cytomegalovirus infection can be ganciclovir, so different virus types are used. The drugs are also different.; title: New drug Remdesivir for injection is undergoing clinical trials.; title: 2 Immune drugs Main drugs Suitable for patients with severe or severe illness, glucocorticoids; title: 2. Calcineurin inhibitors; title: Cyclosporin; title: Tacrolimus; title: 3.Antimetabolites; title: Azathioprine; title: Methotrexate; title: Mercaptopurine; title: Mycophenolate mofetil; title: 4, alkylating agent; title: Cyclophosphamide; title: Busulfan; title: Thiotepa; title: 5.Antibodies; title: 1. Lack of selectivity and specificity, and inhibits both normal and abnormal immune responses.; title: 2. It has a strong inhibitory effect on the primary immune response and a weak inhibitory effect on the secondary immune response.; title: 3. The drug effect is closely related to the time of administration and the time interval and sequence of antigen stimulation.; title: 4. Most drugs still have non-specific anti-inflammatory effects.; title: 5. After long-term application, in addition to the unique toxicity of each drug, adverse reactions such as reducing the body’s resistance and inducing infection, increasing the incidence of tumors, and affecting the function of the reproductive system are still easy to occur. Calcineurin inhibitor; title: Cyclosporin (ciclosporin, cyclosporin A) is a fat-soluble cyclic undecapeptide compound produced by the mold Tolypocladium inflatum. It selectively acts on the early stage of T lymphocyte activation. Helper T cells are activated to produce the proliferation factor interleukin 2, IL-2, and cyclosporine can inhibit its production; however, it has no effect on suppressor T cells. Another important role is to inhibit the production of interferon by lymphocytes. It has no effect on phagocytic cells of the reticuloendothelial system. Therefore, cyclosporine is different from cytotoxic drugs in that it only inhibits T cell-mediated cellular immunity without significantly affecting the general defense ability of the body.; title: In research, scientists discovered a strange substance called a liposome. This substance is mainly composed of phospholipids, has a cell-like structure, and is easily swallowed by the reticular skin system when it enters the body, thus activating the body’s autoimmune function. Therefore, scientists use this passive targeting feature of liposomes to encapsulate drugs with large toxic and side effects, poor stability in blood, and fast degradation in liposomes, which can be accumulated and released at the site of the lesion to achieve targeted drug delivery Projective directional blasting, and tracking target in the lesion area. This is known as the fourth generation of “bio-missile” targeted drug delivery, and most people call it liposome technology. Viral bio-missiles, 1. Target tracking and tracking of lesions, lungs, respiratory tract, etc. 2. Other systems and tissues of the body, inhibit antagonistic viruses 3. Increase certain immune antagonistic functions 4. Biological daughter missiles, drugs will be distributed through blood cells and tissues, etc. Because of its function and function, it is called biomedical missile drug, which can be used for biochemical medicine or compound medicine development, including gene medicine, etc., and has played an important role in the field of biomedical medicine. The preparation of synthetic composites is relatively complicated, and it can be called a disruptive revolution in medicine, pharmacy and science and technology. Biomedical missiles, biomedical missile drugs, are mainly targeted at coronavirus and new coronavirus pneumonia, cancer, AIDS, etc., as well as research and development of space drugs, planet life medical protection drugs are very useful, their future is incalculable.; title: The maiAzithromycin oxytetracycline chloroquine phosphate and pneumonia drugs, immune drugs, gene drugs, antiviral drugs, plant drugs, antibacterial drugs, influenza drugs, etc. Reasonable use and coordination of other drugs, combined use, the main drug Secondary medicines should be used flexibly according to the specific conditions of the patient’s body. Clinical attention to individual differences, whether there are other basic diseases, drug resistance, whether there are complications and adverse reactions, etc., age, family history, history of infectious diseases, individual differences, etc., use medication as appropriate, supplemented by other treatments, especially It is a critically ill patient and the elderly and the disabled. The main medicine and auxiliary medicine should be divided into major, minor and coordination to prevent adverse reactions and other side effects of the medicine. Intensify treatment, reduce mortality, and reduce the probability of morbidity and mild to severe development. Of course, due to the specific treatment of people, due to the severity of the disease, and other specific treatments, we cannot be rigid. These drugs can also be used and taken in advance in the majority of epidemic areas and severely affected areas, especially for susceptible people, the elderly, the sick, and the disabled. Of course, they can also be used for immunization, anti-virus, anti-infection, anti-infective, or injection, regardless of infection , Whether the test is negative or not, whether or not fever and high fever. This will play an important role in epidemic prevention and epidemic prevention, and will achieve the isolation and blockade of viral pneumonia infection and infection. This is also an important prevention and control method in addition to dry mouths. This will greatly reduce the probability of morbidity and death from infection.; title: n excipient of liposomes is phospholipids, and the elimination of phospholipids in the blood is extremely slow. Therefore, liposome drugs remain in the blood circulation system for a long time, so that the site of the lesion can be fully treated. Because of this, scientists have used this technology to use a large number of known highly toxic active drugs as warheads for “biomissiles”, such as anticancer drugs, antiviral drugs, antibiotics, antifungal drugs, antiparasitic drugs, Protein or peptide drugs are safely and effectively used in clinical treatment, which reduces the patient’s pain and greatly improves the treatment effect. At the same time, the monoclonal antibody can be linked to the liposome, and the drug-loaded liposome can be directed into the body lesion by the specific reaction of the antigen and the antibody. Genes can also be loaded into liposomes, and the special “skills” of liposomes to carry out gene repair. “Missile drugs”, also called biological missiles, are the most important drugs developed by scientists to save patients’ lives. This drug can track targets according to design and automatically find targets, which plays a positive role in treating diseases. The first generation ” “Biological missiles”, called monoclonal antibodies. Scientists have found that every bacterium that invades the human body has a corresponding antibody against it. If the antibodies produced by cancer cells are combined with a certain toxin, they can destroy 100% of the cancers in culture Cells without harming any normal cells, so “clone” replicates a single antibody that specializes in this cancer cell, and then attaches a very radioactive “warhead” to the antibody, attacking the cancer cell with lethal radioactivity, thereby achieving a curative effect .; title: Cyclosporine is mainly used in clinical practice to prevent adverse immune reactions such as rejection during allogeneic organ or bone marrow transplantation, and is often used in combination with glucocorticoids. The clinical application in the treatment of autoimmune diseases is still being explored.; title: Commonly used alkylating agents: cyclophosphamide, busulfan, thiotepa, etc. They can selectively suppress B lymphocytes, and large doses can also suppress T lymphocytes. It can also inhibit immune blasts, thereby blocking humoral and cellular immune responses. The effect of cyclophosphamide is obvious,; title: Selective inhibition of T cells, in the early stage of T cell activation, has a weaker inhibitory effect on B cells.; title: Inhibits production of IL-1 by macrophages.; title: Inhibits the expression of IL-2 receptors by antigen or mitogen-activated lymphocytes.; title: It has no obvious inhibitory effect on NK cells, but can indirectly affect the vitality of NK cells by interfering with the production of IFN-γ. In vivo processes of cyclosporine; title: Oral absorption is rapid, but incomplete absorption due to first pass elimination. The blood concentration reached a peak in 0.5 ~ 3 h, t1 / 2 was 5 ~ 8 h, and the effective concentration continued for 12 h. Mainly metabolized by the liver, metabolites are excreted by feces.; title: 3 Pneumonia drugs and vaccines The main drugs are suitable for patients with severe and critical illness, the impact of compound antibacterial drugs combined with azithromycin on the inflammatory indexes of lobar pneumonia; title: The main drug of 4 gene drugs is suitable for patients with severe or severe illness, interferon (IFN) series, interleukin (IL) series, colony stimulating factor (CSF) series, erythropoietin (EPO), basic fibroblast factor (BFGF), other cytokine drugs of concern are tumor necrosis factor (TNF). Hepatocyte growth factor (HGF), nerve growth factor (NGF), etc.; title: 5 Anti-infective drugs The main drugs are suitable for patients with severe or severe illness; title: Respiratory infectious disease drugs The main drug is suitable for patients with severe and critical illness; title: 7Botanical drugs Pure botanical drugs (Gold and Silver Peanut Astragalus Radix Ginseng Ginseng, Codonopsis Astragalus, Guizhi, Ziheche, Tremella, Jujube Kernel, Jujube Salvia Miltiorrhiza, Peach Kernel, Safflower, Turmeric, Chicken Blood Vine, Pueraria Root, etc. Moderate and trace amount of anti-virus, enhance immunity, treat respiratory symptoms such as pneumonia, etc.) It is suitable for patients with severe or severe illness, decoction or pills; title: Viral pneumonia and coronavirus pneumonia; title: Viral pneumonia is inflammation of the lungs caused by viral infection of the upper respiratory tract and spreading downward. The disease can occur all year round, but most of it occurs in winter and spring, and can be outbreak or spread epidemic. It is contagious, because contact and breathing between people is the most likely to cause large-scale infection and spread. Clinical manifestations are fever, headache, general soreness, dry cough, and pulmonary infiltration. The occurrence of viral pneumonia is related to the virulence of the virus, the route of infection, the age of the host, and the state of immune function. Proved more effective virus inhibitory drugs are: 1, ribavirin has a broad-spectrum antiviral function, including respiratory syncytial virus, adenovirus, parainfluenza virus and influenza virus. 2. Acyclovir is a chemically synthesized antiviral drug, which has the characteristics of broad spectrum, potency and fast onset. Clinically used for herpes virus, chickenpox virus infection. Especially for immunodeficiency or immunosuppressants should be applied as soon as possible. 3. Ganciclovir is an acyclovir analog that inhibits DNA synthesis. It is mainly used for cytomegalovirus infection. 4. Oseltamivir is a neuraminidase inhibitor, which has a good effect on influenza A and B viruses, and has a low incidence of drug resistance. 5. Arabinoside is a purine nucleoside compound, which has a wide range of antiviral effects. It is mostly used to treat herpes virus and chickenpox virus infection in immunodeficiency patients. 6. Amantadine is a synthetic amine drug, which can prevent certain viruses from entering human cells and reducing fever. 7. Other drugs. Clinically used for infections such as influenza virus. According to the analysis of a large number of clinical cases, the onset was slow, with headache, fatigue, fever, cough, and a small amount of sticky sputum. Signs are often absent. X-ray examination of the lungs showed spotty, flaky, or even shadows. The total number of white blood cells can be normal, decreased or slightly increased. The course of disease is usually 1 to 2 weeks. In patients with immune deficiency, viral pneumonia is often more severe, with persistent high fever, palpitations, shortness of breath, cyanosis, extreme failure, and can be accompanied by shock, heart failure, and azotemia. Due to alveolar interstitial and alveolar edema, respiratory distress syndrome can occur in severe cases. Physical examination may have wet rales. X-ray examination showed diffuse nodular infiltration, which was more common in two thirds of the lung field. There are many similarities and differences between this disease and severe pneumonia, bacterial pneumonia, white lung disease and other respiratory diseases and respiratory infectious diseases, as well as new coronary pneumonia, Sars, and Middle East respiratory syndrome, which require clinical differential diagnosis. Viral pneumonia and bacterial pneumonia are generally extremely large-scale infectious, occult toxicity, repetitive, lethal, seasonal, susceptible to humans, difficult to detect and prevent, Sars, Middle East Respiratory Syndrome, Eber This is the case for infectious pneumonia such as pull virus, neocoronavirus pneumonia.; title: Antiviral and antipyretic honeysuckle are the most common Chinese medicine. Honeysuckle has a very significant effect on the suppression of influenza virus pneumonia, and is often used as a traditional Chinese medicine for clearing heat and detoxifying. Clinical experiments have proven that it can have a very effective preventive effect against influenza viral pneumonia. Forsythia is also often used as a heat-clearing and antiviral drug. Forsythia is rich in hypericin and has significant effects in the treatment of viral infections in poultry. It can treat infectious bronchitis virus and poultry infection virus, and has obvious bactericidal effect.; title: The antiviral effect of Ganoderma Lucidum is also very good. He can effectively inhibit the growth of viruses in the body and play a bactericidal role. Ginseng, which we are familiar with, is also one of the antiviral Chinese medicines. It has a strong protective effect on virus-infected cells. The ingredients in ginseng have a significant inhibitory effect on rabies virus.; title: Takino chrysanthemum is also a commonly used antiviral drug, which has a very strong effect of clearing heat and detoxifying, can inhibit the activity of influenza virus, and can be used as a preventive drug for influenza virus.; title: Viral pneumonia is caused by adenovirus, respiratory syncytial virus, influenza virus, parainfluenza virus, coxsackie virus, and ecovirus, etc. There are symptoms of upper respiratory infection before onset, white blood cell count is normal or low, and antibiotic treatment is not effective.; title: At present, there is no ideal antiviral drug. Therefore, the treatment of viral pneumonia is mainly symptomatic. At the same time, care should be taken to prevent complications, and antibiotics are not necessary when there is no bacterial infection. There are several antiviral agents commonly used in clinical practice.; title: (1) Ribavirin: It can inhibit a variety of DNA and RNA viruses. It is a broad-spectrum antiviral drug with low toxicity. The route of administration is nasal drip, buccal administration, nebulized inhalation, intramuscular injection, intravenous drip, etc.; title: Nasal drops: 5% ribavirin solution 5mg / ml, nose drops every 2 hours. Tablets: Each tablet contains 2mg of ribavirin,; title: It is effective for adenoviral pneumonia and respiratory syncytial virus pneumonia.; title: (2) Interferon: It can inhibit the replication of intracellular virus, interrupt the spread of inflammation, and improve the phagocytosis ability of macrophages.; title: (3) Polymyocyte: an interferon inducer,; title: (4) Shuanghuanglian powder injection: It is extracted from traditional Chinese medicine and has antiviral effect.; title: In addition, modern pharmacological studies have confirmed that many traditional Chinese medicines have good antiviral effects, such as Daqingye, Isatis indigotica, Forsythia, Forsythia, Shegan, Scutellaria baicalensis, Coptis chinensis, Houttuynia cordata, Chrysanthemum, wild chrysanthemum, Bupleurum, burdock, Guanzhong, Lithospermum, Tilia, Red sedge, Danpi, Prunella vulgaris, raw licorice, Polygonatum sibiricum, Fatty sea, Hu Huanglian, etc. Therefore, in the treatment of viral pneumonia, taking decoction can also have a good effect.; title: 8 Compound drugs Structural modification of chemical drugs and pure botanical drugs, with powerful effects and obvious effects (modification of antiviral drugs +) Suitable for patients with severe or severe illness (1) Igglobulin (2) Indinavir, ritonavir; title: (3) Amantadine; title: (4) Interferon; title: The right amount of these chemicals is Daqingye, Isatis indigotica, Silver flower, Forsythia, Shegan, Scutellaria baicalensis, Coptis chinensis, Houttuynia cordata, Chrysanthemum, wild chrysanthemum, Bupleurum, Arctium lappa, Guanzhong, sage, aster Botanicals, prunella vulgaris, raw licorice, huangji, fathai, huanghuanglian and other botanical drugs are combined or chemical drugs and botanical drugs are purified and compounded. In order to avoid adverse chemical structural reactions and iatrogenic interference of drugs, it is necessary to do Fine chemical production of composite technology to ensure the reliability, safety and redundancy of composite products.; title: Biochemical drugs Bacterial pneumonia drugs Influenza drugs Adjuvant drugs etc. General patients chloroquine phosphate etc.; title: 10. Animal Coronavirus Pneumonia Drugs Adjuvant Drugs General Patients; title: 11. Coronavirus preventive drugs (anti-infective drugs) A. Compound preparation; title: B. Biochemical Drug C. Pure botanicals (use the dosage and individual differences, increase and decrease as appropriate); title: Based on a large number of clinical cases and death cases, combined with pathological anatomy of experts and professors and pathogen research, including the etiology and production of new coronavirus pneumonia, there are many research results and experience in prevention and treatment. Corresponding cities around the world are worthy of recognition. It is a very special means in the extraordinary period, and it is a last resort. The outbreak of the plague has swept the world, and the consequences of this good strategy can be imagined. However, the closure of the city cannot fundamentally eliminate and treat the disease. Only effective and effective technologies and drug vaccines can be effective and effective, and can save the lives of more people.; title: The new coronavirus has considerable homology and heterogeneity with infectious pneumonia coronaviruses such as Sars and respiratory infections in the Middle East. The basic commonalities between the two cannot be denied, but there are certain differences and characteristics. Whether the mutation and evolution of the coronavirus requires further research and experiments to prove.; title: Neocoronavirus pneumonia poses a great threat to human beings. It has a strong vitality and a strong and widespread spread. In particular, its occult, recalcitrant, and rapid nature shows that the spread of this new virus has spread beyond Sars, the Middle East Respiratory Syndrome, and Ebola virus. The lung is the most important respiratory organ for animals and humans and has other functions and functions. Respiratory tract infections and transmission can easily cause large-scale population infections to spread. This is the same as coronavirus in animal pneumonia animals. Groups of infections cause rapid deaths in groups. Neocoronavirus pneumonia exists in susceptible populations, as well as in young and middle-aged patients. There are also some specific cases of family genetic history of infection history with no obvious symptoms and no obvious contact history. Such cases occur in Asia, Europe, America, and Africa. This requires people to be more alert and to take effective precautions against invisible patients (including invisible patients and transmission). The great plague of the century, a worldwide infectious disease, swept the world, more than 160 countries and regions, and nearly 6-7 billion people. In just a few months, it poses a major hazard to all mankind worldwide. According to incomplete estimates and calculations, the number of infected people can reach 300,000 to 400,000, the number of deaths can reach 1-3 million or more, and the epidemic can take up to six months or more to completely subside and end. Direct economic losses and indirect economic losses will reach 3.9 trillion to 5.8 trillion US dollars, which will account for 25% -37.8% of the world’s total output value, and world GDP will fall by several percentage points. The persistence and repetitive variability of this disease must not be underestimated. Otherwise, human society will pay a higher price and enter the “end of the world virus.” Of course, we don’t have to be stubborn all day long and can’t do anything about it. Only scientific and rational wisdom can meet and face the threatening virus disease demons, which will eventually defeat them completely. Viral biological missiles and other advanced and effective medical technologies are powerful weapons to defeat viral disease.; title: (B) About the origin of this type of virus The new coronavirus is basically conclusive with human animals. The invasion and spread of animal (plant) coronavirus and coronavirus pneumonia to humans are first affirmed. (Of course, it is not absolutely ruled out. Spontaneous spontaneous cases of patients without contact and infection, family history, history of infectious diseases, history of lung diseases, regional environment, bacterial pneumonia, respiratory infections, immune deficiency syndrome, climate, vegetation environment, Diseases caused by diet, etc., other viruses may also be converted into new coronaviruses. (Of course, viral and bacterial infections are the most important).; title: (C) The lung is an extremely important physiological organ for human beings. The mortality rate of lung diseases such as pneumonia, lung cancer and tuberculosis is extremely high. The number of deaths from lung diseases every year in the world is tens of millions. Pneumonia is a large-scale epidemic of respiratory infectious diseases. No matter bacterial pneumonia or viral pneumonia, pneumonia is particularly susceptible and susceptible to death in the winter and spring season. Mortality from viral pneumonia is also extremely high. Therefore, medical scientists are often veterinarians, and medicine and veterinary virology and bacteriology are closely related.; title: (D) The new type of coronavirus pneumonia is not theoretically an incurable disease. It is as killing human as AIDS and cancer, and there is no cure for it. For most patients, health care will be restored as long as they are carefully treated. Of course, it is extremely dangerous for certain groups such as critically ill, old, weak, and young, and the mortality rate is as high as 59.8% -97.8%. Of course, there are also other factors such as race, family, regional epidemic history, individual difference medicine, treatment technology prevention technology and other factors. Only by analyzing the data and computer models of cases and deaths in countries around the world can science be achieved. The conditions of specific treatments are different in different countries around the world, and the data may be changed. That is quite normal, and no need to be surprised.; title: (E) Coronaviruses and bacteria exist widely in the microbial and biological worlds in nature. They live in symbiosis with animals and plants as well as humans. They will dance with humans for a long time and will not easily die. Therefore, the prevention and control of new-type coronary pneumonia is not only temporary, but also a long-lasting protection war for human beings. If the paralysis is loosened, viruses and illnesses will come back and give humans a devastating attack. This is especially true for susceptible populations, seasons and regions. Respiratory infectious diseases pneumonia itself is susceptible to common and common infectious diseases, which is no less harmful than infectious diseases such as large-scale influenza hepatitis. This year has passed, and next year, strict control is needed. Viruses are also evolving genetic mutations, otherwise humans would still have to pay extremely high prices for this.; title: (F) Virology Involved Virology of Human Infectious Diseases Animal Virology Medicine and Veterinary Medicine; title: Microbiology and plant virology; title: Infectious Diseases; title: Pneumonia; title: cytology; title: molecular biology; title: Pharmaceutical chemical structure Pathology and pharmacology Drug screening, drug design, modification of pharmaceutical chemical structure, intermediate of pharmaceutical chemical structure, etc.; title: Immunology; title: Respiratory infectious disease virology; title: Molecular biology and many other disciplines and biomedical fields are extensive and complex.; title: ———————————————————————————————————————————————————————————————__________________-____; title: The main reference references reference books medical website biomedical data gene library, etc .:; title: Official website of the United Nations; title: Official website of China Health Committee; title: Wikipedia; title: COVID-19 Resource Centre; title: CORRESPONDENCE; title: COVID-19 battle during the toughest sanctions against Iran; title: Amirhossein Takian, Azam Raoofi, Sara Kazempour-Ardebili; title: The Lancet; title: COMMENT; title: Prisons and custodial settings are part of a comprehensive response to COVID-19; title: Stuart A Kinner, Jesse T Young, Kathryn Snow, Louise Southalan, Daniel Lopez-Acuña, Carina Ferreira-Borges, and others; title: The Lancet Public Health; title: COMMENT; title: Clinical course and mortality risk of severe COVID-19; title: Paul Weiss, David R Murdoch; title: The Lancet; title: CORRESPONDENCE; title: Prevention of SARS-CoV-2 infection in pa; title: International Medical Gene Bank; title: : Veterinary Virology (4th Edition); title: Price: 298.00 yuan; title: Author  US) Mark Lachlan, (US) Du Bowei editor, Kongxian Gang, LIU Sheng-wang; title: Publisher: China Agricultural Press; title: “Overview of virology,” the authors  US) Songpeilake (Sompayrac; title: Immunology (2nd edition, Chinese translation); title: [] Peter Lydyard; title: “Application of Pharmacokinetic Technology in Drug Design and Development” was officially published. Original ADME-Enabling Technologies in Drug Design and Development by Dr. Zhang Donglu and Dr. Sekhar Surapaneni; title: Goodman Gilman’s Therapeutic Pharmacology Basics “edited by McGraw-Hill, a world-renowned publishing company (original work); title: Laurence L. Brunton; title: Clinical Manifestations and Assessment of Respiratory Disease; title: By: George Burton, Terry Des Jardins; title: Publisher: Elsevier (HS-US); title: Plants and Herbs That Repair Lung Damage, Combat Infections, and Boost Lung Health; title: By: Beverly Hill; title: Narrated by: Wayne F. Perkins; title: The Infectious Diseases Manual: Edition 2; title: David WilksMark FarringtonDavid RubensteinApril 14, 2008; title: Sold by John Wiley & Sons; title: The Microbiology of Respiratory System Infections, Volume 1 (Clinical Microbiology Diagnosis, treatment and prophylaxis of infections) 1st Edition Author: Kateryna Kon, Mahendra Rai; title: Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases E-Book: Edition 7; title: John E. Bennett Raphael DolinMartin J. BlaserGerald L. MandellOctober 19, 2009; title: Elsevier Health Sciences; title: GPnotebook Medical Encyclopedia; title: MSF; title: . Embase; title: Cochrane Online Library; title: Health Technology Assessment Database; title: Cochrane; title: .Pubmed; title: OVID Electronic Journal Full-text Database (OVFT); title: Clinical trials; title: Medline; title: Overview of Essentials of Virology Bilingual [English] T. Schoen, Zhu Junping and others; title: Handbook of Prevention and Treatment of the Pneumonia Caused by the Novel Coronavirus (2019-nCoV) Cyberspace Administration of Tianjin; title: WeDoctor Digital General Hospital; title: WeDoctor Tianjin Digital Hospital; title: January 2020; title: Heath Medicine West Medicine; title: Lee Goldman; title: Nursing diagnosis manual; title: Cabenito Moyette; title: Molecular virology; title: Author: Kahn; title: Luria S E et al., General Virology; title: The essence of chest image; title: Cellis edit /; title: Coronary virus pneumonia and other related picture materials are quoted from relevant network resources and media sites, Wikipedia, etc.; title: ************************************; title: Carstensen, J. M. March 2020 Munich(Editor); title: The manuscript is the research paper of Professor Fang Ruida’s medical research and the monograph on novel coronavirus pneumonia, as well as the research and invention results of the “viral biomissile” compound drug developed by Professor Fang Ruida’s medical drugs for coronavirus and coronavirus pneumonia. Netizens, in particular the requirements of medical workers, medical staff, disease control personnel, researchers, government agencies, pharmaceutical development companies and technicians worldwide, are now editing and publishing them to meet the medical institutions of various countries around the world The majority of medical staff in research institutions learn about research, communication, and sharing to meet the urgent needs of anti-epidemic diseases and technical exchanges in countries around the world, especially for clinicians in countries with global epidemic areas for reference and sharing to save more patients’ lives and treat them. More outbreaks. Due to time constraints, there is very little medical literature and scientific literature on this disease, especially the lack of first-hand clinical data and physiological cases in many countries around the world. Therefore, there will be many errors and deficiencies in editing. I hope that readers will correct it so that it can be corrected and supplemented in the next edition of the editor.; title: Edito; title: ———————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————————Fangruida: Intégration de 10 médicaments majeurs pour l’application clinique de médicaments pour le traitement efficace de la nouvelle et nouvelle pneumonie à coronavirus et conception redondante de médicaments pour application clinique – “Virus bio-missile”, “Coronavirus pneumonia (pneumonie respiratoire grave maladie infectieuse) alphabétique bio bio -missile”; title: **************************************; title: 15 mars 2020 (Carstensen, J. M. Munich); title: —————————————————————————————————————————; title: Mots clés; title: Nouveau coronavirus Pneumonie sévère, pneumonie blanche Pneumonie Intégration de 10 médicaments et technologie de conception redondante Médicaments composés Modification de la structure chimique des médicaments et médicaments végétaux purs; title: La transmission sexuelle occulte du nouveau virus de la pneumonie à coronavirus est facilement ignorée. Par conséquent, les pays des zones touchées devraient généralement adopter diverses mesures de défense aérienne, des médicaments antiviraux, des médicaments immunitaires, des vaccins contre la pneumonie, des médicaments contre la pneumonie, des médicaments végétaux, des médicaments composés, des médicaments génétiques, etc. Ces médicaments doivent être pris parmi les populations clés sensibles à la population, indépendamment du fait que le test soit négatif, qu’ils soient ou non en contact étroit ou suspects. Ces médicaments constitueront également des missiles biologiques viraux, qui ont un grand effet sur l’immunité et les antivirus et anti-infections, en particulier dans les zones épidémiques clés, ce qui est d’une grande importance.; title: ●● La pneumonie à néocoronavirus présente en réalité les caractéristiques et les points communs considérables de la pneumonie coronarienne (Sars et al.), De la pneumonie sévère, de la pneumonie de la maladie pulmonaire blanche et de la pneumonie par infection infectieuse épidémique, et de leurs spécificités respectives. Il s’agit d’une nouvelle pneumonie virale et d’une extension de la pneumonie sévère infectieuse traditionnelle. Cela démontre pleinement l’évolution et la variation génétique du monde biologique naturel, y compris les micro-organismes et les animaux, et les humains.; title: ●● Études sur la pathogenèse et la pathogénicité de nouveaux coronavirus (y compris divers inhibiteurs de virus) et le développement de médicaments à action rapide efficaces et efficients; title: ●● Le nouveau type de pneumonie à coronavirus n’est pas incurable. Il ne dépasse pas le cancer du SIDA. La plupart des patients peuvent récupérer et retrouver la santé. Les populations vulnérables et les patients gravement malades ont des taux de mortalité plus élevés.; title: ●● La pneumonie à coronavirus et le coronavirus ne sont pas inconnus des humains. Il s’agit d’une épidémie à grande échelle de maladies courantes et sensibles chez les animaux et les humains. Ces maladies infectieuses sont facilement ignorées et mal jugées par les humains, et elles sont très susceptibles de provoquer de vastes zones Démarrage et propagation rapides. Le coronavirus existera longtemps dans la nature biologique. Sa variabilité occulte, rapide, répétitive et ne se retirera pas facilement et complètement du monde humain, animal et végétal.; title: ●● La gravité de la maladie du patient et les différences individuelles et d’autres facteurs varient dans l’utilisation des médicaments de traitement clinique, qui doivent être adaptés aux conditions locales, adaptés aux personnes et traités en fonction de la maladie. Les médicaments biochimiques et composés, les médicaments végétaux purs et les vaccins sont la clé de la prévention et du traitement des symptômes.; title: ●● Les nouveaux agents pathogènes des coronavirus et les virus animaux sont étroitement liés. Le coronavirus animal est le même que la pneumonie à coronavirus animal et la pneumonie à virus zoonotique, avec une analogie considérable. Bien que l’hôte pathogène soit difficile à trouver pendant un certain temps, il n’y a pas beaucoup d’objection de la part des animaux.; title: ●● Traitement et traitement efficaces et efficients de la nouvelle pneumonie à coronavirus << plan médical 5 + 2 >>, << plan médical 7 + 3 >> 10 nouveaux médicaments pour l’application clinique de la nouvelle et nouvelle pneumonie à coronavirus Intégration et solutions techniques redondantes, d’abord de tous, en l’absence de médicaments et de vaccins spécifiques, les scientifiques médicaux, les pharmacologues, les pathologistes, les scientifiques des maladies infectieuses, les virologues et les cliniciens et les infirmières doivent travailler ensemble Technologie intégrée et technologie redondante de médicaments pour traiter la vie et la santé des patients avec un nouveau type de pneumonie à coronavirus. “Bio-missile viral”, “Pneumonie à coronavirus (maladie infectieuse de pneumonie respiratoire sévère) bio-missile alphabétique” (modification et amélioration des médicaments biochimiques + substance raffinée végétale = inhibiteur des oligo-éléments), principaux médicaments, médicaments auxiliaires, médicaments immunitaires et toute autre combinaison scientifique et raisonnable, appliquée à la clinique, adaptée à l’infection par le virus de la pneumonie virale. Ab; title: réviation anglaise “VBM” “CPPAbM >>—r; title: —-______————————————————————————————————————————————————————————————————————————————————————————————Fangruida: Integración de 10 fármacos principales para la aplicación clínica de fármacos para el tratamiento eficaz de la neumonía por coronavirus nueva y nueva y diseño redundante de fármacos para la aplicación clínica – “Virus biomisil”, “Neumonía por coronavirus (enfermedad infecciosa por neumonía severa respiratoria) biobiótico -misil”; title: **************************************; title: 15 de marzo de 2020 (Carstensen, J. M. Munich); title: ————————————————————————————————————————; title: Palabras clave; title: Nuevo Coronavirus Neumonía severa, neumonía blanca Neumonía Integración de 10 fármacos y tecnología de diseño redundante de fármacos Fármacos compuestos Modificación de la estructura del fármaco químico y fármacos de plantas puras; title: La transmisión sexual oculta del nuevo virus de la neumonía por coronavirus se pasa por alto fácilmente, por lo tanto, los países en las áreas afectadas generalmente deben adoptar varias medidas de defensa aérea anti-kong, medicamentos antivirales, medicamentos inmunes, vacunas contra la neumonía, medicamentos para la neumonía, medicamentos vegetales, medicamentos compuestos, genes. Las drogas y similares deben tomarse entre las poblaciones clave susceptibles a la población, independientemente de si la prueba es negativa y si están en contacto cercano o casos sospechosos, generalmente deben tomarse o inyectarse. Estos medicamentos también constituirán misiles biológicos virales, que tienen un gran efecto sobre la inmunidad y los antivirus y antiinfecciones, especialmente en áreas epidémicas clave, lo cual es de gran importancia….; title: ●● La neumonía por neocoronavirus en realidad tiene las características y aspectos comunes considerables de la neumonía coronaria (Sars et al.), La neumonía grave, la neumonía por enfermedad del pulmón blanco y la neumonía por infección infecciosa epidémica, y sus respectivas especificidades. Es un nuevo virus de la neumonía y una extensión de la neumonía severa infecciosa tradicional. Esto demuestra completamente la evolución y la variación genética del mundo biológico natural, incluidos los microorganismos y los animales, y los humanos.; title: ●● Estudios sobre la patogénesis y patogenicidad de nuevos coronavirus (incluidos varios inhibidores de virus) y el desarrollo de fármacos eficaces y eficientes de acción rápida.; title: ●● El nuevo tipo de neumonía por coronavirus no es incurable. No supera el cáncer de SIDA. La mayoría de los pacientes pueden recuperarse y recuperarse a la salud. Las poblaciones vulnerables y los pacientes críticos tienen tasas de mortalidad más altas.; title: ●● La neumonía por coronavirus y el coronavirus no son desconocidos para los humanos. Son una epidemia a gran escala de enfermedades comunes y susceptibles en animales y humanos. Estas enfermedades infecciosas son fácilmente ignoradas y mal juzgadas por los humanos, y es más probable que causen grandes áreas Inicio rápido y propagación. El coronavirus existirá en la naturaleza biológica durante mucho tiempo. Su oculto, rápido, repetitivo y variabilidad no se retirará fácil y completamente del mundo humano, animal y vegetal.; title: ●● La gravedad de la enfermedad del paciente y las diferencias individuales y otros factores varían en el uso de medicamentos de tratamiento clínico, que deben adaptarse a las condiciones locales, adaptarse a las personas y tratarse según la enfermedad. Los medicamentos bioquímicos y compuestos, los medicamentos vegetales puros y las vacunas son la clave para la prevención y el tratamiento sintomáticos.; title: ●● Los nuevos patógenos de coronavirus y virus animales están absolutamente estrechamente relacionados. El coronavirus animal es lo mismo que la neumonía por coronavirus animal y la neumonía por virus zoonótico, con una analogía considerable. Aunque el huésped patógeno es difícil de descubrir por un tiempo, no hay mucha objeción por parte de los animales.; title: ●● Tratamiento y tratamiento eficaz y eficiente de la nueva neumonía por coronavirus << plan médico 5 + 2 >>, << plan médico 7 + 3 >> 10 nuevos medicamentos para la aplicación clínica de la nueva y nueva neumonía por coronavirus Integración y soluciones técnicas redundantes, primero ante todo, en ausencia de medicamentos y vacunas específicos, los científicos médicos, farmacólogos, patólogos, científicos de enfermedades infecciosas, virólogos, médicos y enfermeras deben trabajar juntos. Tecnología integrada y tecnología redundante de medicamentos para tratar la vida y la salud de los pacientes con un nuevo tipo. de la neumonía por coronavirus. “Bio-misil viral”, “Neumonía por coronavirus (enfermedad infecciosa por neumonía severa respiratoria) bio-misil alfabético” (modificación y mejora bioquímica del fármaco + sustancia refinada de la planta = inhibidor de oligoelementos), fármacos líderes, fármacos auxiliares, fármacos inmunes y otra combinación científica y razonable, aplicada a la clínica, adecuada para la infección por el virus de la neumonía viral. Abreviatura en inglés “VBM” “CPPAbM >>; title: Fangruida: Integrazione di 10 principali farmaci per l’applicazione clinica di farmaci per un trattamento efficace della polmonite coronavirus nuova e nuova e design ridondante di farmaci per applicazione clinica – “Bio-missile virus”, “Polmonite da coronavirus (malattia infettiva polmonare respiratoria grave) bio alfabetica -missile”; title: **************************************; title: 15 marzo 2020 (Carstensen, J. M. Munich); title: —————————————-; title: Parole chiave; title: Nuovo Coronavirus Polmonite grave, polmonite bianca Polmonite Integrazione di 10 farmaci e farmaci Tecnologia di progettazione ridondante Farmaci composti Modifica della struttura di farmaci chimici e Farmaci vegetali puri; title: La trasmissione sessuale occulta del nuovo virus della polmonite da coronavirus viene facilmente ignorata. Pertanto, i paesi nelle aree interessate dovrebbero generalmente adottare varie misure di difesa aerea, farmaci antivirali, farmaci immunitari, vaccini contro la polmonite, farmaci contro la polmonite, farmaci vegetali, farmaci composti, farmaci genetici, ecc. Questi farmaci dovrebbero essere assunti tra le popolazioni chiave sensibili alla popolazione, indipendentemente dal fatto che il test sia negativo e che siano o meno in stretto contatto o casi sospetti. Questi farmaci costituiranno anche missili biologici virali, che hanno un grande effetto sull’immunità, l’antivirus e l’anti-infezione, specialmente nelle aree epidemiche chiave, che è di grande significato.; title: ●● La polmonite da neocoronavirus ha effettivamente le caratteristiche e le notevoli caratteristiche comuni di polmonite coronarica (Sars et al.), Polmonite grave, polmonite da polmone bianco e polmonite da infezione da infezione epidemica e le loro rispettive specificità. È una nuova polmonite virale e un’estensione della polmonite grave infettiva tradizionale. Ciò dimostra pienamente l’evoluzione e la variazione genetica del mondo biologico naturale, compresi i microrganismi e gli animali, e gli esseri umani.; title: ●● Studi sulla patogenesi e patogenicità di nuovi coronavirus (compresi vari inibitori del virus) e sviluppo di farmaci efficaci ed efficienti ad azione rapida; title: ●● Il nuovo tipo di polmonite da coronavirus non è incurabile. Non supera il cancro dell’AIDS. La maggior parte dei pazienti può recuperare e recuperare in salute. Le popolazioni vulnerabili e i pazienti in condizioni critiche presentano tassi di mortalità più elevati.; title: ●● La polmonite da coronavirus e il coronavirus non sono familiari all’uomo. Sono un’epidemia su larga scala di malattie comuni e sensibili negli animali e nell’uomo. Tali malattie infettive sono facilmente ignorate e giudicate erroneamente dall’uomo e hanno maggiori probabilità di causare vaste aree. Avvio rapido e diffusione. Il coronavirus esisterà nella natura biologica per lungo tempo. La sua occulta, rapida, ripetitiva e variabilità non si ritirerà facilmente e completamente dal mondo umano, animale e vegetale.; title: ●● La gravità della malattia del paziente e le differenze individuali e altri fattori variano nell’uso dei farmaci per trattamenti clinici, che devono essere adattati alle condizioni locali, adattati alle persone e trattati in base alla malattia. I farmaci biochimici e composti, i farmaci vegetali puri e i vaccini sono la chiave per la prevenzione e il trattamento sintomatici.; title: ●● I nuovi patogeni e virus animali del coronavirus sono strettamente correlati. Il coronavirus animale è lo stesso della polmonite da coronavirus animale e polmonite da virus zoonotico, con notevole analogia. Sebbene l’ospite patogeno sia difficile da scoprire per un po ‘, non ci sono molte obiezioni da parte degli animali.; title: ●● Trattamento e trattamento efficaci ed efficienti della nuova polmonite da coronavirus << 5 + 2 piano medico >>, << 7 + 3 piano medico >> 10 nuovi farmaci per l’applicazione clinica della nuova e nuova polmonite da coronavirus Integrazione e soluzioni tecniche ridondanti, prima di tutto, in assenza di specifici farmaci e vaccini, scienziati medici, farmacologi, patologi, scienziati delle malattie infettive, virologi e clinici e infermieri devono lavorare insieme Tecnologia integrata e tecnologia ridondante di farmaci per trattare la vita e la salute dei pazienti con un nuovo tipo di polmonite da coronavirus.; title: Fangruida: Integration von 10 Hauptmedikamenten für die klinische Anwendung von Medikamenten zur wirksamen Behandlung neuer und neuer Coronavirus-Pneumonien und redundantes Design von Medikamenten für die klinische Anwendung – “Virus-Bio-Rakete”, “Coronavirus-Pneumonie (Infektionskrankheit mit schwerer Lungenentzündung der Atemwege), alphabetische Bio -Rakete”; title: ******************************************; title: 15. März 2020 (Carstensen, J. M. München); title: ——————————————————————————————————————————; title: Schlüsselwörter; title: Neues Coronavirus Schwere Lungenentzündung, Weiße Lungenentzündung Lungenentzündung Integration von 10 Arzneimitteln und medikamentenredundanter Designtechnologie Zusammengesetzte Arzneimittel Chemische Änderung der Arzneimittelstruktur und reine pflanzliche Arzneimittel; title: Die okkulte sexuelle Übertragung des neuen Coronavirus-Pneumonie-Virus wird leicht ignoriert. Daher sollten Länder in den betroffenen Gebieten im Allgemeinen verschiedene Luftverteidigungsmaßnahmen, antivirale Medikamente, Immunmedikamente, Lungenentzündungsimpfstoffe, Lungenentzündungsmedikamente, pflanzliche Medikamente, zusammengesetzte Medikamente, Genmedikamente usw. ergreifen. Diese Medikamente sollten unter Schlüsselpopulationen eingenommen werden, die für die Bevölkerung anfällig sind. unabhängig davon, ob der Test negativ ist und ob sie in engem Kontakt stehen oder in Verdacht stehen. Diese Medikamente werden auch virale biologische Raketen darstellen, die einen großen Einfluss auf die Immunität sowie auf Antiviren- und Infektionsbekämpfung haben, insbesondere in wichtigen epidemischen Gebieten, was von großer Bedeutung ist.; title: ●● Die Neocoronavirus-Pneumonie weist tatsächlich die Merkmale und beträchtlichen Gemeinsamkeiten der Koronarpneumonie (Sars et al.), Der schweren Pneumonie, der Lungenentzündung der weißen Lungenkrankheit und der epidemischen infektiösen Infektionspneumonie sowie deren jeweilige Spezifitäten auf. Es ist eine neue Viruspneumonie und eine Erweiterung der traditionellen infektiösen schweren Lungenentzündung. Dies zeigt vollständig die Evolution und genetische Variation der natürlichen biologischen Welt, einschließlich Mikroorganismen und Tiere sowie des Menschen.; title: ●● Studien zur Pathogenese und Pathogenität neuer Coronaviren (einschließlich verschiedener Virusinhibitoren) und zur Entwicklung wirksamer und effizienter schnell wirkender Arzneimittel; title: ●● Die neue Art der Coronavirus-Pneumonie ist nicht unheilbar. Es überschreitet nicht AIDS-Krebs. Die meisten Patienten können sich erholen und wieder gesund werden. Gefährdete Bevölkerungsgruppen und kritisch kranke Patienten weisen höhere Sterblichkeitsraten auf.; title: ●● Coronavirus-Pneumonie und Coronavirus sind dem Menschen nicht unbekannt. Sie sind eine groß angelegte Epidemie häufiger und anfälliger Krankheiten bei Tieren und Menschen. Solche Infektionskrankheiten werden vom Menschen leicht ignoriert und falsch eingeschätzt, und sie verursachen höchstwahrscheinlich große Gebiete. Schneller Start und Ausbreitung. Das Coronavirus wird in der biologischen Natur für eine lange Zeit existieren. Seine okkulte, schnelle, sich wiederholende und Variabilität wird sich nicht leicht und vollständig aus der Welt von Mensch, Tier und Pflanze zurückziehen.; title: ●● Die Schwere der Erkrankung des Patienten sowie individuelle Unterschiede und andere Faktoren variieren bei der Verwendung von Arzneimitteln zur klinischen Behandlung, die auf die örtlichen Gegebenheiten zugeschnitten, auf Menschen zugeschnitten und entsprechend der Erkrankung behandelt werden müssen. Biochemische und zusammengesetzte Arzneimittel, reine pflanzliche Arzneimittel und Impfstoffe sind der Schlüssel zur symptomatischen Vorbeugung und Behandlung.; title: ●● Neue Coronavirus-Krankheitserreger und Tierviren sind absolut eng miteinander verbunden. Das tierische Coronavirus ist das gleiche wie die tierische Coronavirus-Pneumonie und die zoonotische Virus-Pneumonie, mit beträchtlicher Analogie. Obwohl der pathogene Wirt für eine Weile schwer herauszufinden ist, gibt es von Tieren nicht viel Einwände.; title: ●● Effektive und effiziente Behandlung und Behandlung der neuen Coronavirus-Pneumonie << 5 + 2 medizinischer Plan >>, << 7 + 3 medizinischer Plan >> 10 neue Medikamente für die klinische Anwendung der neuen und neuen Coronavirus-Pneumonie Integration und redundante technische Lösungen In Ermangelung spezifischer Medikamente und Impfstoffe müssen Mediziner, Pharmakologen, Pathologen, Wissenschaftler für Infektionskrankheiten, Virologen, Kliniker und Krankenschwestern zusammenarbeiten. Integrierte Technologie und redundante Technologie von Medikamenten müssen das Leben und die Gesundheit von Patienten mit neuem Typ behandeln von Coronavirus-Pneumonie.; title: Fangruida: دمج 10 أدوية رئيسية للتطبيق السريري للعقاقير من أجل العلاج الفعال للالتهاب الرئوي التاجي الجديد والجديد والتصميم الزائد للأدوية للتطبيق السريري – “الصاروخ الحيوي للفيروسات” ، “الالتهاب الرئوي التاجي (مرض الالتهاب الرئوي الحاد التنفسي) الأبجدية الحيوية – صواريخ “; title: **************************************; title: 15 مارس 2020 (Carstensen، J. M. Munich); title: ————————————————————————————————————————; title: الكلمات الدالة; title: فيروس كورونا الجديد الالتهاب الرئوي الحاد ، الالتهاب الرئوي الأبيض ، الالتهاب الرئوي ، تكامل 10 أدوية وأدوية تقنية زائدة عن الحاجة ، العقاقير المركبة ، تعديل التركيب الكيميائي للعقاقير وأدوية النباتات النقية; title: من السهل تجاهل الانتقال الجنسي الخفي لفيروس الالتهاب الرئوي التاجي الجديد. لذلك ، يجب على الدول في المناطق المتضررة اعتماد تدابير مختلفة للدفاع الجوي ، والأدوية المضادة للفيروسات ، والعقاقير المناعية ، ولقاحات الالتهاب الرئوي ، وعقاقير الالتهاب الرئوي ، والعقاقير النباتية ، والأدوية المركبة ، والأدوية الجينية ، وما إلى ذلك. وينبغي أن تؤخذ هذه الأدوية بين السكان الرئيسيين المعرضين للسكان ، بغض النظر عما إذا كان الاختبار سلبيًا ، وما إذا كانوا على اتصال وثيق أو حالات مشتبه فيها. ستشكل هذه الأدوية أيضًا صواريخ بيولوجية فيروسية ، والتي لها تأثير كبير على المناعة والمضادة للفيروسات ومضادة للعدوى ، خاصة في المناطق الوبائية الرئيسية ، والتي لها أهمية كبيرة.; title: ● ● يتميز الالتهاب الرئوي الفيروسي العصبي الجديد بالسمات والالتهاب الرئوي التاجي (Sars et al.) ، والالتهاب الرئوي الحاد ، والالتهاب الرئوي الرئوي الأبيض ، والالتهاب الرئوي المعدي الوبائي ، وخصائصه الخاصة. إنه التهاب رئوي جديد للفيروس وامتداد للالتهاب الرئوي الحاد المعدي التقليدي. يوضح هذا تمامًا التطور والتنوع الجيني للعالم البيولوجي الطبيعي ، بما في ذلك الكائنات الحية الدقيقة والحيوانات والبشر.; title: ● ● دراسات حول إمراضية ومرضية الفيروسات التاجية الجديدة (بما في ذلك مختلف مثبطات الفيروسات) وتطوير عقاقير سريعة وفعالة وفعالة.; title: ● ● النوع الجديد من الالتهاب الرئوي التاجي غير قابل للشفاء. لا يتجاوز سرطان الايدز. يمكن لمعظم المرضى الشفاء والشفاء. ترتفع معدلات الوفيات بين الفئات الضعيفة والمرضى المصابين بأمراض خطيرة.; title: ● ● الالتهاب الرئوي التاجي والفيروس التاجي ليسا غير مألوفين لدى البشر. هم وباء واسع النطاق من الأمراض الشائعة والحساسة في الحيوانات والبشر. هذه الأمراض المعدية يتم تجاهلها بسهولة وإساءة تقديرها من قبل البشر ، ومن المرجح أن تسبب مناطق كبيرة بداية سريعة وانتشار. سوف يتواجد الفيروس التاجي في الطبيعة البيولوجية لفترة طويلة. لن ينسحب غموضه وسرعته وتكراره وتنوعه بسهولة وبشكل كامل من عالم الإنسان والحيوان والنبات.; title: ● ● تتفاوت شدة مرض المريض والاختلافات الفردية والعوامل الأخرى في استخدام أدوية العلاج السريري ، والتي يجب أن تكون مصممة خصيصًا للظروف المحلية ، ومصممة خصيصًا للأشخاص ، وتعالج وفقًا للمرض. الأدوية البيوكيميائية والمركبة ، وأدوية النباتات النقية ، واللقاحات هي المفتاح للوقاية والعلاج من الأعراض.; title: ● ● ترتبط مسببات الأمراض التاجية والفيروسات الحيوانية الجديدة ارتباطًا وثيقًا. الفيروس التاجي الحيواني هو نفس الالتهاب الرئوي للفيروس التاجي الحيواني والالتهاب الرئوي بفيروس حيواني ، مع تشابه كبير. على الرغم من صعوبة اكتشاف المضيف الممرض لفترة ، إلا أنه لا يوجد اعتراض كبير من الحيوانات.; title: ● ● العلاج والعلاج الفعال والفعال للالتهاب الرئوي التاجي الجديد << خطة طبية 5 + 2 >> ، << خطة طبية 7 + 3 >> 10 أدوية جديدة للتطبيق السريري للالتهاب الرئوي التاجي الجديد والجديد التكامل والحلول التقنية الزائدة ، أولاً الكل ، في غياب عقاقير ولقاحات محددة ، يحتاج علماء الطب وعلماء الأدوية وعلماء الأمراض وعلماء الأمراض المعدية وعلماء الفيروسات والأطباء والممرضات إلى العمل معًا التكنولوجيا المتكاملة والتكنولوجيا الزائدة للأدوية لعلاج حياة وصحة المرضى من النوع الجديد الالتهاب الرئوي التاجي.; title: Fa; title: Fangruida : 새로운 및 새로운 코로나 바이러스 폐렴의 효과적인 치료를위한 약물의 임상 적용을위한 10 가지 주요 약물의 통합 및 임상 응용을위한 약물의 중복 디자인- “Virus bio-missile”, “Coronavirus pneumonia (호흡기 중증 폐렴 감염성 질환) 알파벳 바이오 -미사일”; title: ***************************************; title: 2020 년 3 월 15 일 (Carstensen, J. M. Munich); title: —————————————————————————————————————; title: 핵심어; title: 새로운 코로나 바이러스 중증 폐렴, 백색 폐렴 폐렴 10 가지 약물 및 약물 이중화 설계 기술 복합 약물; title: ^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^呼吸道感染性肺炎和難治性冠狀病毒性肺炎的化學藥品的鑑別診斷和有效治療; title: Sars，冠狀病毒性肺炎等的發展/冠状型病毒性肺炎生物标志物及治疗防治（方瑞達） 修改版2020v5.0中文版本; title: ****************************; title: According to real-time data from Johns Hopkins University in the United States, as of around 2:12 on June 28, Beijing time, the cumulative number of new cases of new coronary pneumonia has reached 9,866,685; the cumulative number of deaths has reached 495,692.; title: United States; title: New coronavirus confirmed cases continue to rise in many US states,; title: The number of new coronavirus diseases admitted to hospitals in Texas, Utah, Arkansas, Arizona and other states has increased. California and Florida saw the largest increase in newly diagnosed cases in a single day.; title: According to data from Johns Hopkins University, more than 2.38 million confirmed cases in the United States and more than 120,000 deaths.; title: Pneumonia epidemic: the total number of confirmed new crowns in the world is approaching 10 million; title: Pneumonia epidemic: The number of deaths in the United States exceeded 100,000, and the number of diagnoses in Brazil rose to second in the world.; title: Germany; title: Germany has previously been regarded as a model for European countries to fight against the new coronavirus disease. The key anti-epidemic measures include virus screening and epidemic follow-up investigations that began very early, so it can maintain a relatively low number of infections and deaths.; title: The most serious of these is the meat processing plant. The Tönnies meat processing plant in North Rhine-Westphalia has approximately 7,000 employees and is the largest meat processing plant in Germany. In total, more than 1500 workers were infected.; title: These recent outbreaks of cluster infections have also caused Germany's basic infection number "R value" to climb again to 2.88.; title: Brazil; title: Brazil has more than 1.18 million confirmed cases and nearly 54,000 deaths, making it the second highest country in the world.; title: On Wednesday (June 24), the number of newly diagnosed people in Brazil was 42,725. Although it has declined, it is still high, with 1,185 deaths.; title: Brazil's new coronavirus confirmed the world's third; title: India; title: India's newly confirmed cases in a single day broke through a new high again this week. On Thursday, the number of newly diagnosed cases reached 16,922, surpassing 15,968 people the day before.; title: Data from Johns Hopkins University show that more than 470,000 cases have been diagnosed in India and 14,894 people have died.; title: According to the Indian Ministry of Health, Maharashtra, New Delhi and Tamil Nadu are the most severely affected areas, accounting for about 60% of all confirmed cases in India. The situation is not optimistic.; title: The Russian epidemic is also very serious. Parade in Moscow, Russia.; title: 現代科學技術和生物醫學工程發展迅速。醫學，基因工程，細胞，酶和蛋白質微生物學尤為重要。諸如肺炎等呼吸道傳染病在臨床研究中也取得了重大進展。非典，細菌性病毒性肺炎和其他常見的困難疾病也有所增加。肺炎，肺部疾病，肺癌和其他肺部疾病首當其衝。細菌性和病毒性肺部疾病是代表性的。在生物學和醫學上，病毒類型很多，冠狀病毒是一種重要的病毒。它擴散到人，動物和牲畜的許多組織和器官，引起各種嚴重的疾病，嚴重威脅著人類的健康。特別是她的專一性和困難性，感染的危害性特別顯著，傳染性的爆炸性也不同。特別是在冬季和春季，病毒性肺炎，細菌性肺炎，流感和肺炎極易發生，在大範圍傳播，並且死亡率很高。被這些疾病感染的動物還具有很高的死亡率，起效快，潛伏期短和傳播力強。它是人類最有可能發生的第一種疾病和瘟疫。而且，當今的醫療技術和藥物在對症治療中並不有效。像非典，癌症，艾滋病和世界上其他主要殺手一樣，他們奪走了數百萬人的生命。疑難疾病的研究和治療，醫療技術，臨床診斷，藥物開發，重症監護等需要長期研究，病理分析，病理分析，病毒化學分析，對症藥物開發，化學結構設計和修飾，動物學研究，獸醫研究醫學實驗研究，獸醫和醫學雙向研究，臨床試驗，病毒模型研究，生化生物物理學研究實驗，微生物學，生物工程，基因工程，細胞學，酶化學，蛋白質學等，巨額投資，研發週期長，研究困難。它需要所有人類和醫學藥劑師的關注。這不可能一overnight而就。; title: 肺炎的類型很多，重點是病毒和細菌。 Sars和病毒（冠狀病毒等），這裡主要討論後者。當然，病毒的產生和進化存在多種可能性和途徑，例如遺傳變異，並且新病毒也可能發芽，但是病毒的相關特徵和穩定性也具有某些條件和機制，這需要嚴格的經驗。; title: 冠狀病毒是一類RNA病毒的總稱。它們經常感染哺乳動物和鳥類，例如導致牛和豬的消化系統疾病或雞的上呼吸道疾病。冠狀病毒還會引起人類呼吸道感染，通常是輕微的，但有時是致命的。冠狀病毒可引起普通感冒的10％至15％。; title: 從分類學上講，冠狀病毒是指網狀病毒科的冠狀病毒家族，它被分為冠狀病毒亞家族和輪狀病毒亞家族的兩個亞家族。冠狀病毒亞科分為四個屬：α，β，γ和δ。冠狀病毒的基因組大小在26000至32000個鹼基對之間，使其成為基因組中最大的RNA病毒。; title: 在電子顯微鏡下，日冕病毒的邊緣具有日冕狀突起，看起來像冠狀，因此被稱為日冕病毒。這種模式是由病毒棘突（S）的棒狀包膜顆粒形成的，這些顆粒用於與宿主受體連接並感染宿主細胞。冠狀病毒是包膜病毒，其遺傳物質為正鏈RNA基因組，並具有螺旋對稱的外殼蛋白。; title: 冠狀病毒是自然界中常見的病毒，不同的冠狀病毒可以感染多種哺乳動物和鳥類。已知有七種冠狀病毒可感染人類。其中，重症急性呼吸綜合徵冠狀病毒，中東呼吸綜合徵冠狀病毒HcoV-229E，HcoV-NL63，HcoV-HKU1和HcoV-OC43的四種冠狀病毒是人感冒的常見病原體，通常不會引起嚴重的疾病。少數免疫力較差的患者可能會出現肺炎等並發症。; title: 已證明有效的病毒抑製藥物包括：①利巴韋林具有廣譜抗病毒功能，包括呼吸道合胞病毒，腺病毒，副流感病毒和流感病毒。 ②阿昔洛韋是化學合成的抗; title: 抗病毒藥物是一類專門用於治療病毒感染的藥物。 （殺病毒劑）不同，前者用於抑制體內的病毒，而後者則用於在體外破壞病毒。; title: 抗病毒藥物的機制是通過影響某些干擾病毒複製週期的環節來防止病毒進一步感染。例如，直接抑製或殺死病毒，干擾病毒的吸附，防止病毒滲透到細胞中，抑制病毒的生物合成，抑制病毒的釋放或增強宿主的抗病毒能力等。; title: 目前，大多數抗病毒藥物都用於抵抗HIV，皰疹病毒，乙型和丙型肝炎病毒以及甲型和乙型流感病毒。; title: 抗病毒藥分為以下幾類：; title: 1.滲透和脫殼抑製劑：金剛烷胺，金剛烷胺，Envevirdi，Maravero; title: 2. DNA聚合酶抑製劑：阿昔洛韋，更昔洛韋，伐昔洛韋，泛昔洛韋，膦酸鈉; title: 3.逆轉錄酶抑製劑：; title: 1.核苷：拉米夫定，齊多夫定，恩曲他濱，替諾福韋，阿德福韋酯; title: 2.非核苷：依非韋倫，奈韋拉平; title: 4.蛋白質抑製劑：沙奎那韋; title: 5，神經氨酸酶抑製劑：奧司他韋，扎那米韋; title: 6.廣譜抗病毒藥：利巴韋林，干擾素; title: 這些藥物具有顯著的療效或顯著的療效，值得認可。新藥設計和化學結構修飾，結合生物醫學工程技術和基因工程等，將逐步開發新藥。特別是用於開發Sars，冠狀病毒性肺炎等藥物。當然，植物藥或複方製劑將逐步開發。有關治療藥物和獸醫治療肺炎藥物要仔細研究，對比研究，從而做出比對和選擇。應用人體的醫學藥物，聯合用藥也要科學適量，無毒副作用無，致癌，無畸變，嚴格配伍禁忌，確保有效。; title: A.傳統醫學    冠状型病毒性肺炎生物标志物及治疗防治; title: B.化學藥品重症患者的抗病毒藥，免疫藥，抗菌藥，遺傳藥（聯合藥）等。; title: C.植物藥; title: D.複合藥物; title: E.免疫，疫苗; title: F.其他理療; title: G.基因治療; title: H.用於呼吸道傳染病的醫療消毒解毒室物理儀器治療呼吸治療; title: J.肺物理醫療器械; title: K.某些獸藥（肺炎藥，例如牛，羊，豬，狗，貓等，選擇性減少和適應，嚴格選擇對人體無傷害和有毒副作用），這些藥物也可以指代，包括臨床研究，新藥開發。有關治療藥物和獸醫治療肺炎藥物要仔細研究，對比研究，從而做出比對和選擇。應用人體的醫學藥物，聯合用藥也要科學適量，無毒副作用無，致癌，無畸變，嚴格配伍禁忌，確保有效。; title: L.其他。; title: M．服用上述技術和藥物會產生一定的效果。對于冠狀病毒的消防，它將在細菌性病毒性肺炎（Sars，呼吸帶傳染病，例如冠狀病毒性肺炎）中發揮非常重要的作用。在這個階段，效率是顯而易見的。儘管這是一種困難的疾病，但它不是無法治癒的疾病，其效率和治愈率將是最好的。這對於抑制肺炎疾病的大規模蔓延以及對該疾病患者的醫學治療很重要。; title: 當前已知的流感病毒是A，B和C型，其流行主要是A和B。金剛烷胺和金剛乙胺僅對A型流感病毒具有抑製作用，並且具有相似的功效。早期治療輕度甲型流感可以減少發燒並縮短病程。這種藥物是一種方便的口服藥物，但是它容易產生耐藥性，並且還可能引起不良反應，例如頭暈和失眠。利巴韋林是一種廣譜抗病毒藥物，可在體內和體外抑制多種DNA和RNA病毒。它適用於呼吸道融合性支氣管炎，帶狀皰疹和小兒腺病毒性肺炎，也可用於治療流行性出血。發燒的首選藥物。中國學者在上呼吸道病毒感染的噴霧劑和滴鼻劑以及小兒腺病毒感染的靜脈注射劑方面也取得了良好的效果。其氣霧劑和氣霧劑在國外用於治療流感和呼吸道合胞病毒性肺炎，效果確切。流感病毒神經氨酸酶可以促進新形成的流感病毒從感染細胞中釋放，並從呼吸道粘膜擴散到周圍組織。神經氨酸酶抑製劑扎那米韋是一種新型抗病毒藥物，可以有效抑制甲型和乙型流感病毒。它對許多神經氨酸酶依賴性病毒流行病具有相同的治療效果，並且具有多種選擇，具有性別高，毒性低，活性強，劑量小，作用範圍廣，預防效果好的優點。扎那米韋的口服生物利用度非常低，只能口服或經鼻給藥。 Osmimivir（Damifi）是神經氨酸酶的另一種有效抑製劑，是活性藥物GS-4071的前體，對流感病毒神經氨酸酶的抑制活性是zanamivir的3至6倍。美味的藥。 Primivir是一種新型的抗流感神經氨酸酶抑製劑; title: 人 類 的冠狀 病 毒種 類 比較 多 ，; title: 分別 屬 於第 1類 和 第 Ⅱ類 。一些 陸 續 被 發現 的冠 狀 病; title: 毒新 種 如 水 貂 冠 狀 病 毒 、兔 冠 狀 病 毒 等 ，; title: 抗 病 毒 金 剛胺 和 Isathiazone化 合; title: 物 能 夠 抑 制 TGEV 在 細 胞 培 養 中 的增 殖 ；人 冠 狀 病; title: 毒 229E株 和 TGEV 的 受 體 抑 制 劑 為 Ubenimex(商; title: 品 名 為 百 士欣 或烏 苯 美 司 )以及; title: 奧司他韋; title: 苯佐那酯等藥物也有參考使用價值。; title: 犬冠狀病毒貓冠狀病毒豬肺炎病毒 羊肺炎病毒 牛肺炎病毒 馬肺炎病毒 土黴素、替米考星、氟苯尼考或泰拉菌素牛病毒性肺炎。馬鼻肺炎病毒（EHV1）可分為2個亞型，即亞型1又叫胎兒亞型，主要導致流產；亞型2又叫呼吸系統型，主要導致呼吸道症狀。 EHV1能在雞胚成纖維細胞以及馬、牛、羊、豬、犬、貓、倉鼠、兔和猴等多種動物的原代細胞上增殖，此外不能在牛胎腎、綿羊胎腎和兔胎腎等多種傳代細胞內增殖; title: SV40全名猿猴空泡病毒40（Simian vacuolating virus 40）或猿猴病毒40（Simian virus 40），是一種多瘤病毒，也是一種DNA病毒。; title: （Simian virus 40），是一種多瘤病毒，也是一種DNA病毒; title: 中東呼吸系統綜合徵冠狀病毒是導致中東呼吸系統綜合徵的病原體（英文縮寫：MERS-CoV 或代號：EMC/2012‘HCoV-EMC/2012’; title: 肺是很多進行空氣呼吸的動物的呼吸系統中重要的一個器官哺乳動物和其他身體結構較為複雜的動物則擁有兩個肺，其位於胸腔中靠近脊柱，並分別位於心臟的左右兩側。; title: 世界肺炎日(World Pneumonia Day)於2009年11月2日由全球近百個組織和機構組成的聯盟——全球消滅兒童肺炎聯盟(The Global Coalition against Child Pneumonia)發起。並確定與每年的11月12日是世界肺炎日，以督促政府加強對肺炎的預防和治療。世界衛生組織和聯合國兒童基金會發布了《肺炎預防和控制全球行動計劃》（The Global Action Plan for the Prevention and Control of Pneumonia (GAPP）肺炎，這種大多數人並不陌生的疾病，卻是全世界5歲以下兒童的頭號“殺手”，每年造成約200萬名5歲以下兒童死亡，平均每15秒鐘就會有一名兒童死於肺炎。（肺結核，肺癌等也是肺部疾病患者的殺手） 。中老年死於肺病的人數每年也是百萬計數。; title: 綜上所述，對於Sars和冠狀型新病毒性肺炎等的研究和治療預防，都是十分重要的，特別是對於傳染性冠狀型病毒肺炎的治療預防關係重大，事關人們的生命健康，意義重大。 1.傳染源 自然與動物有極大關係，但也不排除其他傳染途徑。 2醫學研究和防治除了人體的特殊基因細胞外，動物試驗研究也很重要，不排除人畜共患的因素。所以，對動物家畜的相關冠狀型病毒肺炎菌毒病毒要加大研究，獸醫學和醫學的緊密結合，包括實驗，病原病理藥物治療等。 3.在現有的技術條件下，如何醫療救治是重中之重，救治生命，防止疫病擴散傳播蔓延，事關重大。大的瘟疫和傳染病的危害性後果不堪設想。抑製藥物醫療藥物免疫藥物滅病毒藥物尤為重要。 4.隨著時代的發展，生命物種的繁衍和進化，自然界生物界也在發生變化。病菌病毒的進化及其變異也會發生，值得高度關注和人類警惕警覺。新型的病菌病毒會向人類襲來，不可低估。 5.現代科學技術發展迅猛，生物工程，基因工程，細胞，酶，蛋白質，航天醫學，生物醫學機器人工程，藥物設計和研製，疫苗的研製，藥化學結構的篩选和修飾等等日顯重要，特別對於嚴重威脅人類生命的重大疾病，艾滋病，癌症，心髒病，肺病，傳染性疾病（Sars，冠狀型病毒肺炎等），疑難病症等等更具有極其重大意義。 6.冠狀型病毒肺炎的變異和生物標誌物，特效和高效防治技術，療效高的藥物和疫苗，都提出了重大研究課題。 Sars和冠狀型肺炎的研究防治，呼吸道傳染病的多次出現的原因和人類的預防對策，都需要我們高度關注。否則，人類還會遭遇病魔的侵襲，這些病毒會反復出現反復發作，或以新的變種新的變態出現。; title: First, the general treatment: to protect diarrhea, keep the airway open, prevent water, electrolytes and acid-base imbalance, if necessary, oxygen therapy. Antiviral drugs: Amantadine 0.1g, 2 times / d for 3 to 5 days; ribavirin, 10mg / kg, 2 or 3 times / d, orally or by injection; Banlangen, Astragalus, Honeysuckle, Daqingye , Forsythia, etc. have certain antiviral effects. Also available are alpha-interferon, thymosin, and the like. Third, the corresponding antibiotics should be given for secondary bacterial infections.; title: Alpha-interferon inhalation (5 million U each time for adults, add 2ml of sterile water for injection twice daily);; title: Lopinavir / ritonavir 2 capsules each time, twice a day.; title: Antiviral drugs are a class of drugs used to specifically treat viral infections. (Viricide) is different, the former is used to suppress the virus in the body, while the latter is used to destroy the virus in vitro.; title: The mechanism of antiviral drugs is to protect against further infections of the virus by affecting certain links that interfere with the viral replication cycle. For example, directly inhibit or kill the virus, interfere with the adsorption of the virus, prevent the virus from penetrating into the cell, inhibit the virus biosynthesis, inhibit the virus release, or enhance the host's anti-virus capabilities, etc.; title: Most antiviral drugs are currently used against HIV, herpes virus, hepatitis B and C viruses, and influenza A and B viruses.; title: Antiviral drugs are divided into the following categories:; title: 1. Penetration and Hulling Inhibitors: Amantadine, Amantadine, Envevirdi, Maravero; title: 2. DNA polymerase inhibitors: acyclovir, ganciclovir, valacyclovir, famciclovir, sodium phosphonate; title: 3. Reverse transcriptase inhibitor:; title: 1. Nucleosides: lamivudine, zidovudine, emtricitabine, tenofovir, adefovir dipivoxil; title: 2. Non-nucleosides: efavirenz, nevirapine; title: 4. Protein inhibitor: saquinavir; title: 5.Neuraminidase inhibitors: oseltamivir, zanamivir; title: 6. Broad-spectrum antiviral drugs: ribavirin, interferon; title: These drugs have considerable curative effect or significant effect, which is worthy of recognition. New drug design and chemical structure modification, combined with biomedical engineering technology and genetic engineering, etc., new drugs will be developed gradually. Especially for the development of Sars, Coronavirus pneumonia and other drugs. Of course, botanicals or compound preparations will be developed gradually.; title: A. Traditional medicine; title: B. Chemical drugs Antiviral drugs, immunizing agents, antibacterial drugs, genetic drugs (combined drugs) for critically ill patients, etc.; title: C. Botanical drugs; title: D. Compound drugs; title: E. Immunizations, vaccines; title: F. Other physical therapy; title: G. Gene therapy; title: H. Medical sterilization detoxification chamber for respiratory infectious diseases Physical instrument therapy Respiratory therapy; title: I. surgery; title: J. Lung physical medical device; title: K. Some veterinary medicines (pneumonia drugs such as cattle, sheep, pigs, dogs, cats, etc., selective reduction and adaptation, strict selection without harm to the human body and toxic and side effects) These drugs can also refer to, including clinical research, new drug development .; title: L. Other.; title: M. Taking the above technologies and medical drugs will have a certain effect. For the firefighting of coronavirus, it will play a very important role in bacterial viral pneumonia (Sars, respiratory belt infectious diseases such as coronavirus pneumonia). At this stage, efficiency is obvious. Although it is a difficult disease, it is not an incurable disease, and the efficiency and cure rate will be the best. This is important for the suppression of large-scale spread of pneumonic disease and for medical treatment of patients with the disease.; title: Currently known influenza viruses are types A, B, and C, and the prevalence is mainly A and B. Amantadine and rimantadine only have inhibitory effects on influenza A virus and have similar efficacy. Early medication for mild influenza A can reduce fever and shorten the course of the disease. This type of drug is a convenient oral drug, but it is prone to drug resistance and can also cause adverse reactions such as dizziness and insomnia. Ribavirin is a broad-spectrum antiviral drug that inhibits a variety of DNA and RNA viruses in vivo and in vitro. It is suitable for respiratory fusion bronchitis, herpes zoster and pediatric adenoviral pneumonia, and is also used to treat epidemic bleeding. The drug of choice for fever. Chinese scholars have also achieved good results with their sprays and nasal drops for upper respiratory tract viral infections and intravenous injections for pediatric adenovirus infections. Its aerosol and aerosol administration is used abroad to treat influenza and respiratory syncytial virus pneumonia, and the effect is exact. Influenza virus neuraminidase can promote the release of newly formed influenza virus from infected cells and spread from the respiratory mucosa to surrounding tissues. Neuraminidase inhibitor zanamivir is a new type of antiviral drug that can effectively inhibit influenza A and B viruses. It has the same therapeutic effect on many neuraminidase-dependent viral epidemics and has options It has the advantages of high sex, low toxicity, strong activity, small dosage, wide range of action, and good prevention effect. Zanamivir has very low oral bioavailability and can only be administered orally or nasally. Osmimivir (Damifi), another potent inhibitor of neuraminidase, is a precursor of the active drug GS-4071, and has 3 to 6 times the inhibitory activity against neuraminidase of influenza virus than zanamivir. Delicious medicine. Primivir is a new type of anti-influenza neuraminidase inhibitor. Its activity is similar or stronger than that of zanamivir and osimivir. In vitro studies have shown that it has a very high selectivity for influenza virus. Good absorption, longer plasma half-life, can be used once a day.; title: Abidol tablets Lopinavir / Ritonavir tablets (Lopinavir / ritonavir, LPV / r, trade name: Cleeve; title: In the absence of the development of a new special drug, the use of the above-mentioned drugs and technical means is the best choice, and its effectiveness and high efficiency are worth affirming. It also takes time and process to be able to clinically treat drugs and vaccines. As long as we work hard, medical scientists and pharmacists must make breakthroughs and make significant progress in the time we can see.; title: Pneumonia diseases, including severe viral bacterial influenza pneumonia, are a major scourge of human survival, especially Sars viral pneumonia (coronary virus pneumonia, etc.) is extremely harmful to humans, and must not be underestimated. A large-scale plague will occur, with the majority of deaths, with extremely dire consequences. To this end, strict precautions must be taken and the right medicine can be prescribed. Infectious diseases such as influenza, pneumonia, and hepatitis are high in the winter and spring seasons, and it is especially critical for vulnerable groups to resist. It is crucial to strengthen protection for specific and ordinary people to prevent the spread of large-scale infections. It is also critical to contain and prevent pathogens and sources of disease transmission. Coronavirus pneumonia is quite comparable to the pathogenesis and harm of various pneumonia in animals and livestock. Cattle, sheep, pigs, dogs, cats, birds, birds, etc. also have certain transmission of viral infections, and must not be taken lightly.; title: (Network Diagram) Chemical Structure Diagram-Medicinal Chemical Structure Modification Quoted from Related Websites; title: BetaCoV / Wuhan / IVDC-HB-01 / 2019, BetaCoV / Wuhan IVDC-HB-04 / 2020, BetaCoV / Wuhan / IVDC-HB-05 / 2019, BetaCoV / Wuhan / WIV04 / 2019 and BetaCoV / Wuhan / IPBCAMS-WH -01/2019 [6] [14] [15]. Its RNA sequence is approximately 30,000 nucleotides in length (source Wikipedia); title: Severe Acute Respiratory Syndrome (SARS) SARS Incident (2003) Middle East Respiratory Syndrome Coronavirus; title: (MERS) Middle East Respiratory Syndrome (2012) Variant A H1N1 Influenza (H1N1) 2009 H1N1 Influenza (2009) Ebola Virus Ebola Virus Outbreak in 2005 (2005 ); title: ————————————————————————————————————————Les voies de transmission des coronavirus montrent que les animaux; title: Infections par voie respiratoire ou par la bouche et la conjonctive. Le virus est exhalé par; title: Ou de la toux, des aérosols, des sécrétions trachéales et des excréments, mais; title: Suspendu dans l'air ou répandu dans des outils de pollution, des enclos, de la nourriture, etc.; title: Il est nécessaire, par conséquent, dans la détection des anti-prototypes, l'immunisation avec la technologie des enzymes peroxydases est souvent utilisée.; title: Techniques, Techniques de microscopie électronique d'immunisation, Techniques de détection d'acide nucléique viral; title: Les coronavirus comprennent principalement les inhalateurs respiratoires humains et les coronavirus; title: (VHC), virus coronarien intestinal humain (HECV), virus de la bronchite infectieuse du poulet (IBV), virus de la gastro-entérite infectieuse du porc (TGEV), grippe porcine; title: Virus de la diarrhée pédiatrique (VDEP), virus de la myélite cérébrospinale hémagglutinante porcine; title: (HEV), Virus de l'hépatite de la souris (MHV), Flaming Chicken Blue Crown Disease Virus; title: (TCDV), Coronavirus de la diarrhée du veau nouveau-né (NCDCV), Estomac poulain; title: Virus de l'entérite coronaire (FGEV), Virus coronaire canin (CCV), Transmission du chat; title: Virus de la péritonite sexuelle (FIPV), virus coronaire du rat (RCV, voies respiratoires; title: Et pneumonie), virus de l'inflammation des glandes salivaires du rat (SDAV) virus de la maladie coronarienne du vison (ECV), virus de la maladie coronarienne du lapin; title: Autres animaux (y compris divers animaux de la colonne vertébrale aquatique; title: Et les animaux vertébrés terrestres) ont également découvert successivement des maladies causées par des virus coronaires,; title: Comprenant principalement le virus de Berne, le virus Brida; title: (Bredavirus) et les rhumatismes humains.; title: Propriétés essentielles de la maladie coronarienne; title: Coronavirus pour coronavirus de poulet, porc, chien, chat, humain et souris; title: L'observation d'échantillons colorés négativement a montré que le coronavirus était polymorphe.; title: Virus coronaire sur l'alcool, l'éther, le chloroforme, les sels biliaires et autres solvants lipidiques; title: Sensible; très sensible à la température, donc l'épidémie provoquée par celle-ci est plus fréquente; title: En hiver et au début du printemps. Sensibilité à l'acide, divers coronavirus ne; title: Ils sont tous identiques et généralement sensibles à pH3 ou inférieur.; title: Prolifération sur cellules péritonéales et cellules CRFK de chatons primaires; TGEV et; title: Le VHE peut s'adapter aux cellules rénales primaires de porc, aux cellules de la rate, aux cellules thyroïdiennes et aux testicules; title: Cellules pilules, etc.; le PEDV peut s'adapter aux cellules intestinales du porc fœtal; le NCDCV peut s'adapter; title: Cellules rénales de singe de la rivière Yingheng, cellules rénales bovines fœtales; le MHV peut s'adapter aux souris; title: Macrophages, cellules DBT de souris, cellules 17CL-1 de souris; le VHC convient à la succession de cellules rénales embryonnaires humaines, de cellules wI-38,; title: Macrophages, cellules DBT de souris, cellules 17CL-1 de souris; le VHC est applicable aux cellules rénales embryonnaires humaines, aux cellules w-38, aux cellules Hela et ainsi de suite.; title: Il existe de nombreux types de coronavirus chez l'homme.; title: Ils appartiennent respectivement aux classes 1 et II. Une maladie coronarienne a été trouvée; title: Nouvelles espèces vénéneuses telles que le coronavirus de vison, le coronavirus de lapin, etc.; title: Amantadine antivirale associée à l'isathiazone; title: Les matériaux peuvent inhiber la prolifération du TGEV dans la culture cellulaire; maladie coronarienne humaine; title: Ubenimex (inhibiteur commercial de la souche 229E et du TGEV); title: (Le nom du produit est Bestox ou Ubenimex)) et; title: Oseltamivir; title: Les médicaments tels que le benzonatate ont également une valeur de référence.; title: Coronavirus canin coronavirus félin virus de la pneumonie porcine virus de la pneumonie ovine virus de la pneumonie bovine virus de la pneumonie équine oxytétracycline, telmicoxine, flufénicol ou tylosine pneumonie virale bovine Le virus de la pneumonie rhinocéros équine (EHV1) peut être divisé en deux sous-types, à savoir le sous-type 1 est également appelé sous-type fœtal, ce qui provoque principalement l'avortement; le sous-type 2 est également appelé type du système respiratoire, ce qui provoque principalement des symptômes respiratoires. L'EHV1 peut proliférer sur les fibroblastes d'embryons de poulet et les cellules primaires de chevaux, de bovins, de moutons, de porcs, de chiens, de chats, de hamsters, de lapins et de singes. De plus, l'EHV1 ne peut pas être utilisé chez les fœtus de bovins, ovins et lapins. Prolifération intracellulaire; title: Le nom complet de SV40 est Simian vacuolating virus 40 (Simian viruslating virus 40) ou Simian virus 40 (Simian virus 40), qui est un virus polyome et un virus à ADN.; title: (Virus Simian 40), un virus du polyome et un virus à ADN; title: Le syndrome respiratoire du Moyen-Orient Le coronavirus est l'agent pathogène qui cause le syndrome respiratoire du Moyen-Orient (abréviation anglaise: MERS-CoV ou nom de code: EMC / 2012’HCoV-EMC / 2012 »; title: Le poumon est un organe important dans le système respiratoire de nombreux animaux qui respirent de l'air. Les mammifères et les autres animaux aux structures plus complexes ont deux poumons, qui sont situés dans la cavité thoracique près de la colonne vertébrale et sur les côtés gauche et droit du cœur.; title: La Journée mondiale de la pneumonie a été lancée le 2 novembre 2009 par la Coalition mondiale contre la pneumonie infantile, une coalition de près d'une centaine d'organisations et d'institutions à travers le monde. Et il est déterminé que le 12 novembre de chaque année est la Journée mondiale de la pneumonie pour exhorter le gouvernement à renforcer la prévention et le traitement de la pneumonie. L'Organisation mondiale de la santé et l'UNICEF ont publié le Plan d'action mondial pour la prévention et le contrôle de la pneumonie (GAPP), une maladie qui n'est pas inconnue de la plupart des gens Le tueur numéro un mondial d'enfants de moins de 5 ans tue environ 2 millions d'enfants de moins de 5 ans chaque année, et en moyenne un enfant meurt d'une pneumonie toutes les 15 secondes (la tuberculose pulmonaire, le cancer du poumon, etc. sont également des tueurs de patients atteints de maladies pulmonaires) Le nombre de personnes d'âge moyen et de personnes âgées qui meurent d'une maladie pulmonaire représente également des millions de comptes chaque année.; title: References Citing data charts, etc .: Internet resources, Wikipedia, Chinese encyclopedia and related websites.; title: _________________________________________________________________________________________________________________________________________________________________________; title: The Great Plague of Humans in the World in the 21st Century---New Coronavirus Pneumonia (by Fangruida) 2020v1.3; title: compiled by Lisa; title: ——————————————————————————————————————————————; title: preface; title: 10 million people get sick and more than 500,000 people die----The number of patients with new coronavirus; title: pneumonia will exceed 100 million in the world, and the prevention and control alarm will sound again; title: According to a report by Johns Hopkins University in the United States, there have been more than 10 million cases of; title: new coronavirus infections worldwide, and more than 500,000 deaths.; title: The World Health Organization said that the daily new cases set a new record on Sunday, reaching 189,000. Brazil has; title: the most new cases, with 47,000 new cases in the past 24 hours.; title: Many health experts say that the actual number of global infection cases may far exceed published figures, because; title: some countries may underreport the relevant data.; title: Over 10.11 million, with a cumulative death of over 500,000.According to Reuters data, 1 person dies of a disease; title: associated with the new coronavirus every 18 seconds.; title: A total of more than 2.5 million people have been diagnosed with the virus in the United States, the most in the world.; title: Brazil is the country with the second highest number of new coronavirus cases in the world, with 1.13 million people; title: diagnosed with infection and 57,000 deaths. Some researchers say that by October this year, the death toll of the new; title: coronavirus in LatinAmerica may exceed 380,000.; title: (The relevant chart materials in the book are quoted from related websites or network screenshots, Wiki, Who, Cell,; title: Lancet, Encyclopedia, etc.); title: Reuters calculated based on the average data from June 1 to 27, more than 4,700 people died of diseases related to the; title: new coronavirus every 24 hours, that is, 196 people died every hour, or every 18 seconds. 1 person died.; title: The New Corona virus nuclear bomb explosion, if countries do not take more effective and decisive effective; title: prevention and control measures, the virus will be unscrupulous, from 10 million to continue to climb to a new height,; title: will reach a new peak of 50 million-100 million people, died The number of people reaches one million or more, which; title: seriously threatens the life, health and safety of 8 billion people worldwide. Viruses seriously threaten the living; title: environment of human beings, destroying human beings, destroying the economy, and causing more fearful and terrible; title: consequences. If the epidemic continues to spread and expand, the consequences Unbearable. Countries including; title: invisible patients, invisible transmission, or resurgence of death, the situation is more dangerous, it is bound to directly; title: affect the survival of mankind. Governments and people of all countries must attach great importance and be vigilant,; title: otherwise, the consequences will be unimaginable. Different countries have different national conditions, restrictions on; title: medical resources, differences in economic environment, cultural systems and other reasons. They need to be treated; title: differently, without dispute or blame. The top priority is to strictly prevent and control and treat, minimize the spread,; title: and maximize the treatment and rescue of the patient. If you fail to make a decision, indecision, the consequences are; title: terrible and unimaginable. Vaccine development takes time and must not be delayed, making a big mistake. Global; title: patients include severe patients, and a considerable number of invisible patients, asymptomatic patients, conservative; title: estimates of new patients, at least one million or more. This is not alarmist, indeed, the statistics of WHO, Hopps; title: University, etc. do not include this part of patients and patients. The number of outbreaks in the United States, Brazil,; title: India, Russia, and other countries is partly spreading infections, and the other part includes invisible patients,; title: asymptomatic infections, and newly occurred patients with virus conversion. The number is difficult to count accurately.; title: The epidemic situation has expanded and worsened due to various factors. Of course, prevention and control measures,; title: medical measures, etc., including resumption of work, school, and market are too early, and prevention and control; title: measures are missing. The new shows that the number of young patients is increasing. This shows that the harmful; title: spread of viruses cannot be underestimated. The continuous development of the global plague requires effective; title: measures to face it.; title: 1.; title: With the global epidemic of the New Crown epidemic, people in the British scientific community and others have; title: successively put forward the idea of ​; title: ​; title: "group immunity". The so-called "group immunity" refers to the large-scale; title: infection of an infectious disease by a biological group.After recovery, the body will automatically generate immunity; title: to the infectious disease, thereby ensuring that this infectious disease will not be outbreak in the future.; title: “COVID-19migrant‘crisiswithina crisis’; title: Tens of millions of migrant workers, forced to return home after losing their jobs due to the; title: COVID-19 lockdown, face unemployment and poverty in their home countries, warned the ILO.; title: Millions of migrant workers may be required to return home where labour markets, are now; title: further weakened by the additional strain of high levels of unemployment and serious business; title: disruptions. In addition, their families will suffer from the loss of the remittances normally sent to; title: them.”（un.org Network screenshot )）; title: Population genetics refers to the genetic composition of a population, ie the frequency of genes and genotypes in this; title: population. For example, the population of pure line breeds is homogenous, and individuals are homozygous; while the; title: population of open pollination group varieties is heterogeneous, and individuals are heterozygous. Studying the genetic; title: composition of populations in crop breeding can help decision-making in breeding programs.; title: In terms of cultivation, the individual group composition of the crops planted on the same field is antagonized. This; title: individual group may be composed of mixed crops, intercropping or single species of several crops. Studying the space; title: occupied by each individual in the individual group and the composition of its phenotype and the dynamic coordination; title: between individuals will help guide the cultivation of high-yield crops. In the face of group immunization, if the virus; title: undergoes gene mutation and the sequence and structure of the protein change, so that people who were originally; title: immune cannot recognize these changed viruses, then group immunization will be ineffective. There are two types of; title: viruses—DNAviruses and RNA viruses. DNAviruses are more stable and less prone to mutation, while RNA viruses; title: are unstable and prone to mutation. This new coronavirus is an RNA virus, which has a potential high risk of mutation; title: and should be highly concerned.; title: The viral genome sequence data of the new coronavirus is very important for the treatment and prevention of the new; title: coronavirus, and the development of vaccines and drugs is very important. Virus strains,; title: Viral genome sequence data, etiology, pathology, molecular biology, quantum chemistry, pharmacology, etc. are all; title: important scientific data.; title: The Chinese Center for Disease Control and Prevention has officially released the new coronavirus epidemic situation; title: and viral genome sequence data in June 2020 in Beijing through the "New Coronavirus National Science and; title: Technology Resource Service System". Mainly includes genomic sequence data of confirmed cases in Beijing; title: (NMDC60013902-01, NMDC60013903-02) and genomic sequence data of environmental samples (NMDC60013903-; title: 03), these three samples were collected on June 11, 2020, as a recent virus sample outbreak in Beijing. At the same time,; title: the Chinese Center for Disease Control and Prevention also submitted the new crown epidemic situation and viral; title: genome sequence data to the World Health Organization and the Global Influenza Data Initiative (GISAID) to share; title: data globally.; title: (Network screenshot; title: Scientific research, factual speaking, data speaking, empirical speaking. Otherwise, it will violate scientific truth.; title: Network materials, network pictures, network screenshots are all historical memories and records.); title: The 2019 New Coronavirus Resource Library contains meta information of the 2019 New Coronavirus (2019-nCoV); title: virus strains released from the NCBI's GenBank database and GISAID database. .; title: http://virological.org/) published the genome sequence of this virus. Soon after, the China CDC similarly published the; title: SARS-CoV-2 genome sequence (and related epidemiological data) on the publicly accessible GISAID database; title: (https://www.gisaid.org/). Importantly, the release of SARS-CoV-2 genomic sequence data has facilitated the rapid; title: development of diagnostic tests and infectious clones. The race to develop effective vaccines and antiviral drugs is in; title: progress, and clinical trials for antiviral drugs are gradually in progress. (Relevant genomic sequence data are quoted; title: from relevant databases, medical journals such as "Cell", attached drawings, etc.),; title: Genomic sequence data; title: In the 1930s, avian infectious bronchitis virus (IBV) was found in the respiratory tract of chickens. Subsequently,; title: viruses similar in structure to IBV were also found in human nasal lavage fluid and other animals. Because the surface; title: of the virus has crown-shaped fibrillar proteins, it is named coronavirus.; title: Avian infectious bronchitis virus, as the name implies, infects chickens through the respiratory tract, causing respiratory; title: diseases in chickens. However, different IBV strains may attack the kidneys of chickens and some will attack the; title: fallopian tubes. IBV was also isolated from other organs of the chicken, such as the glandular stomach and caecum; title: tonsil.; title: As a potential drug for inhibiting 2019-nCoV coronavirus, the 2019-nCoV_PLP sequence was found in the 2019-nCoV; title: protein sequence and found to have 86% amino acid homology with SARS-CoV_PLP.; title: .Gilead Sciences (Gilead Sciences); title: The drug remdesivir, developed by Gilead, is undergoing five clinical trials worldwide. Ascletis Pharma; title: Chinese pharmaceutical company Geli Biotechnology Co., Ltd. is conducting a trial to use two drugs that have been; title: approved to treat HIV and hepatitis C to treat coronavirus infections.; title: . Moderna Therapeutics; title: Moderna set a record in the pharmaceutical industry with mRNA-1273 (a candidate vaccine), a candidate vaccine; title: screened 42 days after the new coronavirus was successfully sequenced.; title: CanSino Biologics; title: The headquarters of Kangxinuo Bio-stock Co., Ltd. is located in Tianjin. The company is about to conduct clinical trials; title: of a new coronavirus vaccine in China. Kang Xinuo's method is to extract a coronavirus gene code and entangle it with; title: a harmless virus,; title: .Arcturus Therapeutics; title: Arcturus Therapeutics is developing a vaccine that relies on engineering RNA. The company plans to develop an RNA; title: virus whose edited code produces a protein that resists viral infections and contains it in liquid nanoparticles.; title: .BioNTech; title: The German BioNTech company is developing an mRNA vaccine against a new coronavirus. .CureVac; title: Similar to Moderna, CureVac uses synthetic mRNA to stimulate the production of antibody proteins. Eli Lilly; title: Eli Lilly and AbCellera of Canada cooperate to develop antibody therapy against coronavirus infection.; title: GlaxoSmithKline; title: As one of the world's largest vaccine manufacturers, GSK is providing its technology to a Chinese biotechnology; title: company that is developing a coronavirus vaccine. .Inovio Pharmaceuticals (Inovio Pharmaceuticals); title: For the past 40 years, Inovio has been working to convert DNAinto drugs, and the company believes that its technology; title: can quickly develop vaccines against new coronaviruses.; title: . Johnson & Johnson (Johnson & Johnson); title: Johnson & Johnson, which has responded to outbreaks of Ebola and Zika in the past, is developing a multi-pronged; title: therapy to deal with coronavirus.; title: .Pfizer Pharmaceuticals (Pfizer); title: Vaccines and medicines; title: Renewable Pharmaceuticals; title: (Regeneron Pharmaceuticals); title: Based on the technique of preparing human antibodies in genetically engineered mice. , Sanofi Pharmaceutical; title: Company (Sanofi); title: A; title: Sanofi has successfully developed yellow fever and diphtheria vaccines. The company is currently working with the; title: BiomedicalAdvanced Research and Development Authority (BARDA) to find a solution to the coronavirus problem.; title: The method used by Sanofi includes extracting some coronavirus DNA and mixing it with the genetic material of a; title: harmless virus to form a chimera that can trigger the human immune system without causing the patient to become ill .; title: Takeda Pharmaceutical Company (Takeda); title: Drugs; title: Japanese pharmaceutical giant Takeda Pharmaceuticals is researching a therapy that originates from a blood sample of a; title: coronavirus infection. The company takes blood samples from coronavirus infection survivors, collects plasma, and; title: then isolates protective antibodies. This method is not a new idea. At least since the Spanish influenza pandemic in 1918,; title: blood transfusions have been used to deal with virus outbreaks. 16. Vir Biotechnology; title: Drugs; title: Vail Biotech is committed to the development of infectious disease drugs. The company has isolated antibodies from; title: SARS survivors and is studying whether this antibody can be used to treat new coronavirus infections.; title: 2 .; title: Viral pneumonia is more common in winter and spring, and can be sporadic or outbreaks. The main clinical; title: manifestations are fever, body aches, a small number of breathing difficulties, and lung infiltration. Viral pneumonia is; title: related to the virulence of the virus, the route of infection, and the age and immune status of the host. The viruses that; title: cause viral pneumonia are commonly known as influenza viruses, and the others are parainfluenza viruses,; title: cytomegaloviruses, adenoviruses, rhinoviruses, and coronaviruses. The diagnosis depends on pathogenic examination,; title: including virus isolation, serological examination, and detection of viral antigens and nucleic acids. The disease can be; title: prevented and controlled, prevent indoor air circulation, avoid public places and places where people are crowded and; title: closed, and wear masks when going out. Symptomatic treatment is the main clinical practice, and bed rest is required.; title: The incidence and spread of new coronavirus pneumonia is very serious, and there are currently no special drugs and; title: vaccines for prevention and treatment.; title: The new coronavirus pneumonia epidemic has 10 million patients and more than 500,000 deaths. It is estimated that the; title: number of patients may be hundreds of millions, and the number of deaths will reach as many as one million. The; title: epidemic has not ended, and it is still spreading. Especially in the United States, Brazil, India, Russia and other; title: countries, there are not only middle-aged and elderly people, but also a large number of young patients. Invisible; title: patients, asymptomatic infections, and new patients with new coronary pneumonia caused by cross-infection of various; title: bacterial viruses cannot be ignored (including repeated epidemics). There are also about one million people in the world,; title: which cannot be underestimated.Although the vaccine is important, it is time-consuming and urgent, and new special; title: drugs cannot be successfully developed for the time being. Therefore, it is imperative to choose effective drugs,; title: combined with other medical methods and technologies, to treat many patients, especially mild patients and general; title: patients. In addition to strict prevention and control, effective drug treatment is the first choice. Some people think that; title: the existing drugs are ineffective, and redisevir, hydroxychloroquine, etc., and antiviral drugs have no curative effect or; title: obvious effect. These views are not correct. Because of the pathological display and certification of a large number of; title: clinical cases, there are not many people who have recovered and recovered, including many who have been severely ill.; title: In addition to medical measures such as breathing and artificial lungs, the rational and comprehensive application of; title: drugs has played an important role and must not be ignored. Of it. Under the current real conditions, the rational and; title: scientific use of drugs is very important. Otherwise, the mortality rate will increase greatly, and there will be more; title: patients. Therefore, the choice of medicines is scientific and reasonable, and it is particularly important to adapt to local; title: conditions and human diseases. Clinicians have a heavy responsibility. Scientific, reasonable and effective use of drugs,; title: combined with other treatment methods, is the wise and realistic choice, there is no other way to find.; title: Viral infectious diseases have a huge impact on human health. Anti-hepatitis virus drugs mainly include interferons; title: (such as interferon, pegylated interferon, etc.), nucleosides (acids) (such as emtricitabine, la Mifudine, adefovir; title: dipivoxil, entecavir, etc.), anti-influenza virus drugs (such as inosine monophosphate deoxygenase inhibitor ribavirin,; title: interferon-inducing drug abidol hydrochloride, M2 protein ion channel inhibitor adamantine Alkylamine and; title: rimantadine, neuraminidase inhibitors oseltamivir and zanamivir, etc.), anti-human immunodeficiency virus drugs; title: (zidovudine, nevirapine, delavirdine, efavirenz, etc.) The research of antiviral drugs has become an important topic in; title: the research and development of new drugs worldwide.Antiviral drugs are facing the challenge of drug resistant; title: mutants. In order to overcome the shortcomings of antiviral drugs, effective new chemical entity drugs should be sought; title: as much as possible. Existing drugs are structurally modified to prepare new derivatives; finding effective drug-loading; title: drug release systems to improve the efficacy of antiviral drugs is the current research focus.; title: 4Anti-SARS-CoV drugs The new coronary virus SARS-CoV is the pathogen that causes SARS.; title: There are four broad categories of antiviral drugs. Inosine monophosphate deoxygenase inhibitors such as ribavirin.; title: Interferon-inducing drugs such as Abidol Hydrochloride. Protein ion channel inhibitors, such as amantadine and; title: amantadine, block the M protein to prevent viral unpacking and the release of their RNA to interfere with the entry of; title: the virus into human cells, interrupt the early replication of the virus, and also inhibit viral assembly to play an anti-; title: influenza virus . Neurolase inhibitors, etc.; title: (Relevant genomic sequence data are quoted from relevant databases, medical journals such as "Cell", attached; title: drawings, etc.),; title: Through sequence alignment with other coronaviruses, the researchers first annotated the SARS-CoV-2 genome and; title: found that its main components are the same as those of SARS-CoV and bat SL-CoVs, as shown in Figure 3.An amino; title: acid homology comparison of its encoded proteins revealed that the amino acid homology of non-structural protein; title: (nsp), envelope protein (E), and membrane protein (M) was higher, while that of spike protein S1 The variability is; title: greater.; title: Coronavirus Sp protein is a key domain that binds to host cells. The S1 subunit contains the receptor binding domain; title: (RBD). Through amino acid sequence alignment and protein tertiary structure prediction , it was found that SARS-; title: The RBD of CoV-2 is very similar to SARS-CoV . It is speculated that theACE2 receptor of SARS-CoV can also be; title: combined with SARS-CoV-2, which mediates the invasion of SARS-CoV-2 into host cells.; title: And then published in "nature microbiology" and "Science" -ligand binding experiments verified this conjecture,; title: confirming that ACE2 is the receptor of SARS-CoV-2 on the host cell.; title: Remdesivir is a nucleoside analog and is an RNA-dependent RNA polymerase inhibitor. It can synthesize anti-virus by; title: inhibiting viral nucleic acid. The current clinical research on Ebola virus infection has reached stage II.Although there; title: is currently no data demonstrating the anti-2019-nCoV activity of remdesivir, remdesivir has shown activity data in; title: other coronaviruses. It shows good activity against MERS and SARS viruses in vitro and animal models. These viruses; title: Similar to 2019-nCoV structure.; title: Compared with SARS virus and MERS virus, new coronaviruses are different new strains. According to the recent; title: clinical data, the virus's spread seems to have increased, and the virus's toxicity and pathogenicity need to be based on; title: more clinical data.Analysis and judgment.; title: Protease inhibitors that may be used in the treatment of new coronavirus infections include Disulfiram, a drug approved; title: for the treatment of alcohol dependence, and Lopinavir/Ritonavir, which is Krezhi (Kaletra), Darunavir/Cobicistat; title: (Prezcobix), etc.; title: For example, the approved immunomodulator Chloroquine and the approved Nitazoxanide for diarrhea have shown the; title: ability to inhibit the new coronavirus in vitro. Chloroquine has been used as a cheap and safe drug for more than 70; title: years. It is a widely used antimalarial and autoimmune disease drug, and it has recently been reported as a potential; title: broad-spectrum antiviral drug. 3CLPro is the main protease produced by the new coronavirus (2019-nCoV, SARS-CoV-; title: 2). Most functional proteins (non-structural proteins) of coronavirus are encoded by the ORF1ab gene; title: 3.; title: Severe infectious diseases in history have changed human history countless times. The Black Death, the American; title: Plague, and the plague in the Song, Jin, Yuan, and Ming and Qing Dynasties have all had important impacts in history.; title: The black death from 1347 to 1351. The plague is probably the most infectious disease that has the greatest impact; title: on the development process of the world history.According to the literature, the disease has experienced many large-; title: scale outbreaks in the history of the world, and the epidemic in Europe was the most serious from 1347 to 1351.; title: Black Death is a natural epidemic infectious disease caused by Yersinia pestis. Because the patient's skin has dark spots,; title: it is called "Black Death". The Black Death in the 14th century caused a sharp decline in the European population, with; title: one third to one half of the population dying from this terrible disease. For the next 300 years, the Black Death; title: continued to spread in Eurasia, causing great harm and the largest number of deaths.; title: Smallpox is a severe infectious disease caused by smallpox virus.At the beginning, smallpox was only a funny virus in; title: domestic animals. Later, as the virus evolved, it spread to humans and became a terrible serious infectious disease. The; title: earliest recorded human smallpox virus infection occurred in ancient Egypt. At that time, the smallpox virus had a huge; title: lethality, causing at least 300 million deaths and hundreds of millions of people were cured; title: The Spanish flu originated in the spring of 1918, which happened to be the first world war.Alarge number of outbreaks; title: occurred in the world in the autumn of 1918. By 1920, about 100 million people were infected and 50 million to 100; title: million people died.; title: (Graphic data sources Wiki, <<cell> and other network resources and related journals, cited from these websites, hereby; title: explain); title: The focus of prevention and control: 1. Farmer's market 2. Hospital 3.Animal farm 3, slaughterhouse 4. Seafood meat; title: market 5. Catering, shopping malls, supermarkets, etc. 6. Stations. Hall 7. Stations, ferries, airplanes, cars, trains and; title: other places with dense personnel 8.Animal experiment places 8. Large-scale gatherings and performing arts sports; title: events 9. Schools, kindergartens, nursing homes 10. Factory workshops 11. Customs, entry and exit 12. Religion Place,; title: church 13,. Parks, beaches 14. Prisons 15 military camps 16. Canteens 17. Others and so on. Key groups: 1. Medical; title: staff 2. Farmers' market merchants 3. Slaughter staff 4. Old and weak patients 5. Seafood meat processing 6. Customs,; title: border inspection 7. Family history of infectious diseases, history of local infectious diseases 8. Others. Keep close; title: contact with infectious patients. Bacteria and viruses can easily breed infected places and environments.; title: Pre-control and prevention: 1. People in the epidemic area take anti-virus, immune drugs 2 wear masks to avoid; title: spreading infections at close range 3. mouth, nasal cavity, hands, pay attention to infections, airborne transmission,; title: droplets, saliva, etc. 4. diet hygiene 5. animals Strictly eliminate meat and other food 6. Environment, water and other; title: pollution-free 7.Air quality, ventilation and ventilation 8. Respiratory tract infectious diseases, pneumonia, influenza; title: and other treatments and protection 9.Avoid the accumulation of personnel Prevention and control of the epidemic; title: rebounded. 11.Asia, Europe, Latin America, Africa and other countries and regions adopt a variety of prevention and; title: control models and methods. Even if the city is closed and the city is closed, it should be tailored to local conditions and; title: people, scientific, rigorous, reasonable and appropriate. The key points are as above. Narrate. The combination of; title: advanced technology and traditional ancient methods of prevention and treatment will allow most patients to recover; title: and the mortality rate will be reduced. Otherwise, the epidemic will continue to expand, and the consequences can be; title: imagined. Ordinary people, susceptible people, follow the doctor's advice, scientific, reasonable, take appropriate; title: amount of drugs antiviral immune drugs, etc., to achieve the purpose of prevention and control.; title: 4.; title: New Crown Virus Pneumonia, New Crown Pneumonia (COVID-19); title: ————————————————————————————————————————————————; title: —————— ————————“The 2019 coronavirus outbreak is a global pandemic caused by severe acute; title: respiratory syndrome coronavirus 2 (SARS-CoV-2). The epidemic was first discovered in Wuhan, Hubei Province, the; title: People's Republic of China in December 2019, and then quickly spread to many countries around the world in early; title: 2020, gradually becoming a global plague, described by many international organizations and media as the second since; title: The most severe crisis facing the world since the World War.As of July 1, 2020, more than 220 countries and regions; title: have reported more than 10 million confirmed cases and more than 500,000 patients have died.” (wikipedia website); title: Globally, there have been 9 million cases of US deaths and 120,000 deaths. The deaths will exceed 500,000-700,000,; title: and will seriously reach 1 million. Cases may exceed 10 million, because the epidemic is still developing, especially in; title: the Americas, the United States, and Brazil. Countries such as Asia and India, Africa, and China's Beijing epidemic; title: have rebounded. The epidemic has not completely ended. There will be some differences in virus development and; title: variation inAsia, America, Europe,Africa and other strains, but the state is the standard model of the new coronavirus; title: model, and there will be no fundamental difference. Of course, the virus has certain differences in areas, countries,; title: environmental group individuals, and human body differences. In addition, culture, concepts, national conditions,; title: epidemic prevention and control methods are different. The patients in Europe,America, Latin America and other; title: countries are still high, and they deserve attention and research. Thr ough a large number of case comparison studies; title: and comparative analysis, the existence of differences in regions, races, groups and individuals, viral characteristics,; title: infections, mortality differences and differences cannot be ruled out. Of course, the epidemic prevention model is very; title: important. Certain differences in the effects of drug use in regions, races, groups, and individuals also exist and cannot; title: be denied. The prevention and recurrence of the new coronavirus pneumonia and repeated epidemics are prominent; title: problems. The epidemic has rapidly spread from Asia to Europe and LatinAmerica and other regions and countries. It; title: can be seen that the infection and long-term recurrence of the new coronavirus. 1. The spread of the virus is widespread; title: and long-lasting 2. The occurrence of susceptible people 3. The prevention and control of the epidemic and the use of; title: effective drugs, the key populations in the epidemic area should take antiviral immune respiratory infections and other; title: dru gs. Prevention and pre-control. 3. Viruses and human animals coexist. Viruses exist for a long time and will not go; title: back easily. To prevent a new epidemic from happening, fall/winter 2020, winter/spring 2021, can not be careless. 4.; title: Although there are no special drugs and vaccines for new coronavirus pneumonia, it is not an incurable disease. Most; title: patients can be cured by using effective drugs and other suppression methods. 5. New Coronavirus pneumonia is mainly; title: transmitted by mouth, nose , body, and air (close contact transmission, air gas enters the nasal cavity, oral cavity, etc.),; title: especially including recessive transmission, asymptomatic infection, minor patients, various viruses Patients with; title: mutual induction of bacteria have a long virus incubation period and cross infection with various bacterial viruses.; title: Under certain conditions, non-new coronavirus will also become new coronavirus pneumonia. Induced infection by; title: bacterial viruses is also a condition for the initiation of a larg e number of cases. 6.Alarge number of experimental; title: studies and pathological studies have shown that the new coronaviruses mainly come from animals, farmers' markets,; title: wild animals, meat, seafood, poultry, etc., which are most likely to produce and spread such viruses. Of course, it is also; title: possible to spread the infection through other methods and means. These need to be proved by further research in the; title: future. However, the chain of transmission is very clear. Whether bats, pangolins, or other animals, all need to be proved; title: by future research. 7. The new coronavirus pneumonia is highly contagious, with tens of millions of patients and nearly; title: 500,000 or more deaths. This infectious disease is coronavirus is a serious respiratory tract, and has similarities and; title: differences with Sars, Middle East respiratory infectious disease, Ebola virus and so on. Respiratory tract infectious; title: diseases such as severe pneumonia, white lung disease, large-scale influenza, pneumonia, etc. are one of the most; title: susceptible diseases of human beings, and there are many deaths every year. Therefore, to prevent pre-control, key; title: regions, key populations, key industries, etc. should not be paralyzed. Winter and spring, old and weak patients,; title: hospitals, large gatherings, customs, ferries, trains, planes and other confined spaces. Stations, farmers' markets,; title: slaughtering and processing, catering, dirty and messy environments, water sources, vegetables and local epidemics, etc.; title: are particularly 5.; title: Fangruida: ↈ ♣ Top 10 drugs of the new coronavirus pneumonia（Davis）2020v3.0; title: ...————————————————————————————————————; title: The new coronavirus pneumonia epidemic has 10 million patients and more than 500,000 deaths. It is estimated; title: that the number of patients may be hundreds of millions, and the number of deaths will reach as many as one; title: million. The epidemic has not ended, and it is still spreading. Especially in the United States, Brazil, India, Russia; title: and other countries, there are not only middle-aged and elderly people, but also a large number of young; title: patients. Invisible patients, asymptomatic infections, and new patients with new coronary pneumonia caused by; title: cross-infection of various bacterial viruses cannot be ignored (including repeated epidemics). There are also; title: about one million people in the world, which cannot be underestimated. Although the vaccine is important, it is; title: time-consuming and urgent, and new special drugs cannot be successfully developed for the time being.; title: Therefore, it is imperative to choose effective drugs, combined with other medical methods and technologies, to; title: treat many patients, especially mild patients and general patients. In addition to strict prevention and control,; title: effective drug treatment is the first choice. Some people think that the existing drugs are ineffective, such as; title: ridcive, etc., and antiviral drugs have no curative effect or obvious effect. These views are not correct. Because of; title: the pathological display and certification of a large number of clinical cases, there are not many people who have; title: recovered and recovered, including many who have been severely ill. In addition to medical measures such as; title: breathing and artificial lungs, the rational and comprehensive application of drugs has played an important role; title: and must not be ignored. Of it. Under the current real conditions, the rational and scientific use of drugs is very; title: important. Otherwise, the mortality rate will increase greatly, and there will be more patients. Therefore, the; title: choice of medicines is scientific and reasonable, and it is particularly important to adapt to local conditions and; title: human diseases. Clinicians have a heavy responsibility. Scientific, reasonable and effective use of drugs,; title: combined with other treatment methods, is the wise and realistic choice, there is no other way to find.; title: The cumulative number of confirmed cases of new coronary pneumonia in the world exceeded 9.08 million,; title: reaching 9.87078 million cases and 471.396 deaths. The number of confirmed cases in the United States reached; title: 2.36 million 593 cases, and there were 122.281 deaths. Statistics from worldometers show that there are 18; title: countries with more than 100,000 confirmed cases of new pneumonia worldwide, namely the United States,; title: Brazil, Russia, Spain, United Kingdom, India, Italy, Peru, Germany, Iran, Turkey, France, Chile, Mexico, Saudi Arabia,; title: Pakistan, Bangladesh, Canada. There are 7 countries with more than 10,000 deaths, namely the United States,; title: Brazil, Spain, the United Kingdom, Italy, France and Mexico.; title: The World Health Organization WHO announced on the 21st local time that the number of newly confirmed; title: cases in the world's new crown reached a single-day high, with more than 183,000 new cases in 24 hours and; title: more than 4,700 deaths; there were 8.7 million diagnosed cases worldwide and more than 460,000 deaths. From; title: various countries and regions, the number of new cases in the United States and Brazil accounted for half of the; title: total number of new cases on the same day.; title: . New coronavirus pneumonia rages across the world and becomes a global plague. The number of patients and; title: deaths are shocking. The time is long. The range is wide. The transmission coefficient and infection coefficient; title: are difficult to effectively treat.; title: For a long time, it has been up to half a year, and there has not been a decline; title: . It has a major impact on global politics, economy, culture, education, sports, religion, etc., with losses of up to; title: one trillion dollars. If mankind fails to respond effectively to suppression, major disasters will occur worldwide,; title: and the consequences and consequences will be unimaginable. Although group immunization makes sense, it is; title: too costly and deserves reflection and discussion. Therefore, it is very important to use effective drugs and; title: vaccines to prevent and treat symptomatic diseases. Before new special drugs and vaccines are developed, it is; title: especially necessary to respond to effective drugs and try to reduce morbidity and mortality.; title: ....................................................................................; title: A; title: Many people believe that the new coronavirus pneumonia has no specific drugs and no vaccine,; title: and it is an incurable disease. Many industry experts share this view. This kind of cognition and; title: viewpoint must say that it is not wrong. However, there are not only high mortality data in clinical; title: practice, but also a relatively high cure rate. In addition to the patient's condition, medical; title: technology and other reasons, various effective drugs have played a major role, of course,; title: including ventilators, artificial lungs, tube cutting and other rescue medical methods and; title: technologies. According to clinical data, 85% to 93% of patients mainly rely on various medicines; title: to cure, including critically ill late rescue. Most patients are mainly treated with various medicines,; title: especially mild patients and ordinary infected patients. This fully proves the important role of; title: drug control. For critically ill patients, the use of ventilator, artificial lung, intubation, etc. andcomprehensive; title: treatment of medical treatment is about 15% -25%. Of course, the cases in; title: different countries in the world are different. Difference or contrast. It is calculated based on the; title: cure rate and average value of the total cases worldwide. Therefore, the significance and clinical; title: effectiveness of various drug treatments cannot be underestimated. This is the most obvious; title: truth, obvious. If you ignore or ignore the important role of drugs, where does the cure rate; title: come from? Where do the large-scale recovery rates, such as sheltered hospitals, come from?; title: What is a magic medicine? What is a new special medicine? Nowadays, we can only look for the; title: wonderful things from the existing effective medicines. If you just wait for new special medicines; title: and new vaccines to come out, the mortality rate will be as high as 56% -92.5%, which is even; title: common knowledge for even three-year-olds. Time is life, time is money, time is price, time is; title: victory or defeat. Even if the isolation such as the closure of the city is effective again, the final; title: victory over the disease mainly requires the completion of various effective drugs. Only when the; title: chemical substances enter the human body will it have a curative effect. (Intubation, ventilator,; title: artificial lung, etc. undoubtedly play an irreplaceable role for drugs, and the two complement; title: each other). Global shutdown for one minute, the economic loss is 300-800 billion US dollars; the; title: United States will die one patient in 26-35 minutes (average count).; title: A; title: A; title: A; title: ,; title: Antivirus The drug of choice is; title: Ribavirin (triazole ribonucleoside, Virazole). [Mechanism of action] is a broad-spectrum antiviral; title: drug, which may inhibit phosphocreatinine dehydrogenase, prevent guanine nucleotides from; title: being synthesized and prevent viral nucleic acids synthesis. It is effective against influenza viruses; title: (type A and B), DNA and RNA viruses, but has no obvious effect on hepatitis B virus; it has; title: preventive and therapeutic effects on viral pneumonia, hepatitis A, herpes, and measles, but; title: clinical evaluations are mixed.; title: Amantadine hydrochloride Rimantadine Hydioch1oride antiviral drugs; title: Polyinosinic Polycytidylic Acid; title: Interferons [Mechanism of Action] This product is a class of antiviral glycoproteins produced by; title: vertebrate cells after other infections caused by viral infection. It is used for the treatment oradjuvant treatment; title: of viral infections, such as viral keratitis, hepatitis, influenza, etc., and; title: malignant tumors.; title: Amantadini Hydrochloridum; title: Aulenuridine Holpin, Brivudine, Audenyl Deoxyuridine, Aufuridine; title: Hydroxymethyl acyclovir ganciclovir; title: Redoxivir azithromycin chloroquine phosphate and so on.; title: A; title: 3 ribavirin; title: 4 Amantadine hydrochloride; title: 5 acyclovir; title: 6 Deoxyacyclic guanosine desciclovir 7 Polyinosinic acid; title: 8 interferon; title: 9 Amantadine hydrochloride; title: 10 Briwood; title: 11 Virus Spirit; title: 12 Adenosine arabinoside 13 Zidovudine; title: 14 dideoxythymidine; title: 15 ganciclovir; title: 16 iodine herpes net; title: 17 telbivudine; title: 18.Dexamethasone For the treatment of severe new coronary pneumonia, British doctors found the effect and; title: effectiveness of dexamethasone. The common side effects of dexamethasone in the treatment of other diseases; title: include anxiety, difficulty sleeping, weight gain, and fluid retention.; title: Less common side effects include eye discomfort, blurred vision, and bleeding.; title: However, patients with new coronavirus only need to use a relatively small amount of medicine to follow the; title: doctor's advice, so side effects should be limited.; title: A; title: ██ Immunopharmaceuticals First choice drug protein powder, thymus pentageptide, thymus; title: peptide, and injections to improve immunity, such as human albumin, lentinan, etc.; title: A; title: ███ Antipneumonia Drugs The first choice for viral pneumonia. The commonly used drugs; title: used to be beneficial to bevirin, but now oseltamivir can also be taken by mouth.; title: For bacterial infections, we usually use various penicillin drugs and cephalosporin drugs.; title: For mycoplasmal pneumonia infections, usually azithromycin, or erythromycin, roxithromycin,; title: etc.; title: A; title: A; title: █████ * Anti-bacteria Anti-bacterial drugs mainly include chemical synthesis: (1) quinones; title: (2) sulfonamides. Antibiotics: (1) Penicillins (2) Chloramphenicol (3) Macrolides (4) Tetracyclines; title: drug*************************************************; title: █ █ █ █ █; title: First choice drug against; title: respiratory infections; title: ███████ due to drug protease inhibits recombinant hepatitis B vaccine (various other; title: recombinant vaccines); title: Recombinant Erythropoietin; title: Interleukin; title: Antagonist; title: A; title: A█████████ compound drug preferred drug bio-missile-virus target tracking bio-virus; title: missile-compound drug; title: ████████████ Pneumonia vaccine The drug of first choice Pneumonia vaccine is; title: a very mature vaccine. The first population is patients with chronic underlying diseases.; title: Especially suffering from congenital heart disease, congestive heart failure, cardiomyopathy, and; title: chronic lung disease, especially chronic obstructive pulmonary disease, pulmonary edema; title: asthma, chronic liver disease, cirrhosis and diabetic cochlear implant, cerebrospinal fluid leakage,; title: etc. Diseases are all people who need pneumonia vaccine.; title: The second population is functional or anatomical asplenium.; title: Chain cell disease and other hemoglobin diseases, congenital or acquired asplenia, splenic; title: dysfunction, splenectomy patients are also pneumonia vaccination groups.; title: The third type of population is those with impaired immune function.; title: If there is congenital or acquired immunodeficiency, or hIv infection or chronic renal failure; title: nephrotic syndrome, systemic malignant tumor, bone marrow transplantation and the need for; title: immunosuppressive drugs, long-term treatment with sebaceous hormones, and radiotherapy; title: and chemotherapy Patients also need to be vaccinated against pneumonia.; title: In addition to the pneumonia vaccines for the three groups above, in fact, infants, young children,; title: elderly people, and patients with alcoholism and smoking are also at high risk of pneumonia.; title: They should also be vaccinated according to their physical conditions.; title: The pneumonia vaccine is not a newly developed vaccine for the new coronavirus pneumonia.; title: Pneumonia combined vaccine, pneumonia combined vaccine is vaccination PC v7; title: Pneumonia polysaccharide vaccine, 23-valent polysaccharide vaccine is also known as; title: pneumonia polysaccharide vaccine. This vaccine can cover 23 serotypes that can cause; title: pneumonia. In life, about 90% of pneumonia are caused by these 23 Caused by various serotypes.; title: And this pneumonia polysaccharide vaccine can play a good role in preventing pneumonia. At; title: present, it has been applied in many regions, and the vaccination protection rate can generally; title: reach 92%, which is very safe. The persistence of the drug effect is also very strong.; title: A; title: It also has a certain preventive effect on the prevention of new coronavirus pneumonia.; title: ██████████████ auxiliary medicine; title: █████████████████ plant medicine; title: A; title: ……… the first choice and screening of drugs, mainly for the diagnosis and treatment of new; title: coronavirus pneumonia, (with underlying diseases not included, comprehensive treatment based; title: on the patient's condition and individual differences, including the treatment of critical illness.); title: The clinical application should be based on the human system It is suitable for flexible application.; title: Pay attention to drugs and various adverse reactions, effective and safe, dosage, and follow the; title: doctor's advice. It should be more cautious for critically ill patients such as elderly and weak; title: patients.; title: ………………………………………; title: The latest number of global outbreaks, relevant sources of information on the website.; title: A total of 1694954 cases, 102607 deaths, and 376102 cases were cured. There were more than; title: 98,000 newly diagnosed cases outside China, with a cumulative total of 1.61 million cases; the; title: number of new deaths exceeded 7097 cases, with a cumulative total of more than 99,000 cases.A; title: According to the epidemic data released by Johns Hopkins University in the United States, as of; title: 9:30 on April 11, Beijing time, a total of 499,252 cases have been diagnosed in the United States; title: and a total of 18,637 deaths.; title: A; title: 147577 cases diagnosed in Italy; title: On the 10th local time, the Italian Civil Protection Department said that Italy had 3951 new cases; title: of newly diagnosed coronary pneumonia with a total of 147577 diagnoses; 570 new deaths and a; title: total of 18849 deaths.; title: A; title: A total of 157,022 cases have been diagnosed in Spain; title: The official website of the Spanish Ministry of Health reported on the 10th that in the past 24; title: hours, the country has added 4,576 new cases of new coronary pneumonia, with a total of; title: 157,022 cases diagnosed. There were 605 new deaths and a total of 15,843 deaths. Another; title: 55,668 people have recovered.; title: A total of 68,192 cases were diagnosed in Iran. The government plans to implement the "Smart; title: Alienation Plan"; title: Iran ’s Ministry of Health announced the latest data on the new coronavirus epidemic on the; title: 10th. As of noon on that day, Iran had 1972 newly diagnosed cases, with a total of 68192; title: confirmed cases, including 4232 deaths, 35465 cases cured, and 3969 cases in critical condition.; title: According to real-time data from Johns Hopkins University, Germany has accumulatively; title: diagnosed 122,171 cases of new coronary pneumonia, 2767 deaths, and cured 53,913 people.; title: A; title: A total of 125,930 cases were diagnosed in France, and only 50 people were diagnosed on the; title: only active aircraft carrier.; title: According to real-time statistical data from Johns Hopkins University in the United States, the; title: number of confirmed cases of new coronary pneumonia in France increased to 125,931, with a; title: total of 13,215 deaths and 25,195 people recovering.; title: A; title: 73,758 cases diagnosed in the UK; title: According to the report of the British Ministry of Health and Social Security on the 10th, there; title: were 5706 new cases of newly diagnosed coronary pneumonia in the UK, and a total of 73,758; title: cases were diagnosed. There were 980 new deaths and a total of 8958 deaths.; title: A; title: A total of 47,029 cases were diagnosed in Turkey, intended to repair patients admitted to; title: abandoned military hospitals; title: According to real-time statistical data from Johns Hopkins University in the United States, the; title: number of confirmed cases of new pneumonia in Turkey increased to 47,029, with a total of; title: 1,006 deaths and 2,423 people recovering.; title: A; title: A total of 22,059 cases were diagnosed in Canada, the official prediction of the new crown; title: epidemic or the death of 10,000 people; title: According to real-time statistics from Johns Hopkins University in the United States, the number; title: of confirmed cases of new coronary pneumonia in Canada increased to 22,148, with a total of570 deaths and; title: 5,892 people recovering.; title: The new Crown Epidemiological Model released by the Canadian government recently shows; title: that even according to the median value of the most ideal situation, 2.5% of the country ’s; title: population, that is, about 934,000 people may be infected with the new crown virus, and about; title: 11,000 people will die.; title: A total of 6134 cases were diagnosed in Japan.; title: According to the Japan Broadcasting Association, as of 11 p.m. local time, 589 new cases of new; title: coronary pneumonia were diagnosed in Japan, with a total of 119 deaths and a total of 6134; title: confirmed diagnoses. Among them, there were 189 newly confirmed cases in Tokyo. Currently,; title: 1,705 cases have been diagnosed in Tokyo.; title: A; title: A; title: In addition to Italy, Spain, France, Germany, and the United Kingdom, 26667 cases were; title: diagnosed in Belgium; 24551 cases were diagnosed in Switzerland and Liechtenstein; 23249 cases; title: were diagnosed in the Netherlands; 15472 cases were diagnosed in Portugal; 9685 cases were; title: diagnosed in Sweden; 6314 cases were diagnosed in Norway;; title: 10408 cases were diagnosed in Israel; 4346 cases were diagnosed in Malaysia; 4695 cases were; title: diagnosed in Pakistan; 2473 cases were diagnosed in Thailand; 3651 cases were diagnosed in; title: Saudi Arabia; 7598 cases were diagnosed in India; 2108 cases were diagnosed in Singapore; 1279; title: cases were diagnosed in Iraq; 993 cases were confirmed in Kuwait; 257 cases were confirmed in; title: Vietnam.; title: 6215 cases were diagnosed in Australia; 1283 cases were diagnosed in New Zealand.; title: There were 19638 cases in Brazil, 5897 cases in Peru and 171 cases in Venezuela.; title: (Source: Johns Hopkins University data, World Health Organization, bbc, Wikipedia, encyclopedia; title: website, etc.); title: --------------------------------------------------------------------------------------------; title: Compilation instructions; title: This book is a study of the new coronavirus pneumonia. It is of great significance to publish this book while the new; title: coronary pneumonia is still spreading in the world. The New Crown Virus Gene Atlas, pathological etiology, New; title: Crown Virus Pneumonia drug treatment and other major issues are all shown in the book.; title: The new coronavirus pneumonia is a particularly important public health event in the world. It has a large scale and; title: great impact. It has 10 million illnesses and more than 500,000 deaths. It involves billions of people around the world.; title: The epidemic is still spreading. It has special significance for the study of new coronavirus pneumonia. 1. Pathogenic; title: transmission 2. Pathology 3, virology, immunity. 4. Epidemiology. 5. Medical 6. Drugs, vaccines. 7. Epidemic; title: prevention, anti-epidemic. 8. Respiratory tract infections and pneumonia. 9. Gene map. 10. Molecular biology, viral; title: quantum chemistry. 11.Antiviral drug chemistry. 13. Response and epidemic prevention measures for large-scale; title: epidemic infectious diseases, emergency management 14. Integration of medical resources, global forecast and early; title: warning system for major epidemic infectious diseases 15. Emergency diagnosis and treatment of unexplained major; title: infectious diseases, drug selection and use 16. Medical The system responds to sudden large-scale epidemic infectious; title: disease treatment procedures and medical technology management procedures and specifications. 17. Sequencing and; title: analysis of viruses. 18. Epidemic reports and international notifications. 19. Global network forecasting and early; title: warning system for major epidemic infectious diseases. 20.Asian cases, European cases, LatinAmerican cases,African; title: cases, gene sequences, etc. 21. Invisible transmission, asymptomatic transmission. 22. Various bacterial viruses induce; title: cross-infection with each other to germinate new coronaviruses 23. The damage of new coronary pneumonia to the body,; title: complications and sequelae. twenty three,. The mutation and evolution of the new coronavirus, the long-term repetitive; title: complexity of prevention and control. 24 others. A lot of space is needed to discuss and demonstrate these issues. Here,; title: it is simple to delete the complex, mainly to discuss some major medical issues, such as the New Crown Virus Gene; title: Atlas, pathological etiology, New Crown Virus pneumonia drug treatment and other major issues, which is the top; title: priority, and the whole body is affected. This is the core and the key. Of course, other issues are also very important, this; title: book mainly discusses and studies these key issues. In the future, it will be discussed in detail when publishing large-; title: scale works. In a hurry, this book is mainly for the needs of the general public, netizens and readers from all over the; title: world, including the majority of medical workers, medical and pharmaceutical colleagues, vaccine and pharmaceutical; title: manufacturers, etc., and is published after the author has revised and finalized it. There are many shortcomings, I hope; title: to correct it when reprinting. (The relevant chart materials in the book are quoted from related websites or network; title: screenshots, Wiki, Who, Cell, Lancet, Encyclopedia, etc.); title: Compilation June 26, 2020; title: ————————————————————————————————————————————————; title: ——————-——Mainly refer to cited materials, literature, websites, gene banks, charts, books, encyclopedia; title: network resources, etc.:; title: ---------------------------------------------------- ------------------------------------------; title: Wikipedia; title: British Encyclopedia; title: GenBank database (https://www.ncbi.nlm.nih.gov/genbank/sars-cov-2-seqs/) and GISAID database; title: (https://www.gisaid.org/); title: "Cell" Cell; title: Lancet; title: Science; title: Nature; title: British Medical Journal; title: West's Internal Medicine; title: https://www.omicshare.com/; title: https://www.bmj.com/search/advanced/2019-nCoV; title: https://bestpractice.bmj.com/info/cn/subscribe-2/free/; title: https://bestpractice.bmj.com/topics/zh-cn/3000165; title: https://novel-coronavirus.onlinelibrary.wiley.com/; title: https://pubs.acs.org/page/vi/chemistry_coronavirus_research; title: http://www.ncbi.nlm.nih.gov/geo; title: Genbank; title: Who; title: un.org; title: International Virus Commission; title: http://www.ebi.ac.uk/embl/。; title: http://srs.ebi.ac.uk/。; title: ：http://www.ddbj.nig.ac.jp/; title: http://www.gdb.org。; title: http://pir.georgetown.edu/; title: ：http://www.ncbi.nlm.nih.gov/; title: https://www.springernature.com/gp/researchers/campaigns/coronavirus; title: 1. https://www.cell.com/2019-nCOV?from=groupmessage&isappinstalled=0; title: 2. https://www.elsevier.com/connect/coronavirus-information-center; title: 3. https://www.thelancet.com/coronavirus; title: 4. Lancet Coronavirus Center: http://www.thelancet.com/; title: 5. The latest coronavirus information: http://mp.weixin.qq.com/s?__biz; title: https://www.biomedcentral.com/collections/; title: And other information.; title: ………………………………………………………………………………………………………………………………; title: ……………………; title: La grande peste des humains dans le monde au 21e siècle --- Nouvelle pneumonie à coronavirus (par Fangruida); title: 2020v1.3 compilé par Lisa; title: ———————————————————————————————————————————————; title: préface; title: 10 millions de personnes tombent malades et plus de 500 000 personnes meurent ---- Le nombre de patients atteints; title: d'une nouvelle pneumonie à coronavirus dépassera 100 millions dans le monde, et l'alarme de prévention et de contrôle; title: retentira à nouveau; title: Selon un rapport de l'Université Johns Hopkins aux États-Unis, il y a eu plus de 10 millions de cas de nouvelles; title: infections à coronavirus dans le monde et plus de 500 000 décès.; title: L'Organisation mondiale de la santé a déclaré que les nouveaux cas quotidiens avaient établi un nouveau record; title: dimanche, atteignant 189 000. Le Brésil compte le plus de nouveaux cas, avec 47 000 nouveaux cas au cours des; title: dernières 24 heures.; title: De nombreux experts de la santé affirment que le nombre réel de cas d'infection dans le monde peut dépasser de loin les; title: chiffres publiés, car certains pays peuvent sous-déclarer les données pertinentes.; title: Plus de 10,11 millions, avec un décès cumulé de plus de 500 000. Selon les données de Reuters, 1 personne décède; title: d'une maladie associée au nouveau coronavirus toutes les 18 secondes.; title: Au total, plus de 2,5 millions de personnes ont été diagnostiquées avec le virus aux États-Unis, le plus au monde. Le; title: Brésil est le pays avec le deuxième plus grand nombre de nouveaux cas de coronavirus dans le monde, avec 1,13; title: million de personnes diagnostiquées avec une infection et 57 000 décès. Certains chercheurs affirment qu'en octobre de; title: cette année, le nombre de morts du nouveau coronavirus enAmérique latine pourrait dépasser 380 000.; title: (Les éléments graphiques pertinents dans le livre sont cités à partir de sites Web connexes ou de captures d'écran de; title: réseaux, Wiki, Who, Cell, Lancet, Encyclopedia, etc.); title: Selon Reuters, sur la base des données moyennes du 1er au 27 juin, plus de 4700 personnes sont décédées de maladies; title: liées au nouveau coronavirus toutes les 24 heures, soit 196 personnes sont décédées toutes les heures ou toutes les 18; title: secondes. 1 personne est décédée.; title: L'explosion de la bombe nucléaire du nouveau virus Corona, si les pays ne prennent pas de mesures de prévention et de; title: contrôle plus efficaces et décisives, le virus sera sans scrupules, de 10 millions à continuer de grimper à un nouveau; title: niveau, atteindra un nouveau pic de 50 millions - 100 millions de personnes décédées Le nombre de personnes atteint; title: un million ou plus, ce qui menace gravement la vie, la santé et la sécurité de 8 milliards de personnes dans le monde.; title: Les virus menacent gravement le milieu de vie des êtres humains, détruisant les êtres humains, détruisant l'économie et; title: causant des conséquences plus effrayantes et terribles. Si l'épidémie continue de se propager et de s'étendre, les; title: conséquences sont insupportables. Des pays comprenant des patients invisibles, une transmission invisible ou une; title: résurgence de décès, la situation est plus dangereuse, elle affectera directement la survie de l'humanité. Les; title: gouvernements et les peuples de tous les pays doivent attacher une grande importance et être vigilants, faute de quoi les; title: conséquences seront inimaginables. Différents pays ont des conditions nationales différentes, des restrictions sur les; title: ressources médicales, des différences dans l'environnement économique, les systèmes culturels et d'autres raisons. Ils; title: doivent être traités différemment, sans contestation ni blâme. La priorité absolue est de prévenir et de contrôler et de; title: traiter strictement, de minimiser la propagation et de maximiser le traitement et le sauvetage du patient. Si vous ne; title: prenez pas de décision, indécis, les conséquences sont terribles et inimaginables. Le développement d'un vaccin prend; title: du temps et ne doit pas être retardé, ce qui fait une grosse erreur. Les patients globaux comprennent les patients sévères; title: et un nombre considérable de patients invisibles, les patients asymptomatiques, les estimations prudentes de nouveaux; title: patients, au moins un million ou plus. Ce n'est pas alarmiste, en effet, les statistiques de l'OMS, Hopps University, etc.; title: n'incluent pas cette partie des patients et des patients. Le nombre d'épidémies aux États-Unis, au Brésil, en Inde, en; title: Russie et dans d'autres pays propage en partie les infections, et l'autre partie comprend les patients invisibles, les; title: infections asymptomatiques et les nouveaux patients avec conversion virale. Le nombre est difficile à compter avec; title: précision. La situation épidémique s'est étendue et s'est aggravée en raison de divers facteurs. Bien sûr, les mesures de; title: prévention et de contrôle, les mesures médicales, etc., y compris la reprise du travail, l'école et le marché sont trop tôt et; title: les mesures de prévention et de contrôle font défaut. La nouvelle montre que le nombre de jeunes patients augmente.; title: Cela montre que la propagation nocive des virus ne peut pas être sous-estimée. Le développement continu de la peste; title: mondiale nécessite des mesures efficaces pour y faire face.; title: 1.; title: Avec l'épidémie mondiale de l'épidémie de New Crown, des membres de la communauté scientifique britannique et; title: d'autres ont successivement mis en avant l'idée d'une "immunité de groupe". La soi-disant "immunité de groupe" se; title: réfère à l'infection à grande échelle d'une maladie infectieuse par un groupe biologique. Après la récupération, le corps; title: générera automatiquement une immunité contre la maladie infectieuse, garantissant ainsi que cette maladie infectieuse; title: ne sera pas déclenchée à l'avenir.; title: «Migrants COVID-19« crise dans une crise »; title: Des dizaines de millions de travailleurs migrants, contraints de rentrer chez eux après avoir perdu leur emploi en raison; title: de la fermeture de COVID-19, sont confrontés au chômage et à la pauvreté dans leur pays d'origine, a averti l'OIT. Des; title: millions de travailleurs migrants pourraient être obligés de rentrer chez eux, là où les marchés du travail sont désormais; title: affaiblis par la pression supplémentaire du taux de chômage élevé et de graves perturbations commerciales. De plus,; title: leurs familles souffriront de la perte des envois de fonds qui leur sont normalement envoyés. »Screenshot Capture; title: d'écran du réseau un.org)）; title: La génétique des populations fait référence à la composition génétique d'une population, c'est-à-dire la fréquence des; title: gènes et des génotypes dans cette population. Par exemple, la population de races lignées pures est homogène et les; title: individus sont homozygotes; tandis que la population des variétés des groupes de pollinisation ouverte est hétérogène et; title: que les individus sont hétérozygotes. L'étude de la composition génétique des populations dans la sélection végétale; title: peut aider à la prise de décision dans les programmes de sélection.; title: En termes de culture, la composition individuelle des groupes de cultures plantées sur le même champ est antagonisée.; title: Ce groupe individuel peut être composé de cultures mixtes, de cultures intercalaires ou d'espèces uniques de plusieurs; title: cultures. L'étude de l'espace occupé par chaque individu dans le groupe individuel et la composition de son phénotype; title: et la coordination dynamique entre les individus aideront à guider la culture des cultures à haut rendement. Face à; title: l'immunisation de groupe, si le virus subit une mutation génique et que la séquence et la structure de la protéine; title: changent, de sorte que les personnes initialement immunisées ne peuvent pas reconnaître ces virus modifiés, alors; title: l'immunisation de groupe sera inefficace. Il existe deux types de virus: les virus à ADN et les virus àARN. Les virus à; title: ADN sont plus stables et moins sujets à la mutation, tandis que les virus àARN sont instables et sujets à la mutation. Ce; title: nouveau coronavirus est un virus àARN, qui présente un risque potentiel élevé de mutation et devrait être très; title: préoccupé.; title: Les données sur la séquence du génome viral du nouveau coronavirus sont très importantes pour le traitement et la; title: prévention du nouveau coronavirus, et le développement de vaccins et de médicaments est très important. Souches de; title: virus,; title: Les données de séquence du génome viral, l'étiologie, la pathologie, la biologie moléculaire, la chimie quantique, la; title: pharmacologie, etc. sont toutes des données scientifiques importantes.; title: Le Centre chinois de contrôle et de prévention des maladies a officiellement publié la nouvelle situation épidémique du; title: coronavirus et les données de séquence du génome viral en juin 2020 à Pékin par le biais du "Nouveau système national; title: de services de ressources scientifiques et technologiques du coronavirus". Comprend principalement les données de; title: séquence génomique des cas confirmés à Pékin; title: (NMDC60013902-01, NMDC60013903-02) et des données de séquence génomique d'échantillons environnementaux; title: (NMDC60013903-03), ces trois échantillons ont été collectés le 11 juin 2020, lors d'une récente épidémie de virus à; title: Beijing. Dans le même temps, le Centre chinois de contrôle et de prévention des maladies a également soumis la; title: nouvelle situation épidémique de la couronne et les données de séquence du génome viral à l'Organisation mondiale de; title: la santé et à la Global Influenza Data Initiative (GISAID) pour partager les données à l'échelle mondiale.; title: (Capture d'écran du réseau; title: Recherche scientifique, expression factuelle, expression des données, expression empirique. Sinon, cela violera la vérité; title: scientifique. Les matériaux du réseau, les images du réseau, les captures d'écran du réseau sont tous des souvenirs et des; title: enregistrements historiques.); title: La bibliothèque de ressources du nouveau coronavirus 2019 contient des métadonnées sur les souches de virus du; title: nouveau coronavirus 2019 (2019-nCoV) publiées à partir de la base de données GenBank et de la base de données; title: GISAID du NCBI. .; title: http://virological.org/) a publié la séquence du génome de ce virus. Peu après, le CDC chinois a également publié la; title: séquence du génome du SARS-CoV-2 (et les données épidémiologiques connexes) sur la base de données GISAID; title: accessible au public (https://www.gisaid.org/). Il est important de noter que la publication des données sur la séquence; title: génomique du SRAS-CoV-2 a facilité le développement rapide de tests de diagnostic et de clones infectieux. La course; title: à la mise au point de vaccins et de médicaments antiviraux efficaces est en cours et les essais cliniques des médicaments; title: antiviraux progressent progressivement. (Les données pertinentes sur la séquence génomique sont citées dans des bases; title: de données pertinentes, des revues médicales telles que "Cell", des dessins joints, etc.),; title: Données de séquence génomique; title: Dans les années 1930, le virus de la bronchite infectieuse aviaire (IBV) a été trouvé dans les voies respiratoires des; title: poulets. Par la suite, des virus de structure similaire à IBV ont également été trouvés dans le liquide de lavage nasal; title: humain et d'autres animaux. Parce que la surface du virus a des protéines fibrillaires en forme de couronne, il est appelé; title: coronavirus.; title: World-renowned medical scientist virologist pharmacologist Fangruida major discovery of the new coronavirus research * May 14, 2020 Research Newsletter (Walk); title: Fangruida: The new coronavirus pneumonia virus is also changing or undergoing a certain heterogeneity and isotropic double mutation or multidirectional variability, and the virus bacteria will also induce mutual conversion (the latest research news on May 14, 2020) ******************************************************************************* Fangruida new coronavirus found that the new coronavirus pneumonia virus is also changing or a certain out of phase and isotropic double mutation or multidirectional variability, and the virus bacteria will also induce mutual conversion Genetic replication Highly wary of the recurrence of the global new coronavirus pneumonia, ███ global warning: must not be paralyzed, prevent and control the epidemic repeatedly, and the virus will fight back, otherwise, the various costs will be greater. The new coronavirus pneumonia is a protracted war. It is naive and short-sighted to fight scientifically and try to make a quick decision. May 14, 2020 ************************************************** ***************************************** ███ █ (invisible infections of invisible patients, etc.), part of which is the pathology of non-new corona virus gradually transformed into new corona virus, the source of infection includes direct contact infection and non-direct contact infection (induced gradient infection), the former accounts for more than 90% of infections, The latter is less than 10%, or lower. Non-crown virus (bacteria, etc.) → genetic replication conjugation transformation → → new corona virus. This type of patient is often difficult to diagnose and detect, and is a major hidden danger and blind spot for prevention. Even if the nucleic acid test is negative, it is difficult to guarantee that it will gradually become positive. Latently positive patients and asymptomatic patients are the key to defeating the plague. Diagnosis, treatment and prevention are very complicated and difficult. If hidden dangers are left behind, the epidemic prevention will undergo a major reversal, and the virus will make a comeback, causing great harm. Conversion mechanism: virus (bacteria etc.) inheritance → replication → junction → coupling → recombination → {differentiation} → new crown virus → new crown pneumonia █ (under certain conditions, the generation of new viruses or bacterial pneumonia and mutual cross-infection and mutual conversion, etc.) under certain environmental conditions will also produce germination, mutual infection transmission, (various viral bacteria between non-coronavirus Etc. will also induce mutual conversion. Influenza viruses can adhere to the surface of common respiratory bacteria, and will significantly enhance the ability of bacteria to adsorb on the organ wall. Infected with bacteria-virus complexes, bacteria and viruses can benefit from interaction When the infected person coughs or sneezes and the transmission of pathogens occurs, bacteria and viruses will reciprocate with each other. They will use different receptors to adsorb to the host's respiratory system tissues, thus working together to cause the patient's illness to increase. The virus is not complete The enzyme system, which is parasitic in living cells, uses the enzyme system in the cells to replicate, that is to say, the energy for their replication also comes from the mutual transformation of ATP and ADP. The bacterial transformation phenomenon was originally developed by British bacteriology Griffith (F. Griffith) discovered in 1928, until 1944 American scientist Avery (O T. Avery) and other personnel have confirmed that the conversion factor is deoxyribonucleic acid, which has made a significant; title: contribution to the development of genetics. The transformation phenomenon in nature generally occurs in the same species or closely related species. Bacterial transformation methods have been introduced into other organisms For example, the protoplast transformation method can be used to inject foreign DNA into organisms that do not have the ability to take up DNA, so that it can obtain some new characteristics. Experimental materials Recipient bacteria: E. coli K12 HB101 Plasmid: pGLO plasmid Conversion solution (CaCl2) Ampicillin (amp) Arabinose (ara) Culture medium: solid LB, liquid LB Inoculation loop, pipette, etc. Experimental steps and methods 1. Prepare the plate: Each group: 1 LB plate, 2 LB / amp plates, 1 LB / amp / ara plate 2. Prepare competent cells: use 250 μl of sterile water or transformation solution to suspend the E. coli bacteria powder provided in the kit, this is the competent cells. A 3. Activate the receptor cells: Pick one loop of E. coli K12 HB101 bacterial solution and activate it on LB medium at 37 ℃ for 16-24h. A 4. Conversion: 1) Separately mark on two sterile centrifuge tubes Remember + DNA, -DNA. 2) Add separately in the above two tubes 250 μl of transformation solution. 3) Quickly place on ice. 4) Pick one of the activated receptor bacteria A single colony, suspended in two tubes of transformation solution. 5) Add one to the tube labeled + DNA Circular plasmid DNA, but not added to the tube labeled -DNA. 6) Place the above two tubes on ice for 10 minutes. 7) At the bottom of the prepared medium. 8) Put two small tubes into a 42 ℃ water bath for 50 seconds, and then put them on ice for 2 minutes. 9) Add 250 μl LB-broth to each of the two small tubes. 10) Pipette 100 μl from the + DNA vial onto two plates marked with + DNA, and pipette 100 μl from the -DNA vial onto two plates marked with -DNA. A 11) Use a sterile inoculating ring to evenly spread the dropped liquid on the plate. 12) Fix the above four plates and incubate in a 42 ℃ incubator for 2 days. A 13) Observe the result under the long wave ultraviolet lamp and record the number of colonies on each plate Virus transformed cells experimental method 1. Blood preparation: Citric acid (Citric Acide) or heparin anticoagulation blood collection 1 ~ 2ml, divided into tubes, 0.5ml whole blood per tube, placed in a refrigerator at 4 ℃ for 30 minutes. 2. EBV virus transformation: Remove 0.5ml of frozen whole blood from liquid nitrogen and; title: quickly thaw in 37 ° C water. 3. The thawed cells were mixed with 10 ml of serum-free RPMI 1640, centrifuged at 2500 rpm for 2 minutes, the supernatant was discarded, and resuspended in RPMI 1640 growth medium containing 20% fetal bovine serum, penicillin, streptomycin and gentamicin cell. 4. Add 0.3 ~ 0.5ml of EBV virus solution, 37 ° C water bath for 30 minutes to 2 hours, shaking from time to time to avoid clots. 5. Dispense into 50ml culture flasks, add appropriate amount of culture solution at the same time, put into 5% CO2 incubator, and culture at 100% temperature. 6. One week later, 2 ml of medium was added. 7. The culture is often examined by microscopy, and the liquid is added or changed every 3 to 4 days. As the number of cells increases, it can be divided into large bottles for culture. █ New coronavirus pneumonia According to pathological etiology and virology research, as well as a large number of hundreds of millions of clinical cases and analysis of a large number of death cases worldwide, the pathology of the new coronavirus pneumonia is quite complicated, and the general coronavirus strains Similarities and differences, even if a new vaccine is developed, and the virus is changing or a certain degree of heterogeneity and isotropic double mutation or multiple variability, this will also produce a certain range of resistance to the vaccine. This shows that the evolutionary changes of microorganisms are closely related to the physical changes and chemical changes of the entire natural universe, especially the evolution of biological species. █ The new coronavirus pneumonia is associated with respiratory infectious diseases such as SARS, similarities and differences. The infection of the new coronavirus is mainly through contact, mouth, nose and mouth, saliva, respiratory nasal cavity, including objects, animals, etc. The most important is the respiratory tract and contact transmission, etc., a certain range of air breathing. Cytokine storm (cytokine storm) refers to the cytokine storm caused by the body after infecting microorganisms such as TNF-α, IL-1, IL-6, IL-12, IFN-α, IFN-β, IFN-γ, MCP Phenomena such as -1 and IL-8 are rapidly produced in large quantities and are important causes of acute respiratory distress syndrome and multiple organ failure. █Various viruses and bacteria among non-coronaviruses will also induce mutual conversion. The new coronavirus pneumonia is derived from coronaviruses, and the pathogens of such viruses come from animals. There is no objection. All kinds of viruses and bacteria can also produce isotropic or anisotropic infections. █ Non-Coronaviruses and bacteria can also mutate under certain conditions. (1) Cocci: According to their arrangement, they can be divided into single cocci, double cocci, quadruple cocci, sarcoma, staphylococci and streptococci. (2) Bacillus: The cell morphology is more complicated, with short rod shape, rod shape, spindle shape, moon shape, branch shape. (3) Spiral bacteria: can be divided into vibrio and spirulina. In addition, people also found star-shaped and square bacteria. Viruses and bacteria are genetically duplicated and transformed under certain conditions. Viruses can also be viruses, DNA viruses, RNA viruses, protein viruses (eg prions) under certain conditions. Classification by virus structure: true virus (Euvirus, referred to as virus) and subvirus (Subvirus, including viroid, pseudovirus, prion); title: From the host type classification: bacteriophage (bacterial virus), plant virus (such as tobacco mosaic virus), animal virus (such as avian influenza virus, smallpox virus, HIV, etc.) can also occur genetic replication mutation transformation mutation recombination. Non-crown viruses are transformed into coronaviruses. This is also the difficulty and blind spot of the epidemic prevention, the focus. The incubation period of virus bacteria is long, asymptomatic or mild, slowly transformed into new coronavirus, erodes the respiratory tract and lungs, and is not easy to be detected and found, including nucleic acid detection, etc., and will also be misdiagnosed and missed. This is also one of the specificities of the new coronavirus pneumonia. █ Zoology, veterinary medicine, medicine, virology, microbiology, anthropology, and other interdisciplinary combinations are very complicated. For the prevention and control of epidemics, the prevention and treatment of the new coronavirus pneumonia requires comprehensive research before it can be understood and gradually clarified. The specificity of the new coronavirus requires special attention. █ Old and new drugs, currently without special drugs and vaccines, antiviral drugs, immune drugs, severe pneumonia drugs for respiratory infectious diseases, etc., can play a considerable role, and their effectiveness must not be underestimated. Clinical data shows that a large number of patients can be treated and recovered, and the role of drugs is indispensable. █ The complications of new coronary pneumonia require follow-up observation and treatment. Patients after rehabilitation should take protective health care. ........................................................................................................................ Although the global outbreak of the new coronavirus pneumonia has improved, many countries have begun to unblock, resume work and resume production, etc. The overall situation of the outbreak has been effectively controlled. The situation is generally going in a good direction, but this does not mean that the disease has been subdued and the epidemic has been completely suppressed and controlled. On the contrary, the global epidemic situation is still very complicated and severe. There are still a lot of people infected with the disease. Some countries have seen a partial rebound in the epidemic situation, and some countries still have a rising rate, including the number of deaths. The total number of patients is more than 4 million, and the deaths are more than 300,000. (After the detailed data is listed) According to the latest epidemic data, the epidemic has repeated, including missed reports, false positives, etc. Invisible transmission of invisible patients (including under certain conditions, the generation of new viruses or pneumonia and mutual conversion of cross-infection, etc. ) Under certain environmental conditions, germination and mutual infection will also occur. (Various viruses and bacteria between non-coronaviruses will also induce mutual conversion.) No matter in Asia, America, Europe, Africa and other countries and regions, strict prevention and control are required. New changes in the epidemic and the specificity, repetitiveness, concealment, infectivity, and variability of the new coronavirus. Take more effective measures and methods to prevent the epidemic from recurring and the virus to counterattack. Otherwise, humans will continue to pay various high prices . The virus is new and weird, and it is a serious threat to human life. You must not be paralyzed and let your guard down. This virus is more viable and infectious than other coronaviruses. At present, there are no special drugs and vaccines, and the mortality rate will be high. Moreover, the new coronavirus pneumonia is based on pathological etiology, virology and other studies, as well as a large number of hundreds of thousands of clinical cases worldwide,; title: and analysis of nearly 300,000 death cases. The pathology of the new coronavirus pneumonia is quite complicated, and the general coronavirus The similarities and differences of the strains, even if a new vaccine is developed, and the virus is changing or a certain anisotropy and isotropic double mutation or multi-directional variability, which will also have a certain range of resistance to the vaccine. This shows that the evolutionary changes of microorganisms are closely related to the physical changes and chemical changes of the entire natural universe, especially the evolution of biological species. The fight against diseases by humans is a long-term repetition, not a temporary battle. It is especially important to focus on the epidemic areas and countries. When resuming work, resuming production and returning to school, we must be cautious and guard against new waves of viruses. Otherwise, the cost will be greater and more dangerous. The new coronavirus pneumonia has repeatedly struck, and countries around the world should not be paralyzed carelessly and be highly vigilant in prevention and control. Root official media reports and relevant announcements from China's National Health Commission indicate that there are currently three infections in China that have not yet released the source of infection, namely Shulan City, Jilin Province, Dongxihu District, Wuhan City, and Zengcheng District, Guangzhou City. (Invisible infections of invisible patients, etc.). Recently, the epidemic situation in Jilin City, China has repeatedly closed the city. The epidemic situation in Wuhan, Hubei has also been repeated. Tens of thousands of people have been screened for nucleic acid testing. This shows that the complexity and recurrence of epidemic prevention and epidemic prevention cannot be paralyzed. Therefore, invisible transmission of invisible patients in various countries around the world is also a very important epidemic. (Under certain conditions, the generation of new viruses or pneumonia and the cross-infection of each other, etc.) Under certain environmental conditions, they will also germinate and pass on each other, (various viral bacteria between non-coronaviruses, etc.) Will also induce mutual conversion)). Therefore, high vigilance and strict scientific precautions are particularly important. Paralyzing, thinking that victory is on the horizon and neglecting the enemy and relaxing will repeat the same mistakes. The latest statistics of epidemic situation in major countries in the world sorted by cumulative diagnosis Newly diagnosed areas Accumulated diagnoses Cure deaths Epidemic situation United States 20353 1408636 296746 83425 Details Spain 0 269520 180470 26920 Details Russia 10028 242271 43512 2212 United Kingdom 1278 227741 1023 32769 Details Italy 1402 221216 109039 30911 Details France 802 178349 57898 26994 Details Brazil 8193 178214 72597 12461 Germany 274 173971 151789 7834 Details Turkey 1704 141475 98889 3894 Iran 1958 112725 89428 6783 Details India 1887 74480 24453 2415 Canada 1155 72419 34055 6669 Peru 3237 72059 23324 2057 Belgium 202 53981 13732 8843 Netherlands 0 43183 322 5529; title: Saudi Arabia 0 42925 15257 264 Mexico 1997 38324 25935 3926 Pakistan 1662 34336 8812 737 Ecuador 0 31881 3433 The total number of illnesses in the world is more than 4 million, and 300,000 deaths. The new coronavirus pneumonia is a new major infectious disease. For its pathological virology, molecular biology, immunology, pharmacology, etc., understanding and research requires scientific and meticulous analysis and a lot of experimental work. Humans need serious reflection and discussion. Of course, the disease is not going to wreak havoc forever. Humans will be able to overcome it. Therefore, be optimistic, full of confidence, and unafraid. (Sources Related websites, American Johns Hopps University, British Medical Journal, Who, News website, WiKi encyclopedia, etc.) ——————————————————————————————————————— ——————— Fangruida: Le nouveau virus de la pneumonie à coronavirus est également en train de changer ou de subir une certaine hétérogénéité et une double mutation isotrope ou une variabilité multidirectionnelle, et les bactéries du virus induiront également une conversion mutuelle (les dernières nouvelles de la recherche du 14 mai 2020) ******************************************************************************* *Le nouveau coronavirus de Fangruida a révélé que le nouveau virus de la pneumonie à coronavirus est également en train de changer ou qu'il existe une certaine double mutation isotrope et déphasée ou une variabilité multidirectionnelle, et les bactéries du virus induiront également une conversion mutuelle Réplication génétique Très méfiant de la récurrence de la nouvelle pneumonie mondiale à coronavirus, █ █ █ avertissement mondial: ne doit pas être paralysé, prévenir et contrôler l'épidémie à plusieurs reprises, et le virus se défendra, sinon, les différents coûts seront plus élevés. La nouvelle pneumonie à coronavirus est une guerre de longue durée. Il est naïf et à courte vue de combattre scientifiquement et de prendre une décision rapide. 14 mai 2020 ************************************************** ***************************************** ███ █ (infections invisibles de patients invisibles, etc.), dont une partie est la pathologie du nouveau virus corona progressivement transformé en nouveau virus corona, la source de l'infection comprend l'infection par contact direct et l'infection par contact indirect (infection à gradient induit), la première représente plus de 90% de l'infection Cette dernière est inférieure à 10% ou inférieure. Virus non-couronne (bactéries, etc.) → transformation de conjugaison de réplication génétique → → nouveau virus corona. Ce type de patient est souvent difficile à diagnostiquer et à détecter, et constitue un danger caché majeur et un angle mort pour la prévention. Même si le test d'acide nucléique est négatif, il est difficile de garantir qu'il deviendra progressivement positif. Les patients latents positifs et les patients asymptomatiques sont la clé pour vaincre la; title: peste. Le diagnostic, le traitement et la prévention sont très compliqués et difficiles. Si des dangers cachés sont laissés pour compte, la prévention des épidémies subira un renversement majeur et le virus fera son retour, causant de grands dommages. Mécanisme de conversion: hérédité du virus (bactérie, etc.) → réplication → jonction → couplage → recombinaison → {différenciation} → nouveau virus de la couronne → nouvelle pneumonie de la couronne █ (sous certaines conditions, génération de nouveaux virus ou pneumonie bactérienne et infection croisée mutuelle et conversion mutuelle, etc.) sous certaines conditions environnementales produira également la germination, la transmission mutuelle des infections, (diverses bactéries virales entre non-coronavirus Etc. induira également une conversion mutuelle. Les virus de la grippe peuvent adhérer à la surface des bactéries respiratoires courantes et améliorer considérablement la capacité des bactéries à s'adsorber sur la paroi des organes. Infectés par des complexes bactériens-virus, les bactéries et les virus peuvent bénéficier de l'interaction Lorsque la personne infectée tousse ou éternue et que la transmission d'agents pathogènes se produit, les bactéries et les virus se réciproquent. Ils utiliseront différents récepteurs pour s'adsorber sur les tissus du système respiratoire de l'hôte, travaillant ainsi ensemble pour provoquer une augmentation de la maladie du patient. Le virus n'est pas complet Le système enzymatique, qui est parasite dans les cellules vivantes, utilise le système enzymatique dans les cellules pour se répliquer, c'est-à-dire que l'énergie pour leur réplication provient également de la transformation mutuelle de l'ATP et de l'ADP. Le phénomène de transformation bactérienne a été initialement développé par la bactériologie britannique Griffith (F. Griffith) découvert en 1928, jusqu'en 1944, le scientifique américain Avery (O T. Avery) et d'autres membres du personnel ont confirmé que le facteur de conversion est l'acide désoxyribonucléique, qui a contribué de manière significative au développement de la génétique. Le phénomène de transformation dans la nature se produit généralement chez la même espèce ou des espèces étroitement apparentées. Des méthodes de transformation bactérienne ont été introduites dans d'autres organismes. Par exemple, la méthode de transformation des protoplastes peut être utilisée pour injecter de l'ADN étranger dans des organismes qui n'ont pas la capacité d'absorber de l'ADN, ce qui lui permet d'obtenir de nouvelles caractéristiques Matériaux expérimentaux Bactéries receveuses: E. coli K12 HB101 Plasmide: pGLO plasmid Solution de conversion (CaCl2) Ampicilline (amp) Arabinose (ara) Milieu de culture: LB solide, LB liquide Boucle d'inoculation, pipette, etc. Étapes et méthodes expérimentales 1. Préparez la plaque: Chaque groupe: 1 plaque LB, 2 plaques LB / amp, 1 plaque LB / amp / ara 2. Préparez les cellules compétentes: utilisez 250 μ l d'eau stérile ou de solution de transformation pour suspendre la poudre de bactérie E. coli fournie dans le kit, il s'agit des cellules compétentes. UNE 3. Activer les cellules réceptrices: Choisir une boucle de solution bactérienne E. coli K12 HB101 et l'activer sur du milieu LB à 37 ° C pendant 16-24h. UNE 4. Conversion: 1) Marquer séparément sur deux tubes à centrifuger stériles; title: Rappelez-vous + ADN, -ADN. 2) Ajouter séparément dans les deux tubes ci-dessus 250 μl de solution de transformation. 3) Placer rapidement sur la glace. 4) Choisissez l'une des bactéries réceptrices activées Une seule colonie, suspendue dans deux tubes de solution de transformation. 5) Ajoutez-en un au tube étiqueté + ADN ADN plasmidique circulaire, mais non ajouté au tube marqué -ADN. 6) Placer les deux tubes ci-dessus sur de la glace pendant 10 minutes. 7) Au fond du milieu préparé. 8) Mettez deux petits tubes dans un bain-marie à 42 for pendant 50 secondes, puis placez-les sur de la glace pendant 2 minutes. 9) Ajouter 250 ul de bouillon LB dans chacun des deux petits tubes. 10) Pipeter 100 μl du flacon + ADN sur deux plaques marquées avec + ADN, et pipeter 100 μl du flacon -ADN sur deux plaques marquées avec -ADN. UNE 11) Utilisez un anneau d'inoculation stérile pour répartir uniformément le liquide tombé sur la plaque. 12) Fixer les quatre plaques ci-dessus et incuber dans un incubateur à 42 for pendant 2 jours. UNE 13) Observer le résultat sous la lampe ultraviolette à ondes longues et enregistrer le nombre de colonies sur chaque plaque Cellules transformées par virus méthode expérimentale 1. Préparation du sang: Acide citrique (acide citrique) ou collecte de sang anticoagulant à l'héparine 1 ~ 2 ml, divisé en tubes, 0,5 ml de sang total par tube, placé dans un réfrigérateur 4 for pendant 30 minutes. 2. Transformation du virus EBV: Retirez 0,5 ml de sang total congelé de l'azote liquide et décongelez rapidement dans de l'eau à 37 ° C. 3. Les cellules décongelées ont été mélangées avec 10 ml de RPMI 1640 sans sérum, centrifugées à 2500 tr / min pendant 2 minutes, le surnageant a été jeté et remis en suspension dans du milieu de croissance RPMI 1640 contenant 20% de sérum bovin fœtal, pénicilline, streptomycine et gentamicine cellule. 4. Ajouter 0,3 ~ 0,5 ml de solution de virus EBV, bain-marie à 37 ° C pendant 30 minutes à 2 heures, en agitant de temps en temps pour éviter les caillots. 5. Distribuer dans des flacons de culture de 50 ml, ajouter la quantité appropriée de solution de culture en même temps, mettre dans un incubateur à 5% de CO2 et cultiver à 100% de température. 6. Une semaine plus tard, 2 ml de milieu ont été ajoutés. 7. La culture est souvent examinée par microscopie, et le liquide est ajouté ou changé tous les 3 à 4 jours.A mesure que le nombre de cellules augmente, il peut être divisé en grandes bouteilles pour la culture. █ Nouvelle pneumonie à coronavirus Selon les recherches en étiologie pathologique et en; title: virologie, ainsi que sur un grand nombre de centaines de millions de cas cliniques et l'analyse d'un grand nombre de cas de décès dans le monde, la pathologie d'une nouvelle pneumonie à coronavirus est assez compliquée Similitudes et différences, même si un nouveau vaccin est développé et que le virus évolue ou un certain degré d'hétérogénéité et de double mutation isotrope ou de variabilité multiple, cela produira également une certaine gamme de résistance au vaccin. Cela montre que les changements évolutifs des micro-organismes sont étroitement liés aux changements physiques et chimiques de l'ensemble de l'univers naturel, en particulier l'évolution des espèces biologiques. █ La nouvelle pneumonie à coronavirus est associée à des maladies infectieuses respiratoires telles que le SRAS, les similitudes et les différences. L'infection du nouveau coronavirus se fait principalement par contact, bouche, nez et bouche, salive, cavité nasale respiratoire, y compris les objets, les animaux, etc. Le plus important est les voies respiratoires et la transmission par contact, etc., une certaine gamme de respiration aérienne. Tempête de cytokines (tempête de cytokines) fait référence à la tempête de cytokines provoquée par le corps après avoir infecté des micro-organismes tels que TNF-α, IL-1, IL-6, IL-12, IFN-α, IFN-β, IFN-γ, MCP Des phénomènes tels que -1 et IL-8 sont rapidement produits en grande quantité et sont des causes importantes de syndrome de détresse respiratoire aiguë et de défaillance d'organes multiples. █ Divers virus et bactéries parmi les non-coronavirus induiront également une conversion mutuelle. La nouvelle pneumonie à coronavirus est dérivée de coronavirus, et les agents pathogènes de ces virus proviennent d'animaux. Toutes sortes de virus et de bactéries peuvent également provoquer des infections isotropes ou anisotropes. █ Les non-coronavirus et les bactéries peuvent également muter dans certaines conditions. (1) Cocci: Selon leur disposition, ils peuvent être divisés en cocci simples, cocci doubles, cocci quadruples, sarcome, staphylocoques et streptocoques. (2) Bacillus: La morphologie cellulaire est plus compliquée, avec une forme de tige courte, une forme de tige, une forme de fuseau, une forme de lune, une forme de branche. (3) Bactérie spirale: peut être divisée en vibrio et spiruline. De plus, les gens ont également trouvé des bactéries en forme d'étoile et carrées. Les virus et les bactéries sont génétiquement dupliqués et transformés dans certaines conditions. Les virus peuvent également être des virus, des virus à ADN, des virus à ARN, des virus à protéines (par exemple des prions) dans certaines conditions. Classification par structure virale: vrai virus (Euvirus, appelé virus) et sous-virus (Subvirus, y compris viroïde, pseudovirus, prion) De la classification du type d'hôte: les bactériophages (virus bactériens), les virus végétaux (tels que le virus de la mosaïque du tabac), les virus animaux (tels que le virus de la grippe aviaire, le virus de la variole, le VIH, etc.) peuvent également se produire par replication génétique mutation mutation transformation mutation recombinaison. Les virus non-couronne sont transformés en coronavirus. C'est aussi la difficulté et l'angle mort de la prévention des épidémies, au centre. La période d'incubation des bactéries virales est longue, asymptomatique ou légère, se transforme lentement en nouveau coronavirus, érode les voies respiratoires et les poumons, et n'est pas facile à détecter et à trouver, y compris la détection d'acide nucléique, etc., et sera également mal diagnostiquée et manquée. C'est également l'une des spécificités de la nouvelle pneumonie à coronavirus. █ La zoologie, la médecine vétérinaire, la médecine, la virologie, la microbiologie,; title: l'anthropologie et d'autres combinaisons interdisciplinaires sont très compliquées. Pour la prévention et le contrôle des épidémies, la prévention et le traitement de la nouvelle pneumonie à coronavirus nécessitent une recherche approfondie avant de pouvoir être comprise et clarifiée progressivement. La spécificité du nouveau coronavirus nécessite une attention particulière. █ Les médicaments anciens et nouveaux, actuellement sans médicaments et vaccins spéciaux, médicaments antiviraux, médicaments immunitaires, médicaments contre la pneumonie sévère pour les maladies infectieuses respiratoires, etc., peuvent jouer un rôle considérable et leur efficacité ne doit pas être sous-estimée. Les données cliniques montrent qu'un grand nombre de patients peuvent être traités et récupérés, et le rôle des médicaments est indispensable. █ Les complications d'une nouvelle pneumonie coronarienne nécessitent une observation et un traitement de suivi. Les patients après la rééducation doivent prendre des soins de santé protecteurs. ........................................................................................................................ Bien que l'épidémie mondiale de la nouvelle pneumonie à coronavirus se soit améliorée, de nombreux pays ont commencé à débloquer, reprendre le travail et reprendre la production, etc. La situation générale de l'épidémie a été efficacement contrôlée. La situation va généralement dans le bon sens, mais cela ne signifie pas que la maladie a été maîtrisée et que l'épidémie a été complètement supprimée et contrôlée. Au contraire, la situation épidémique mondiale est encore très compliquée et grave. Il y a encore beaucoup de personnes infectées par la maladie. Certains pays ont connu un rebond partiel de la situation épidémique, et certains pays ont encore un taux en augmentation, y compris le nombre de décès. Le nombre total de patients est supérieur à 4 millions et les décès sont supérieurs à 300 000. (Une fois les données détaillées répertoriées) Selon les dernières données épidémiques, l'épidémie s'est répétée, y compris les rapports manqués, les faux positifs, etc. Transmission invisible de patients invisibles (y compris sous certaines conditions, la génération de nouveaux virus ou pneumonie et la conversion mutuelle des infections croisées, etc. ) Dans certaines conditions environnementales, la germination et l'infection mutuelle se produiront également. (Divers virus et bactéries entre les non-coronavirus induiront également une conversion mutuelle.) Peu importe en Asie, en Amérique, en Europe, en Afrique et dans d'autres pays et régions, une prévention et un contrôle stricts sont requis. De nouveaux changements dans l'épidémie et la spécificité, la répétitivité, la dissimulation, l'infectiosité et la variabilité du nouveau coronavirus. Prendre des mesures et des méthodes plus efficaces pour empêcher l'épidémie de se reproduire et le virus de contre-attaquer. Sinon, les humains continueront de payer divers prix élevés . Le virus est nouveau et bizarre, et il constitue une grave menace pour la vie humaine. Vous ne devez pas être paralysé et baisser la garde. Ce virus est plus viable et infectieux que les autres coronavirus. À l'heure actuelle, il n'y a pas de médicaments et de vaccins spéciaux, et le taux de mortalité sera élevé. De plus, la nouvelle pneumonie à coronavirus est basée sur l'étiologie pathologique, la virologie et d'autres études, ainsi que sur un grand nombre de centaines de milliers de cas cliniques dans le monde, et sur l'analyse de près de 300 000 cas de décès. La pathologie de la nouvelle pneumonie à coronavirus est assez compliquée et le coronavirus général Les similitudes et les différences des souches, même si un nouveau vaccin est développé, et que le virus évolue ou une certaine anisotropie et double mutation isotrope ou variabilité multidirectionnelle, qui auront également une certaine gamme de résistance au vaccin. Cela montre que les; title: changements évolutifs des micro-organismes sont étroitement liés aux changements physiques et chimiques de l'ensemble de l'univers naturel, en particulier l'évolution des espèces biologiques. La lutte contre les maladies humaines est une répétition de longue haleine, pas une bataille temporaire. Il est particulièrement important de se concentrer sur les zones et les pays épidémiques. Lorsque nous reprenons le travail, reprenons la production et retournons à l'école, nous devons être prudents et nous prémunir contre les nouvelles vagues de virus, sinon le coût sera plus élevé et plus dangereux. La nouvelle pneumonie à coronavirus a frappé à plusieurs reprises, et les pays du monde entier ne devraient pas être paralysés négligemment et être très vigilants en matière de prévention et de contrôle. Les rapports officiels des médias et les annonces pertinentes de la Commission nationale de la santé de la Chine indiquent qu'il y a actuellement trois infections en Chine qui n'ont pas encore révélé la source de l'infection, à savoir Shulan City, Jilin Province, Dongxihu District, Wuhan City et Zengcheng District, Guangzhou City. (Infections invisibles de patients invisibles, etc.). Récemment, la