Concepts in medicinal chemistry
By: Marc W. Harrold, Robin M. Zavod
Contributors: Zavod, Robin M.; American Society of Health-System Pharmacists
Publisher: American Society of Health-System Pharmacists
Published: 2013
Place of publication: Bethesda, Md
Language: eng
Number of pages: 460
ISBN-13: 9781585282661
Subjects: Drug Interactions; Pharmaceutical Chemistry; Examination Questions
Description: "Medicinal chemistry is a complex topic. Written in an easy to follow and conversational style, Basic Concepts in Medicinal Chemistry focuses on the fundamental concepts that govern the discipline of medicinal chemistry as well as how and why these concepts are essential to therapeutic decisions. The book emphasizes functional group analysis and the basics of drug structure evaluation. In a systematic fashion, learn how to identify and evaluate the functional groups that comprise the structure of a drug molecule and their influences on solubility, absorption, acid/base character, binding interactions, and stereochemical orientation. Relevant Phase I and Phase II metabolic transformations are also discussed for each functional group." -- Provided by publisher
Notes: Includes bibliographical references and index.
Table of contents: title: Functional group characteristics and roles; title: Identifying acidic and basic functional groups; title: Solving pH and pKa problems; title: Salts and solubility; title: Drug binding interactions; title: Stereochemistry and drug action; title: Drug metabolism; title: Structure activity relationships and basic concepts in drug design.