Membrane transporters in drug discovery and development
Subtitle: methods and protocols
By: edited by Qing Yan
Series: Springer protocols; Methods in molecular biology -- 637; Springer protocols; Methods in molecular biology (Clifton, N.J.) -- v. 637.
Publisher: Humana
Published: 2010
Place of publication: [Clifton, N.J.]
Language: eng
Number of pages: 363
ISBN-13: 9781607616993; 9781607617006
Subjects: Carrier proteins; Membrane Transport Proteins; Methods; Drugs; Physiological transport; Drug Discovery; Laboratory Manuals
Notes: Includes bibliographical references and index.
Table of contents: title: Membrane transporters and drug development : relevance to pharmacogenomics, nutrigenomics, epigenetics, and systems biology / Qing Yan; title: Bioinformatics for transporter pharmacogenomics and systems biology : data integration and modeling with UML / Qing Yan; title: Multidrug resistance : phylogenetic characterization of superfamilies of secondary carriers that include drug exporters / Ming Ren Yen ... [et al.]; title: Targeting drug transporters; title: combining in silico and in vitro approaches to predict in vivo / Praveen M. Bahadduri ... [et al.]; title: Methods to evaluate transporter activity in cancer / Takeo Nakanishi, Douglas D. Ross, and Keisuke Mitsuoka; title: Analysis of expression of drug resistance-linked ABC transporters in cancer cells by quantitative RT-PCR / Anna Maria Calcagno and Suresh V. Ambudkar; title: Fluorescence studies of drug binding and translocation by membrane transporters / Frances J. Sharom, Ronghua Liu, and Balpreet Vinepal; title: A model for transport studies of the blood-brain barrier / Dennis J. Bobilya; title: Genetic variants in the vesicular monoamine transporter 1 (VMAT1/SLC18A1) and neuropsychiatric disorders / Falk W. Lohoff; title: Equilibrium binding and transport by vesicular acetylcholine transporter / Parul Khare ... [et al.]; title: ABC transporters in ophthalmic disease / Corey Westerfeld; title: Imaging of protein translocation in situ in skeletal muscle of living mice / Hans P.M.M. Lauritzen; title: Glucose transporters in parasitic protozoa / Scott M. Landfear; title: NMR studies of membrane proteins / Gabriel A. Cook and Stanley J. Opella; title: Site-directed mutagenesis in the study of membrane transporters / Andra A. McKinzie, Renae M. Ryan, and Robert J. Vandenberg; title: Xenopus laevis oocytes / Stefan Bröer; title: Measurement of Intracellular pH / Frederick B. Loiselle and Joseph R. Casey; title: Measurement of plasma membrane calcium-calmodulin-dependent ATPase (PMCA) activity / Tamer M.A. Mohamed ... [et al.]; title: Assessment of the contribution of the plasma membrane calcium ATPase, PMCA, calcium transporter to synapse function using patch clamp electrophysiology and fast calcium imaging / Chris J. Roome and Ruth M. Empson.