The role of T cells in the regulation of acrolein-induced pulmonary inflammation and epithelial-cell pathology
Subtitle: with a critique by the HEI Health Review Committee
By: Michael T. Borchers ... [et al.].
Contributors: Borchers, Michael T.; Health Effects Institute
Series: Research report -- no. 146; Research report (Health Effects Institute) -- no. 146.
Publisher: Health Effects Institute
Published: 2009
Place of publication: Boston, MA
Language: eng
Number of pages: 42
Subjects: T-Lymphocytes; Acrolein; Toxicity; Epithelial Cells; Pathology; Pneumonia; Epithelial cells; T cells
Notes: "December 2009."

"Walter A. Rosenblith New Investigator Award research report."

Includes bibliographical references.
Table of contents: title: Methods. Mice; title: Acrolein exposure; title: Bronchoalveolar lavage; title: Cell and differential counts; title: Tissue fixation, histology, and immunohistochemistry; title: Quantification of mucous-cell metaplasia; title: BAL mucin assay; title: Lung-cell isolation and flow cytometry; title: T-cell purification; title: RNA isolation and amplification; title: Experimental design of microarrays; title: Microarray hybridization; title: Microarray analysis; title: Quantitative real-time PCR; title: ELISA; title: Statistical analysis; title: Results. Acrolein-induced pulmonary pathology; title: Injury to BAL epithelial cells; title: Apoptosis of pulmonary epithelial cells; title: Pulmonary inflammation; title: Levels of macrophage mediators in the lung; title: Purification of pulmonary lymphocytes; title: Microarray data; title: Cytokines and chemokines; title: Discussion and conclusions. Effects of acrolein on pulmonary pathology; title: Roles of [alpha][beta] T cells and [gamma][delta] T cells; title: Transcriptional analysis of [alpha][beta] T cells and [gamma][delta] T cells.