Osteoimmunology
Subtitle: interactions of the immune and skeletal systems
By: edited by Joseph Lorenzo ... [et al.].
Contributors: ScienceDirect (Online service)
Edition: 1st ed.
Publisher: Academic
Published: 2011
Place of publication: Amsterdam; Boston
Language: eng
Format: [electronic resource] :
ISBN-13: 9780123756701
Subjects: Immunology; Physiology; Bone
Description: Bone and the immune system are both complex tissues, which, respectively, regulate the skeleton and the body's responses to invading pathogens. It has become increasingly clear that critical interactions between these two organ systems frequently occur. This is particularly true for the development of immune cells in the bone marrow and for the function of bone cells in health and disease. However, because these two disciplines developed independently, investigators in each don't always fully appreciate the significance of the other. This book is meant to provide a detailed overview of the many ways that bone and immune cells interact. The goal is to provide basic and clinical scientists with a better understanding of the role that the immune system and bone play in the development and function of each other so that advances in both fields will be facilitated. The focus of the book will be both on basic pathways and translational science, which will apply basic knowledge to clinical diseases. Chapter content will range from basic descriptions of the various cell systems and their development to the signals that cause them to interact during normal physiology and disease. Approximately half the book will focus on the role that osteoimmunology plays in the development of human diseases. This is a rapidly developing area that is of interest to a wide spectrum of researchers, students, and fellows in immunology, rheumatology, hematology, and bone biology - all of whom need to develop a more complete understanding of their previously separate disciplines and the mechanisms by which they interact.
Notes: Includes bibliographical references and index.

Electronic reproduction. Amsterdam : Elsevier Science & Technology, 2010. Mode of access: World Wide Web. System requirements: Web browser. Title from title screen (viewed on Sep. 27, 2010). Access may be restricted to users at subscribing institutions.
Table of contents: title: Overview: The developing Field of Osteoimmunology / Yongwon Choi, Mark Horowitz, Hiroshi Takayanagi, Joseph Lorenzo; title: The Origins of Bone Cells: Osteoclasts / G. David Roodman, Deborah L. Galson; title: Adaptive Immune Response / David G. Hesslein, Hector L. Aguila, Mark C. Horowitz; title: The Role of Bone Cells in Establishing the Hematopoietic Stem Cell Niche / Henry Kronenberg, Joy Wu; title: The Signaling Pathways Regulating Osteoblast Differentiation / Jane Lian, Gary Stein; title: The Signaling Pathways Regulating Osteoclast Differentiation / Steven Teitelbaum, Roberta Faccio, Hiroshi Takayanagi, Yongwon Choi; title: The Effects of Immune Cells Products (Cytokines and Growth Factors) on Bone Cells / Joseph Lorenzo; title: Interactions of Osteoblasts and Osteoclasts / T. John Martin, Natalie A. Sims, Julian M. W. Quinn; title: The Role of the Immune System in the Development of Osteoporosis / Sundeep Khosla, B. Lawrence Riggs, Ulrike I. Moedder; title: The Role of the Immune System in the Bone Loss of Inflammatory Arthritis / Georg Schett, Steven Goldring; title: The Role of the Immune System in the Bone Loss of Inflammatory Bowel Disease / Francisco Sylvester, Anthony T. Vella; title: The Role of the Immune System in Fracture Healing / Louis Gerstenfeld, Thomas Einhorn, Brandon Steen; title: The Role of the Immune System in the Development of Chronic Infections of Bone / Brendan Boyce, Edward Schwarz, Lianping Xing; title: The Role of the Immune System in Hematologic Malignancies, which Affect Bone / Gregory Mundy, Claire M. Edwards, Jessica Fowler; title: The Role of the Immune System in Dental Disease / Dana Graves, Rayyan A. Kayal, Thomas Oates, Gustavo Garlet.