Schematikon, an encyclopedia of structural motifs in proteins.
Published: 2005
Language: eng
Number of pages: 103
Description: We have compiled a comprehensive dictionary of local structural motifs and their corresponding sequence patterns. We start from the hypothesis that frequently recurring structural patterns correspond to low energy conformations, which arise due to specific residue interactions and conformational preferences. As source data we have defined a dataset of non-homologous structures. We define and identify "motifs" as local maxima of density, by applying a procedure called "kernel density estimation". The sequence profiles for motifs with strong sequence preferences are compiled. Our encyclopedia consists of 982 motifs, over 90% of these show significant sequence preference at least one position. The average coverage of protein domains in the non-homologous dataset was found to be 65%. We have identified several of the previously described structural motifs and some novel patterns. The anticipated uses include applications in protein engineering, structure annotation, structure prediction from sequence and detailed studies of sequence-structure relationships.
Notes: Thesis (M.Sc.)--University of Toronto, 2005.

Electronic version licensed for access by U. of T. users.

Source: Masters Abstracts International, Volume: 44-01, page: 0354.

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