Current topics in developmental biology
Subtitle: Cell Surface Proteases
Contributors: Chen, Wen-Tien
Publisher: Elsevier
Published: 2003
Place of publication: Burlington
Language: eng
Format: [electronic resource] :
Number of pages: 475
ISBN-13: 9780080490885
Subjects: Cell membranes; Endopeptidases; Proteolytic enzymes; Peptide Hydrolases; Cell Membrane; Metalloendopeptidases
Description: Cell Surface Proteases provides a comprehensive overview of these important enzymes that catalyze the hydrolysis of a protein as it degrades to a simpler substance. In the 1990s, an explosion of new discoveries shed light on the role of cell surface proteases and extended it beyond degradation of extracellular matrix components to include its influence on growth factors, cell signaling, and other cellular events. This volume unites the scientific literature from across disciplines and teases out unified themes of interactions between cell surface proteases and interconnecting cell surfa.
Notes: Description based upon print version of record.

II. Cathepsin B Expression and Cancer
Table of contents: title: Front Cover; Current Topics in Developmental Biology; Copyright Page; Contents; Dedication; Contributors; Preface; Foreword; Introduction; Chapter 1. Membrane Type-Matrix Metalloproteinases (MT-MMP); I. Introduction; II. Secreted MMPs; III. Membrane Type-Matrix Metalloproteinases (MT-MMPs); IV. Summary and Concluding Remarks; References; Chapter 2. Surface Association of Secreted Matrix Metalloproteinases; I. Introduction; II. Surface Binding of MMP-9; III. Surface Binding of the Soluble Interstitial Collagenases (MMP-1 and MMP-13); IV. Surface Binding of MMP-7; V. Surface Binding of MMP-19; title: VI. Concluding Remarks. Surface Binding: A Balance between Positive and Negative Effects on Pericellular ProteolysisReferences; Chapter 3. Biochemical Properties and Functions of Membrane-Anchored Metalloprotease-Disintegrin Proteins (ADAMs); I. Introduction; II. Structural Chemistry and Biochemistry; III. Expression in Different Tissues and Regulation of Gene Expression; IV. Interactions of ADAMs with Other Extracellular and Intracellular Proteins; V. Roles in Embryogenesis and Development; VI. Roles in Disease; VII. Concluding Comments and Future Directions; References; title: Chapter 4. Shedding of Plasma Membrane ProteinsI. Introduction; II. Functional Consequences of Ectodomain Shedding; III. Proteases Involved in Ectodomain Shedding; IV. How are Substrates Selected?; V. Regulation; References; Chapter 5. Expression of Meprins in Health and Disease; I. Introduction; II. Expression and Proposed Functions of Astacin Family Members; III. Meprin Expression in Cancer; IV. Meprins in Inflammatory Diseases; V. Summary, Concluding Remarks, Future Directions; References; Chapter 6. Type II Transmembrane Serine Proteases; I. Introduction; title: II. General Features of Type II Transmembrane Serine ProteasesIII. Corin; IV. Enteropeptidase; V. Hepsin; VI. Matriptase; VII. Transmembrane Protease, Serine 2 (TMPRSS2); VIII. Transmembrane Protease, Serine 3 (TMPRSS3); IX. Transmembrane Protease, Serine 4 (TMPRSS4); X. Other Transmembrane Serine Proteases; XI. Perspective; References; Chapter 7. DPPIV, Seprase, and Related Serine Peptidases in Multiple Cellular Functions; I. Introduction; II. Structural Chemistry and Biochemistry of SIMP; III. Biologic and Pathologic Roles; IV. Conclusions and Future Directions; References; title: Chapter 8. The Secretases of Alzheimer's DiseaseI. The Amyloid Hypothesis of Alzheimer's Disease; II. ß-Secretase; III. ? -Secretase; IV. a-Secretase; V. Concluding Remarks; References; Chapter 9. Plasminogen Activation at the Cell Surface; I. Introduction; II. Structural Chemistry/Biochemistry; III. Cellular Binding Sites and the Regulation of the Plasminogen Activation System; IV. uPAR as a Regulator of Cell Migration; V. Biological and Pathological Roles; VI. Concluding Remarks; References; Chapter 10. Cell-Surface Cathepsin B: Understanding Its Functional Significance; I. Introduction