Applications of toxicogenomics in safety evaluation and risk assessment
By: edited by Darrell R. Boverhof, B. Bhaskar Gollapudi
Publisher: John Wiley & Sons
Published: 2011
Place of publication: Hoboken, N.J
Language: eng
Number of pages: 377
ISBN-13: 9780470449820; 9781118001042; 9781118008980
Subjects: Toxicogenetics; Toxicity testing; Health risk assessment; Genetic toxicology; Risk Assessment
Notes: Includes bibliographical references and index.
Table of contents: title: Toxicology, "omics" technologies, and toxicogenomics : a primer; title: Introduction to human health risk assessment; title: Practical considerations for the application of toxicogenomics to risk assessment; title: early experience, current drivers, and a path forward; title: Approaches and practical considerations for the analysis of toxicogenomics data; title: Genomics in identifying mutagenic mode of action in carcinogenesis; title: Application of genomics for predicting and understanding the mode of action for non-genotoxic carcinogens; title: Genomics in characterizing endocrine toxicity; title: Studying organ specific toxicity using gene expression profiling; title: Toxicogenomic studies in human populations; title: Toxicogenomics applied to ecological risk assessment; title: Analysis of transcriptomic dose response data for toxicology and risk assessment; title: Toxicogenomics as a tool for validating animal to human extrapolations in chemical risk assessment: concepts, applications and challenges; title: Toxicogenomics and animal alternatives; title: Toxicogenomics and the regulatory framework; title: Standardization of gene expression information for the safety evaluation; title: activities in Japan; title: Applying transcriptional profiling in drug safety evaluation; title: Reframing the risk assessment paradigm : towards a systems biology approach.