Human antibody therapeutics for viral disease
By: Scott K. Dessain, editor.
Contributors: Dessain, Scott K.
Series: Current topics in microbiology and immunology -- 317.
Publisher: Springer Verlag; Berlin; Springer
Published: 2008
Place of publication: Berlin
Language: eng
Number of pages: 188
ISBN-13: 9783540721444; 9783540721468
Subjects: Immunoglobulins; Immunoglobulins -- Therapeutic use; Virus diseases -- Treatment; Virus diseases -- Chemotherapy; Virus Diseases -- therapy; Antibodies -- therapeutic use
Description: The articles in this volume have been selected to demonstrate the progress in the development of human antibody therapeutics for viral disease. Keck et al. review the nature of the immune response to the Hepatitis C virus (HCV) and the details of viral neutralization by antibodies, providing a conceptual model for the clinical use of HCV-specific antibodies. Huber et al. summarize the initial clinical experiences with antibody therapeutics for Human Immunodeficiency Virus that can be targeted to either the HIV virion or to host cell proteins. A discussion of the breadth immune strategies that is required to control human rabies is provided by Nagarajan et al., with a particular focus on India and other countries in which rabies is endemic. The development of pavilizumab for RSV prophylaxis is reviewed in Wu et al., in addition to results of antibody optimization studies that provide surprising insights and have broad general implications for anti-viral antibody engineering. Melhop and Diamond explicate the biology of West Nile Virus as a general model for flaviviruses, while using their cloned antibodies as a springboard to consider the mechanisms of WNV neutralization. The volume concludes with a description of methods to clone human antibodies in their native configurations, which access a class of antibodies that differ from those obtained by recombinant DNA or transgenic mouse methods.
Notes: Includes bibliographical references  and index.
Table of contents: title: Therapeutic control of hepatitis C virus: the role of neutralizing monoclonal antibodies / Z. Y. Keck ... [et al.]; title: Antibodies for HIV treatment and prevention: window of opportunity? / M. Huber ... [et al.]; title: Human monoclonal antibody and vaccine approaches to prevent human rabies / T. Nagarajan ... [et al.]; title: Immunoprophylaxis of RSV infection: advancing from RSV-IGIV to palivizumab and motavizumab / H. Wu ... [et al.]; title: The molecular basis of antibody protection against West Nile virus / E. Mehlhop ... [et al.]; title: Exploring the native human antibody repertoire to create antiviral therapeutics / S. K. Dessain ... [et al.].