Protein-ligand interactions from molecular recognition to drug design
By: edited by H.-J. Böhm and G. Schneider.
Contributors: Böhm, Hans-Joachim.; Schneider, Gisbert, 1965-
Series: Methods and principles in medicinal chemistry ;; v. 19
Publisher: Wiley-VCH
Published: 2003
Place of publication: Weinheim
Language: eng
Number of pages: 242
Subjects: Proteins.; Ligands (Biochemistry); Ligand binding (Biochemistry); Ligands.; Protein Binding.; Drug Design.; Models, Molecular.
Description: The lock-and-key principle formulated by Emil Fischer as early as the end of the 19th century has still not lost any of its significance for the life sciences. The basic aspects of ligand-protein interaction may be summarized under the term 'molecular recognition' and concern the specificity as well as stability of ligand binding. Molecular recognition is thus a central topic in the development of active substances, since stability and specificity determine whether a substance can be used as a drug. Nowadays, computer-aided prediction and intelligent molecular design make a large contribution.
Notes: Includes bibliographical references and index.