Partition Models for Variable Selection and Interaction Detection
Contributors: Liu, Jun S.; Liu, Jun S.; Bulyk, Martha L.; Blitzstein, Joseph K.
Published: 2013
Language: eng
Description: Variable selection methods play important roles in modeling high-dimensional data and are key to data-driven scientific discoveries. In this thesis, we consider the problem of variable selection with interaction detection. Instead of building a predictive model of the response given combinations of predictors, we start by modeling the conditional distribution of predictors given partitions based on responses. We use this inverse modeling perspective as motivation to propose a stepwise procedure for effectively detecting interaction with few assumptions on parametric form. The proposed procedure is able to detect pairwise interactions among p predictors with a computational time of O(p) instead of O(p2) under moderate conditions. We establish consistency of the proposed procedure in variable selection under a diverging number of predictors and sample size. We demonstrate its excellent empirical performance in comparison with some existing methods through simulation studies as well as real data examples.
Notes: Keywords: Hierarchical models, Inverse models, Quantitative trait loci, Sliced inverse regression, Sure independence screening, Transcriptional regulation.

Thesis Ph.D. Harvard University 2013