Hidden Markov Models Predict Epigenetic Chromatin Domains
Contributors: Yuan, Guo-Cheng; Quackenbush, John; Huttenhower, Curtis
Published: 2012
Language: eng
Description: Epigenetics is an important layer of transcriptional control necessary for cell-type specific gene regulation. We developed computational methods to analyze the combinatorial effect and large-scale organizations of genome-wide distributions of epigenetic marks. Throughout this dissertation, we show that regions containing multiple genes with similar epigenetic patterns are found throughout the genome, suggesting the presence of several chromatin domains.
Notes: Keywords: Chromatin, Chromatin Domains, Epigenetics, Hidden Markov Models, Histone Modifications.

Thesis Ph.D. Harvard University 2012