Drug targets in kinetoplastid parasites
By: edited by Hemanta K. Majumder.
Contributors: Majumder, Hemanta K.
Series: Advances in experimental medicine and biology -- v. 625
Publisher: Springer Science+Business Media; Landes Bioscience
Published: 2008
Place of publication: New York; Austin, Tex
Language: eng
Number of pages: 157
ISBN-13: 9780387775692
Subjects: Antiprotozoal agents; Drug targeting; Leishmaniasis -- Chemotherapy; Kinetoplastida; Leishmaniasis -- drug therapy; Membrane Glycoproteins -- drug effects; Protozoan Proteins -- drug effects
Description: If viewed globally, the parasitic diseases pose an increasing threat to human health and welfare. The diseases caused by kinetoplastid protozoan parasites like Leishmania and Trypanosoma continue as a cause of suffering for many millions of people in both tropical and subtropical regions of the world. Leishmania species are found throughout Latin America, Africa and Asia. Trypanosoma cruzi that cause Chagas disease is endemic in Latin America, while members of Trypanosoma brucei group are found in sub-Saharan Africa. Although the past two decades has witnessed commendable research efforts and technical advances in our understanding of the biochemistry, molecular and cell biology of these pathogens, the dreaded protozoal diseases caused by these organisms threaten mankind. Therapeutic tools for the treatment of most parasitic diseases are extremely limited. The development of parasites resistant to many of the available drugs is also responsible for the depressing picture of d.
Notes: Includes bibliographical references and index.
Table of contents: title: Arsenite resistance in leishmania and possible drug targets / Gaganmeet Singh, K.G. Jayanarayan, Chinmoy S. Dey; title: Unique characteristics of the kinetoplast DNA replication machinery provide potential drug targets in  trypanosomatids / Dotan Sela ... [et al.]; title: Drugs and transporters in kinetoplastid protozoa / Scott M. Landfear; title: Selective lead compounds against kinetoplastid tubulin / R.E. Morgan and K.A. Werbovetz; title: Fishing for anti-leishmania drugs: principles and problems / Emanuela Handman ... [et al.]; title: Sterol 14-demethylase inhibitors for trypanosoma cruzi infections / Frederick S. Buckner; title: Histone deacetylases / David Horn; title: Targeting  glycoproteins or glycolipids and their metabolic pathways for antiparasite therapy / Sumi Mukhopadhyay nee Bandyopadhyay and Chitra Mandal; title: DNA topoisomerases of leishmania: the potential targets for anti-leishmanial therapy / Benu Brata Das, Agneyo Ganguly and Hemanta K. Majumder; title: Antiparasitic chemotherapy: tinkering with the purine salvage pathway / Alok Kumar Datta, Rupak Datta and Banibrata Sen; title: Searching the tritryp genomes for drug targets / Peter J. Myler; title: Purine and pyrimidine metabolism in leishmania / Nicola S. Carter ... [et al.].