Skin sensitization in chemical risk assessment.
Contributors: World Health Organization.; International Program on Chemical Safety.; International Labour Organisation.; United Nations Environment Programme.; Inter-Organization Programme for the Sound Management of Chemicals.
Series: Harmonization Project document -- no. 5; Harmonization Project document -- no. 5.
Publisher: World Health Organization
Published: 2008
Place of publication: Geneva, Switzerland
Language: eng
Number of pages: 85
ISBN-13: 9789241563604
Subjects: Chemicals -- Physiological effect; Hazardous substances -- Risk assessment; Skin tests; Toxicology; Health risk assessment; Dermatitis, Contact -- physiopathology; Hazardous Substances -- toxicity; Risk Assessment -- methods; Skin Tests -- methods; Dermatite; Alergia e imunologia
Description: This publication presents the conclusions of an IPCS Workshop on Skin Sensitization in Chemical Risk Assessment. The workshop focused on the question of methods for dose-response assessment, to evaluate the relative ability of a chemical to induce sensitization in the skin, and hence inform risk assessment for humans. In addition this publication includes a series of short articles on this topic by leading experts in the field. The conclusions of the workshop cover such aspects as the nature and utility for risk assessment of the data produced by non-animal test methods (such as quantitative structure-activity relationships), in vitro testing approaches, animal test methods, and epidemiological studies. While traditional animal test methods used for identification and regulation of skin sensitizers have focused on determining whether or not a substance is a sensitizer, this report describes the use of tests for deriving more informative potency information.--Publisher's description.
Notes: "IPCS International Programme on Chemical Safety"--Cover.

"This project was conducted within the IPCS project on the Harmonization of Approaches to the Assessment of Risk from Exposure to Chemicals."

"Published under the joint sponsorship of the World Health Organization, the International Labour Organization and the United Nations Environment Programme, and produced within the framework of the Inter-Oganization Programme for the Sound Management of Chemicals."

Includes bibliographical references.

Also available online.
Table of contents: title: Skin sensitization in chemical risk assessment : report of a WHO/IPCS international workshop focusing on dose-response assessment / H. Van Loveren, ... [et al.].