The influence of CYP2A6 and CYP2B6  genotypes on smoking behaviour in adolescents.
Published: 2004
Language: eng
Number of pages: 129
Description: The CYP2A6 and CYP2B6 genes are involved in nicotine metabolism in humans. The role of CYP2A6 and  CYP2B6 genotypes in smoking behaviour has not been examined in adolescents. We investigated the effect of CYP2A6 genotypes on the risk of becoming nicotine dependent, the effect of a CYP2B6 variant (C1459T) on cigarette cravings and the effects of both on the amount smoked. We found that adolescents with one or more of CYP2A6*2 or  *4 were at increased risk of becoming nicotine dependent and while not significant, there was a trend towards smoking less compared to those homozygous for CYP2A6*1. The C1459T variant tended to increase cigarette cravings in males and decrease cigarette cravings in females, although neither observation reached significance. The C1459T variant did not significantly increase smoking among all subjects and within each gender. These data indicate that CYP2A6 and CYP2B6 genotypes may influence different aspects of adolescent smoking.
Notes: Adviser:  R. F. Tyndale.

Thesis (M.Sc.)--University of Toronto, 2004.

Electronic version licensed for access by U. of T. users.

Source: Masters Abstracts International, Volume: 43-03, page: 0832.

MICR copy on microfiche (2 microfiches).