Genetic alteration of anxiety and stress like behavior in mice lacking CaMKIV.
Published: 2006
Language: eng
Number of pages: 77
ISBN-13: 9780494213810
Description: Calcium-calmodulin-dependent protein kinase IV (CaMKIV) phosphorylates the major transcription factor cyclic AMP-response element binding protein (CREB), which plays a role in emotional behavior. Here, CaMKIV knockout (KO) mice were tested in a battery of stress and anxiety-related behavioral tests, to determine if CaMKIV plays a role in emotional behavior. CaMKIV KO mice exhibited a decrease in anxiety-like behavior in both the elevated plus maze and dark-light emergence tests when compared to wild-type mice. Both the acoustic startle response and prepulse inhibition of startle were decreased with the deletion of CaMKIV. In addition, CaMKIV KO mice displayed a lack of stress-induced analgesia following restraint or cold swim stress. Our results demonstrate a key role for CaMKIV in anxiety and stress-related behavior.
Notes: Source: Masters Abstracts International, Volume: 45-03, page: 1391.

Thesis (M.Sc.)--University of Toronto, 2006.

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