role of 5-HT2A vs. 5-HT2C receptor subtypes in haloperidol-induced dyskinetic effects.
Published: 2006
Language: eng
Number of pages: 91
ISBN-13: 9780494213506
Description: Acute and chronic administration of typical antipsychotic (AP) drugs indures extrapyramidal side effects (EPS) and tardive dyskinesia (TD), respectively. Serotonin 5-HT2A/2C receptors have been suggested to modulate these side effects, but the specific contribution of each 5-HT2 subtype (5-HT2A vs. 5-HT2C) has not been determined. In the first study, acute co-administration of haloperidol (HAL) with 5-HT2A  or 5-HT2C receptor antagonist did not produce a clozapine-like  c-fos induction pattern in the brain, whereas blocking 5-HT 2C, but not 5-HT2A, receptors attenuated HAL-Induced catalepsy in a dose-dependent manner. In a separate study, chronic HAL altered 5-HT 2C receptor mRNA levels in specific brain areas, while 5-HT2A receptor mRNA levels were unaltered in any region. Chronic HAL Induced higher vacuous chewing movements (VCMs) in males than in females suggesting that this model may not be a good representative of the human female vulnerability to TD. Blocking 5-HT2A or 5-HT2C attenuated HAL-Induced VCMs in males, but not in females. Considering all the data, selective 5-HT 2C blockade may be a strategy of choice for countering both acute and chronic dyskinesic effects of APs.
Notes: Source: Masters Abstracts International, Volume: 45-03, page: 1474.

Thesis (M.Sc.)--University of Toronto, 2006.

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