Elastin-like polypeptide coated coronary artery stents.
Published: 2006
Language: eng
Number of pages: 108
ISBN-13: 9780494160787
Description: While stent implantation is one of the most effective methods of treating coronary artery disease, restenosis typically occurs at rates of 15-20% and is due primarily to thrombus formation and neointimal hyperplasia. Elastin, an insoluble cross-linked extracellular matrix protein, as well as small recombinant elastin-like polypeptides (ELPs), have been shown to inhibit platelet activation and degranulation, and to limit platelet adhesion. In this work, a method of coating stainless steel coronary artery stents with ELPs was developed by utilizing their ability to be cross-linked and coacervated. The  in vitro platelet response to these coated stents was evaluated in both whole blood and platelet-rich plasma. While ELP coatings appeared to slightly lower both platelet-derived microparticle generation and P-selectin expression, no statistical significance could be attached to these effects. While platelet and cell adhesion to uncoated stent section was minimal, this adhesion was prevented in the presence of a cross-linked ELP stent coating.
Notes: Source: Masters Abstracts International, Volume: 44-06, page: 2884.

Thesis (M.A.Sc.)--University of Toronto, 2006.

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