An evaluation of healing in critical sized rabbit calvarial defects using modified bone substitutes.
Published: 2004
Language: eng
Number of pages: 101
Description: Limitations of autogenous bone have led to the development of bone substitutes. This study evaluated whether the use of LactosorbRTM and/or calcium phosphate cements as carriers for these osteoinductive materials would allow for bone regenerative.This investigation attempted to address the issues of providing immediate protection of the brain while at the same time allowing for progressive filling of the defect with bone using two strategies. The combination of Lactosorb RTM and DBM putty demonstrated defect closure identical to the autogenous bone control group. These results suggest that these novel combinations of bone regenerative substitutes have the ability to replace our dependence on autogenous bone grafting.Thirty rabbits were divided into 3 groups. Group 1 had autogenous bone placed in one defect while the other defect remained unfilled. Group 2 had one defect filled with DBM putty and the other remained empty while a Lactosorb RTM covered both defects. Group 3 had MimixRTM, a calcium phosphate cement, placed in one defect while the other was filled with CPC/BMP.
Notes: Adviser: Cameron Clokie.

Thesis (M.Sc.)--University of Toronto, 2004.

Electronic version licensed for access by U. of T. users.

Source: Masters Abstracts International, Volume: 43-03, page: 0812.

MICR copy on microfiche (2 microfiches).