Childhood leukemias
By: edited by Ching-Hon Pui.
Contributors: Pui, Ching-Hon, 1951-
Edition: 2nd ed.
Publisher: Cambridge University Press
Published: 2006
Place of publication: Cambridge
Language: eng
Number of pages: 960
Subjects: Leukemia in children; Leukemia; Child; Infant
Description: Childhood leukemias represent nearly one third of all cancers in children and present a unique challenge to oncologists, pediatricians, hematologists, and other health professionals. The editor has assembled an expert team of authors to develop the most comprehensive, clinically-oriented, and authoritative reference dedicated to these diseases. The volume moves from the laboratory bench to the patient bedside in four easily-accessible sections: introductory chapters (including an interesting account of the historical development of treatment of leukemia and a clear review of the epidemiology and causes of leukemia in children), cell biology and pathobiology, evaluation and treatment, and complications and aspects of supportive care. .
Notes: Previous ed.: 1999.

Includes bibliographical references and index.
Table of contents: title: History and general issues. Historical perspective / Donald Pinkel. Diagnosis and classification / Mihaela Onciu and Ching-Hon Pui. Epidemiology and etiology / Logan G. Spector ... [et al.]; title: Cell biology and pathobiology. Anatomy and physiology of hematopoiesis / Connie J. Eaves and Allen C. Eaves. Hematopoietic growth factors / James N. Ihle. Signal transduction in the regulation of hematopoiesis / James N. Ihle. Immunophenotyping / Fred G. Behm. Immunoglobulin and T-cell receptor gene rearrangements / Jacques J.M. van Dongen and Anton W. Langerak. Cytogenetics of acute leukemias / Susana C. Raimondi. Molecular genetics of acute lymphoblastic leukemia / Adolfo A. Ferrando, Jeffrey E. Rubnitz, and A. Thomas Look. Molecular genetics of acute myeloid leukemia / Robert B. Lorsbach and James R. Downing. Apoptosis and chemoresistance / Kirsteen H. Maclean and John L. Cleveland. Heritable predispositions to childhood hematologic malignancies / Doan Le, Kevin Shannon, and Beverly J. Lange; title: Evaluation and treatment. Pharmacokinetic, pharmacodynamic, and pharmacogenetic considerations / Shinji Kishi, William E. Evans, and Mary V. Relling. Assays and molecular determinants of cellular drug resistance / Monique L. den Boer and Rob Pieters. Acute lymphoblastic leukemia / Ching-Hon Pui. Relapsed acute lymphoblastic leukemia / Günter Henze and Arend von Stackelberg. B-cell acute lymphoblastic leukemia and Burkitt lymphoma / John T. Sandlund and Ian T. Magrath. Acute myeloid leukemia / Jeffrey E. Rubnitz, Bassem I. Razzouk, and Raul C. Ribeiro. Relapsed acute myeloid leukemia / Ursula Creutzig. Myelodysplastic syndrome / Henrik Hasle. Chronic myeloproliferative disorders / Charlotte M. Niemeyer and Franco Locatelli. Hematopoietic stem cell transplantation / Rupert Handgretinger, Victoria Turner, and Raymond Barfield. Acute leukemia in countries with limited resources / Raul C. Ribeiro, Scott C. Howard, and Ching-Hon Pui. Antibody-targeted therapy / Eric L. Sievers and Irwin D. Bernstein. Adoptive cellular immunotherapy / Helen E. Heslop and Cliona M. Rooney. Gene transfer: methods and applications / Martin Pulé and Malcolm K. Brenner. Minimal residual disease / Dario Campana, Andrea Biondi, and Jacques J.M. van Dongen; title: Complications and supportive care. Acute complications / Scott C. Howard, Raul C. Ribeiro, and Ching-Hon Pui. Late complications after leukemia therapy / Melissa M. Hudson. Therapy-related leukemias / Carolyn A. Felix. Infectious disease complications in leukemia / Jeremy A. Franklin and Patricia M. Flynn. Hematologic supportive care / Fariba Navid and Victor M. Santana. Pain management / Alberto J. de Armendi and Doralina L. Anghelescu. Psychosocial issues / Raymond K. Mulhern, Sean Phipps, and Vida L. Tyc. Nursing care / Pamela S. Hinds, Jami S. Gattuso, and Belinda N. Mandrell.