Animal models
Subtitle: their value in predicting drug efficacy and toxicity
Series: Annals of the New York Academy of Sciences -- v. 1245; Annals of the New York Academy of Sciences -- v. 1245.
Publisher: Published by Blackwell Pub. on behalf of the New York Academy of Sciences
Published: 2011
Place of publication: Boston, Mass
Language: eng
Number of pages: 64
ISBN-13: 9781573318754
Subjects: Diseases; Drugs; Testing; Animal Disease Models; Animal models; Congresses; Animal models in research; Toxicology; Effectiveness; Drug Toxicity; Preclinical Drug Evaluation
Description: "The Global Medical Excellence Cluster (GMEC) and the New York Academy of Sciences, in collaboration with Imperial College London and King's College London, sponsored the conference "Animal Models and Their Value in Predicting Drug Efficacy and Toxicity." The goal was to provide a neutral forum to critically examine and discuss the traditional role of pre-clinical animal models in drug discovery, and how these models most effectively contribute to translational medicine and therapeutic development. International, multi-disciplinary clinical and basic science investigators convened to discuss and identify changes needed to increase the predictive power of various models for drug efficacy and toxicity in humans, and ways in which to further refine, reduce, and replace animal models in biomedical research in areas such as metabolic and cardiovascular disease, inflammation, pain. Other topics discussed included new technologies in bioimaging, biosimulation, bioinformatics, the generation of genetically modified animals, phenotype screening, alternatives to rodent models, the use of embryonic stem cells, patient-specific induced pluripotent stem cells, and humanized animal models. This volume presents a collection of short papers on some of the topics discussed at this important conference"--Publisher's description.
Notes: "Animal Models and Their Value in Predicting Drug Efficacy and Toxicity, September 15-16, 2011, The New York Academy of Sciences"--Publisher webpage.

Includes bibliographical references.
Table of contents: title: Have animal models of disease helped or hindered the drug discovery process? / Ann Jacqueline Hunter; title: Current models and strategies in the development of antiobesity drugs / James S. Kinsey-Jones and Kevin G. Murphy; title: Relevance of angiotensin II-induced aortic pathologies in mice to human aortic aneurysms / Dennis Bruemmer ... [et al.]; title: Novel, nonreflex tests detect analgesic action in rodents at clinically relevant concentrations / Nick Andrews ... [et al.]; title: Animal welfare and the 3Rs in European biomedical research / Dominic J. Wells; title: Best practices for the use of animals in toxicological research and testing / William S. Stokes; title: Progress toward generating informative porcine biomedical models using induced pluripotent stem cells / Franklin West and Steven Stice; title: A knockout mouse resource for the biomedical research community / K.C. Kent Lloyd; title: Minimizing strain influences in a genetically modified mouse phenotyping platform / Michael D. Hayward, Olesia Buiakova, and David S. Grass; title: The blessings and curses of C57BL/6 substrains in mouse genetic studies / Camron D. Bryant; title: Modeling inflammation and microvascular dysfunction / Felicity N.E. Gavins; title: TRPV1 and TRPA1 channels in inflammatory pain : elucidating mechanisms / Susan D. Brain; title: Imaging of endocrine gene expression in a humanized transgenic rat / Julian R.E. Davis; title: Systems biology of the heart : hype or hope? / T. Alexander Quinn and Peter Kohl; title: Is it time for in silico simulation of drug cardiac side effects? / Gary R. Mirams and Denis Noble; title: Human stem cell-derived cardiomyocytes for pharmacological and toxicological modeling / Sian E. Harding; title: Humanized mice as a preclinical tool for infectious disease and biomedical research / Leonard D. Shultz ... [et al.]; title: Humanized mice for the study of type 1 and type 2 diabetes / Dale L. Greiner ... [et al.]; title: Deconstructing hepatitis C virus infection in humanized mice / Marcus Dorner and Alexander Ploss; title: Animal models got you puzzled? : think pig / Eric M. Walters ... [et al.].