Elastic Filaments of the Cell (Advances in Experimental Medicine and Biology)
Contributors: H.L. Granzier (Editor); Gerald H. Pollack (Editor)
Edition: 1 edition
Series: Advances in Experimental Medicine and Biology  Volume 481
Publisher: https://link.springer.com/book/10.1007/978-1-4615-4267-4
Published: August 31, 2000
Language: eng
Format: Hardcover
Number of pages: 436
ISBN-13: 9780306464102; 9781461369165; 9781461542674
Subjects: Cellular biology; Science/Mathematics; Life Sciences - Biology - Molecular Biology; Cytology; Science; Myofibroblasts; Life Sciences - Cytology; Biochemistry; Medical-Biochemistry; Science / Biochemistry; Science / Cytology; Science-Life Sciences - Biology - Molecular Biology; Congresses; Cytoplasmic filaments; Intermediate filament proteins; Muscle contraction
First sentence: PREFACE
This volume contains the proceedings of the conference Elastic Filaments of
the Cell, held June 16-19,1999, on the campus of the University of Washington
(Seattle, WA).
Description: from Springer

Elastic filaments refer mainly to titin, the largest of all known proteins. Titin was discovered initially in muscle cells, where it interconnects the thick filament with the Z-line. Titin forms a molecular spring that is responsible for maintaining the structural integrity of contracting muscle, ensuring efficient muscle contraction. More recently, it has become clear that titin is not restricted to muscle cells alone. For example, titin is found in chromosomes of neurons and also in blood platelets. This topic is fast becoming a focal point for research in understanding viscoelastic properties at the molecular, cellular, and tissue levels. In titin may lie a generic basis for biological viscoelasticity. It has become clear that titin may hold the key to certain clinical anomalies. For example, it is clear that titin-based ventricular stiffness is modulated by calcium and that titin is responsible for the altered stiffness in cardiomyopathies. It is also clear from evidence from a group of Finnish families that titin mutations may underlie some muscular dystrophies and that with other mutations chromatids fail to separate during mitosis. Thus, it is clear that this protein will have important clinical implications stemming from its biomechanical role. One aspect of this field is the bringing together of bioengineers with clinical researchers and biologists. Genetic and biochemical aspects of titin-related proteins are being studied together with front-line engineering approaches designed to measure the mechanics of titin either in small aggregates or in single molecules.
Notes: https://doi.org/10.1007/978-1-4615-4267-4
Table of contents: title: Front Matter; title: Pages i-ix; title: PDF; title: Elastic Filaments of The Cell; title: Front Matter; title: Pages 1-1; title: PDF; title: Elastic Filaments of the Cell; title: Connecting Filaments: A Historical Prospective; title: Károly Trombitás; title: Pages 1-23; title: Connectin: From Regular to Giant Sizes of Sarcomeres; title: Koscak Maruyama, Sumiko Kimura; title: Pages 25-33; title: Molecular Tools for the Study of Titin’s Differential Expression; title: Thomas Centner, Francoise Fougerousse, Alexandra Freiburg, Christian Witt, Jacque S. Beckmann, Henk Granzier et al.; title: Pages 35-52; title: Sequence and Mechanical Implications of Titin’s PEVK Region; title: Marion L. Greaser, Seu-Mei Wang, Mustapha Berri, Paul Mozdziak, Yashiyuki Kumazawa; title: Pages 53-66; title: Probing the Functional Roles of Titin Ligands in Cardiac Myofibril Assembly and Maintenance; title: Abigail S. McElhinny, Siegfried Labeit, Carol C. Gregorio; title: Pages 67-88; title: Assembly of Myofibrils in Cardiac Muscle Cells; title: Joseph W. Sanger, Joseph C. Ayoob, Prokash Chowrashi, Daniel Zurawski, Jean M. Sanger; title: Pages 89-110; title: Molecular Mechanism of Elasticity; title: Front Matter; title: Pages 111-111; title: PDF; title: Mechanical Manipulation of Single Titin Molecules with Laser Tweezers; title: Miklós S. Z. Kellermayer, Steven Smith, Carlos Bustamante, Henk L. Granzier; title: Pages 111-128; title: Unfolding Forces of Titin and Fibronectin Domains Directly Measured by AFM; title: Matthias Rief, Mathias Gautel, Hermann E. Gaub; title: Pages 129-141; title: Computer Modeling of Force-Induced Titin Domain Unfolding; title: Hui Lu, André Krammer, Barry Isralewitz, Viola Vogel, Klaus Schulten; title: Pages 143-162; title: Extensibility in the Titin Molecule and its Relation to Muscle Elasticity; title: Larissa Tskhovrebova, John Trinick; title: Pages 163-178; title: Titin Elasticity in the Context of the Sarcomere: Force and Extensibility Measurements on Single Myofibrils; title: Wolfgang A. Linke; title: Pages 179-206; title: Titin-Like Proteins; title: Front Matter; title: Pages 207-207; title: PDF; title: Links in the Chain: The Contribution of Kettin to the Elasticity of Insect Muscles; title: Belinda Bullard, David Goulding, Charles Ferguson, Kevin Leonard; title: Pages 207-220; title: Titin as a Chromosomal Protein; title: Cristina Machado, Deborah J. Andrew; title: Pages 221-236; title: Role of the Elastic Protein Projectin in Stretch Activation and Work Output of Drosophila Flight Muscles; title: Jim O. Vigoreaux, Jeffrey R. Moore, David W. Maughan; title: Pages 237-250; title: Drosophila Projectin: A Look at Protein Structure and Sarcomeric Assembly; title: Agnes Ayme-Southgate, Richard Southgate, Michelle Kulp McEliece; title: Pages 251-264; title: Role of Titin in Nonmuscle and Smooth Muscle Cells; title: Thomas C. S. Keller III, Kenneth Eilertsen, Mark Higginbotham, Steven Kazmierski, Kyoung-Tae Kim, Michaella Velichkova; title: Pages 265-281; title: .; title: .; title: Functional Role of Elastic Filaments; title: Front Matter; title: Pages 283-283; title: PDF; title: Mechanical Properties of Titin Isoforms; title: Henk Granzier, Michiel Helmes, Olivier Cazorla, Mark McNabb, Dietmar Labeit, Yiming Wu et al.; title: Pages 283-304; title: Intact Connecting Filaments Change Length in 2.3-nm Quanta; title: Felix Blyakhman, Anna Tourovskaya, Gerald H. Pollack; title: Pages 305-318; title: Titin-Thin Filament Interaction and Potential Role in Muscle Function; title: Jian-Ping Jin; title: Pages 319-335; title: Is Titin the Length Sensor in Cardiac Muscle? Physiological and Physiopathological Perspectives; title: Jean-Yves Le Guennec, Olivier Cazorla, Alain Lacampagne, Guy Vassort; title: Pages 337-351; title: Ca2+-Dependence of Passive Properties of Cardiac Sarcomeres; title: Bruno D. Stuyvers, Masahito Miura, Henk E. D. J. ter Keurs; title: Pages 353-370; title: Possible Contribution of Titin Filaments to the Compliant Series Elastic Component in Horseshoe Crab Skeletal Muscle Fibers; title: Haruo Sugi, Tsuyoshi Akimoto, Takakazu Kobayashi, Suechika Suzuki, Mitsuyo Shimada; title: Pages 371-382; title: Skeletal Muscle-Specific Calpain, p94, and Connectin/Titin: Their Physiological Functions and Relationship to Limb-Girdle Muscular Dystrophy Type 2A; title: Hiroyuki Sorimachi, Yasuko Ono, Koichi Suzuki; title: Pages 383-404; title: From Connecting Filaments to Co-Expression of Titin Isoforms; title: Károly Trombitás, Alexandra Freiburg, Marion Greaser, Siegfried Labeit, Henk Granzier; title: Pages 405-418; title: Back Matter; title: Pages 419-425; title: -; title: .