Oxygen/nitrogen radicals
Subtitle: lung injury and disease
By: edited by Val Vallyathan, Xianglin Shi, Vincent Castranova.
Contributors: Vallyathan, Val.; Shi, Xianglin, Ph. D.; Castranova, Vincent.
Series: Lung biology in health and disease -- v. 187.
Publisher: Marcel Dekker, Inc.; Brand: CRC Press; Informa Healthcare
Published: 2004
Place of publication: New York
Language: eng
Number of pages: 529
Subjects: Lungs -- Pathophysiology.; Active oxygen -- Pathophysiology.; Active nitrogen -- Pathophysiology.; Free radicals (Chemistry) -- Pathophysiology.
Description: (Publisher-supplied data) The first state-of-the-art book dealing specifically with lung injury induced by oxygen and nitrogen radicals, this detailed treatise discusses molecular, cellular, and mechanistic events leading to pathophysiological outcomes; the role of oxidant species in the induction of these events; and potential therapeutic avenues targeting such molecular pathways. Important issues regarding oxidative stress involvement in the initiation and progression of pulmonary diseases-including diseases caused by occupational and environmental inhalation of toxicants-are discussed in the context of amelioration by antioxidants.
Notes: Includes bibliographical references and index.
Table of contents: title: 1. Reactive oxygen/nitrogen species : generation and reactions in the lung; title: 2. Oxidative stress/antioxidant status in health and disease; title: 3. Reactive oxygen species in the activation and regulation of intracellular signaling events; title: 4. Mediators of lung inflammation : role of reactive oxygen and nitrogen species; title: 5. Pulmonary complications of chronic granulomatous disease; title: 6. Genotoxic and carcinogenic mechanisms of mineral fibers : role of reactive oxygen species; title: 7. Influence of mineral dust surface characteristics and generation of reactive species; title: 8. Oxygen/nitrogen radicals and silica-induced diseases; title: 9. Asbestosis and asbestos-related cancers : role of reactive oxygen and nitrogen species; title: 10. Interactions of exogenous or evoked reactive oxygen species and inhaled particles in the lung; title: 11. Smoking-induced inflammation, injury and disease : molecular mechanisms; title: 12. Respiratory health effects of ambient air pollution particles : role of reactive species; title: 13. Ozone-induced lung injury : role of macrophages and inflammatory mediators; title: 14. Oxidative stress in chronic obstructive pulmonary disease; title: 15. Chronic obstructive pulmonary disease : mechanisms of disease development and prevention strategies with antioxidants; title: 16. Acute respiratory distress syndrome and oxidative stress : mechanisms of disease development and opportunities for antioxidant prevention; title: 17. Asthma and oxidative stress; title: 18. Cellular responses of the lungs to hyperoxia; title: 19. Vanadium and chromium-induced cell signal transduction; title: 20. Molecular mechanisms of oxidant-induced pulmonary carcinogenesis.