Camptothecins in cancer therapy
By: edited by Val R. Adams and Thomas G. Burke.
Contributors: Burke, Thomas G., PhD.; Adams, Val R.
Series: Cancer drug discovery and development
Publisher: Humana Press
Published: 2005
Place of publication: Totowa, N.J
Language: eng
Number of pages: 460
Subjects: Camptothecin; Cancer -- Chemotherapy; Camptothecin -- therapeutic use; Neoplasms -- drug therapy; Antineoplastic Agents, Phytogenic -- therapeutic use; Camptothecin -- analogs & derivatives; Camptothecin -- pharmacology
Notes: Includes bibliographical references and index.
Table of contents: title: Mechanism of action of topoisomerase I poisons / Leroy F. Liu and Shyamal D. Desai; title: Crystallographic insight into the mechanism of drug-induced topoisomerase I DNA damage / Alex B. Burgin, Jr., Bart L. Staker, and Lance Stewart; title: Inhibitors of topoisomerase I function / Sidney M. Hecht; title: Cytotoxic mechanisms of the topoisomerase I inhibitors / Yves Pommier ... [et al.]; title: Biochemical and genetic analyses of DNA topoisomerase I-mediated DNA damage / Robert C.A.M. Van Waardenburg and Mary-Ann Bjornsti; title: Preclinical models for evaluating topoisomerase-I targeted drugs / Aarti S. Juvekar ... [et al.]; title: Mechanisms of resistance to camptothecins / Zeshaan A. Rasheed and Eric H. Rubin; title: Recent advances in camptothecin drug design and delivery strategies / Thomas G. Burke ... [et al.]; title: Clinical experience with 9-aminocamptothecin: lessons for new drug development / Chris H. Takimoto; title: Clinical studies of rubitecan (9-nitro 20(s) camptothecin) / Hilary Hewes, Judith A. Smith, and Claire Verschraegen; title: Irinotecan: current clinical status and pharmacological aspects / Laurent P. Rivory; title: Clinical experience with topotecan / Aimee K. Bence and Val R. Adams; title: The clinical development of lurtotecan: experience with water-soluble and liposomal forms / Keith T. Flaherty ... [et al.]; title: Preclinical and clinical development of dx-8951f (exatecan mesylate): a hexacyclic camptothecin analog / Eric K. Rowinsky; title: Camptothecins in the treatment of primary brain tumors / Clinton F. Stewart, Markos Leggas, and Henry S. Friedman; title: Camptothecins in the treatment of lung cancer / Pankaj Kumar ... [et al.]; title: Use of camptothecins in the treatment of leukemia and related disorders / Bejamin M.F. Mow and Scott H. Kaufmann.