Hepatotoxicity
Subtitle: from genomics to in vitro and in vivo models
By: editor, Saura C. Sahu.
Contributors: Sahu, Saura C.
Publisher: John Wiley & Sons
Published: 2007
Place of publication: Chichester, England; Hoboken, NJ
Language: eng
Number of pages: 682
ISBN-13: 9780470057162
Subjects: Hepatotoxicology.; Hepatitis, Toxic -- etiology.; Drug Evaluation, Preclinical.; Liver -- drug effects.; Models, Biological.; Toxicogenetics -- methods.
Notes: Includes bibliographical references and index.
Table of contents: value: Current in vitro models to study drug-induced liver injury / Julio C. Davila ... [et al.]; value: Utilization of an in vitro hepatotoxicity test in the early stage of drug discovery / Ikuo Horii ... [et al.]; value: Use of hepatocytes for characterizing a candidate drug's metabolism and drug interaction potential / Srikanth C. Nallani, John M. Strong, and Shiew Mei Huang; value: Human-based in vitro experimental systems for the evaluation of human drug safety / Albert P. Li; value: Hepatocytes as a model for screening food-related hepatotoxins and studying mechanisms of their toxicity / Saura C. Sahu; value: Some experimental models of liver damage / Pablo Muriel; value: Application of short- and long-term hepatocyte cultures to predict toxicities / Gregor Tuschl ... [et al.]; value: Biomarkers of mycotoxin exposure in liver toxicity / Angela J. Harris; value: Mechanisms of toxic liver injury / Nora Anderson and Jurgen Borlak; value: A role of cytochrome P450 in quinone-induced hepatotoxicity / Yasuhiro Ishihara and Norio Shimamoto; value: A mechanistic view of troglitazone hepatotoxicity / Rawiwan Maniratanachote and Tsuyoshi Yokoi; value: Role of the Kupffer cell in hepatotoxicity and hepatocarcinogenesis / James E. Klaunig ... [et al.]; value: Sinusoidal cells in liver injury and repair / Carol C. Gardner and Debra L. Laskin; value: Cytokines in liver diseases / Pablo Muriel; value: Bile acids as modulators of apoptosis / Rui E. Castro ... [et al.]; value: Drug-induced intrahepatic cholestasis by interaction with the hepatic bile salt export pump (BSEP) / Christoph Funk ... [et al.]; value: Application of toxicogenomics in predicting hepatotoxicity: potentials and challenges / Wen Lin ... [et al.]; value: Genomic profiling of liver injury / Kevin Gerrish and David E. Malarkey; value: Use of DNA arrays in understanding hepatic test systems / Angela J. Harris and Daniel A. Casciano; value: Prediction of hepatotoxicity based on the toxicogenomics database / Tetsuro Urushidani; value: Relationship between N-acetyltransferase-2 gene polymorphism and isoniazid-induced hepatotoxicity / Yasuo Shimazu, Kunio Dobashi, and Masatomo Mori; value: Human and animal-based differences in hepatic xenobiotic metabolism and toxicity / Peter J. O'Brien, Katie Chan, and Raymond J. Poon; value: Hepatotoxicity in oncology drug development / Wei Chen, Kenneth Hastings, and John K. Leighton; value: The potent rat hepatocarcinogen methapyrilene: an hypothesis regarding its hepatotoxicology / Daniel A. Casciano; value: Botanical supplements and hepatotoxicity / Shabana Khan, Ikhlas Khan, and Larry Walker; value: Physiologically based pharmokinetic modeling and risk assessment of hepatotoxicants / Kannan Krishnan.