RNA interference
Subtitle: application to drug discovery and challenges to pharmaceutical development
By: edited by Paul H. Johnson
Publisher: Wiley
Published: 2011
Place of publication: Hoboken, N.J
Language: eng
ISBN-13: 9780471771517
Description: "RNA Interference: Application to Drug Discovery and Challenges to Pharmaceutical Development provides a general overview of this rapidly emerging field, with a strong emphasis on issues and aspects that are important to a drug development team. The first part covers more general background of RNA interference and its application in drug discovery. In the second part, the book addresses siRNA (small interfering RNA), a pharmaceutically potent form, and its use and delivery in therapeutics along with manufacturing and delivery aspects"--Provided by publisher.
Notes: Includes bibliographical references and index.
Table of contents: title: (Publisher-supplied data)  RNA interference: What is it? / James A. Birchler; title: Nucleic acids as regulatory molecules / Faqing Huang, CJ Yu, and Yanlin Guo; title: Use of siRNA oligonucleotides to study gene function / Kristin A. Wiederholt and Adam N. Harris; title: Genome scanning by RNA interference / Roderick L. Beijersbergen and Oliver C. Steinbach; title: Discovery of new siRNA delivery agents / Paul H. Johnson, Diane Frank, Kunyuan Cui, Roger Adami, Harry Wang, Michael Houston, and Steven C. Quay; title: In vivo Delivery of siRNA: challenges and strategies / Aliasger K. Salem and Mark A. Behlke; title: Interferon, cytokine induction and other potential in vivo toxicities / Adam Judge, Marjorie Robbins, and Ian MacLachlan; title: Application of RNA interference to viral diseases / Ralph A. Tripp and Stephen Mark Tompkins.