PNH and the GPI-Linked Proteins
Contributors: Moss, Joel
Publisher: Elsevier
Published: 2000
Place of publication: Burlington
Language: eng
Format: [electronic resource]
Number of pages: 293
ISBN-13: 9780080492094
Subjects: Membrane proteins; Paroxysmal Hemoglobinuria; Paroxysmal hemoglobinuria; Phosphoinositides; Hemoglobinopathies; Hemoglobinopathy; Cellular signal transduction; Glycoproteins; Glycosylphosphatidylinositols
Description: Paroxysmal Nocturnal Hemoglobinuria (PNH) has been recognized for over a century. This mysterious disease is now understood at the level of the gene and the protein. The pathophysiology is related to a class of cell surface proteins with distinctive biochemical and physical characteristics. Recently it has been acknowledged that PNH is not rare, and once sensitive assays--based on the chemistry of the proteins--can be applied to many patients. Written by international experts in the field, this book includes a number of distinctive characteristics, such as the clinical features of PNH, the mec.
Notes: Description based on print version record.
Table of contents: title: Front Cover; Paroxysmal Nocturnal Hemoglobinuria and the Glycosylphosphatidylinositol- Linked Proteins; Copyright Page; Contents; Contributors; Preface; Chapter 1. A Brief History of PNH; Chapter 2. Genetics of PNH; Chapter 3. Hemolysis in PNH; Chapter 4. Thrombotic Complications in PNH; Chapter 5. Bone Marrow Failure in PNH; Chapter 6. Animal Models of PNH; Chapter 7. The Function of GPI-Anchored Proteins; Chapter 8. GPI in Lower Animals; Chapter 9. Synthesis of the GPI Anchor; Chapter 10. Functional and Structural Organization of GPI-Anchored Proteins in Cellular Membranes.