Molecular Controls over Developmental Acquisition of Diverse Callosal Projection Neuron Subtype Identities
Contributors: Macklis, Jeffrey D.; Lichtman, Jeff; Arlotta, Paola; Dowling, John; McMahon, Andy
Published: 2013
Language: eng
Description: The mammalian neocortex is an exquisite, highly organized brain structure composed of hundreds of subpopulations of neurons and glia, precisely connected to enable motor control, sensory perception, information integration, and planning. Unique molecular, structural, and anatomical neuronal properties underlie diverse functionality, endowing much of the neocortex's complex processing power. Neocortical size correlates with information processing capacity, suggesting that increased neuronal number and diversity begets increased sophistication. One excitatory projection neuron type, callosal projection neurons (CPN), has disproportionately expanded with cortical size increase.
Notes: Keywords: Callosal Projection Neurons, Mouse Genetics, Neocortex, Neuronal Development, Projection Neuron Subtypes.

Thesis Ph.D. Harvard University 2013