Functional analysis of Notch signaling during vertebrate retinal development
Contributors: Cepko, Constance; Goodrich, Lisa; Arlotta, Paola; Blacklow, Stephen; Zhong, Weimin
Published: 2012
Language: eng
Description: The process of cell fate determination, which establishes the vastly diverse set of neural cell types found in the central nervous system, remains poorly understood. During retinal development, multipotent retinal progenitor cells generate seven major cell types, including photoreceptors, interneurons, and glia, in an ordered temporal sequence. The behavior of these progenitor cells is influenced by the Notch pathway, a widely utilized signal during embryogenesis which can regulate proliferation and cell fate decisions. To
Notes: Keywords: Notch signaling, progenitor cells, retina.

Thesis Ph.D. Harvard University 2012