Effects of sulfate-rich mineral water on functional constipation
Subtitle: a double-blind, randomized, placebo-controlled study
Contributors: Sadaghiani, Catharina Verfasser; Alt, Felix Verfasser; Huber, Roman Verfasser; Interdisziplinäres Behandlungs- und Forschungszentrum (IBF) Balneologie des Universitätsklinikums Freiburg, Standort Bad Krozingen; Institut für Umweltmedizin und Krankenhaushygiene; Universitätsklinikum Freiburg; Albert-Ludwigs-Universität Freiburg Medizinische Fakultät; Albert-Ludwigs-Universität Freiburg
Publisher: Universität
Published: 2016
Place of publication: Freiburg
Language: eng
Subjects: Sulfate; Magnesium; Iatrogene Krankheit; Therapie; Compliance
Description: Abstract: Background: Magnesium sulfate has a long tradition as a laxative. It osmotically prevents water absorption in the large bowel and thus leads to an acceleration of the intestinal transit and better stool consistency. We wanted to investigate the efficacy of a carbonated calcium/magnesium sulfate-rich natural mineral water in subjects with functional constipation (FC). <br>Patients and Methods: In this double-blind, randomized, placebo-controlled study, subjects with FC (Rome III criteria) received 1 l/day (4 × 250 ml) of mineral water (Ensinger Schiller Quelle) or carbonated tap water (placebo) for 6 weeks. The primary endpoint was the change in the frequency of bowel movements per week between baseline and visit 4 (after 6 weeks). The prespecified main secondary endpoint was the change in the frequency of bowel movements per week between baseline and visit 3 (after 3 weeks). <br>Results: Efficacy was analyzed in 100 subjects (intention-to-treat). After 6 weeks of treatment there was no statistical difference between the groups (p = 0.163). However, statistical significance was reached after 3 weeks, with an increase in the frequency of bowel movements per week of 2.02 ± 2.22 for the mineral water group compared to 0.88 ± 1.67 for the placebo group (p = 0.005). <br>Conclusions: A 3-week treatment with 1 l/day of the sulfate-rich mineral water improved the frequency of bowel movements in subjects with FC compared with tap water; however, the difference was no longer significant after 6 weeks. Further evaluation in rigorously designed clinical studies will be necessary to validate the impact of sulfate-rich natural mineral water on FC
Notes: Forschende Komplementärmedizin. 23 (2016), 1-8, DOI 10.1159/000449436, issn: 1421-9999

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