Clinical trials
Subtitle: a methodologic perspective
By: Steven Piantadosi.
Edition: 2nd ed.
Series: Wiley series in probability and statistics
Publisher: Wiley-Interscience
Published: 2005
Place of publication: Hoboken, N.J
Language: eng
Number of pages: 687
Subjects: Clinical trials -- Statistical methods; Research -- methods; Clinical Trials as Topic -- methods; Statistics as Topic -- methods
Description: A straightforward and authoritative presentation of statistical methods for clinical trials. Readers are introduced to the fundamentals of design for various types of clinical trials and then skillfully guided through the complete process of planning the experiment, assembling a study cohort, assessing data, and reporting results. Throughout the process, the author alerts readers to problems that may arise during the course of the trial and provides commonsense solutions.
Notes: Includes bibliographical references  (p. 613-658 ) and indexes.
Table of contents: title: Preliminaries.; title: Clinical trials as research.; title: Why clinical trials are ethical.; title: Contexts for clinical trials.; title: Statistical perspectives.; title: Clinical trials as experimental designs.; title: Random error and bias.; title: Objectives and outcomes.; title: Translational clinical trials.; title: Dose-finding designs.; title: Sample size and power.; title: The study cohort.; title: Treatment allocation.; title: Treatment effects monitoring.; title: Counting subjects and events.; title: Estimating clinical effects.; title: Prognostic factor analyses.; title: Reporting and authorship.; title: Factorial designs.; title: Crossover designs.; title: Meta-analyses.; title: Misconduct and fraud in clinical research.; title: Appendices: A: Data and programs.; title: B: Notation and terminology.; title: C: Abbreviations.; title: D: Nuremberg Code.; title: E: Declaration of Helsinki.; title: F: NCI data and safety monitoring policy.; title: NIH data and safety monitoring policy.; title: Royal Statistical Society Code of Conduct.