Evolutionary adaptation and antimalarial resistance in Plasmodium falciparum
By: Daniel Joan Park
Published: 2013
Place of publication: June, 2013
Language: eng
Number of pages: 179
Subjects: Evolution (Biology); Natural immunity
Description: The malaria parasite, Plasmodium falciparum, has a demonstrated history of adaptation to antimalarials and host immune pressure. This ability unraveled global eradication programs fifty years ago and seriously threatens renewed efforts today. Despite the magnitude of the global health problem, little is known about the genetic mechanisms by which the parasite evades control efforts. Population genomic methods provide a new way to identify the mutations and genes responsible for drug resistance and other clinically important traits.
Notes: Submitted to: Dept. of Organismic and Evolutionary Biology.

Thesis advisor: Pardis C. Sabeti.

"July 2013."

Ph. D Harvard University 2013.

Includes bibliographical references (pages 145-278).