Identification and characterization of pufferfish, zebrafish, and chicken receptors for proglucagon-derived peptides.
Published: 2004
Language: eng
Number of pages: 231
Description: The pufferfish and zebrafish genome encodes 4 genes that are similar to receptors for proglucagon-derived peptides. 2 receptors are identified as glucagon receptors, 1 as a GIP receptor, and 1 as a GLP-2 receptor. I was unable to identify receptor genes in pufferfish and zebrafish that is most closely related to the human GLP-1 receptor. The chicken genome contains 3 receptors for proglucagon-derived peptides: glucagon, GLP-1, and the GLP-2 receptors. The tissue distribution of the chicken GLP-2 and glucagon receptors parallel the tissue distribution of their mammalian counterpart and therefore, I believe that the chicken receptors may have similar functions to their mammalian homologues. I compared the amino acid residue sequences of my predicted receptors to known receptors for proglucagon-derived peptides and propose that the pufferfish and zebrafish receptors have a broad specificity and the chicken receptors have more narrow specificity that is similar to human receptors for proglucagon-derived peptides.
Notes: Adviser:  David Irwin.

Thesis (M.Sc.)--University of Toronto, 2004.

Electronic version licensed for access by U. of T. users.

Source: Masters Abstracts International, Volume: 43-03, page: 0788.

MICR copy on microfiche (3 microfiches).