Immunological reaction in cell transplantation into the infarcted myocardium.
Published: 2004
Language: eng
Number of pages: 180
Description: Myocardial infarction is a major health problem in developed countries. Autologous cell transplantation is a promising therapeutic modality to regenerate the damaged myocardium and prevent development of congestive heart failure. The improved outcome of this technique depends on survival of implanted cells in the myocardial infarct. However, experimental data showed that only 20% of the implanted cells survived. Immune reaction could be one of the possible causes for cell loss. I hypothesized that cultured autologous/syngeneic cell transplantation into the myocardial infarct elicits adaptive immune response. My data revealed that the profile of infiltrating leukocytes into autologous/syngeneic cell implanted myocardial infarct is close to that in immune rejection of an allogeneic graft, involving leukocytes that mediate adaptive immunity. My study, for the first time, investigated immunological problems associated with autologous cell transplantation and suggested that host immune reaction may hinder success of clinical cell transplantation.
Notes: Adviser:  Ren-Ke Li.

Thesis (M.Sc.)--University of Toronto, 2004.

Electronic version licensed for access by U. of T. users.

Source: Masters Abstracts International, Volume: 43-03, page: 0816.

MICR copy on microfiche (2 microfiches).