Quantitative modeling in toxicology
By: editors, Kannan Krishnan, Melvin E. Andersen.
Contributors: Krishnan, Kannan, 1961-; Andersen, Melvin E.
Publisher: John Wiley & Sons
Published: 2010
Place of publication: Chichester, West Sussex; Hoboken
Language: eng
ISBN-13: 9780470998090
Subjects: Toxicology -- Mathematical models; Toxicology -- methods; Environmental Exposure -- adverse effects; Hazardous Substances -- toxicity; Models, Biological; Toxicity Tests -- methods
Description: "In Quantitative Modeling in Toxicology leading experts outline the current state of knowledge on the modeling of dose, tissue interactions and tissue responses. Each chapter describes the mathematical foundation, parameter estimation, challenges and perspectives for development, along with the presentation of a modeling template. Additionally, tools and approaches for conducting uncertainty, sensitivity and variability analyses in these models are described"--Provided by publisher.
Notes: Includes bibliographical references and index.
Table of contents: title: Machine generated contents note: Preface; title: About the Editors; title: About the Book; title: List of Contributors; title: Section1: Introduction; title: Chapter 1 Quantitative modeling in toxicology: An introduction; title: Melvin E. Andersen and Kannan Krishnan; title: Section2: Physiologically-based toxicokinetic and pharmacokinetic (PBPK) modeling; title: Chapter 2 PBPK modeling: a primer; title: Kannan Krishnan, George Loizou, Martin Spendiff, John Lipscomb and Melvin E. Andersen; title: Chapter 3 Pharmacokinetic modeling with Manganese - An essential element; title: Andy Nong, Michael Taylor, Miyoung Yoon, and Melvin E. Andersen; title: Chapter 4 Physiologically-based modeling of pharmacokinetic interactions in chemical mixtures; title: Sami Haddad, Robert Tardif, Jonathan Boyd, and Kannan Krishnan; title: Chapter 5 Physiological Parameters and Databases for PBPK Modeling; title: Douglas O. Johns, Elizabeth Oesterling Owens, Chad M. Thompson, Babasaheb Sonawane, Dale Hattis and Kannan Krishnan; title: Section3: Modeling toxicant-target interactions; title: Chapter 6 Modeling cholinesterase Inhibition; title: Charles Timchalk, Paul M. Hinderliter,and Torka S. Poet; title: Chapter 7 Modeling of Protein Induction and dose-dependent hepatic sequestration; title: Andy Nong and Melvin E. Andersen; title: Chapter 8 Bistable Signaling Motifs and Cell Fate Decisions; title: Sudin Bhattacharya, Qiang Zhang, and Melvin E. Andersen M.E.; title: Chapter 9 Ultrasensitive Response Motifs in Biochemical Networks; title: Qiang Zhang, Sudin Bhattacharya, Courtney G. Woods, and Melvin E. Andersen; title: Chapter 10 Gene and Protein Expression - Modeling Nested Motifs in Cellular and Tissue Response Networks; title: Melvin E. Andersen, Qiang Zhang, and Sudin Bhattacharya; title: Chapter 11 Modeling Kidney and Liver Cytotoxicity; title: Kai H. Liao, Yu-Mei Tan, Harvey J. Clewell III, and Melvin E. Andersen; title: Section4: Modeling tissue and organism responses; title: Chapter 12 Computational Model for Iodide Economy and the HPT Axis in the Adult Rat; title: Jeffrey W. Fisher and Eva D. McLanahan; title: Chapter 13 Two Stage Clonal Growth Modeling of Cancer; title: Rory B. Conolly and Melvin E. Andersen; title: Chapter 14 Statistical and Physiological Modeling of the Toxicity of Chemicals in Mixtures; title: Hisham A. El-Masri, Michael A. Lyons, and Raymond S.H. Yang; title: Chapter 15 (Q)SAR Models of Adverse Responses: Acute Systemic Toxicity; title: Mark T.D. Cronin, Yana K. Koleva, and Judith C. Madden; title: Section5: Model application and evaluation; title: Chapter 16 Modeling Exposures to Chemicals from Multiple Sources and Routes; title: Panos G. Georgopoulos, Sastry S. Isukapalli, and Kannan Krishnan; title: Chapter 17 Probabilistic Reverse Dosimetry Modeling for Interpreting Biomonitoring Data; title: Yu-Mei Tan and Harvey J. Clewell III; title: Chapter 18 Quantitative Modeling in Noncancer Risk Assessment; title: Q. Jay Zhao, Lynne Haber, Melissa Kohrman., Patricia Nance, and Michael Dourson; title: Chapter 19 Application of Physiologically Based Pharmacokinetic Modeling in Risk Assessment; title: Harvey J. Clewell III; title: Chapter 20 Uncertainty, Variability and Sensitivity Analyses in Simulation Models; title: Sastry S. Isukapalli, Martin Spendiff, Panos G. Georgopoulos and Kannan Krishnan; title: Chapter 21 Evaluation of Quantitative Models in Toxicology: Progress and challenges; title: Kannan Krishnan and Melvin E. Andersen.