The effects of folate deficiency on gene expression in human colorectal adenocarcinoma cell lines.
Published: 2005
Language: eng
Number of pages: 181
Description: Folate is a B vitamin that inversely modulates colorectal carcinogenesis. Folate status is also an important determinant in chemotherapeutic response. Mediating the transfer of one-carbon moieties is the sole biochemical function known for folate, and in this role folate plays a critical role in DNA synthesis, repair and methylation. In vitro models of folate deficiency were used to determine the effects of folate deficiency on gene expression in several human colorectal cancer cell lines. Folate deficiency altered the expression patterns of genes found to be involved in metabolism, intracellular signalling, cell cycle, DNA repair, transcriptional regulation, angiogenesis, cell adhesion, transport, and cytoskeletal organization and microtubule-based movement, in a cell-specific manner. These studies provide insight into the specific molecular targets of folate deficiency, and therefore will allow for a better understanding of the mechanism of action associated with the folate depletion-enhanced cytotoxicity on cancer cells.
Notes: Source: Masters Abstracts International, Volume: 44-02, page: 0764.

Thesis (M.Sc.)--University of Toronto, 2005.

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