Neural tube defects
Subtitle: from origin to treatment
By: edited by Diego F. Wyszynski.
Contributors: Wyszynski, Diego F.
Publisher: Oxford University Press
Published: 2006
Place of publication: Oxford; New York, NY
Language: eng
Number of pages: 399
ISBN-13: 9780195166033
Subjects: Neural tube -- Abnormalities; Neural Tube Defects
Description: Neural tube defects (NTDs) involve incomplete development of the embryonic structure that becomes the brain and spinal cord. They affect about 4,000 pregnancies a year and thus are among the most common of severe birth defects. Spina bifida and anencephaly account for 90% of them. Their incidence is dropping, however, because of the use of folic acid dietary supplements to prevent these defects. Prenatal diagnosis could now detect 70% of NTDs, but the tests produce many false positives, so the question is under what circumstances should they be recommended to pregnant women. This text provides authoritative discussions of a wide range of theoretical, experimental and clinical issues, and is divided into sections on embryology, clinical features, epidemiology, genetics, treatment and patient education, and public health.
Notes: Includes bibliographical references and index.

Includes bibliographical references and index.
Table of contents: title: Neural crest formation / Marianne Bronner-Fraser; title: The embryonic basis of neural tube defects / Nicholas D.E. Greene, Andrew J. Copp; title: The zebrafish as a model for analyzing neural tube defects / Hakryul Jo ... [et al.]; title: Genetic regulation of early nervous system development / Ellen M. Carpenter; title: Physical examination of the spine / Sergio A. Mendoza, Stuart L. Weinstein; title: Classification of neural tube defects / Cynthia A. Moore; title: Syndromes with neural tube defects / Laurie H. Seaver, Roger E. Stevenson; title: The tethered cord syndrome / Cary R. Templin, John F. Sarwark; title: Prenatal screening and diagnosis of neural tube defects / Glenn J. Gardener, Charles H. Rodeck; title: Methodological issues in the study of neural tube defects / Russell S. Kirby; title: Birth defects surveillance systems and neural tube defects / Lowell E. Sever; title: An international perspective on anencephaly and spina bifida : prevalences by the turn of the century / Rolv T. Lie; title: Studies on environmental factors in neural tube defects / Diego F. Wyszynski; title: Non-syndromic neural tube defects : genetic basis and genetic investigations / Evadnie Rampersaud, Elizabeth C. Melvin, Marcy C. Speer; title: Genetic risk factors for neural tube defects: variants in folate metabolism / Rima Rozen; title: Genetics of syndromic neural tube defects / Sonja A. Rasmussen, Jaime L. Fras; title: Mouse mutants as models of neural tube defects / Andrew J. Copp, Nicholas D. E. Greene, Jennifer N. Murdoch; title: Fetal surgery for myelomeningocele / Kelly A. Bennett ... [et al.]; title: Postnatal surgery for myelomeningocele / Jonathan P. Miller, Alan R. Cohen; title: Neurosurgical management of adults with spina bifida / Harold L. Rekate; title: Orthopedic surgery / Luciano Dias; title: Urological needs of patients with neural tube defects / David B. Joseph; title: Cognition, education, and learning disorders / Gregory S. Liptak; title: Transition to adulthood / Gregory S. Liptak; title: Transition, sex, and toilet training / David B. Shurtleff, William Walker, Carole Sobkowiak; title: Psychological adjustment and family relationships in children and adolescents with spina bifida / Rachel Neff Greenley ... [et al.]; title: When and how to communicate to people with spina bifida and their families / Sonya G. Oppenheimer; title: Genetic counseling and interpretation of risk figures / Robert A. Saul; title: Preventing all folic acid-preventable spina bifida / Godfrey P. Oakley Jr.; title: The half-life of cost-of-illness estimates : the case of spina bifida / Norman J. Waitzman, Patrick S. Romano, Scott D. Grosse; title: Insurance and coverage of care for individuals with spina bifida and other neural tube defects / Holly Grason, Jamie J. Perry; title: Assessment of health-related quality of life in individuals with neural tube defects / Jim Stevenson, Ineke M. Pit-ten Cate; title: Ethics at the forefront : moral decisions and responsibility when confronted with spina bifida / Mark J. Bliton.