Genomic insights into bacterial adaptation during infection
Contributors: Kishony, Roy; Mitchison, Timothy J.; Laub, Michael T.; Sabeti, Padis C.; Fortune, Sarah M.
Published: 2014
Language: eng
Description: Bacteria evolve during the colonization of human hosts, yet little is known about the selective pressures and evolutionary forces that shape this evolution. Illumination of these processes may inspire new therapeutic directions for combating bacterial infections and promoting healthy bacteria-host interactions. The advent of high-throughput sequencing has enabled the identification of mutations that occur within the human host, and various tools from computational and evolutionary biology can aid in creating biological understanding from these mutations. Chapter 1 describes recent progress in understanding within-patient bacterial adaption, focusing on insights made from genomic studies.
Notes: Keywords: Evolution, Genomics, Infectious disease, Microbial evolution, Microbial genomics, Systems biology.

Thesis Ph.D. Harvard University 2014