Assessment of porous calcium polyphosphate block implants in a murine model of heterotopic bone formation.
Published: 2004
Language: eng
Number of pages: 96
Description: Background. The in vitro section was undertaken to determine the kinetics of native bone morphogenetic proteins (BMPs) loaded onto a porous calcium polyphosphate material (PCPP). The  in vivo segment was conducted to determine the effectiveness of this material as a delivery system for BMPs.Conclusions. The results indicate that microcrystalline PCPP offers promise as a delivery system for BMPs.Results. In vitro: Approximately 30% of the loading dose was retained on both PCPP structures and released over a 7 day period. In vivo: Histomorphometrically, significantly more bone was present in the PCPP + BMP compared with the PCPP alone.Methods. In vitro: Nanocrystalline and microcrystalline structures of PCPP were loaded with bovine BMPs. Retention of BMPs and their release kinetics was assessed. In vivo: A muscle pouch was made bilaterally in mice muscles and implanted either with a PCPP block, a carrier-BMP combination or BMPs only. Histologic and histomorphometric assessments were performed.
Notes: Thesis (M.Sc.)--University of Toronto, 2004.

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Source: Masters Abstracts International, Volume: 43-03, page: 0811.

MICR copy on microfiche (2 microfiches).