Sensational propellers
Subtitle: novel protein functions in cilia assembly and motility
Contributors: Drummond, Iain A.; Shah, Jagesh; Pazour, Gregory; Burns, Caroline; Henske, Elizabeth
Published: 2013
Language: eng
Description: Cilia and flagella are hair-like projections found on the surface of virtually every vertebrate cell. These microtubule-based organelles are historically known for their striking motility, a valuable tool for the manipulation of fluid environments. In addition, immotile (or `primary') cilia play critical roles in cell signaling. More than ten human diseases have been linked to cilia function, with pleiotropic phenotypes including obesity, kidney and liver disease, skeletal abnormalities, situs defects, mental retardation, and sterility.
Notes: Keywords: C15orf26, C21orf59, Ccdc65, Cep290, cilia, zebrafish.

Thesis Ph.D. Harvard University 2013