Cardiotoxicity of non-cardiovascular drugs
By: editor, Giorgio Minotti.
Contributors: Minotti, Giorgio.
Publisher: Wiley
Published: 2010
Place of publication: Chichester, West Sussex
Language: eng
ISBN-13: 9780470772744
Subjects: Cardiovascular toxicology; Cardiovascular Diseases -- chemically induced; Cardiovascular System -- drug effects; Drug Toxicity
Description: "First book to deal with this important area of adverse drug reactions -- cardiotoxicity is one of the major forms of toxicity seen in drugs and it accounts for most drug recalls and delays experienced in regulatory approvals. Covers four important therapeutic classes: psychoactive drugs; anticancer drugs; non-steroidal anti-inflammatory drugs; and anti-retroviral drugs. - Emphasis on the preclinical screening of drug cardiotoxicity, to enable drug developers to test for this toxicity before starting expensive clinical trials"--Provided by publisher.
Notes: Includes bibliographical references and index.
Table of contents: title: Machine generated contents note: List of Contributors; title: 1. Mitochondrial Dysfunction In Cell Injury and Cardiotoxicity; title: Fabio Di Lisa, Martina Semenzato, Andrea Carpi, Sara Menazza, Nina Kaludercic, Roberta Menabò, Marcella Canton; title: 2. Cardiovascular Liabilities of Drugs: Regulatory Aspects; title: Claudio Arrigoni; title: 3. Cellular Mechanisms, Molecular Targets, and Structure-Function Relationships In Drug-Induced Arrhythmias: The Case Of Antihistamines, Psychoactive Drugs, and Antimicrobial Agents; title: Maria Virginia Soldovieri and Maurizio Taglialatela; title: 4. Cardiovascular Toxicity of Antitumor Drugs: Dimensions of the Problem in Children; title: Rebecca Scully, Louis Pruitt, Steven E. Lipshultz; title: 5. Cardiovascular Toxicity of Antitumor Drugs: Dimension of the Problem in Adult Settings; title: Joseph R. Carver and Chaitali J. Desai; title: 6. Diagnostic Aspects of Cardiovascular Toxicity of Antitumor Drugs; title: Michael S. Ewer, Thomas M. Suter; title: 7. Cardiovascular Toxicity of Antitumor Drugs: Translating Molecular Mechanisms into Clinical Facts; title: Pierantonio Menna, Emanuela Salvatorelli, Carlo Salsano, Luca Gianni*, and Giorgio Minotti; title: 8. NSAID Action and the Foundations for Cardiovascular Toxicity; title: Anna L. Blobaum and Lawrence J. Marnett; title: 9. Cardiovascular toxicities of NSAIDS: Epidemiologic aspects; title: Antonio González-Pe;rez, Luis Alberto Garci;a Rodriguez; title: 10. Cardiovascular Toxicities of Life-Saving Drugs: Antiviral Therapy; title: James J. Kohler & William Lewis.