SuperMEN1
Subtitle: pituitary, parathyroid and pancreas
By: edited by Katalin Balogh, Attila Patocs.
Contributors: Balogh, Katalin, 1977-; Patocs, Attila, 1973-
Series: Advances in experimental medicine and biology -- v. 668; Advances in experimental medicine and biology -- v. 668.
Publisher: Springer Science+Business Media; Landes Bioscience
Published: 2009
Place of publication: New York; Austin, Tex
Language: eng
Number of pages: 118
ISBN-13: 9781441916624; 9781587063190
Subjects: Endocrine glands -- Tumors; Pituitary gland -- Tumors; Parathyroid glands -- Tumors; Pancreas -- Tumors; Multiple Endocrine Neoplasia Type 1 -- physiopathology; Pancreatic Neoplasms -- etiology; Parathyroid Neoplasms -- etiology; Pituitary Neoplasms -- etiology; Tumor Suppressor Proteins -- metabolism
Description: "The vast expansion in research on tumorigenesis has greatly increased our understanding of tumor development in patients with inherited endocrine tumor syndromes. SuperMEN1, Pituitary, Parathyroid and Pancreas provides an up-to-date summary from clinical basics and latest follow-up guidelines to the most recent molecular findings in multiple endocrine neoplasia Type 1 syndrome. Articles have been assembled by acknowledged experts in their respective fields to provide current perspectives on the clinical and genetic backgrounds of this syndrome and to review carefully the latest discoveries concerning the possible functions and interactions of menin, the protein encoded by the MEN1 gene, including its possible role in cell cycle regulation, hematopoiesis, and bone development. The goal of this valume is also to present the most recent findings and the broadest aspects of the role of menin in tumorigenesis of the endocrine glands involved in MEN 1 syndrome (pituitary, parathyroid, endocrine pancreas and adrenal). The connection between the basic experimental and clinical points of view are highlighted through a discussion on animal models, which explores the field in both an inspiring and questioning manner with a focus on areas that remain to be clarified. Our goal was to bring together clinicians and basic researchers who represent a wide range of interests in this particular field of endocrine oncology. Presenting a comprehensive and current overview of basic experimental and clinical findings, this book can bring us closer to understanding endocrine tumorigenesis in multiple endocrine neoplasia Type 1"--Publisher's description.
Notes: Includes bibliographical references and index.
Table of contents: title: MEN1 clinical background / Peter Igaz; title: Genetic background of MEN1 : from genetic homogeneity to functional diversity / Patrick Gaudray and Günther Weber; title: Menin : the protein behind the MEN1 syndrome / Maria Papaconstantinou ... [et al.]; title: Cellular functions of menin / Geoffrey N. Hendy, Hiroshi Kaji and Lucie Canaff; title: The role of menin in hematopoiesis / Ivan Maillard and Jay L. Hess; title: Role of menin in bone development /  Hiroshi Kaji, Lucie Canaff and Geoffrey N. Hendy; title: Activin, TGF-€ and menin in pituitary tumorigenesis / Jean-Jacques Lebrun; title: The role of menin in parathyroid tumorigenesis / Colin Davenport and Amar Agha; title: Role of menin in neuroendocrine tumorigenesis / Terry C. Lairmore and Herbert Chen; title: Adrenal tumors in MEN1 syndrome and the role of menin in adrenal tumorigenesis / Attila Patocs, Katalin Balogh and Karoly Racz; title: Functional studies of menin through genetic manipulation of the MEN1 homolog in mice / Dheepa Balasubramanian and Peter C. Scacheri.