Accounts in drug discovery
Subtitle: case studies in medicinal chemistry
By: edited by Joel C. Barrish ... [et al.].
Contributors: Royal Society of Chemistry (Great Britain)
Series: RSC drug discovery series -- no. 4.; RSC drug discovery series -- 4.
Publisher: Royal Society of Chemistry
Published: 2011
Place of publication: Cambridge
Language: eng
Number of pages: 379
ISBN-13: 9781849731263
Subjects: Drug development; Case studies
Notes: Includes bibliographical references and index.
Table of contents: title: The discovery of the dipeptidyl peptidase-4 (DPP4) inhibitor Onglyza :; title: from concept to market  -- Jeffrey A. Robl and Lawrence G. Hamann; title: The discovery of Vorapaxar (SCH 530348), a thrombin receptor (protease activated receptor-1) antagonist with potent antiplatelet effects  -- Samuel Chackalamannil; title: The discovery of Piragliatin, a glucokinase activator  -- Ramakanth Sarabu, Jefferson W. Tilley and Joseph Grimsby; title: The discovery of OSI-906, a small-molecule inhibitor of the insulin-like growth factor-1 and insulin receptors  -- Mark J. Mulvihill and Elizabeth Buck; title: The genesis of the antibody conjugate gemtuzumab ozogamicin (Mylotarg®) for acute myeloid leukemia  -- Philip R. Hamann; title: Novel androgen receptor antagonists for the treatment of prostate cancer  -- Ashvinikumar V. Gavai, William R. Foster, Aaron Balog and Gregory D. Vite; title: The discovery of UK-390957 :; title: the challenge of targeting a short half-life, rapid Tmax SSRI  -- Mark D. Andrews and Donald S. Middleton; title: The discovery of the long-acting PDE5 inhibitor PF-489791 for the treatment of pulmonary hypertension  -- Andrew S. Bell and Michael J. Palmer; title: From HTS to market :; title: the discovery and development of maraviroc, a CCR5 antagonist for the treatment of HIV  -- Chris Barber and David Pryde; title: The discovery of GS-9131, an amidate prodrug of a novel nucleoside phosphate HIV reverse transcriptase inhibitor  -- Richard Mackman; title: 2'-F-2'-C-methyl nucleosides and nucleotides for the treatment of hepatitis C virus :; title: from discovery to the clinic  -- Michael J. Sofia, Phillip A. furman and William T. Symonds; title: A case history on the challenges of central nervous system and dual pharmacology drug discovery  -- Paul V. Fish, Anthony Harrison, Florian Wakenhut and Gavin A. Whitlock; title: The discovery of TRPV1 antagonists :; title: turning up the heat  -- Mark H. Norman; title: Uncoupling neuroprotection from immunosuppression :; title: the discovery of ILS-920  -- Edmund I. Graziani; title: Identification of [alpha] 7 nicotinic acetylcholine receptor agonists for their assessment in improving cognition in schizophrenia -- Bruce N. Rogers ... [et al.]