Advances in Heterocyclic Chemistry, Volume 60 (Advances in Heterocyclic Chemistry)
Publisher: Academic Press
Published: September 1, 1994
Language: eng
Number of pages: 462
ISBN-13: 9780120207602
First sentence: The high carbon-fluorine bond energy renders the fluorine substituent a bad leaving group in SN2 reactions and resistant to many metabolic tranformations.