Handbook of drug metabolism
By: edited by Thomas F. Woolf.
Contributors: Woolf, Thomas F., 1955-
Publisher: Dekker
Published: 1999
Place of publication: New York
Language: eng
Number of pages: 596
Subjects: Drugs -- Metabolism
Notes: Includes bibliographical references and index.
Table of contents: title: Pt. 1. Fundamental aspects of drug metabolism; title: Ch. 1. Pharmacokinetics of drug metabolites; title: Ch. 2. Oxidative metabolic bioactivation of xenobiotics; title: Ch. 3. Morphofunctional aspects of the hepatic architecture: functional and subcellular correlates; title: Ch. 4. The cytochrome P450 oxidative system; title: Ch. 5. Transformation enzymes: oxidative; non-P450; title: Ch. 6. Transformation reactions: glucuronidation; title: Pt. 2. Factors affecting drug metabolism; title: Ch. 7. Pharmacogenetics.; title: Ch. 8. Inhibition of drug metabolizing enzymes: molecular and biochemical aspects; title: Ch. 9. Metabolic drug interactions; title: Ch. 10. Induction of human drug-metabolizing enzymes: mechanisms and implications; title: Ch. 11. Sites of metabolism: lung; title: Part 3. Technologies; title: Ch. 12. Applications of heterologous expressed and purified human drug-metabolizing enzymes: an industrial perspective; title: Ch. 13. In vivo and in vitro recombinant DNA technology as a powerful tool in drug development; title: Ch. 14. In vitro metabolism: subcellular fractions.; title: Ch. 15. In vitro metabolism: hepatocytes; title: Ch. 16. The isolated perfused liver as a tool in drug metabolism studies; title: Ch. 17. Metabolic models of cytotoxicity; title: Ch. 18. In vitro metabolism: FMO and related oxygenations; title: Ch. 19. Applications of Caco-2 cells in drug discovery and development; title: Ch. 20. The role of nuclear magnetic resonance spectroscopy in drug metabolism; title: Pt. 4. Metabolism in drug discovery and development; title: Ch. 21. Preclinical drug metabolism studies and strategies; title: Ch. 22. Clinical drug metabolism studies.