The prognostic effect of lipids on outcome of early-stage breast cancer.
Published: 2005
Language: eng
Number of pages: 112
Description: Early-stage breast cancer outcome is influenced by insulin and body mass index. These features are associated with dyslipidemia in the insulin resistance syndrome, but the contribution of lipids to breast cancer outcome is unclear. Using a cohort of 535 women without known hyperlipidemia or diabetes, the effect of lipids on recurrence and death was studied. Cox regression modeling was used to calculate hazard ratios with significance set at 0.025 (2-sided). Total cholesterol was correlated with age, and tumor grade. Triglycerides were correlated with insulin and BMI. At 8.7 years median follow-up, lipids were not associated with outcome in univariate analysis or when controlling for BMI and insulin. When controlling for tumor-related variables, triglycerides were not associated with outcome, but a trend towards significance was seen for recurrence (but not death) by total cholesterol (HR recurrence = 1.58, 4th:1st quartile, 2-sided P=0.043). This potential association should be explored in future studies.
Notes: Source: Masters Abstracts International, Volume: 44-02, page: 0826.

Thesis (M.Sc.)--University of Toronto, 2005.

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