Chiral drugs
Subtitle: chemistry and biological action
By: edited by Guo-Qiang Lin, Qi-Dong You, Jie-Fei Cheng
Publisher: Wiley
Published: 2011
Place of publication: Hoboken, N.J
Language: eng
ISBN-13: 9780470587201
Subjects: Pharmaceutical Preparations; Methods; Structure-Activity Relationship; Drug development; Chiral drugs; Drug Discovery; Chemistry; Structure-activity relationships (Biochemistry)
Description: "This book overviews chiral drugs and their impact in the pharmaceutical industry. The chapters detail basics and trends in chiral drug discovery and development, as well as techniques / skills and trends of asymmetric synthesis. The first section introduces the general concept of chirality and its impact on the drug discovery and development. This part includes history of chiral drug development, key technologies for preparation of chiral drugs, and industrial applications of chiral technologies"--Provided by publisher.
Notes: Includes bibliographical references and index.
Table of contents: title: Machine generated contents note: Chapter 1. Overview of chirality and chiral drugs (Guo-Qiang Lin, Jiange Zhang and Jie-Fei Cheng).; title: Chapter 2. Chiral drugs through asymmetric synthesis (Guo-Quiang Lin and Xing-Wen Sun).; title: Chapter 3. Chiral drugs via biocatalytical approaches (Jianqiang Wang and Wenya Lu).; title: Chapter 4. Chiral resolution (Qi-Dong You).; title: Chapter 5. Fluorine-containing chiral drugs (Xiao-Long Qiu, Xuyi Yue and Feng-Ling Qing).; title: Chapter 6. Industrial application of chiral technologies (Hui-Ying (Harry) Li, Rui Liu, Carl Behrens, and Chao-Ying Ni).; title: Chapter 7. Computation modeling study on mechanism-of-action of chiral drugs (Deping Wang and Eric Gu).; title: Chapter 8. Pharmacology of chiral drugs (Yongge Liu and Xiao-Hui Gu).; title: Chapter 9. Pharmacokinetics of chiral drugs (Hanqing Dong, Xiaochuan Guo and Zengbiao Li).; title: Chapter 10. Toxicology of chiral drugs (Guang Yang and Hai-Zhi Bu).; title: Chapter 11. Representative chiral drugs (Jiangqin Sun, Dingguo Liu and Zhimin Wang).