Ions in the Brain
Subtitle: Normal Function, Seizures, and Stroke
Publisher: Oxford University Press, USA; Oxford University Press
Published: January 23, 2004
Language: eng
Number of pages: 470
ISBN-13: 9780195151718
Description: This book deals with the regulation of ions in brain extra- and intracellular fluids. After an introduction to the electrophysiology of epilepsy, and a description of experimental seizure "models," the second part discusses the roles of the faulty regulation of ions and of the diseases of ion channels in generating epileptic seizures. The mechanisms of action of various anticonvulsant drugs are also considered. The third part is devoted to the phenomenon of spreading depression and its likely role in human diseases. The final chapters of the book deal with the role of ions in the devastation caused by lack of oxygen and by insufficient blood flow to brain tissue, and the reasons for the exceptional vulnerability of certain classes of central neurons in hypoxia and stroke. The book will be of interest to neuroscientists, neurobiologists, neurophysiologists, neurologists, neurosurgeons, and to their students and trainees.