anatomy of reward:  The neurobiology and neurochemistry mediating systemic morphine reward in the tegmental pedunculopontine nucleus.
Published: 2007
Language: eng
Number of pages: 74
ISBN-13: 9780494274835
Description: These results provide positive evidence for a GABA and glutamate synapse in the TPP which mediates systemic morphine reward and suggest that a serial pathway for morphine reward in the TPP is unlikely. Possible alternative pathways are discussed.The tegmental pedunculopontine nucleus (TPP) of the midbrain is critical in mediating the acute rewarding effects of opiates. However, the circuitry and neurochemistry underlying this effect has not been determined. In this thesis, I identify receptors and cell types involved in systemic morphine reward and suggest an anatomical and neurochemical model for reward in the TPP.I report that TPP-administered NMDA and GABA-B receptor antagonists while having no motivational effects on their own, blocked systemic morphine reward as measured by conditioned place preference. A NMDA receptor agonist on its own produced reward.
Notes: Source: Masters Abstracts International, Volume: 45-06, page: 3066.

Thesis (M.Sc.)--University of Toronto, 2007.

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