Sleep related risk factors in progressive glaucoma.
Published: 2005
Language: eng
Number of pages: 365
Description: Conclusion. Results from this large survey and accompanying clinical experimental studies indicated, for the first time, that good sleep is related to progressive GON in women, whereas poor sleep is related to stable GON. Results from the presented studies do not support an association between sleep disturbed breathing and progression of glaucoma.Primary objectives. To investigate the association between progressive GON and (i) habitual sleep quality, and (ii) SDB.Context. The deleterious relationship between glaucomatous optic neuropathy (GON) and sleep related risk factors such as nocturnal blood pressure variation and sleep disordered breathing (SDB), has previously been proposed but is not fully understood.Results. In females, but not in males, better perceived sleep quality (PSQI score &lt; 8) was significantly more prevalent in patients with progressive glaucoma than in patients with stable glaucoma. Polysomnographic measures showed a trend towards more deep sleep (stage 3 + 4) in females with progressive glaucoma than in females with stable glaucoma. No associations were found in men. Depressive symptoms were less common in the progression group in both genders. Survey and polysomnographic indices of SDB did not differ between stable and progressive cases in either gender. Simulated sleep apnea showed a significant reduction in intraocular pressure in healthy young adults.Methods. The Toronto Glaucoma Health and Sleep Survey (TGHSS) was mailed to glaucoma patients registered at a hospital glaucoma referral center in Toronto, Canada. Responders were classified as stable or progressive based on retrospective analyses of clinical visual field results. Supplementary experimental studies were conducted in a subsample of patients and in healthy volunteers.Main outcome measures. Habitual sleep quality and SDB: Measured using the Pittsburgh Sleep Quality Index (PSQI), selected questions on SDB and the Epworth Sleepiness Scale; Objective sleep quality: Measured by polysomnography; Intraocular pressure and pulsatile ocular blood flow: Measured by pneumotonography. Depressive symptoms and health related quality of life: Measured using the Center for Epidemiologic Studies Depression Scale and Medical Outcome Study Short Form 20, respectively.
Notes: Thesis (Ph.D.)--University of Toronto, 2005.

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Source: Dissertation Abstracts International, Volume: 66-06, Section: B, page: 3074.