Transcriptional Regulation of Synapse Remodeling in C. elegans
Contributors: Kaplan, Joshua M.; Ruvkun, Gary; Van Vactor, David; Hensch, Takao K.; Sengupta, Piali
Published: 2012
Language: eng
Description: The ability of a neuron to alter its synaptic connections during development is essential to circuit assembly. Synapse remodeling or refinement has been observed in many species and many neuronal circuits, yet the mechanisms defining which neurons undergo remodeling are unclear. Moreover, the molecules that execute the process of remodeling are also obscure. To address this issue, we sought to identify targets of the transcription factor unc-55 COUP-TF, which acts as a cell-specific repressor of synapse remodeling in C. elegans. unc-55 COUP-TF is expressed in VD neurons, where it prevents synapse remodeling. DD neurons can remodel synapses because they do not express unc-55 COUP-TF. Ectopic expression of unc-55 COUP-TF in DD neurons prevents remodeling.
Notes: Keywords: C elegans, Circuit Refinement, COUP-TF, HBL-1, Heterochronic gene, Synaptic Plasticity.

Thesis Ph.D. Harvard University 2012