Neutrophil function in refractory aggressive periodontitis.
Published: 2007
Language: eng
Number of pages: 2007
ISBN-13: 9780494273081
Description: Results. PMNs from patients with RAP displayed significantly increased PMA-induced oxygen radical production compared to those from the HC and CP patients. PMN's from RAP patients also displayed increased phagocytosis compared to those from the CP group.Background. This study examined neutrophil respiratory burst and phagocytic activity in a unique population of patients diagnosed with refractory aggressive periodontitis (RAP).Conclusions. The findings demonstrate a larger receptor independent respiratory burst and higher phagocytotic activity in PMNs derived from patients with RAP, when compared to PMNs derived from successfully treated CP patients and periodontally HC.Method. Peripheral blood PMNs were obtained from 12 RAP patients, 10 patients with successfully treated Chronic Periodontitis (CP) and 13 periodontally healthy controls (HC) and were loaded with dihydrorhodamine 123 (DHR) and stimulated with phorbol 12-myristate 13-acetate (PMA). Phagocytosis via the complement and Fcgamma-receptors was also assessed.
Notes: Source: Masters Abstracts International, Volume: 45-06, page: 3115.

Thesis (M.Sc.)--University of Toronto, 2007.

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