Growth factors and their receptors in cell differentiation, cancer and cancer therapy
By: G.V. Sherbet
Edition: 1st ed.
Series: Elsevier insights; Elsevier insights
Publisher: Elsevier
Published: 2011
Place of publication: London; Waltham, MA
Language: eng
Number of pages: 347
ISBN-13: 9780123878199
Subjects: Cells; Cell differentiation; Etiology; Growth Factor Receptors; Treatment; Therapeutic use; Metabolism; Intercellular Signaling Peptides and Proteins; Growth factors; Cancer; Neoplasms; Metastasis; Cell Differentiation; Growth; Therapy; Cellular therapy
Description: Recent years have seen a considerable emphasis on growth factors and the elucidation of their mode of function, which has led to the recognition that growth factors, their receptors as well as downstream elements of signalling associated with their function might be potential targets in therapeutic management of human diseases. Humanised monoclonal antibodies raised against growth factor receptors have proved to be valuable for targeted cancer treatment and in patient management. This book reviews the latest developments providing insights into the signalling processes involved in morphogenesis and pathogenesis with emphasis on using the elements of the signalling cascades as targets for therapeutic deployment. Provides a fundamental understanding of the basic functions of growth factors and their receptors, describing how they are linked in biological processes. Aids the development of therapeutic treatments for cancer. Focuses on the interrelationships and convergence of growth factors and their receptors in development and pathogenesis and encourages greater cooperation and integration in the areas of developmental, cancer and cancer therapeutic research.
Notes: Includes bibliographical references (p. [249]-347).
Table of contents: title: Convergence of growth-factor signalling pathways in developmental systems and pathogenesis; title: Growth factor families; title: Growth factors in differentiation and morphogenesis; title: Vascular endothelial growth factor; title: Hepatocyte growth factor; title: Platelet-derived growth factor family; title: Nerve growth factors; title: Insulin-like growth factors; title: Connective tissue growth factors; title: Thrombospondins; title: Cytokines; title: Growth factor and hedgehog signalling pathways meet in developmental systems; title: Epidermal growth factors and their signalling systems; title: Epidermal growth factor (EFG) family; title: Fibroblast growth factor family; title: Intracellular receptor building growth factors; title: Androgens and androgen receptors in development, differentiation and neoplasia; title: Vitamin D₃ in cell proliferation, apoptosis and differentiation; title: Retinoids in development and pattern formation; title: Oestrogens and progesterone in normal physiology and neoplasia; title: Glucocorticoid signalling in normal and aberrant physiology.