Handbook of metabolic pathways of xenobiotics
By: editor-in-chief, Dr. Philip W. Lee
Publisher: John Wiley & Sons Inc.
Published: 2014
Place of publication: Chichester, West Sussex
Language: eng
ISBN-13: 9780470749104
Subjects: Xenobiotics; Metabolism
Notes: Includes bibliographical references and index.
Table of contents: title: Contents of Volume 1; title: A personal and historical perspective on drug metabolism / Gerald T. Miwa and Arthur K. Cho; title: Fundamentals of organic chemistry as applicable to the biotransformation of foreign compounds / Antonia F. Stepan and Amit S. Kalgutkar; title: Functional group biotransformations / R. Scott Obach; title: Drugs as victims and perpetrators and the pharmacokinetic concept of maximum exposure / Brian W. Ogilvie and Andrew Parkinson; title: Drug-metabolizing enzymes: a group of promiscuous catalysts / Qiang Ma and Anthony Y.H. Lu; title: Unusual metabolic reactions and pathways / F. Peter Guengerich and Emre M. Isin; title: Role of biotransformation in drug discovery / Ronald E. White; title: Role of metabolism in drug development / Suresh K. Balani; title: Role of biotransformation in pesticide discovery and development / Michael E. Krolski and Stephen C. Dacus; title: Role of cytochrome P450 enzymes in biotransformation / Paul R. Ortiz de Montellano; title: Major human conjugative drug-metabolizing enzymes / Daniel R. Albaugh and Michael B. Fisher; title: Metabolic activation and associated drug toxicity / Thomas A. Baillie; title: In vitro experimental models for studying drug biotransformation / Tonika Bohnert and Liang-Shang Gan; title: In vivo experimental models for studying drug biotransformation / W. Griffith Humphreys; title: Contents of Volume 2; title: Theory and instrumentation of mass spectrometry and its application to drug metabolism / Stacy L. Gelhaus and Ian A. Blair; title: Mass spectral interpretation / Li-Kang Zhang and Birendra N. Pramanik; title: Computational approaches in drug biotransformation studies: metabolite prediction / Nigel J. Waters and Michelle K. Dennehy; title: High-throughput metabolite detection and quantitative/qualitative bioanalysis / Donghui Cui and Sean Yu; title: Metabolic stability screen in drug discovery / Chuang Lu; title: Application of triple-quadrupole and its hybrid mass spectrometers for the identification of drug metabolites / Zhi-Yi Zhang, Chandra Prakash, and Lin Xu; title: Role of ion trap LC-MS techniques for the identification of drug metabolites / Robert D. Pelletier and W. George Lai; title: Drug metabolite identification with high-resolution mass spectrometry / Haiying Zhang and Mingshe Zhu; title: Strategies for the identification of unusual and novel metabolites using derivatization, hydrogen/deuterium exchange (HDX), and liquid chromatography-nuclear magnetic resonance (LC-NMR) spectroscopy techniques / Amin Kamel, Shawn Harriman, and Chandra Prakash; title: The use of nanoelectrospray mass spectrometry for the quantitation of metabolites in the absence of synthetic standards / Jing-Tao Wu; title: Quantitation of drug metabolites by radioactivity detection including accelerator mass spectrometry (AMS) / Angus N.R. Nedderman and Mark E. Savage; title: Application of quantitative NMR in drug metabolism studies / Abdul E. Mutlib; title: Early assessment of exposure of drug metabolites in humans using mass spectrometry / Natalia A. Penner, Joanna Zgoda-Pols, and Chandra Prakash; title: Profiling and characterization of bioactive substances of herbal medicine and their metabolites using mass spectrometry; title: Xiaoyan chen; title: Application of in silico metabolism and environmental degradation data to support chemical PBT assessment / Sabcho Dimitrov, Gilman Veith, and Ovanes Mekenyan.