Prognostic factors for first clinical fracture in patients with primary osteoporosis
Subtitle: analyses of data from the Canadian Database of Osteoporosis and Osteopenia.
Published: 2005
Language: eng
Number of pages: 174
Description: Much research has delineated risk factors for osteoporotic fractures while the clinical course and prognosis of osteoporosis remain unexplored. Using data from the Canadian Database of Osteoporosis and Osteopenia, we examined time-to-first clinical fracture during a 30-month follow-up and prognostic factors for first clinical fracture in an inception cohort of 1142 female and male patients aged 40 years and over, with bone mineral density-diagnosed primary osteoporosis and no history of clinical fracture.The cohort, followed for 27 516 person-months, had a 5.08% cumulative fracture incidence or a fracture rate of 10.9/1000 person-months. The multivariable Cox regression complete case analysis revealed two significant prognostic factors: increasing age (Hazard Ratio (HR) = 1.03, 95% CI: 1.01-1.06) and lack of osteoporosis drug treatment (HR = 3.69, 95% CI: 1.94-7.01). Although slight bias toward informative censoring was detected, sensitivity analyses demonstrated no drastic distortions in the parameter estimates, confirming the findings of the complete case analysis.
Notes: Source: Masters Abstracts International, Volume: 44-02, page: 0835.

Thesis (M.Sc.)--University of Toronto, 2005.

Electronic version licensed for access by U. of T. users.

GERSTEIN MICROTEXT copy on microfiche (2 microfiches).