Adaptive and flexible clinical trials
By: Richard Chin
Publisher: CRC Press
Published: 2012
Place of publication: Boca Raton
Language: eng
Number of pages: 184
ISBN-13: 9781439838327
Subjects: Research Design; Trends; Database Management Systems; Organizational Efficiency; Clinical trials; Clinical Trials as Topic
Notes: Includes bibliographical references and index.
Table of contents: title: 1. Background; title: 2. Conventional statistics; title: 3. Statistics used in adaptive clinical trials; title: 4. Specific requirements for adaptive trials; title: 5. Adaptive randomization and allocation; title: 6. Sample size reestimation; title: 7. Traditional dosing; title: 8. Adaptive dosing; title: 9. Interim analysis and adaptive termination of study and study arms; title: 10. Adaptive changes in study design and decision rules; title: 11. Seamless designs and adaptive clinical trial conduct; title: 12. Analysis and interpretation of results.