Exploring Dengue Virus Entry Through Small Molecule Inhibition and Mutagenesis of the Envelope Protein
Contributors: Yang, Priscilla L.; Hogle, James M.; Gack, Michaela U.; Bossart, Katharine
Published: 2014
Language: eng
Description: Over one-third of the world's population is at risk for infection with dengue virus (DENV), a mosquito-borne virus that can cause a severe febrile disease. There are no specific treatments available for dengue infection, and much remains unknown about how DENV interaction with the host cell leads to a successful infection. This dissertation examines DENV entry using small molecule inhibitors and mutagenesis of the envelope (E) protein, the major protein on the viral surface.
Notes: Keywords: dengue, entry, envelope, inhibitor, small molecule, virus.

Thesis Ph.D. Harvard University 2014