Effects of insulin on the mechanisms of neointimal growth after balloon catheter injury of the carotid artery in rats.
Published: 2004
Language: eng
Number of pages: 137
Description: Hyperinsulinemia is present in metabolic syndrome and is associated with atherosclerosis and restenosis. In vitro studies show atherogenic and anti-atherogenic effects of insulin, however the mechanisms of these effects in vivo remain unclear. To investigate the effects of euglycemic hyperinsulinemia on neointimal growth after balloon catheter injury of the carotid artery, we administered subcutaneous control implants (C) or insulin implants (3U/day;I) in male rats. Euglycemia was achieved in I with glucose drinking water and intraperitoneal glucose infusion after surgery. Plasma samples and carotid arteries were collected at 4, 7, 14 and 28 days after vessel injury. Hyperinsulinemia and euglycemia was attained in insulin-treated rats throughout the treatment periods. Insulin decreased intimal cross-sectional area (P &lt; 0.01) and the total number of intimal SMCs (P &lt; 0.05) at 28 days. Insulin also inhibited SMC migration by 56% at 4 days (P &lt; 0.01). Thus, insulin decreases SMC migration in vivo, resulting in an inhibition of neointimal growth.
Notes: Adviser:  Adria Giacca.

Thesis (M.Sc.)--University of Toronto, 2004.

Electronic version licensed for access by U. of T. users.

Source: Masters Abstracts International, Volume: 43-03, page: 0761.

MICR copy on microfiche (2 microfiches).