Trinucleotide repeat protocols
By: edited by Yoshinori Kohwi and Cynthia T. McMurray
Edition: 2nd ed.
Series: Springer protocols; Methods in molecular biology -- 1010; Methods in molecular biology (Clifton, N.J.) -- v. 1010.; Springer protocols (Series)
Publisher: Humana Press
Published: 2013
Place of publication: New York
Language: eng
Number of pages: 296
ISBN-13: 9781627034104
Subjects: Trinucleotide repeats; Laboratory manuals; Trinucleotide Repeats; Laboratory Manuals; Nervous System Heredodegenerative Disorders; Genetics
Notes: Includes bibliographical references and index.
Table of contents: title: A brief history of triplet repeat diseases --; title: Huntington's disease and cell therapies: Past, present, and future --; title: Transcranial two-photon imaging of synaptic structures in the cortex of awake head-restrained mice --; title: In vivo imaging of synapse plasticity in the mouse motor cortex --; title: Pluripotent hybrid stem cells from transgenic Huntington's disease monkey --; title: Mesenchymal stem cells for trinucleotide repeat disorders --; title: Lentiviral-mediated gene transfer of siRNAs for the treatment of Huntington's disease --; title: Purification of dFMR1-containing complexes using tandem affinity purification --; title: Combined FISH and immunofluorescent staining methods to co-localize proteins and mRNA in neurons and brain tissue --; title: Epigenetic modifications of the FMR1 gene --; title: The CGG repeat and the FMR1 gene --; title: Study of oxidative damage and antioxidant systems in two Huntington's disease rodent models --; title: Regulation of ataxin-1 phosphorylation and its impact on biology --; title: Towards understanding region-specificity of triplet repeat diseases: Coupled immunohistology and mass spectrometry imaging --; title: Antibodies and intrabodies against huntingtin: Production and screening of monoclonals and single-chain recombinant forms --; title: Cell recovery from DM1 transgenic mouse tissue to study (CTG) n instability and DM1 pathogenesis --; title: Markerless modification of trinucleotide repeat loci in BACs --; title: DRPLA: Recent advances in research using transgenic mouse models.