Parameters for pesticide QSAR and PBPK/PD models for human risk assessment
By: James B. Knaak, editor, Charles Timchalk, editor, Rogelio Tornero-Velez, editor ; sponsored by the ACS Division of Agrochemicals
Contributors: American Chemical Society; American Chemical Society. Division of Agrochemicals
Series: ACS symposium series -- 1099; ACS symposium series -- 1099.
Publisher: American Chemical Society
Published: 2012
Place of publication: Washington, DC
Language: eng
ISBN-13: 9780841226456
Subjects: Toxicity; Congresses; Risk Assessment; Pharmacokinetics; Chemical Models; Pesticides; Quantitative Structure-Activity Relationship
Notes: Includes bibliographical references and index.
Table of contents: title: Parameters for pesticide QSAR and PBPK/PD models to inform human risk assessments; title: Chiral chemistry and toxicity assessments for pyrethroid pesticides; title: Direct chiral separation of pyrethroid isomers by HPLC with chiral stationary phases; title: Biotransformation and enzymes responsible for metabolism of pyrethroids in mammals; title: Characterization of potential age-related differences in pyrethroid pharmacokinetics; title: 15 factors of percutaneous penetration of pesticides; title: Percutaneous absorption of pesticide formulations; title: Human metabolic interactions of pesticides : inhibition, induction and activation; title: Paraoxonase 1 (PON1) status in risk assessment for organophosphate exposure and pharmacokinetics; title: Carboxylesterases : a multifunctional enzyme involved in pesticide and lipid metabolism; title: Behavioral changes in adult and young rats as indications of cholinesterase inhibition; title: Comparison of esterase sensitivity, metabolic efficiency, and toxicity levels of two organophosphorus insecticides, parathion and chlorpyrifos; title: Regional brain dosimetry for the organophosphorus insecticide chlorpyrifos in the preweanling rat; title: Pyrethroid actions on sodium channels : isoform and species specificity; title: In vitro and in vivo experimental data for development and use of pharmacokinetic models for in vitro to in vivo extrapolation of pyrethroid insecticides; title: In silico strategies for modeling stereoselective metabolism of pyrethroids; title: Quantitative structure-activity relationships for organophosphate enzyme inhibition; title: Computational approaches for developing informative prior distributions for bayesian calibration of PBPK models; title: Use of cytochrome P450-specific parameters and human biomarker data to develop a human physiologically based pharmacokinetic/pharmacodynamic model for dermal chlorpyrifos exposure; title: Use of in vitro data in PBPK models : an example of in vitro to in vivo extrapolation with carbaryl.