Nuclear receptors in drug metabolism
By: [edited by] Wen Xie.
Contributors: Xie, Wen, 1967-
Publisher: John Wiley & Sons
Published: 2008
Place of publication: Hoboken, NJ
Language: eng
ISBN-13: 9780470086797
Subjects: Drugs -- Metabolism; Nuclear receptors (Biochemistry); Genetic regulation; Receptors, Cytoplasmic and Nuclear -- metabolism; Drug Delivery Systems -- methods; Pharmaceutical Preparations -- metabolism; Receptors, Steroid -- metabolism
Notes: Includes bibliographical references and index.
Table of contents: title: Drug metabolism : significance and challenges; title: Establishing orphan nuclear receptors PXR and CAR as xenobiotic receptors; title: Nuclear receptor-mediated regulation of phase II conjugating enzymes; title: Nuclear receptor-mediated regulation of drug transporters; title: Structure and function of PXR and CAR; title: Xenobiotic receptor co-factors and co-regulators; title: Animal models of xenobiotic nuclear receptors and their utility in drug development; title: Nuclear receptors and drug-drug interactions of prescription drugs and herbal medicines; title: Genetic variants of xenobiotic receptors and their implications in drug metabolism and pharmacogenetics; title: Beyond PXR and CAR : xenobiotic regulation by other nuclear receptors; title: The emerging role of retinoid-related orphan receptor (ROR) and its crosstalk with LXR in the regulation of drug metabolizing enzymes.