Synthesis of Cortistatin Alkaloids and a Versatile Synthesis of Isoquinolines
Contributors: Myers, Andrew G.; Shair, Matthew D.; Ritter, Tobias
Published: 2012
Language: eng
Description: The cortistatins are a recently identified class of marine natural products that were found to exhibit potent and selective inhibition of human umbilical vein endothelial cells (HUVECs), making them promising leads for the development of anti-angiogenic drugs. In our synthesis, we envisioned that natural cortistatins and unnatural analogs could be prepared by late-stage introduction of isoquinolines to 17-keto precursors, and that these differentially substituted precursors could all be derived from a common key intermediate 112.
Notes: Keywords: angiogenesis, cortistatin, isoquinoline, organolithium addition, radical deoxygenation.

Thesis Ph.D. Harvard University 2012