Molecular and cellular biology of neuroprotection in the CNS
By: edited by Christian Alzheimer.
Contributors: Alzheimer, Christian.
Series: Advances in experimental medicine and biology -- 513; Advances in experimental medicine and biology -- 513; Advances in experimental medicine and biology -- v. 513.
Publisher: Kluwer Academic / Plenum Publishers; Springer
Published: 2002
Place of publication: New York
Language: eng
Number of pages: 501
Subjects: Brain -- Diseases.; Brain -- Diseases -- Prevention.; Brain damage.; Brain -- Degeneration.; Molecular neurobiology.; Central Nervous System Diseases -- physiopathology.; Central Nervous System Diseases -- prevention & control.; Brain Injuries.; Central Nervous System -- cytology.; Nerve Degeneration -- prevention & control.
Description: Univ. of Kiel, Germany. Text provides an overview of the recent developments in neuroprotective signaling and experimental neuroprotection. Also offers a detailed look at many of the highly intertwined processes that determine the fate of CNS neurons in the face of acute or chronic insults.
Notes: Includes bibliographical references and index.
Table of contents: title: Neuronal cell death; title: Overview of basic mechanisms; title: Excitatory amino acid neurotoxicity; title: Neuronal survival and cell death signaling pathways; title: Detrimental and beneficial effects of injury-induced inflammation and cytokine expression in the nervous system; title: Cellular and molecular determinants of glial scar formation; title: Ion channels, receptors and signaling pathways; title: N⁺a channels and C²⁺a channels of the cell membrane as targets; title: Intercellular C²⁺a handling; title: Neuroprotective activity of metabotropic glutamate receptors ligands; title: A role for glutamate transporters in neurodegenerative diseases; title: Purines and neuroprotection; title: Heat shock proteins and neuroprotection; title: Neurotrophic factors as neuroprotective agents; title: Neurotrophins; title: Fibroblast growth factors and neuroprotection; title: TGF-βS and their roles in the regulation of neuron survival; title: Vascular endothelial growth factor; title: Advances in drug delivery to CNS neurons; title: Blood-brain barrier drug targeting enables neuroprotection in brain ischemia following delayed intravenous administration of neurotrophins; title: Invasive drug delivery; title: Neuroprotective strategies in animal and in vitro models of neuronal damage; title: Ischemia and stroke; title: Neuroprotective strategies in Alzheimer's disease.