Discovery of Novel Lipid Pathways Associated with the Metabolic Syndrome
Contributors: Saghatelian, Alan; Kahne, Daniel; Liu, David R.
Published: 2012
Language: eng
Description: The prevalence of obesity and type 2 diabetes has increased at alarming rates in recent decades. These diseases are prominent components of the metabolic syndrome, which is characterized by marked dyslipidemia. Adipose tissue contributes to the development of obesity-related diabetes through increased release of hormones and non-esterified fatty acids. The development of sensitive analytical tools for the broad detection of lipid biomolecules, such as liquid chromatography-mass spectrometry (LC-MS), has spurred interest in the molecular determinants of the metabolic syndrome.
Notes: Keywords: lipid signaling, liquid chromatography, mass spectrometry, metabolomics, obesity, type 2 diabetes.

Thesis Ph.D. Harvard University 2012