High-throughput lead optimization in drug discovery
By: edited by Tushar Kshirsagar.
Contributors: Kshirsagar, Tushar.
Series: Critical reviews in combinatorial chemistry
Publisher: CRC Press
Published: 2008
Place of publication: Boca Raton
Language: eng
Number of pages: 243
ISBN-13: 9780849372681
Subjects: High throughput screening (Drug development); Combinatorial chemistry.; Drug development.; Combinatorial Chemistry Techniques.; Drug Design.; Databases, Genetic.; Gene Library.
Notes: Includes bibliographical references and index.
Table of contents: title: Application of parallel synthesis to the optimization of inhibitors of the ZipA-FtsZ protein-protein interaction / Lee D. Jennings; title: Case studies of parallel synthesis in hit identification, hit exploration, hit-to-lead, and lead optimization programs / Alexander Ernst and Daniel Obrecht; title: A successful application of parallel synthesis to computer-assisted structural optimization of new leads targeting human immunodeficiency virus-1 reverse transcriptase : the case of acylthiocarbamates and thiocarbamates / Angelo Ranise, Andrea Spallarossa, and Sara Cesarini; title: How high-throughput medicinal chemistry can expedite lead discovery, lead optimization, and beyond / Rongshi Li; title: Rapid lead identification of inhibitors of adenine nucleotide translocase: a case study of applying combinatorial chemistry techniques in drug discovery / Yazhong Pei, Walter H. Moos, and Soumitra Ghosh; title: Parallel synthesis of anticancer, antiinflammatory, and antiviral agents derived from L- and D-amino acids / Robert C. Reid and David P. Fairlie; title: Application of solid-phase parallel synthesis in lead optimization studies / Bijoy Kundu; title: High-throughput solid-phase synthesis of nucleoside-based libraries in the search for new antibiotics / Dianqing Sun and Richard E. Lee.