Enzyme inhibition in drug discovery and development
Subtitle: the good and the bad
By: [edited by] Chuang Lu, Albert P. Li.
Contributors: Lu, Chuang.; Li, A. P.
Publisher: John Wiley
Published: 2009
Place of publication: Hoboken, N.J
Language: eng
ISBN-13: 9780470281741
Subjects: Enzyme inhibitors; Drug development; Drugs -- Metabolism; Enzyme Inhibitors -- pharmacology; Drug Discovery -- methods; Enzyme Inhibitors -- chemical synthesis
Notes: Includes bibliographical references and index.
Table of contents: title: The drug discovery process / Gerald T. Miwa; title: Medicinal chemistry of the optimization of enzyme inhibitors / Geraldine Harriman, Amy Elder, and Indranath Ghosh; title: Bioanalytical technologies in drug discovery / Jing-Tao Wu; title: Safety biomarkers in drug development : emerging trends and implications / Eric R. Fedyk; title: The role of drug metabolism in drug discovery / Tonika Bohnert and Liang-Shang Gan; title: Applied pharmacokinetics in drug discovery and development / Hua Yang ... [et al.]; title: Enzyme inhibition and inactivation : cytochrome P450 enzymes / R. Scott Obach; title: Cytochrome P450 degradation and its clinical relevance / Mingxiang Liao ... [et al.]; title: Inhibition of drug metabolizing enzymes in gastrointestinal tract and its influence on the drug-drug interaction prediction / Aleksandra Galetin and J. Brian Houston; title: Grapefruit juice and its constituents as new esterase inhibitors / Suresh K. Balani; title: The complexities working with UDP-glucuronosyltransferases (UGTs) : focus on enzyme inhibition / Michael B. Fisher; title: Enzyme inhibition in various in vitro systems / Ping Zhao; title: Evaluation of inhibitors of drug metabolism in human hepatocytes / Albert P. Li and Chuang Lu; title: Clinical drug interactions due to metabolic inhibition : prediction, assessment, and interpretation / Lisa L. von Moltke and David J. Greenblatt; title: Cytochrome P450 induction / Edward L. LeCluyse ... [et al.]; title: Transporter-xenobiotic interactions : an important aspect of drug development studies / Gang Luo, Richard Ridgewell, and Thomas Guenthner; title: Polymorphisms of drug transporters and their clinical Implications / Cindy Q. Xia and Johnny J. Yang; title: Predicting inter-individual variability of metabolic drug-drug Interactions : identifying the causes and accounting for them using systems approach / Amin Rostami-Hodjegan; title: NF-B -mechanism, tumor biology, and inhibitors / Lenny Dang; title: G protein-coupled receptors as drug targets / Wenyan Miao and Lijun Wu; title: Pharmacological modulation of ion channels for the treatment of chronic pain / Yi Liu and Ning Qin; title: Targeting the mTOR pathway for tumor therapeutics / Wei Chen; title: HIV-1 protease inhibitors as antiretroviral agents / Sergei V. Gulnik, Elena Afonina, and Michael Eissenstat.