Medication development for the treatment of cocaine dependence
Subtitle: issues in clinical efficacy trials
By: editors, Betty Tai, Nora Chiang, Peter Bridge.
Contributors: Tai, Betty.; Chiang, C. Nora.; Bridge, Peter.; National Institute on Drug Abuse. Office of Science Policy and Communications.; National Institutes of Health (U.S.)
Series: NIDA research monograph -- 175; NIH publication -- no. 98-4125
Publisher: U.S. Dept. of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, Office of Science Policy and Communications
Published: 1997
Place of publication: Rockville, MD
Language: eng
Number of pages: 329
Subjects: Cocaine; Substance-Related Disorders -- drug therapy; Substance Abuse Detection; Drug Evaluation; Clinical Trials as Topic
Notes: "Based on the papers from a technical review ... held on October 20-21, 1994."--p. ii.

Includes bibliographical references.
Table of contents: title: Goals and rationale for pharmacotherapeutic approach in treating cocaine dependence: insights from basic and clinical research; title: Overview of potential treatment medications for cocaine dependence; title: Methodologic recommendations for cocaine abuse clinical trials: a clinician-researcher's perspective; title: Management of clinical trials with new medications for cocaine dependence and abuse; title: Outcome measurement considerations: pharmacological treatments for substance abuse; title: Variability in treatment-seeking cocaine abusers: implications for clinical pharmacotherapy trials; title: Baseline assessment, study entry, and stabilization: double-blind clinical trials in drug dependence; title: Addiction severity index in clinical efficacy trials of medications for cocaine dependence; title: Cognitive-neuromotor assessment of substance abuse: focus on issues related to cocaine abuse treatment; title: Treatment effectiveness score as an outcome measure in clinical trials; title: Pharmacokinetics of cocaine: considerations when assessing cocaine use by urinalysis; title: Quantitative urine levels of cocaine and other substances of abuse; title: Use of quantitative urinalysis in monitoring cocaine use; title: Is quantitative urinalysis more sensitive?; title: Comparison of immunoassays for semiquantitative measurement of benzoylecgonine in urine; title: Appendix I: Workshop summary outcome measures and success criteria; title: Appendix II: Workshop summary clinical decision tree for cocaine addiction pharmacotherapy.