Development profile of the intrinsic hippocampal network oscillations.
Published: 2004
Language: eng
Number of pages: 56
Description: The rodent hippocampus is capable of exhibiting rhythmic electrical activities that are tightly linked to behavioral states. The generation of such rhythmic activities results from interactions of intrinsic hippocampal network activities and extra-hippocampal structures. However, the precise mechanisms of such rhythms are generated and controlled are not fully understood. Our lab has recently shown that the hippocampi isolated from developed mice are able to exhibit a basal rhythm of 1--4 Hz in vitro, called spontaneous rhythmic field potentials (SRFPs). This rhythm is inhibitory in nature, reflecting summed IPSPs from pyramidal neurons and synchronous discharges of inhibitory interneurons. The goal of our study was to determine the time course of SRFPs appearance in the immature postnatal mouse hippocampus. SRFPs were observed in isolated hippocampi at the end of second postnatal week, and that experimental manipulations of GABAA inhibition or glutamate excitation were insufficient to alter the postnatal appearance of SRFPs in vitro .
Notes: Adviser:  Liang Zhang.

Thesis (M.Sc.)--University of Toronto, 2004.

Electronic version licensed for access by U. of T. users.

Source: Masters Abstracts International, Volume: 42-06, page: 2123.

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