Mechanisms of Transcriptional Control in Phosphate-responsive Signaling Pathway of Saccharomyces cerevisiae
Contributors: Murray, Andrew; Regev, Aviv; Denic, Vlad
Published: 2013
Language: eng
Description: Regulation of gene expression is essential for many biological processes. Binding of transcription factors to DNA is a key regulatory step in the control of gene expression. It is commonly observed that DNA sequences with high affinity for transcription factors occur more frequently in the genome than the instances of genes bound or regulated by these factors. However, the mechanism by which transcription factors selectively identify and regulate these genes was unclear. I utilized the transcriptional control of the phosphate-responsive signaling pathway (PHO) in Saccharomyces cerevisiae as a model system to address this problem.
Notes: Keywords: chromatin structure, competition, cooperativity, PHO respnose, systematic dissection, transcriptional control.

Thesis Ph.D. Harvard University 2013