EXAMINATION OF PHYSIOLOGIC RESPONSES TO ENDOTRACHEAL SUCTIONING TECHNIQUES (HYPERTENSION, PULMONARY ARTERIAL PRESSURE).
Contributors: University of Florida.
Published: 1993
Number of pages: 158
Subjects: Health Sciences, Nursing.; Biology, Animal Physiology.
Description: Maintaining patency of the endotracheal tube during mechanical ventilation is essential in maintaining respiratory function. This is accomplished by using endotracheal suctioning (ETS) to clear the airway of secretions. However, ETS may produce serious physiologic alterations.

The overall purpose of this research was to examine the physiologic responses to ETS in newborn lambs with and without acute pulmonary hypertension. Acute pulmonary hypertension was induced by lowering the fraction of inspired oxygen (FiO$\sb2$) to approximately.10. In the first experiment (n = 7), selected physiologic variables, pulmonary arterial pressure (PAP), arterial blood pressure (ABP), heart rate (HR), pulmonary vascular resistance (PVR), mixed venous oxygen saturation (SvO$\sb2$), partial pressure of oxygen (PaO$\sb2$), and peak inspiratory pressure (PIP) were examined in association with two ETS techniques. The ventilator controlled technique (VCT) was accomplished by inserting a suction catheter through a side port of an adaptor attached to the endotracheal tube making disconnection of the ventilator unnecessary. The bag controlled technique (BCT) required disconnection of the ventilator to insert the suction catheter. The second experiment (n = 8) involved the use of intratracheal lidocaine in an attempt to attenuate the hypertensive response associated with ETS.

Results of the first experiment indicated that the changes in PAP from baseline were not statistically significant. Mean peak increases in systolic ABP from baseline (both techniques) were 14 mmHg (P =.0004) under normoxic conditions and 28 mmHg (VCT) and 42 mmHg (BCT) under hypoxic conditions (P =.0002). The mean peak decrease in HR from baseline was 52 beats per minute (bpm) using the VCT and 48 bpm using the BCT (P =.0012) under hypoxic conditions. Changes in PVR and PIP from baseline were not statistically significant. Increases in SvO$\sb2$ and PaO$\sb2$ from baseline were statistically significant under normoxic conditions only (P $\leq$.00625). The overall difference in physiologic responses was not statistically significant between the VCT and BCT.

Results of the second experiment indicated that lidocaine attenuated the overall hypertensive response to ETS under normoxic conditions (F = 3.64, P =.0034). The overall mean difference in systolic ABP, with and without lidocaine, was 4 mmHg.
Notes: Source: Dissertation Abstracts International, Volume: 55-07, Section: B, page: 2645.

Thesis (PH.D.)--UNIVERSITY OF FLORIDA, 1993.

School code: 0070.