ctSkennerton/crass — Issue #13: The specificity needs to be improved
Author: ctSkennerton
Created: 2011-11-09 01:42:15+00:00
State: open
Labels: feature add, improvment

currently when crass is run on metagenomic samples there are a large number of false positive groups are created. some of these groups appear to be SINEs, for example:

GCAACTGGGGCAACTGGGGCAACTGGGGCAACTGGGGCAACTGG

which has an obvious internal repeating structure and is definitely not a CRISPR direct repeat. Other groups have few reads and a low number of nodes in the spacer graph. It should be possible to filter out these groups by removing NodeManagers and DR groups with low numbers of reads and nodes.