### substance | corpuscle:

Neutrophil
* accentuate ischemia-reperfusion injury in isolated perfused rat kidneys.
* also phagocytose any bacteria present
  - possess a heterogenic group of hydrolase gathered under the term esterase
* are a particular type of white blood cell that helps fight infections
  - type of phagocyte and are normally found in the bloodstream
* are a type of white blood cell found wherever inflammation is present
  - cell important in fighting bacteria infections
  - cell that defend the body against infection
  - white blood cell important in defending the body against infections
  - also phagocytes and have a similar range of enzymes and toxic substances
  - always present in association to areas of spotty or confluent necrosis
  - among the first cells to respond in a bacterial infection
  - an important part of the body's immune system
  - another type of white blood cell capable of becoming phagocytotic
  - blood cells that are produced in the marrow, or core of the bones
  - commonly present in heavily infiltrated acini and sometimes form micro-abscesses
  - complex cells that are needed for mammalian life
  - generally the first cells to arrive at the site of inflammation
  - leucocytes
  - members of a class of white blood cells known as granulocytes
  - mostly in the blood, while macrophages are mostly found in tissue
  - normal morphologically, but exhibit defects in motility and phagocytosis
  - notableas one of the first cell types to arrive at a site of infection
* are one of the components of the white blood cells in our blood
  - most important types
  - phagocytes , capable of ingesting microorganisms or particles
  - phagocytotic cells capable of ingesting and killing bacteria and other pathogens
* are present in association with areas of necrosis or acinar cell damage
  - large numbers
  - sexually dimorphic
* are the body's first line of defense against infection
  - primary cellular defense system against bacteria and fungi
  - cells that fight bacterial infection
  - end stage of a differentiated cell line
  - first line of defence against invading bacteria
  - immune system's main defense against bacterial infections
  - most active of the phagocytes and form the first line of cellular defense
* are the most common granulocyte
  - white blood cell in dogs and cats
  - numerous leukocytes in blood
  - other major component
  - white blood cells that remove or kill bacteria
  - very important because they fight infection
  - white blood cells that find, engulf, and destroy foreign microbes
* arrive first, followed by monocytes that develop into macrophages.
* can kill microbes through generation of oxidatitive killing products
  - non-oxidative substances found in their granules
* constitute the vast majority of granulocytes.
* contain granules of concentrated antimicrobial peptides and hydrolytic enzymes.
* damage the blood-brain barrier.
* develop from immature cells of the myeloid line.
* die and lyse after extended phagocytosis, killing, and digestion of bacterial cells.
* enhance removal of ozone-injured alveolar epithelial cells in vitro.
* enter the epidermis at an early stage.
* enzymes in urine for the detection of urethral infection in men.
* form a primary defense against bacterial infection.
* hasten to inflammatory sites.
* have salmon pink granules and multi-lobulated nuclei
  - the greatest activity following bacterially destroyed tissue
  - their origin in multi-potential stem cells in the bone marrow
  - vesicles that contain collagenase, lactoferrin, histamine and lysosomal enzymes
* help fight infection.
* infiltrate between and into epithelial cells as well as the lamina propria.
* injure cultured skeletal muscle myotubes.
* is negative for myeloperoxidase.
* kill by producing nitric oxide, while macrophages are a major source of cytokines
  - invading pathogens through phagocytosis
* leave the blood to go to tissues where infection or inflammation is developing.
* move out of the blood vessels into the infected tissue to attack the bacteria
  - to infected parts of the body to engulf and consume invading bacteria
  - with amoeboid motion
* often show nuclear and cell-based abnormalities, as well as loss of granulation.
* originate from stem cells in the bone marrow.
* play a critical role in fighting infection
  - host defense against a variety of microbial pathogens
  - pivotal role in host defense
* proteases ad the pathophysiology of chronic wounds.
* represent the largest group.
* roll on adherent neutrophils via L-selectin on the rolling cells.
* secrete a fever inducing agent called pyrogen which also helps the body fight infection.
* stay in the blood until they receive a signal that injury or infection has occurred.
* surround the degenerating hepatocytes.
* then trigger other parts of the immune system.
* undergo chemotaxis
  - spontaneous apoptosis at inflamed sites
* use both aerobic and anaerobic respiration.
+ Innate immune system, Inflammation
  * Chemical factors produced during inflammation attract phagocytes, especially neutrophils. Neutrophils then trigger other parts of the immune system.
  * The process of taking in bacteria is called phagocytosis. The bacteria end up in a vacuole inside the neutrophil. The enzymes then get to work on the bacteria. Neutrophils are an important part of the body's immune system. They are a kind of granulocyte, and have a short life-span of a couple of days.