### science | medicine:

Antidepressant drug
* All antidepressant drugs are effective, but certain types work best for certain kinds of depression
  - work by impairing the brain
* Many antidepressant drugs act by elevating serotonin.
* Most antidepressant drugs increase serotonergic activity
  - relieve the symptoms, usually more quickly than they relieve depression
* affect dopamine uptake.
* are also beneficial in certain types of anxiety disorders
  - effective in more than half of the cases of moderate to severe depression
  - sometimes helpful if distress persists
* are very effective in treating major depression
  - potent and have a number of possible sideeffects
  - be helpful in some cases
* have serious, sometimes deadly, side-effects
  - similar effects on serotonin and norepinephrine neurons
* is medicine
* reduce mental depression.
* relieve symptoms of obsessive-compulsive disorder.
* take over a normal function of the body.

### science | medicine | antidepressant drug:

Amitriptyline
* are drugs
* increases chemicals in the brain.
* is an antidepressant drug
* relieves diabetic neruopathy pain in patients with normal or depressed mood
  - diabetic-neuropathy pain in patients with normal and depressed mood

Clomipramine
- tricyclic
* increases chemicals in the brain.
* is an anti-depressant
  - in a class of drugs called tricyclic antidepressants
  - used to treat obsessive-compulsive disorder
* works by affecting brain serotonin.

Desipramine
* is the drug of choice
  - metabolite of imipramine, and nortriptyline is the metabolite of amitriptyline
* relieves post- herpetic neuralgia
  - post-herpetic neuralgia

Fluoxetine
* alters the effects of cocaine on vigilance taskperformance of rats
  - intravenous cocaine in humans
* attenuates alcohol intake and desire to drink.
* improves emotional incontinence.
* is an antidepressant drug
* is available as capsules for oral administration
  - or liquid on prescription only

Imipramine
* inhibits re-uptake of norepinephrine.
* tones up the sphincter a bit and relaxes the bladder as well.

Nefazodone
* also blocks norepinephrine reuptake.
* are drugs.
* inhibits the reuptake of serotonin and, to a lesser extent, norepinephrine.
* is an antidepressant drug
  - more expensive compared to generically prescribed TCAs
* nonhygroscopic, white crystalline solid.

Protriptyline
* are drugs
* crosses the placenta.
  - available as tablets for oral administration
  - excreted in human milk

Reboxetine
* are antidepressant
* increases the amount of noradrenaline in the brain.
  - clearly effective in both the short and the long term compared with placebo
* is used to help the symptoms of anxiety and a number of other symptoms
  - improve mood in people who are feeling low or depressed
* only effects the adrenaline system.
* seems to be an option for the treatment of bulimia nervosa
  - work by increasing noradrenergic availability

Sertraline
* can cause weight loss
  - increase the anticoagulant effects of warfarin if used concomitantly
* fairly potent inhibitor of dopamine release.
  - effective for the treatment of social phobia
  - indicated for the symptomatic relief of depressive illness
* passes into breast milk.
* stands out as having the best effects on behavior among all antidepressants.