### increasing problem worldwide:

Hypoxia
* accelerates the development of respiratory regulation in brine shrimp - but at a cost.
* affects every person differently.
* also impairs lymphocyte proliferation.
* can lead to vasoconstriction of uterine blood flow to the fetus
  - modify normal behavior
  - occur in severe illness
* can, in turn, precipitate angina or tachycardia.
* causes fragility of blood vessel cells and eventually tissue death, which is bruising
  - hypothermia in most mammals via increased heat loss
  - unconsciousness, possibly before the diver reaches the surface
* condition defined by a low supply of oxygen.
* condition of decreased levels of dissolved oxygen in the bottom waters
  - low dissolved oxygen occurring in vital Gulf of Mexico fisheries
  - that is present in the Gulf of Mexico off the coast of Louisiana
* decreases lung neprilysin expression and increases pulmonary vascular leak
  - opioid receptor expression in mouse brain
* deficiency of oxygen at the tissue level.
* develops when a series of conditions occur together.
* elicits new behaviors and arrests both development and the cell cycle.
* increases bromodeoxyuridine labeling indices in bovine neonatal pulmonary arteries
  - glutamine uptake and metabolism
  - human keratinocyte motility on connective tissues
  - persistent sodium current in rat ventricular myocytes
  - with altitude, and the retina of the eye is the first organ to be affected
* induces apoptosis in cultured third trimester trophoblasts.
* inhibits l-arginine uptake by pulmonary artery endothelial cells
  - nitric oxide synthesis in isolated rabbit lung
* is an increasing problem worldwide
  - insufficient amount of oxygen
  - associated with postoperative sleep disturbance
  - both a cause and effect of sickling and becomes part of a vicious cycle
  - caused by excessive discharges of nitrogen
  - known to be one of the commonest physiological stress to which the neonates are exposed
  - one way to stop tumors from growing
* is the best predictor of severe illness and correlates best with the degree of tachypnea
  - condition of low dissolved oxygen levels in water
  - effects of an insufficient supply of oxygen to the body
  - equivalent of drunken driving
  - loosing of oxygen content in organs, resulting in wrinkles
* is the main contributor to high-altitude illness
  - stress that all animals, including humans, encounter at high altitudes
  - most immediate problem following a decompression
  - when water has little to no dissolved oxygen in it
* lack of oxygen in the blood
  - body that prevents it from functioning properly
* leads to appetite suppression.
* means an absence of oxygen reaching living tissues.
* modulates neutrophil transepithelial migration.
* more potent vasodilator than carbon dioxide in the coronary circulation.
* occurs nationwide and is present in over half of our major estuaries.
* occurs when a person is deprived of oxygen, resulting in poor judgment and reaction time
  - the dissolved oxygen level in water is too low to sustain life
* reduces airway epithelial sodium transport in rats.
* refers to water with low DO levels and anoxia refers to water with no DO levels.
* regulates gene expression of alveolar epithelial transport proteins.
* results from a combination of natural and human-influenced factors.
* state of decreased oxygen availability.
* stimulates expression of urokinase receptor in human breast and lung carcinoma cells
  - inflammatory cytokine production by the human term placenta
* tends to be more severe than the child's clinical appearance suggests
  - the clinical appearance of the child suggests
* universal finding during acute attacks.
* upregulates xanthine oxidase in synovial endothelial cells.

### increasing problem worldwide | hypoxia:

Acute hypoxia
* induces elevation of ornithine decarboxylase activity in neonatal rat brain slices.
* upregulates nos gene expression in rats.