### science | medicine:

Statin
* All statins are safe and effective for treating high cholesterol.
* also alter the immune system in subtle ways
  - contain antioxidants which are known to protect the retina
  - help prevent LDLs from reaching the bloodstream
* are a new group of drugs used to bring down cholesterol levels
  - also effective for the dyslipidemia of diabetes
  - currently the most powerful cholesterol lowering drugs available
  - generally safe and well tolerated by most people
  - medications that are often prescribed to lower cholesterol
  - most effective cholesterol lowering drugs
* are the main type of drug used to reduce cholesterol levels
  - major type of medicines used to lower cholesterol levels
  - most widely used cholesterol medications
  - well known for their cholesterol-lowering abilities
* block the enzymatic pathway for cholesterol synthesis in the liver.
* can also cause liver problems
  - cause damage to muscle cells
* directly inhibit that enzyme and reduce the amount of cholesterol that the liver makes.
* have few, mostly mild, documented side effects
  - no effect on dietary cholesterol, and presently, diet is the only remedy
  - other effects that also help prevent heart disease
* lower the level of LDLs in the bloodstream.
* reduce the production or increase the breakdown of LDLs.
* work by inhibiting a liver enzyme critical to the production of cholesterol
  - interfering with the body's ability to make cholesterol
+ Hypercholesterolemia, Medicines to treat hypercholesterolemia: Diseases and disorders of the cardiovascular system :: Diseases
  * Rhabdomyolysis means a disease where muscle cells are damaged and die. Statins can cause damage to muscle cells. This can cause weakness and muscle pain. The worse problem though is that when muscle cells die, they release cell proteins into the blood. The kidney removes the muscle protein from the blood. If the kidney takes up too much protein, it can be hurt. If it is bad enough it can cause kidney failure.
  * Statins can also cause liver problems. They can cause mild irritation of the liver. They can rarely cause very bad liver damage. Because of this, when someone starts taking a statin, doctors check liver blood tests after six weeks.

Statin drug
* can even help make atherosclerosis better.
* is medicine
  * The HMG-CoA Reductase enzyme causes the body to make more cholesterol. If it is inhibited, the body makes 'less' cholesterol. Statin drugs can even help make atherosclerosis better.

### science | medicine | statin:

Fluvastatin
* are drugs
* is currently the least expensive statin
* is used to lower elevated cholesterol and to slow or prevent hardening of the arteries
  - high levels of cholesterol found in the blood

Pravastatin
* are statin.
* is an antilipemic agent indicated for the treatment of primary hypercholesterolemia
  - generally well tolerated
  - only part of a total cholesterol-lowering program
* reduces cardiovascular events in older patients after a myocardial infarction.
* works best if taken with food.

Simvastatin
* is statin
* reduces graft vessel disease and mortality after heart transplantation.

### science | medicine:

Sulfonamide
* are available in varied formulations and treatment schedules
  - competitive inhibitors of the incorporation of p -aminobenzoic acid
  - less likely to produce crystallurea
  - loosely and reversibly bound in varying degrees to serum albumin
  - prepared by the reaction of a sulfonyl chloride with ammonia or an amine
  - the treatment of choice for nocardiosis
* block the folate synthase by a process of non-competitive inhibition.
* cause hemolysis less commonly.
* help control coccidiosis, and nitrofurans have limited effect on enteritis.
* pass into the breast milk.
+ Sulfonamide (drug), How they are made: Antibiotics