Issue
* All issues related to abuse, suffering and discrimination are societal issues.
* Many issues affect the quality of life for families and individuals
  - also arise in the relationship between the developing and the developed world
  - including food safety, animal health and pesticide use affect how a farm is managed.
  * I left today some more comments on the article's talk page. Many issues needs fixing. There are important things missing. I didn't had a look at the articles related to refs and so on. There is enough to do for now. The article is not ready for GA status
* affect ability
  - countries
  - development
  - industries
  - marine life
  - people
* are content
  - periodicals
  - printing
  - problems, situations and circumstances
  - provision
* are raised by students
  - testers
  - stores
* become concern
  - hot topics
* cause immediate problems
* concern genetics
  - responses
* contribute to complexity
* cover concepts
  - science concepts
* create confidence.
* dealing with environmental quality, energy, global change and health affect nearly everyone.
* demand attention
  - immediate attention
* deserve attention
  - consideration
  - special attention
* face business
  - societies
* have biological contexts
  - disorder
* impact cost
* include information
* inform choices.
* involve infrastructures.
* is content
* lead to trouble.
* present opportunity.
* relate to activities
  - affairs
  - business activities
  - care
  - causes
  - contributions
  - effects
  - foreign affairs
  - functions
  - growth
  - integrity
  - natural resources
  - reproductive health
  - treatments
  - values
* related to sexuality become more salient as sexual feelings emerge in early adolescence.
* require actions
  - approaches
  - examinations
  - management
  - medical care
  - separation
* take into consideration
  - places
* threaten existence.
+ Costa Rican colón, Banknotes, Banco Central, 1950–: Currency of North America
  * Every issue also features the signatures, date, and the agreement number printed in black.
+ Jennifer Government: NationStates, Gameplay, Issues: 2002 video games :: Online games
  * Issues are the most important part of the game. In it, you have to choose an option to solve a problem in your country. After the 30 original issues, Max Barry realized that more were needed so he gave players with a population of over 500 million an option to send him their own issue ideas.
+ Nuclear espionage, Manhattan Project: Nuclear weapons
  * During the Manhattan Project, which was when the United States, the United Kingdom, and Canada worked together during World War II to make the first nuclear weapons, there was much nuclear espionage in which scientists or technicians working for the project sent information about bomb development and designs to the Soviet Union. These people are often called the Atomic Spies, and their work continued into the early Cold War. These were secret messages between Soviet agents and the Soviet government that were discovered and decoded. Some issues remain unsettled, however.
  * Some issues are the same no matter what wiki a person is on. Leaving things too long has gotten us in trouble in the past.
+ TV Guide (magazine): American magazines :: Television :: Weekly magazines
  * In addition to TV listings, the publication features television-related news, celebrity interviews, gossip and film reviews and crossword puzzles. Some issues also have horoscope listings.

### issue worldwide:

Antimicrobial resistance
* can reduce the power of once life-saving medicines to that of a sugar pill.
* genes Genes in micro-organisms which confer resistance to antimicrobials.
* growing concern worldwide in both developed and developing countries.
* is an issue worldwide
  - ongoing challenge for gonorrhea treatment and control
* occurs through plasmid-mediated determinants.

Complex issue
* Some complex issues affect animals.
* affect life