### cell | vegetative cell:

Mast cell
* Some mast cells are part of alsatians
  - ankles
  - arms
  - backbones
  - beagles
  - bridges
  - bulldogs
  - chests
  - chicks
  - cochleas
  - craniums
  - cygnets
  - diaphragms
  - doggies
  - ducklings
  - endoskeletons
  - esophagi
  - fangs
  - fawns
  - fingers
  - fishbones
  - foxhounds
  - heads
  - incisors
  - jaws
  - knees
  - legs
  - ligaments
  - mandibles
  - marrow
  - molars
  - necks
  - noses
  - notochords
  - partridges
  - pelves
  - penises
  - poodles
  - proboscises
  - puppies
  - shinbones
  - skin
  - skulls
  - snouts
  - spines
  - sterna
  - studs
  - teeth
  - tendons
  - thighs
  - thumbs
  - toes
  - toms
  - tusks
  - vertebrae
  - wishbones
  - wrists
* are a kind of blood cell
  - non-circulating counterpart to the basophil
  - population of cells in the skin which are closely associated with blood cells
  - type of innate immune cell in connective tissue and the mucous membranes
  - abundant in the skin, eyes, nose, mouth and lungs
  - active participants in immune reactions against foreign substances
  - all over the place within our skin, and basophils circulate within our bloodstream
  - almost identical to basophils
  - cells which help to mediate the immune system of man and animals
  - fragile, granular cells that can rupture during tissue preparation and staining
  - granule-containing cells in tissue
  - important mediators of certain allergic reactions
  - indigenous cells in the body's connective tissues and arise from the bone marrow
  - instrumental in resistance to some other intestinal helminthiases
* are normal cells in the body that serve a normal defense mechanism
  - constituents of bone marrow
  - part of connective tissue
  - plentiful in the lungs, skin, tongue, and linings of the nose and intestinal tract
  - present in tissues
  - responsible for many of the symptoms of allergy
  - somatic cells
  - tissue cells that are present in almost all organs
  - tissue-resident granule containing cells with IgE receptors
* can degranulate by other signals.
* degranulate as a result of physical, chemical, pharmacological and immunological stimuli.
* disrupt epithelial barrier function during enteric nematode infection.
* express connexins on their cytoplasmic membrane.
* function to promote an inflammatory response to things the cells perceive as foreign.
* have IgE receptors on their surface
  - high affinity IgE receptors
  - many granules rich in histamine and heparin
* is present in the blood smear of a dog with cutaneous neoplasms.
* live in the lungs, skin, tongue, and mucosal linings of the body.
* make a chemical called histamine
  - substance called histamine
* migrate from blood to brain.
* participate in allergic and inflammatory reactions in the body's tissues.
* play a central role in the pathophysiology of urticaria
  - an important protective role in wound healing and defence against pathogens
* play an important role in the body's allergic response
  - body's immune response
  - self-defence of the human body
* produce a chemotactic factor for eosinophils
  - histamine and other signal molecules
* release histamine and all sorts of inflammation-promoting substances
  - heparin, chemicals which mediate allergic reactions
  - the histamine
  - three sets of mediators with dramatic, immediate, local and systemic effects
* reside in tissues while basophils are found in the blood.
* seem to have other roles as well.
* stain strongly metachromatic with toluidine blue as shown below.
+ Innate immune system, Cells of the innate immune response, Mast cells
  * Mast cells are a type of innate immune cell in connective tissue and the mucous membranes. They are intimately associated with defence against pathogens and wound healing. They are also often associated with allergy and anaphylaxis. When activated, mast cells rapidly release characteristic granules, rich in histamine and heparin, along with various hormonal mediators, and chemotactic cytokines into the environment. Histamine dilates blood vessels, causing the signs of inflammation, and recruits neutrophils and macrophages.
  * Mast cells have many granules rich in histamine and heparin. Mast cells play an important protective role  in wound healing and defence against pathogens.