### substance | corpuscle:

Monocyte
* also penetrate enflamed body tissue to help defend against infections.
* are a type of white blood cell , or leukocyte.
* are also capable of killing infected host cells using antibodies
  - important to the immune response
  - phagocytic and clean up cellular debris following an infection
  - amoeboid in appearance, and have a granulated cytoplasm
  - another type of white blood cell
  - attracted to a damaged site by chemical substances , triggered by a range of stimuli
* are generally scarce in peripheral blood
  - the largest leukocyte
  - immature macrophages
* are large cells that can enter tissues where they become macrophages
  - engulf and destroy invading bacteria and fungi
  - leukocytes
  - macrophages with a large horse shoe shaped nucleus and are the largest of all cells
* are motile cells that can migrate using ameboid movements
  - which can migrate using ameboid movements
* are phagocytes and frequently contain vacuoles
  - that circulate in the blood
  - poorly phagocytic until stimulated to become more active by a progressing infection
  - produced by the bone marrow from stem cell precursors called 'monoblasts'
  - the immature form of macrophages
* are the largest corpuscles in the blood
* are the second type of agranulocyte, and the largest of the circulating formed elements
  - very large and act as phagocytes during immune responses
  - white blood cells that become macrophages when they migrate into the tissues
* become fixed macrophages and then have specific names depending of area.
* can also travel into tissue and become macrophages , or big eaters
  - become macrophagic in appearance in some serious chronic infections
  - migrate into tissues where they are known as macrophages
* carry out phagocytosis and are also called macrophages.
* circulate in the blood and lymphatics but become macrophages when they enter the tissues
  - peripheral blood prior to emigration into the tissues
* closely resemble large lymphocytes in size and shape.
* defend the body against bacterial infection.
* develop and are stored in the spleen and bone marrow.
* differentiate into macrophages.
* do secrete active TGFb, a major fibrogenic cytokine.
* enter damaged epithelium and become macrophages.
* evolve into macrophages.
* further differentiate in tissues into macrophages.
* have a kidney bean shaped center and lots of cytoplasm.
* originate in the bone marrow as immature monoblasts and promonocytes
* possess similar granules.
* recognize a variety of microorganisms, especially gram-negative bacteria.
* tend to have a relatively short lifespan within the circulation.
+ Macrophage, Life cycle: Cells :: Immunology
  * When a monocyte enters damaged tissue through the wall of a blood vessel it changes to become a macrophage. Monocytes are attracted to a damaged site by chemical substances, triggered by a range of stimuli. At some sites such as the testis, macrophages have been shown to populate the organ through proliferation.
+ Monocyte, Physiology: Immunology :: Blood cells
  * Monocytes are produced by the bone marrow from stem cell precursors called 'monoblasts'. Monocytes circulate in the bloodstream for about one to three days and then typically move into tissues throughout the body. They make up three to eight percent of the leukocytes in the blood.
+ White blood cell, Types of white blood cells, Monocytes: Cell biology :: Immunology :: Blood cells
  * Monocytes are reserve cells which turn into macrophages and dendritic cells, which work together in tissues to fight disease. Monocytes have a kidney bean shaped center and lots of cytoplasm.

### substance | corpuscle | monocyte:

Monoblast
* are generally very large with abundant grey-blue or basophilic cytoplasm
  - hematopoietic cells
* develop into promonocyte , a large cell with a slightly indented nucleus.
* never appear in the normal peripheral blood.