Most of the longevity supplements and drugs fail. They don't show any actual longevity benefits in animals, not to mention humans. But there are a handful of these very basic compounds that promote longevity in multiple ways. Without further ado, here's the whole eternity of longevity supplements. Do it! If you remember one of my previous videos, then I did go through this big recent study about glycine and anti-aging and longevity. Glacine has the longevity benefits by increasing autobogym and mimicking methanine restriction. So it's quite important to balance your methanine and glycine in terms of preventing the rise of homocysteine and methanine toxicity. And glycine supplementation mimics methanine restriction. Glacine is also one of the rate limiting amino acids in synthesizing glutathione, which is the body's master anti-oxidant that protects against oxidative stress and bolsters your body against. The oxidative stress and inflammation that you see from aging and they do find that the glionac, so supplementing glycine and NLCL-16, has been found to extend to the lifespan of mice by up to 24%. In humans, glionac supplementation reduces the whole amount of aging and improves just the health span. Glionac supplementation in older adults for 16 weeks was safe and well tolerated. Compared to younger adults, older adults had good alternative efficiency, oxidative stress, mitochondrial dysfunction, inflammation and the theory of dysfunction, incident resistance, multiple aging hallmarks in paired physical function, increased waste circumference and systolic blood pressure. Glionac and NOT placebo supplementation in older adults improved or corrected these defects. And these effects have also been shown in other human adults. So, a glionac just because of increasing glutathione levels can have quite an important role in healthy aging. Glutathione is the body's master antioxidant. Deficient glutathione increases oxidative stress that contributes to age-related diseases and newer degeneration, supplementing with cystine and glycine can fix the glutathione deficiency. Glycine, cystine and glutamine make up glutathione and glutathione synthesis is rate limited by glycine. Now you need about 3 grams of glycine for daily glutathione synthesis and most people generally eat only around 3 to 5 grams of glycine from diet and their body makes around 3 grams of glycine itself as well and doggenously. So, if you have the 3 grams of the body makes itself and the 3 grams usually people get from diet, then only 3 grams will be enough to cover the 3 gram demand for synthesizing creatine, glutathione and heme by glycine. However, there is an additional requirement for 12 grams of glycine for collagen synthesis and collagen turnover. So, if you are not really increasing your glycine intake or you are not eating a lot of glycine and you are not supplementing glycine, for example, then you are almost at a 12 gram deficit in terms of glycine. That's why I think that supplementing some glycine and boosting the glutathione with NAC as well is just such an easy combo to do and it has many benefits in terms of increasing your glutathione levels and managing inflammation levels. Glicine alone has many other benefits that you can check out from my previous video, but the short description about glycine is that it boosts glutathione, it increases creatine synthesis, it has benefits for inflammation, oxidistress, lowering blood sugar levels, protecting against advanced glycation and products and many other things like improved sleep. So, glycine is pretty much like a universal supplement that I think most people would benefit from, it has little to no side effects aside from like a headache or low blood sugar levels and all the benefits are quite immense in terms of the glutathione, the collagen synthesis and it's just something that many people can just add to their diet quite easily. The body makes 3 grams a day and many people just get 3 to 5 grams from diet at minimum you need 15 grams of glycine, so most people would generally benefit from supplementing like 10 grams of glycine a day. What? This brings me to the third supplement on the whole eternity which is creatine. Like I said, glycine also supports creatine synthesis. Creatine is synthesized in the liver and pancreas from the amino acids, Arginine, glycine and Methionine. In glycine deficient animals muscle creatine content is quite low and supplementing glycine has been seen to raise creatine levels. Creatine is one of the oldest and most researched supplements in the world, it has many proven benefits for muscle strength, muscle performance and muscle mass. However, creatine also has many anti-aging and longevity benefits such as neuroprotection, methylation, support, obviously the muscle mass and muscle strength are also quite vital for healthy aging. When it comes to life extension, then at least in mice, the ones that got creatine, they had a 9% higher survival than the control mice. Creatine has many neuroprotective and atherosclerotic protective effects as well, so it just impludes your brain function, prevents or protects against neurodegeneration and atherosclerosis and heart disease as well in many ways. And when you're older, then your creatine levels decrease, your muscle mass decreases, which is a huge risk factor for mortality and hip pressures and immobility and all those things. You don't want to lose your mobility, you don't want to lose your muscle strength and muscle mass with age. Those are quite critical, one of the biggest predictors of longevity and mortality is your muscle mass. And creatine just by increasing your body's muscle creatine stores and improving muscle strength is a longevity supplement from that side and from the neurological side or the brain side, then yeah, creatine slows down, protects against the brain aging and it just improves cognition as well. So as you can see, these three supplements, creatine, glycine and NAC, they have kind of, you know, even supportive effects of each other. First of all, glycine supports creatine synthesis and both glycine and NAC support guothan synthesis, so they all work kind of synergistically. And the best of all is that they're all pretty cheap, they're very easily available and everyone can pretty much take them if you've ever played like video games, and then there's also the concept of the Holy Trinity, which describes three different roles of characters that there are. So there's the tank, which is kind of the one that soaks up all the damage and you know, is the one that is kind of the shield of the group. NAC is kind of the tank of the Holy Trinity, that it boosts your guothan levels and it protects your immunity. So to say, glycine is like the healer, so glycine like supports healing in many ways cools down, reduces inflammation, res blood sugar, those kind of things supports the tank and creatine is the damage. Creatine is the damage dealer kind of the muscle of the group and all of them work synergistically and with all these three supplements, you're covering pretty much all the meaningful, the most meaningful, most impactful aspects of aging and health span, which are the physical function, the motor, motor function, the muscle strength plus a mass, then you have the neuroparticular effects of both the guothan and creatine, you have immunity, you have metabolic health, all those things body composition and they work pretty well synergistically and I think that they can be used as a staple for any like a longevity supplement stack. If you do want to slow down aging, then I'm looking for more people who want to reverse their biological clock. If you're interested, then email me the word health to infoatseamlant.com and I'll send you the details. But I don't let the thanks for watching this video. Make sure to click the like subscribe notification but as well, my name is Seem, stay optimized, stay empowered.