The Supremes. Originally called the Permets, this Motown Girl group was the most successful vocal group to ever come out of the US. They had 12 singles to hit number one on the Billboard Top 100 throughout the 60s. The Supreme success helped pave the way for future African-American musicians. The group still stands as the 16th greatest artist to top the charts. Spice Girls, there was no bigger musical group throughout half of the 90s than the Spice Girls. Little girls to adult women were all entranced by the calls for Girl Power and the fun. Pop music the group put out. After selling over 100 million records, the Spice Girls are the best selling girl group of all time. They are also the most successful pop group to come out of Great Britain since the Beatles. TLC, this three-person girl group had a unique combination of talents. T-Baws had a low-pitched and sultry sound. Chili's was a bit sweeter of an R&B voice and left I brought in hip-hop. Together, through four albums, TLC dominated the airwaves and TV with music that had both playful and serious messages. After racking up 65 million sales worldwide, they are America's best selling girl group. Don't forget to like and subscribe for more content.