We can assume that the Avenger Prime is the strongest variant of Loki. In this reality, his brother Thor died at a young age due to accident, allowing him to become the next ruler of Asgard. Afterward, plagued by a sense of emptiness, he turned to seek guidance from fellow Locus, only to find them to be wretched failures who were perpetually hindered by the Avengers. As he travels through various universes, he discovered that he was the catalyst behind the formation of the Avengers in each reality he visited. However, upon returning to his own universe, he made it his mission to prevent the rise of any Avenger. This decision, though successful in achieving his goal, came at a great price. As cosmic threats emerged like Thanos and Galactus, Loki had to face them alone, using his magic to triumph over these dangers. Unfortunately, the immense power he wielded resulted in the annihilation of all life in his universe, leaving him feeling empty and devoid of purpose.