omniomni/omni-engineering huggingface dataset:
N-ethylmaleimide sensitive fusion protein. N-ethylmaleimide-sensitive factor, also known as NSF or N-ethylmaleimide sensitive fusion proteins, is an enzyme which in humans is encoded by the NSF gene.

Function 

NSF is a homohexameric AAA ATPase involved in membrane fusion. NSF is ubiquitously found in the membrane of eukaryotic cells. It is a central component of the cellular machinery in the transfer of membrane vesicles from one membrane compartment to another. During this process, SNARE proteins on two joining membranes (usually a vesicle and a target membrane such as the plasma membrane) form a complex, with the α-helical domains of the SNAREs coiling around each other and forming a very stable four-helix bundle. As SNAREs intertwine, they pull the vesicle towards the target membrane, excluding water and promoting fusion of the vesicle with the target membrane. NSF unravels SNARE complexes once membrane fusion has occurred, using the hydrolysis of ATP as an energy source, allowing the dissociated SNAREs to be recycled for reuse in further rounds of membrane fusion.  This proposal remains controversial, however.  Recent work indicates that the ATPase function of NSF does not function in recycling of vesicles but rather functions in the act of fusing vesicles with the plasma membrane.

SNARE hypothesis 

Because neuronal function depends on the release of neurotransmitters at a synapse — a process in which synaptic vesicles fuse with the presynaptic membrane — NSF is a key synaptic component. Thus, conditional temperature-sensitive mutations in the Drosophila melanogaster gene for NSF lead to a comatose behaviour at the restrictive temperature (and hence the gene is called comatose), presumably because neuronal functions are blocked. In Dictyostelium discoideum amoebae, similar mutations lead to a cessation of cell movement at the restrictive temperature, indicating a role for intracellular membrane transport in migration. Another neuronal role for NSF is indicated by its direct binding to the GluR2 subunit of AMPA type glutamate receptors (which detect the neurotransmitter glutamate). This gives NSF a putative role in delivery and expression of AMPA receptors at the synapse.

NSF was discovered by James Rothman and colleagues in 1987 while at Stanford University; they identified NSF after observing that a cytoplasmic factor, required for membrane fusions, was inactivated by treatment with N-ethylmaleimide. This assay enabled them to purify NSF.

Interactions 

N-ethylmaleimide sensitive fusion protein has been shown to interact with NAPA.

References

Further reading 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 

Proteins
Human proteins
Desktop Linux Consortium. The Desktop Linux Consortium (DLC) was a non-profit organization which aims at enhancing and promoting the use of the Linux operating system on desktop computers.

It was founded on 4 February 2003.

Members 

Ark Linux
CodeWeavers
Debian
KDE
Linux Professional Institute (LPI)
The Linux Terminal Server Project (LTSP)
Lycoris (company)
Mandriva (formerly known as Mandrakesoft)
NeTraverse
OpenOffice.org Organisation, does not exist any more
Questnet (Support4Linux.com)
Samba
Sunwah Linux (rays Linux Distribution)
SUSE
theKompany
TransGaming Technologies
TrustCommerce
Xandros
Ximian

See also 
 Desktop Linux

References

External links 
 Archived version of the official website as of 2007

Linux organizations
PDX. PDX may refer to:

Places
Portland, Oregon, US
Portland International Airport (IATA code)
Portland Union Station (railway code)

Brands and enterprises
PDX, a line of musical instruments and equipment by Vestax
Paradox Interactive, a Swedish video game publisher
Paradox Development Studio, the in-house game development team of the above

Computing and technology
Paradox (warez), a warez–demogroup; an anonymous group of software engineers that devise ways to defeat software and video game licensing protections, a process known as cracking

Science and healthcare
Pancreatic and duodenal homeobox protein, a transcription factor
Patient-derived xenograft, human tumor grown in mice
PDX, principal diagnosis (see Medical diagnosis#Concepts related to diagnosis), the main cause of a patient's need for treatment

Other uses
PDX.edu, domain name of Portland State University, Oregon
Performance Driving eXperience, an event sanctioned by the Sports Car Club of America

See also
KPDX, a television station in the Portland, Oregon area
Timeline of project management. This article covers the historical timeline of project management. There is a general understanding that the history of modern project management started around 1950. Until 1900, projects were generally managed by creative architects and engineers themselves, among those, for example, Christopher Wren, Thomas Telford and Isambard Kingdom Brunel.

Early civilizations 
 2570 BC Great Pyramid of Giza completed. Some records remain of how the work was managed: e.g. there were managers of each of the four faces of the pyramid, responsible for their completion (subproject managers). 
 208 BC The first major construction of the Great Wall of China.

17th - 19th century 
 Christopher Wren (1632–1723) was a 17th-century English designer, astronomer, geometer, mathematician-physicist and architect. Wren designed 55 of 87 London churches after the Great fire of London in 1666, such as St Paul's Cathedral in 1710, as well as many secular buildings.
 Thomas Telford (1757-1834) was a Scottish stonemason, architect and civil engineer and a road, bridge and canal builder, who managed the Ellesmere Canal and Pontcysyllte Aqueduct.
 Isambard Kingdom Brunel (1806–1859) was a British engineer who created the Great Western Railway, a series of steamships, such as the first with a propeller, and numerous bridges and tunnels.

20th century 
 1910s The Gantt chart developed by Henry Laurence Gantt (1861–1919)

1950s
 1950s The Critical path method (CPM) invented
 1950s The US DoD used modern project management techniques in their Polaris project.
 1956 The American Association of Cost Engineers (now AACE International) formed
 1958 The Program Evaluation and Review Technique (PERT) method invented
 
1960s
 1969 Project Management Institute (PMI) launched to promote project management profession

1970s
 1975 PROMPT methodology (acronym for Project Resource Organisation Management Planning Technique) created by Simpact Systems Ltd (source: PRINCE2 manual)
 1975 The Mythical Man-Month: Essays on Software Engineering by Fred Brooks published

1980s
 1984 The Goal by Eliyahu M. Goldratt published
 1986 Scrum was named as a project management style in the article The New New Product Development Game by Takeuchi and Nonaka
 1987 First Project Management Body of Knowledge Guide published as a white paper by PMI
 1989 PRINCE method derived from PROMPTII is published by the UK Government agency CCTA and becomes the UK standard for all government information projects

1990s
 1996 PRINCE2 published by CCTA (now Office of Government Commerce OGC) as a generic product management methodology for all UK government projects.
 1997 Critical Chain by Eliyahu M. Goldratt published

21st century 
 2001 AgileAlliance formed to promote "lightweight" software development projects
 2006 Total Cost Management Framework release by AACE
 2009 PRINCE2 2009 edition, compatible with other methods and more flexible in approach

See also
 List of project management topics

References

External links 
 "A Brief History of Project Management" Infographics

Project management
Schedule (project management)
Platform-specific model. A platform-specific model is a model of a software or business system that is linked to a specific technological platform (e.g. a specific programming language, operating system, document file format or database). Platform-specific models are indispensable for the actual implementation of a system.

For example, if a business needs to implement an online shop, then their software system will need to store different kinds of information: available goods, user info such as credit cards, etc. The designer might decide to use for this purpose an Oracle database. For this to work, the designer will need to express concepts (e.g. the concept of a user) in a relational model using the Oracle's SQL dialect. This Oracle's specific relational model is an example of a Platform-specific model.

In Model-driven architecture, a platform-specific model is where the design of the model is constructed with the intended execution-platform driving design choices.

Related Concepts 
 ATLAS Transformation Language (ATL)
 Domain Specific Language (DSL)
 Domain-specific modelling (DSM)
 Eclipse Modeling Framework (EMF)
 Generic Modeling Environment (GME)
 Graphical Modeling Framework (GMF)
 Meta-Object Facility (MOF)
 Meta-modeling
 Model-based testing (MBT)
 Model-driven architecture (MDA) 
 Model Transformation Language (MTL)
 Object Constraint Language (OCL)
 Object-oriented analysis and design (OOAD)
 Visual Automated model Transformations VIATRA 
 XML Metadata Interchange (XMI)

References 

Software architecture
Systems engineering
Henry Laurence Gantt Medal. The Henry Laurence Gantt Medal was established in 1929 by the American Management Association and the Management section of the American Society of Mechanical Engineers for "distinguished achievement in management and service to the community" in honour of Henry Laurence Gantt. By the year 1984 in total 45 medals had been awarded.

Award winners 

20th-century winners, a selection
 1929: Henry Laurence Gantt (posthumously)
 1930: Fred J. Miller,
 1931: Leon Pratt Alford
 1932: Henry S. Dennison
 1933: Henry Wallace Clark
 1934: Horace B. Cheney
 1935: Arthur Howland Young
 1936: Morris Evans Leeds (1869–1952)
 1940: William Loren Batt
 1941: Paul Eugene Holden
 1943: Dexter S. Kimball
 1944: Frank Bunker Gilbreth Sr. (posthumously) and Lillian Moller Gilbreth
 1945: John Milton Hancock
 1946: Paul G. Hoffman
 1947: Alvin E. Dodd
 1948: Harold Fowler McCormick
 1949: Arthur Clinton Spurr
 1950: Charles R. Hook Sr.
 1951: Thomas Roy Jones
 1952: Frank Henry Neely (1884–1979)
 1953: Thomas E. Millsop
 1954: Clarence Francis
 1955: Walker Lee Cisler
 1956: Henning Webb Prentis Jr.
 1957: Harold F. Smiddy 
 1958: Richard Redwood Deupree
 1959: Peter Drucker
 1960: Charles McCormick
 1961: Lyndall Urwick
 1962: Austin J. Tobin
 1963: Lawrence A. Appley
 1964: Harold Bright Maynard
 1965: Ralph J. Cordiner
 1968: J. Erik Jonsson
 1969: Dave Packard
 1970: Frederick R. Kappel
 1971: Donald C. Burnham 
 1972: Robert Elton Brooker
 1973: John T. Connor 
 1974: Willard Rockwell
 1975: Patrick E. Haggerty
 1976: Kenneth Daniel
 1982: Charles Luckman
 1983: Walter A. Fallon
 1984: Rawleigh Warner Jr.
 1987: Edmund T. Pratt Jr.
 1988: William S. Lee
 1996: George N. Hatsopoulos

 21st-century winners
 2000: Paul Soros
 2001: Roy Huffington
 2002: Alexander W. Dreyfoos Jr.
 2003: William R. Timken
 2004: Julie Spicer England
 2006: Charla K. Wise
 2007: Dean L. Kamen
 2009: Charles M. Vest
 2018: Todd R. Allen
 2019: Margaret G. McCullough

References

External links 
ASME Official Medal Page

 
Awards established in 1929
1929 establishments in the United States
Management awards
ASME Medals
Index of articles related to the theory of constraints. This is a list of topics related to the theory of constraints.

B
 Bottleneck (production)
This is a resource that has enough capacity or more capacity when needed to satisfy the demand placed upon it.  Bottlenecks need not be taken into account when scheduling.

C
 Causality

E
 Eliyahu M. Goldratt
 Evaporating Cloud
 Event chain methodology

F
 Failure mode and effects analysis (FMEA)
 Focused improvement
 Future Reality Tree

G
 Game theory
 The Goal (novel)
 Goldratt, Eliyahu M.

I
 It's Not Luck (novel)

L
 Lean Construction

M
 Meadows, Donella Twelve leverage points - protocols to intervene in a system

N
 Necessary and sufficient conditions
 Necessary But Not Sufficient (novel)

P
 POOGI
 Prerequisite Tree
 Project Management

R
 Reengineering
 Reverse hierarchy

S
 Strategy & Tactics (TOC)

T
 Thinking processes
 Throughput (business)
 Throughput
 Total quality management
 Transition Tree
 Twelve leverage points

See also
 Business philosophies and popular management theories
 List of management topics
 List of project management topics
 Management

 
Constraints, Theory of
Theory of Constraints topics
American Plastics Council. The American Plastics Council (APC) is a defunct trade association for the U.S. plastics industry. Through a variety of outreach efforts, APC worked to promote the benefits of plastics and the plastics industry. APC comprised 22 of the leading resin manufacturers, plus one affiliated trade association representing the vinyl industry. APC's membership represented more than 80 percent of the U.S. monomer and polymer production and distribution capacity.

Initially autonomous, the APC merged in 2002 with the American Chemistry Council (ACC, formerly known as the Manufacturing Chemists' Association, then the Chemical Manufacturers Association, renamed ACC in June 2000).
Members are now represented by the ACC.

References

External links
 Organization website
 Organization's public relations page
 My Plastics Industry

Trade associations based in the United States
Speed prior. The speed prior is a complexity measure similar to Kolmogorov complexity, except that it is based on computation speed as well as program
length.
The speed prior complexity of a program is its size in bits plus the logarithm of the maximum time we are willing to run it to get a prediction.

When compared to traditional measures, use of the Speed
Prior has the disadvantage of leading to less optimal predictions, and
the advantage of providing computable predictions.

See also 

 Computational complexity theory
 Inductive inference
 Minimum message length
 Minimum description length

References

External links 

Speed Prior web site

Bayesian statistics
Amalgamated Engineering and Electrical Union. The Amalgamated Engineering and Electrical Union (AEEU) was a British trade union. It merged with the MSF to form Amicus in 2001.

History
The union was founded in 1992, when the Amalgamated Engineering Union (AEU) finally achieved a merger with the Electrical, Electronic, Telecommunications and Plumbing Union (EETPU), after a hundred years of off-and-on discussions. The new union took the name Amalgamated Engineering and Electrical Union.

The AEU had been affiliated to the Trades Union Congress, while the EETPU was not, so the merged organisation held a ballot on the question of affiliation; members voted for the new union to affiliate. The AEEU was also the largest member of the Confederation of Shipbuilding and Engineering Unions.

Membership of the new union continued to fall in line with the decline in employment in the sectors it covered. By 2001, its membership had fallen to 728,200. That year, it merged with the Manufacturing, Science and Finance union to form Amicus.

General Secretaries
1992: Gavin Laird and Paul Gallagher
1994: Paul Gallagher
1995: Ken Jackson

Presidents
1992: Bill Jordan and Ken Jackson
1994: Bill Jordan
1994: John Weakley (acting)
1996: Davey Hall

References

External links
Catalogue of the AEEU archives, held at the Modern Records Centre, University of Warwick
Catalogue of further AEEU archives, held at the Modern Records Centre, University of Warwick

Defunct trade unions of the United Kingdom
Engineering trade unions
1992 establishments in the United Kingdom
Trade unions established in 1992
Trade unions disestablished in 2001
Trade unions based in London
Interface bloat. Interface bloat is a phenomenon in software design where an interface incorporates too many (often unnecessary) operations or elements, causing issues such as difficulty navigating and usability.

Definition 
While the term bloat can refer to a variety of terms in software design, Interface bloat refers to the phenomenon where the user interface (UI) becomes unnecessarily complex and overloaded with features, options, or elements that can overwhelm users. This often leads to a cluttered experience, decreased usability, and increased difficulty for users to accomplish their tasks efficiently. Interface bloat can arise from various sources, including the addition of excessive functionality without proper consideration of user needs, the merging of disparate features, or pressure to include numerous options to cater to a broader audience.

References
Anti-patterns
Computer programming folklore
Software engineering folklore
66 (number). 66 (sixty-six) is the natural number following 65 and preceding 67.

In mathematics
66 is a sphenic number, a semiperfect number, and a Erdős–Woods number.

In computing
66 (more specifically 66.667) megahertz (MHz) is a common divisor for the front side bus (FSB) speed, overall central processing unit (CPU) speed, and base bus speed. On a Core 2 CPU, and a Core 2 motherboard, the FSB is 1066 MHz (~16 × 66 MHz), the memory speed is usually 666.67 MHz (~10 × 66 MHz), and the processor speed ranges from 1.86 gigahertz (GHz) (~66 MHz × 28) to 2.93 GHz (~66 MHz × 44), in 266 MHz (~66 MHz × 4) increments.

In motor vehicle transportation

The designation of the historic U.S. Route 66, dubbed the "Mother Road" by novelist John Steinbeck, and other roads.

References

External links

Integers
USS F-2 (SS-21). USS F-2 (SS-21) was an F-class submarine built for the United States Navy during the 1910s.

Description
The F-class boats had a length of  overall, a beam of  and a mean draft of . They displaced  on the surface and  submerged. The F-class submarines had a crew of 1 officer and 21 enlisted men. They had a diving depth of .

For surface running, the boats were powered by two  NELSECO diesel engines, each driving one propeller shaft. When submerged each propeller was driven by a  electric motor. They could reach  on the surface and  underwater. On the surface, the boats had a range of  at  and  at  submerged.

The F-class submarines were armed with four 18-inch (450 mm) torpedo tubes in the bow, no reloads were carried.

Construction and career
The boat was named Barracuda when she was laid down by Union Iron Works of San Francisco, California, but was renamed on 17 November 1911.  She was launched on 19 March 1912 sponsored by Miss A. R. Rolph, daughter of James Rolph, the mayor of San Francisco, and commissioned on 25 June 1912.

F-2 joined the 1st Submarine Group, Pacific Torpedo Flotilla, in operations between San Diego, California, and San Pedro, Los Angeles out of San Pedro Submarine Base, the Flotilla's base. She continued to play an important part in developing tactics and coordinating the use of undersea craft with the fleet during an extended training period in the Hawaiian Islands's Naval Submarine Base Pearl Harbor from August 1914-November 1915.

After lying in ordinary at Mare Island Naval Shipyard from 16 March 1916 – 13 June 1917, F-2 became flagship of Division 1, Submarine Force, Pacific Fleet. Returning to operations out of San Pedro, she participated in surface and submerged exercises, torpedo-proving practice, experiments in balancing at various depths, and trained prospective crews of new submarines. On 18 September 1919, she was placed in reserve commission at San Pedro to be used in elemental school work until decommissioned at Mare Island on 16 March 1922. She was sold on 17 August.

Notes

References

External links

F-2
World War I submarines of the United States
Ships built in San Francisco
1912 ships
Ships built by Union Iron Works
Jim Hall (computer programmer). Jim Hall (James F. Hall) is a computer programmer and advocate of free software, best known for his work on FreeDOS. Hall began writing the free replacement for the MS-DOS operating system in 1994 when he was still a physics student at the University of Wisconsin-River Falls. He remains active with FreeDOS, and is currently the coordinator for the project.

Hall has said he created FreeDOS in response to Microsoft announcing end of support for MS-DOS in 1994, a year before Windows 95 was released. As a user and fan of MS-DOS, Hall did not want the functionality of DOS to go away. Prompted by a March 31, 1994 post on comp.os.msdos.misc asking if "anyone, for example GNU et al. ever considered writing a Public Domain DOS", Hall decided to garner support for a free version of DOS, written under a free or public domain model. In a June 29, 1994 post, Hall announced an effort to create a free DOS, called PD-DOS, writing:

Within a few weeks, other programmers including Pat Villani and Tim Norman joined the project. A kernel, the COMMAND.COM command line interpreter (shell) and core utilities were created by pooling code they had written or found available. Hall wrote over a dozen of the first DOS utilities for the project, mostly file and batch utilities. In a July 26, 1994 post, Hall announced the PD-DOS project had been renamed to "Free-DOS", having updated the project's goals to intend to distribute source code under the GNU General Public License. The project would later be renamed "FreeDOS", without the hyphen, after the publication of FreeDOS Kernel, by Pat Villani. Hall was the project's release coordinator from Beta1 until about Beta7, and also released the first alpha distribution of Free-DOS, as announced in a post on comp.os.msdos.misc. He is again the project coordinator since April 2011 after Pat Villani's departure, and subsequent death in August of the same year.

Hall is also the original developer of GNU Robots, but he is no longer active on this project and has since handed maintainership over to Tim Northover. It is now being developed by Bradley Smith.

References

Further reading

External links
 

Free software programmers
American computer programmers
FreeDOS people
People from Virginia
University of Wisconsin–River Falls alumni
20th-century births

Living people
Year of birth missing (living people)
Fujita Airlines. was an airline in Japan, formerly known as Nippon Yuran Airlines.  Founded in 1956, it operated various types of propeller aircraft, including the Cessna 170, de Havilland Dove and Fokker F27. In 1963, the company merged with All Nippon Airways.

Incidents and accidents
 On August 17, 1963, a Fujita Airlines de Havilland Heron 1B (registration JA6155) struck a mountain near Hachijo Island shortly after takeoff due to possible engine failure, killing all 19 passengers and crew on board.

References

Defunct airlines of Japan
Airlines established in 1952
Airlines disestablished in 1964
EGP. EGP may refer to:

Organizations
 Edinburgh Global Partnerships, a student-run charity
 Guerrilla Army of the Poor (), in Guatemala
 European Green Party, a political party

Technology 
 Experimental Geodetic Payload, Japanese satellite
 Exploration Gateway Platform, 2012 Boeing-NASA discussion for a space station
 Exterior gateway protocol, a class of routing protocols used between Autonomous Systems
 Exterior Gateway Protocol, a specific protocol formerly used on the Internet

Other uses 
 Eagle Pass Municipal Airport
 Eastern Gas Pipeline, in Australia
 Egyptian pound, the currency of Egypt
 Enel Green Power, an Italian energy company
 Engineered Glass Products, an American manufacturing company