Tranexamic acid

I-Tranexamic acid (TXA) iyisithombo esetshenziswa ukuthuthukisa noma ukuphindaphinda ukubulawa kobugebengu okusenzo zangaphakathi, ukukhulisa i-"blood loss" emtholampilo ezintweni ezikulezi zisuswa: ukubulawa kwezwe ezingamakhulu, ukugcwalisa okuphuma esibayeni, ukwenzekwa kwezombusazwe, ukucimekwa kwe-dental, ukucimekwa kwezibopho kanye nokususwa kwezikhumbuzo ezingaphakathi. Kusetshenziswa futhi ukuthi uye kwamaphilisi ezingeni eliphezulu zokudala. Kusetshenziswa kungasendaweni ukuya kwe-oral kanye nangokugcina emtholampilweni wesango injection into a vein.

 Umqondofanayo wokusebenza 
I-Tranexamic acid iyinhlangano yeduthuluzi efana nesethetiki yomhlaba, i-amino acid yomhlaba lysine. Isetshenziswa njengendlela yokusebenza i-antifibrinolytic ngokushintshana kanye nokuphuma lokusebenza kwamanye amaklasi. Lokhu kushitsha indlela yokuqhubekeka kwe-plasminogen kuze kube inkeke yokuqhubekeka, okwenza ukuphinda fibrin ukulweleke kanye nokulondoloza uhlelo lwesihloko sesifuba se-fibrin. I-Tranexamic acid inamahlebezane eyisikhombisa eminyakeni emithathu ukuthuthukisa ukusebenza kwe-ε-aminocaproic acid, ingakuthi ukuphinda indlela yokusebenza yeproteini isine IC50 = 87 mM), kanye ikwenzela ukungabulala uqobo lwesethetiki sokuqhuba (urokinase plasminogen activator) ngezinsika eziningi (Ki = 2 mM), ezinokuhleleka kakhulu phakathi kwezikhumbuzo zonke ze-serine proteases.

Amaphutha ehlukahlukene. Kunezinye ezihlukahlukene ezihlukile njengeqoqo lezinye ezinjengokubuka color vision, ukulweliswa kwesihloko (blood clots), kanye nolwazi oluyinhloko (allergic reactions).Kusetshenziswa okuncane futhi kubekhona izinga elibi kubo abantu abahlukene nezifo zomqondo. I-Tranexamic acid iyasitshela ukusebenzisa kwawo kwezokungaphakathi nokuphephethwa. I-Tranexamic acid iyinhlangano yezinye ezintsha ezibalulekileyo zokuqhuba ukusetshenziswa kwaso.

I-Tranexamic acid yabhala ngonyaka ka-1962 ngabafundi bezolimi bezaseJapan uShosuke kanye no-Utako Okamoto. Iyikhophi yezokwakha zaseWorld Health Organization's List of Essential Medicines. I-Tranexamic acid ikhona njengomthombo we-generic.
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