WWE protein domain

Umsebenzi 
Izizinda ze-WWE zenzeka ngezigaba ezimbili ezisebenzayo zamaprotheni, okungukuthi lezo ezihambisana nobiquitination kanye nalezo ezihlobene ne-poly-ADP ribosylation ( PARP ).Ngakho-ke, izizinda ze- WWE zibamba umsebenzi obalulekile ekudlulisweni kwesiginali, ukonakala kwamaprotheni, ukulungiswa kwe-DNA kanye ne- apoptosis . 

 Ukusebenzisana kwamaprotheni 
I WWE lesizinda yaqanjwa ezintathu zalo alondolozwe izinsalela, W no-E izinsalela ( tryptophans futhi glutamate ngokulandelana), futhi kubikezelwa ukuthi ethize ngasolinye amaprotheni-amaprotheni ekusebenzisaneni e ubiquitin futhi Adp ribose lokuhlanganisa izinhlelo (midi Adp ribose polymerase).Lesi sizinda itholakala njengendlela Ngohlelo uphinda ngesikhathi N-ukuphela Deltex, a cytosolic effector ka Notch mkhosi okucatshangwa uxhumano nomsebenzisi N-ukuphela kwe-Notch yokwamukela .  Iphinde itholakale njengemodyuli yokuxhumana kuma- protein ubiquination kanye ne-ADP ribosylation protein . Aravind L (2001). "The WWE domain: a common interaction module in protein ubiquitination and ADP ribosylation". Trends Biochem Sci. 26 (5): 273–5. doi:10.1016/s0968-0004(01)01787-x. PMID 11343911.

 Isakhiwo 
Ngaphakathi kwemodyuli ngayinye ye-WWE, izinsalela zakha izakhiwo ezimbili ezifanayo ezibalulekile ekusimeni kwaso.Amamojula amabili e-WWE ahlangana futhi akha umsantsa omkhulu ofanele ukubopha ama-polypeptides anwetshiwe.Amamojula amabili e-WWE amukela ukwakheka okuhlanganisiwe ikakhulu okuqukethe imicu ye-beta, nge- alpha helix eyodwa kumamojula womabili nangengxenye eyengeziwe emfushane ye-helical kusigaba sesibili seWWE.Amamojula amabili we-WWE abamba i- eksisi yokujikeleza kabili. Zweifel ME, Leahy DJ, Barrick D (November 2005). "Structure and Notch receptor binding of the tandem WWE domain of Deltex". Structure. 13 (11): 1599–611. doi:10.1016/j.str.2005.07.015. PMID 16271883.

 Izinkomba 

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