瑞巴派特

瑞巴派特（）是2-(1H)-喹啉酮的氨基酸衍生物，用于黏膜保护、Arakawa T, Kobayashi K, Yoshikawa T, Tarnawski A (September 1998). "Rebamipide: overview of its mechanisms of action and efficacy in mucosal protection and ulcer healing". Digestive Diseases and Sciences. 43 (9 Suppl): 5S–13S. PMID 9753220.治疗消化性溃疡以及胃炎的治疗。Arakawa T, Watanabe T, Fukuda T, Yamasaki K, Kobayashi K (November 1995). "Rebamipide, novel prostaglandin-inducer accelerates healing and reduces relapse of acetic acid-induced rat gastric ulcer. Comparison with cimetidine". Digestive Diseases and Sciences. 40 (11): 2469–72. doi:10.1007/bf02063257. PMID 7587834. S2CID 22807270.它通过增强黏膜防御、清除自由基Takumida M, Anniko M (January 2009). "Radical scavengers for elderly patients with age-related hearing loss". Acta Oto-Laryngologica. 129 (1): 36–44. doi:10.1080/00016480802008215. PMID 18607930. S2CID 16906464.以及暂时激活编码（COX-2）的基因来发挥作用。Tarnawski AS, Chai J, Pai R, Chiou SK (February 2004). "Rebamipide activates genes encoding angiogenic growth factors and Cox2 and stimulates angiogenesis: a key to its ulcer healing action?". Digestive Diseases and Sciences. 49 (2): 202–9. doi:10.1023/b:ddas.0000017439.60943.5c. PMID 15104358. S2CID 31756608.

研究表明，瑞巴派特可以对抗非甾体抗炎药（NSAIDs）对胃肠道黏膜的损伤作用，Zhang S, Qing Q, Bai Y, Mao H, Zhu W, Chen Q, Zhang Y, Chen Y (July 2013). "Rebamipide helps defend against nonsteroidal anti-inflammatory drugs induced gastroenteropathy: a systematic review and meta-analysis". Digestive Diseases and Sciences. 58 (7): 1991–2000. doi:10.1007/s10620-013-2606-0. PMID 23456504. S2CID 4887031.最近的研究还发现其对小肠也有保护作用，但对萘普生引起的胃损伤无效。Gagliano-Jucá T, Moreno RA, Zaminelli T, Napolitano M, Magalhães AF, Carvalhaes A, Trevisan MS, Wallace JL, De Nucci G (June 2016). "Rebamipide does not protect against naproxen-induced gastric damage: a randomized double-blind controlled trial". BMC Gastroenterology. 16 (1): 58. doi:10.1186/s12876-016-0472-x. PMC 4893238. PMID 27259970.

瑞巴派特在多个亚洲国家使用，包括日本（商品名Mucosta）、韩国、中国"Rebamipide". Drugs.com.和印度（商品名Rebagen）。该药也在俄罗斯获得批准，商品名为Rebagit。"Registration Sertificate: Rebagit (rebamipide) Film-Coated Tablets" . Russian State Register of Medicines. Retrieved 10 June 2017.

 作用机制 

瑞巴派特可增加胃黏膜前列腺素E2的水平，保护胃黏膜，从而抑制胃黏膜损伤，并增加胃黏液分泌和胃黏膜血流量，改善血流动力学障碍，抑制炎症并修复胃黏膜。

 参考文献 

 外部链接 
 Rebamipide Tablets 100mg "Kyorin" - 日本药品信息 
 DrugBank: Rebamipide - 药物数据库信息 

Category:氨基酸衍生物
Category:2-喹诺酮
Category:Α-胺基酸
Category:苯甲酰胺
Category:对氯苯基化合物