4-碘-2-甲基吡啶

4-碘-2-甲基吡啶是一种碘代芳烃，化学式为C6H6IN。它可由4-溴-2-甲基吡啶和碘化钠在碘化亚铜和N,N'-二甲基-1,2-环己二胺催化下于1,4-二氧六环中反应制得。Chen, Mao; et al. Rapid and Efficient Copper-Catalyzed Finkelstein Reaction of (Hetero)Aromatics under Continuous-Flow Conditions. Angewandte Chemie, International Edition (2015), 54(1), 263-266. .4-三甲基锡基-2-甲基吡啶和碘反应，也能得到4-碘-2-甲基吡啶。Yamamoto, Yutaka; et al. Studies on organometallic compounds. II. Facile and convenient method for the synthesis of iodoazines through iododestannation of trimethylstannylazines. Chemical & Pharmaceutical Bulletin (1982), 30(5), 1731-1737. .

它和三甲基硅基乙炔在催化下反应，可以得到2-甲基-4-(2-三甲基硅基乙炔基)吡啶。Jaeschke, Georg; et al. Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators: Discovery of 2-Chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (Basimglurant, RO4917523), a Promising Novel Medicine for Psychiatric Diseases. Journal of Medicinal Chemistry (2015), 58(3), 1358-1371. .
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Category:吡啶