四硝酸二氯六氨二(1,6-己二胺)合三铂

四硝酸二氯六氨二(1,6-己二胺)合三铂是一种配位化合物，化学式为[ClPt(NH3)2]2μ-{trans-Pt(NH3)2[H2N(CH2)6NH2]2}(NO3)4，有专利报道了它的合成。Valsecchi, Mariella; Conti, Marco; Del Greco, Luisa; Bugatti, Carlo; Menta, Ernesto; Giuliani, Ferdinando C.; Manzotti, Carla; Spinelli, Silvano; Farrell, Nicholas. Trinuclear cationic platinum complexes having antitumor activity and pharmaceutical compositions containing them. 1995. WO9526968.它具有抗癌活性，在对三种卵巢瘤和四种黑色素瘤的研究中发现它的IC50比顺铂至少低20倍。Carla Manzotti; Graziella Pratesi; Ernesto Menta; Roberto Di Domenico; Ennio Cavalletti; Heinz H. Fiebig; Lloyd R. Kelland; Nicholas Farrell; Donatella Polizzi; Rosanna Supino; Gabriella Pezzoni; Franco Zunino. BBR 3464: A Novel Triplatinum Complex, Exhibiting a Preclinical Profile of Antitumor Efficacy Different from Cisplatin. Clin Cancer Res (2000) 6 (7): 2626–2634.
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延伸阅读
 Michael E. Oehlsen; Yun Qu; Nicholas Farrell.  Reaction of Polynuclear Platinum Antitumor Compounds with Reduced Glutathione Studied by Multinuclear (1H, 1H−15N Gradient Heteronuclear Single-Quantum Coherence, and 195Pt) NMR Spectroscopy. Inorg. Chem. 2003, 42, 18, 5498–5506. .

Category:铂配合物
Category:二价铂化合物
Category:胺配合物
Category:硝酸盐
Category:氯配合物