2-氯烟酸

2-氯烟酸是一种有机化合物，化学式为C6H4ClNO2，它可以以正交晶系Pna21空间群结晶。Marcus V. N. de Souza, Solange M. S. V. Wardell and R. Alan Howie. 2-Chloro­pyridine-3-carboxylic acid. Acta Cryst E. 2005, 61 (5). .

它和氯化亚砜在110 °C反应，可以得到2-氯烟酰氯。Satyajit Roy; et al. Iron-Catalyzed Radical Activation Mechanism for Denitrogenative Rearrangement Over C(sp3)–H Amination. Angew Chem Int Ed, 2021. 60 (16). 它在银(I)盐的催化下，于120 °C 二甲基亚砜/重水中可以选择性的脱羧氘化，得到3-氘代-2-氯吡啶。Grainger, Rachel; Nikmal, Arif; Cornella, Josep; Larrosa, Igor. Selective deuteration of (hetero)aromatic compounds via deutero-decarboxylation of carboxylic acids. Org. Biomol. Chem., 2012,10, 3172-3174. .

参考文献

Category:氯吡啶
Category:吡啶甲酸