25-NB

（25x-NBx，既N-芳甲基-2,5-二甲氧基苯乙胺衍生物，缩写NBOMe）是一类苯乙胺衍生物，常作为迷幻药物。

化合物列表
基于2C家族
许多25-NB化合物都可看作是2,5-二甲氧基苯乙胺衍生物（2C化合物、2C家族）形成的仲胺，其R1基团为氢。
 结构 名称 化学名 分子式 CAS号 R基团 对应的2C化合物 Cyc 125px 25B-NB N-benzyl-1-(2,5-dimethoxy-4-bromophenyl)-2-aminoethane C17H20BrNO2 155639-26-2 2,5-二甲氧基-4-溴 2C-B 苯基 125px 25C-NB N-benzyl-1-(2,5-dimethoxy-4-chlorophenyl)-2-aminoethane C17H20ClNO2 1391487-65-2 2,5-二甲氧基-4-氯 2C-C 苯基 125px 25I-NB N-benzyl-1-(2,5-dimethoxy-4-iodophenyl)-2-aminoethane C17H20INO2 919797-18-5 2,5-二甲氧基-4-碘 2C-I 苯基 125px 25I-NMeTh N-[(thiophen-2-yl)methyl]-1-(2,5-dimethoxy-4-iodophenyl)-2-aminoethane C15H18INO2S 1391499-03-8 2,5-二甲氧基-4-碘 2C-I 2-噻吩基 125px 25B-NMePyr N-[(pyridin-2-yl)methyl]-1-(2,5-dimethoxy-4-bromophenyl)-2-aminoethane C16H19BrN2O2 1391499-21-0 2,5-二甲氧基-4-溴 2C-B 2-吡啶基 125px 25I-NMeFur N-[(furan-2-yl)methyl]-1-(2,5-dimethoxy-4-iodophenyl)-2-aminoethane C15H18INO3 1391498-93-3 2,5-二甲氧基-4-碘 2C-I 2-呋喃基 125px 25I-NMeTHF N-[(tetrahydrofuran-2-yl)methyl]-1-(2,5-dimethoxy-4-iodophenyl)-2-aminoethane C15H22INO3 2,5-二甲氧基-4-碘 2C-I 2-四氢呋喃基 125px 25B-NBF N-(2-fluorobenzyl)-1-(2,5-dimethoxy-4-bromophenyl)-2-aminoethane C17H19BrFNO2 1539266-17-5 2,5-二甲氧基-4-溴 2C-B 2-氟苯基 125px 25B-NBOH N-(2-hydroxybenzyl)-1-(2,5-dimethoxy-4-bromophenyl)-2-aminoethane C17H20BrNO3 1335331-46-8 2,5-二甲氧基-4-溴 2C-B 2-羟苯基 125px 25B-NBOMe N-(2-methoxybenzyl)-1-(2,5-dimethoxy-4-bromophenyl)-2-aminoethane C18H22BrNO3 1026511-90-9 2,5-二甲氧基-4-溴 2C-B 2-甲氧基苯基 125px 25B-NB23DM N-(2,3-dimethoxybenzyl)-1-(2,5-dimethoxy-4-bromophenyl)-2-aminoethane C19H24BrNO4 1391493-68-7 2,5-二甲氧基-4-溴 2C-B 2,3-二甲氧基苯基 125px 25B-NB25DM N-(2,5-dimethoxybenzyl)-1-(2,5-dimethoxy-4-bromophenyl)-2-aminoethane C19H24BrNO4 2,5-二甲氧基-4-溴 2C-B 2,5-二甲氧基苯基 125px 25B-NMe7BF N-[(benzofuran-7-yl)methyl]-1-(2,5-dimethoxy-4-bromophenyl)-2-aminoethane  1391492-46-8 2,5-二甲氧基-4-溴 2C-B benzofuran-7-yl 125px 25B-NMe7DHBF N-[(2,3-dihydrobenzofuran-7-yl)methyl]-1-(2,5-dimethoxy-4-bromophenyl)-2-aminoethane  1391492-40-2 2,5-二甲氧基-4-溴 2C-B 2,3-dihydrobenzofuran-7-yl 125px 25B-NMe7BT N-[(benzothiophen-7-yl)methyl]-1-(2,5-dimethoxy-4-bromophenyl)-2-aminoethane  1391492-59-3 2,5-二甲氧基-4-溴 2C-B benzothiophen-7-yl 125px 25B-NMe7Box N-[(benzoxazol-7-yl)methyl]-1-(2,5-dimethoxy-4-bromophenyl)-2-aminoethane  1391498-73-9 2,5-二甲氧基-4-溴 2C-B benzoxazol-7-yl 125px 25B-NMe7Ind N-[(indol-7-yl)methyl]-1-(2,5-dimethoxy-4-bromophenyl)-2-aminoethane  1391498-28-4 2,5-二甲氧基-4-溴 2C-B indol-7-yl 125px 25B-NMe7Indz N-[(indazol-7-yl)methyl]-1-(2,5-dimethoxy-4-bromophenyl)-2-aminoethane  1391498-43-3 2,5-二甲氧基-4-溴 2C-B indazol-7-yl 125px 25B-NMe7Bim N-[(benzimidazol-7-yl)methyl]-1-(2,5-dimethoxy-4-bromophenyl)-2-aminoethane  1391498-62-6 2,5-二甲氧基-4-溴 2C-B benzimidazol-7-yl 125px FECIMBI-36 N-[(2-fluoroethoxy)benzyl]-1-(2,5-dimethoxy-4-bromophenyl)-2-aminoethane  2,5-二甲氧基-4-溴 2C-B 2-(2-氟乙氧基)苯基 125px 25C-NB3OMe N-(3-methoxybenzyl)-1-(2,5-dimethoxy-4-chlorophenyl)-2-aminoethane C18H22ClNO3 1566571-34-3 2,5-二甲氧基-4-氯 2C-C 3-甲氧基苯基 125px 25C-NB4OMe N-(4-methoxybenzyl)-1-(2,5-dimethoxy-4-chlorophenyl)-2-aminoethane C18H22ClNO3 1566571-35-4 2,5-二甲氧基-4-氯 2C-C 4-甲氧基苯基 125px C30-NBOMe N-(3,4,5-trimethoxybenzyl)-1-(2,5-dimethoxy-4-chlorophenyl)-2-aminoethane C20H26ClNO5 1445574-98-0 2,5-二甲氧基-4-氯 2C-C 3,4,5-三甲氧基苯基 125px 25C-NBF N-(2-fluorobenzyl)-1-(2,5-dimethoxy-4-chlorophenyl)-2-aminoethane C17H19ClFNO2 1539266-21-1 2,5-二甲氧基-4-氯 2C-C 2-氟苯基 125px 25C-NBCl N-(2-chlorobenzyl)-1-(2,5-dimethoxy-4-chlorophenyl)-2-aminoethane C17H19Cl2NO2 2,5-二甲氧基-4-氯 2C-C 2-氯苯基 125px 25C-NBOH N-(2-hydroxybenzyl)-1-(2,5-dimethoxy-4-chlorophenyl)-2-aminoethane C17H20ClNO3 1391488-16-6 2,5-二甲氧基-4-氯 2C-C 2-羟苯基 125px 25C-NBOMe N-(2-methoxybenzyl)-1-(2,5-dimethoxy-4-chlorophenyl)-2-aminoethane C18H22ClNO3 1227608-02-7 2,5-二甲氧基-4-氯 2C-C 2-甲氧基苯基 125px 25C-NBOEt N-(2-ethoxybenzyl)-1-(2,5-dimethoxy-4-chlorophenyl)-2-aminoethane C19H24ClNO3 2,5-二甲氧基-4-氯 2C-C 2-乙氧基苯基 125px 25C-NBOiPr N-(2-isopropoxybenzyl)-1-(2,5-dimethoxy-4-chlorophenyl)-2-aminoethane C20H26ClNO3 2,5-二甲氧基-4-氯 2C-C 2-异丙氧基苯基 125px 25F-NBOMe N-(2-methoxybenzyl)-1-(2,5-dimethoxy-4-fluorophenyl)-2-aminoethane C18H22FNO3 1373917-84-0 2,5-二甲氧基-4-氟 2C-F 2-甲氧基苯基 125px 25CN-NBOH N-(2-hydroxybenzyl)-1-(2,5-dimethoxy-4-cyanophenyl)-2-aminoethane C18H20N2O3 1539266-32-4 2,5-二甲氧基-4-氰基 2C-CN 2-羟苯基 125px 25CN-NBOMe N-(2-methoxybenzyl)-1-(2,5-dimethoxy-4-cyanophenyl)-2-aminoethane C19H22N2O3 1354632-16-8 2,5-二甲氧基-4-氰基 2C-CN 2-甲氧基苯基 125px 25D-NBOMe N-(2-methoxybenzyl)-1-(2,5-dimethoxy-4-methylphenyl)-2-aminoethane C19H25NO3 1354632-02-2 2,5-二甲氧基-4-甲基 2C-D 2-甲氧基苯基 125px 25D-NBOH N-(2-hydroxybenzyl)-1-(2,5-dimethoxy-4-methylphenyl)-2-aminoethane C18H23NO3 1391488-44-0 2,5-二甲氧基-4-甲基 2C-D 2-羟苯基 125px 25E-NBOMe N-(2-methoxybenzyl)-1-(2,5-dimethoxy-4-ethylphenyl)-2-aminoethane C20H27NO3 1354632-14-6 2,5-二甲氧基-4-乙基 2C-E 2-甲氧基苯基 125px 25E-NBOH N-(2-hydroxybenzyl)-1-(2,5-dimethoxy-4-ethylphenyl)-2-aminoethane C19H25NO3 1391489-79-4 2,5-二甲氧基-4-乙基 2C-E 2-羟苯基 125px 25G-NBOMe N-(2-methoxybenzyl)-1-(2,5-dimethoxy-3,4-dimethylphenyl)-2-aminoethane C20H27NO3 1354632-65-7 2,5-二甲氧基-3,4-二甲基 2C-G 2-甲氧基苯基 125px 25H-NBOMe N-(2-methoxybenzyl)-1-(2,5-dimethoxyphenyl)-2-aminoethane C18H23NO3 1566571-52-5 2,5-二甲氧基 2C-H 2-甲氧基苯基 125px 25I-NB34MD N-(3,4-methylenedioxybenzyl)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminoethane C18H20INO4 1391497-81-6 2,5-二甲氧基-4-碘 2C-I 3,4-亚甲二氧基苯基 125px 25I-NB3OMe N-(3-methoxybenzyl)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminoethane  C18H22INO3 1566571-40-1 2,5-二甲氧基-4-碘 2C-I 3-甲氧基苯基 125px 25I-NB4OMe N-(4-methoxybenzyl)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminoethane C18H22INO3 1566571-41-2 2,5-二甲氧基-4-碘 2C-I 4-甲氧基苯基 125px 25I-NBF N-(2-fluorobenzyl)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminoethane C17H19FINO2 919797-21-0 2,5-二甲氧基-4-碘 2C-I 2-氟苯基 125px 25I-NBBr N-(2-bromobenzyl)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminoethane C17H19BrINO2 1648649-98-2 2,5-二甲氧基-4-碘 2C-I 2-溴苯基 125px 25I-NBTFM N-[2-(trifluoromethyl)benzyl]-1-(2,5-dimethoxy-4-iodophenyl)-2-aminoethane  2,5-二甲氧基-4-碘 2C-I 2-三氟甲基苯基 125px 25I-NBMD N-(2,3-methylenedioxybenzyl)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminoethane C18H20INO4 919797-25-4 2,5-二甲氧基-4-碘 2C-I 2,3-亚甲二氧基苯基 125px 25B-NBMD N-(2,3-methylenedioxybenzyl)-1-(2,5-dimethoxy-4-bromophenyl)-2-aminoethane  1354632-19-1 2,5-二甲氧基-4-溴 2C-B 2,3-亚甲二氧基苯基 125px 25C-NBMD N-(2,3-methylenedioxybenzyl)-1-(2,5-dimethoxy-4-chlorophenyl)-2-aminoethane  1373879-26-5 2,5-二甲氧基-4-氯 2C-C 2,3-亚甲二氧基苯基 125px 25D-NBMD N-(2,3-methylenedioxybenzyl)-1-(2,5-dimethoxy-4-methylphenyl)-2-aminoethane  1391488-97-3 2,5-二甲氧基-4-甲基 2C-D 2,3-亚甲二氧基苯基 125px 25I-NBOH N-(2-hydroxybenzyl)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminoethane C17H20INO3 919797-20-9 2,5-二甲氧基-4-碘 2C-I 2-羟苯基 125px 25I-NBOMe N-(2-methoxybenzyl)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminoethane C18H22INO3 919797-19-6 2,5-二甲氧基-4-碘 2C-I 2-甲氧基苯基 125px 25I-NBMeOH N-[2-(hydroxymethyl)benzyl]-1-(2,5-dimethoxy-4-iodophenyl)-2-aminoethane C18H22INO3 1391494-71-5 2,5-二甲氧基-4-碘 2C-I 2-羟甲基苯基 125px 25I-NBAm N-[2-(carbamoyl)benzyl]-1-(2,5-dimethoxy-4-iodophenyl)-2-aminoethane  1391494-85-1 2,5-二甲氧基-4-碘 2C-I 2-氨基甲酰基苯基 125px 25I-NMe7DHBF N-[(2,3-dihydrobenzofuran-7-yl)methyl]-1-(2,5-dimethoxy-4-iodophenyl)-2-aminoethane  2,5-二甲氧基-4-碘 2C-I 2,3-dihydrobenzofuran-7-yl 125px 25I-N2Nap1OH N-[(1-hydroxynaphthalen-2-yl)methyl]-1-(2,5-dimethoxy-4-iodophenyl)-2-aminoethane  2,5-二甲氧基-4-碘 2C-I 1-hydroxynaphthalen-2-yl 125px 25I-N3MT2M N-[(3-methoxythiophen-2-yl)methyl]-1-(2,5-dimethoxy-4-iodophenyl)-2-aminoethane  1354632-66-8 2,5-二甲氧基-4-碘 2C-I 3-methoxythiophen-2-yl 125px 25I-N4MT3M N-[(4-methoxythiophen-3-yl)methyl]-1-(2,5-dimethoxy-4-iodophenyl)-2-aminoethane  1354632-73-7 2,5-二甲氧基-4-碘 2C-I 4-methoxythiophen-3-yl 125px 25iP-NBOMe N-(2-methoxybenzyl)-1-(2,5-dimethoxy-4-isopropylphenyl)-2-aminoethane C21H29NO3 1391487-83-4 2,5-二甲氧基-4-异丙基 2C-iP 2-甲氧基苯基 125px 25N-NBOMe N-(2-methoxybenzyl)-1-(2,5-dimethoxy-4-nitrophenyl)-2-aminoethane C18H22N2O5 1354632-03-3 2,5-二甲氧基-4-硝基 2C-N 2-甲氧基苯基 125px 25N-NBOEt Wallach J, et al. Selective, Partial and Arrestin-Biased 5-HT2A Agonists with Utility in Various Disorders. Patent WO 2022/241006 N-(2-ethoxybenzyl)-1-(2,5-dimethoxy-4-nitrophenyl)-2-aminoethane C19H24N2O5 2,5-二甲氧基-4-硝基 2C-N 2-乙氧基苯基 125px 25N-NB-2-OH-3-Me N-(2-hydroxy-3-methylbenzyl)-1-(2,5-dimethoxy-4-nitrophenyl)-2-aminoethane C18H22N2O5 2,5-二甲氧基-4-硝基 2C-N 2-羟基-3-甲基苯基 125px 25N-NBOCF2H N-(2-difluoromethoxybenzyl)-1-(2,5-dimethoxy-4-nitrophenyl)-2-aminoethane C18H20F2N2O5 2,5-二甲氧基-4-硝基 2C-N 2-二氟甲氧基苯基 125px 25N-NBPhWallach J, Cao AB, Calkins MM, Heim AJ, Lanham JK, Bonniwell EM, Hennessey JJ, Bock HA, Anderson EI, Sherwood AM, Morris H, de Klein R, Klein AK, Cuccurazzu B, Gamrat J, Fannana T, Zauhar R, Halberstadt AL, McCorvy JD. Identification of 5-HT2A Receptor Signaling Pathways Responsible for Psychedelic Potential. bioRxiv 2023 Jul 31:2023.07.29.551106.   N-[(2-phenyl)benzyl]-1-(2,5-dimethoxy-4-nitrophenyl)-2-aminoethane C23H24N2O4 2865185-29-9 2,5-二甲氧基-4-硝基 2C-N 邻联苯基 125px 25N-N1-Nap N-[(naphthalen-1-yl)methyl]-1-(2,5-dimethoxy-4-nitrophenyl)-2-aminoethane C21H22N2O4 2865185-31-3 2,5-二甲氧基-4-硝基 2C-N 1-萘基 125px 25P-NBOMe N-(2-methoxybenzyl)-1-(2,5-dimethoxy-4-propylphenyl)-2-aminoethane C21H29NO3 1391489-07-8 2,5-二甲氧基-4-丙基 2C-P 2-甲氧基苯基 125px 25P-NBOH N-(2-hydroxybenzyl)-1-(2,5-dimethoxy-4-propylphenyl)-2-aminoethane C20H27NO3 1391490-34-8 2,5-二甲氧基-4-丙基 2C-P 2-羟苯基 125px 25TFM-NBOMe N-(2-methoxybenzyl)-1-[2,5-dimethoxy-4-(trifluoromethyl)phenyl]-2-aminoethane C19H22F3NO3 1027161-33-6 2,5-二甲氧基-4-三氟甲基 2C-TFM 2-甲氧基苯基 125px 25O-NBcP N-(2-cyclopropylbenzyl)-1-(2,4,5-trimethoxyphenyl)-2-aminoethane C21H27NO3 2865186-10-1 2,4,5-三甲氧基 2C-O 2-环丙基苯基 125px RS130-180 N-(2-propargyloxy)-2,5-dimethoxy-4-(dimethylamino)phenethylamine C22H28N2O3  2,5-二甲氧基-4-二甲氨基  2-炔丙氧基苯基 125px 25T-NBOMe N-(2-methoxybenzyl)-1-[2,5-dimethoxy-4-(methylthio)phenyl]-2-aminoethane C19H25NO3S 1539266-47-1 2,5-二甲氧基-4-甲硫基 2C-T 2-甲氧基苯基 125px 25T2-NBOMe N-(2-methoxybenzyl)-1-[2,5-dimethoxy-4-(ethylthio)phenyl]-2-aminoethane C20H27NO3S 1539266-51-7 2,5-二甲氧基-4-乙硫基 2C-T-2 2-甲氧基苯基 125px 25T4-NBOMe N-(2-methoxybenzyl)-1-[2,5-dimethoxy-4-(isopropylthio)phenyl]-2-aminoethane C21H29NO3S 1354632-17-9 2,5-二甲氧基-4-异丙硫基 2C-T-4 2-甲氧基苯基 125px 25T7-NBOMe N-(2-methoxybenzyl)-1-[2,5-dimethoxy-4-(propylthio)phenyl]-2-aminoethane C21H29NO3S 1539266-55-1 2,5-二甲氧基-4-丙硫基 2C-T-7 2-甲氧基苯基 125px 25T7-NBOH N-(2-hydroxybenzyl)-1-[2,5-dimethoxy-4-(propylthio)phenyl]-2-aminoethane C20H27NO3S 1354632-41-9 2,5-二甲氧基-4-丙硫基 2C-T-7 2-羟苯基 125px 25AM-NBOMe Kruegel AC. Phenalkylamines and Methods of Making and Using the Same. Patent WO 2022/192781 N-(2-methoxybenzyl)-1-[2,5-dimethoxy-4-pentylphenyl]-2-aminoethane  2,5-二甲氧基-4-正戊基  2-甲氧基苯基 125px NBOMe-mescaline N-(2-methoxybenzyl)-1-(3,4,5-trimethoxyphenyl)-2-aminoethane  1354632-01-1 3,4,5-三甲氧基 2C-O 2-甲氧基苯基

其它
 结构 名称 化学名 分子式 CAS号 R基团 R1基团 Cyc 125px NBOMe-escaline N-(2-methoxybenzyl)-1-(3,5-dimethoxy-4-ethoxyphenyl)-2-aminoethane  3,5-二甲氧基-4-乙氧基 H 2-甲氧基苯基 125px NBOMe-thiobuscaline N-(2-methoxybenzyl)-1-(3,5-dimethoxy-4-butylthiophenyl)-2-aminoethane  3,5-dimethoxy-4-(n-butylthio) H 2-甲氧基苯基 125px MDPEA-NBOMe N-(2-methoxybenzyl)-1-(3,4-methylenedioxyphenyl)-2-aminoethane  3,4-methylenedioxy H 2-甲氧基苯基 125px 2C2-NBOMe N-(2-methoxybenzyl)-1-(2-methoxy-4,5-methylenedioxyphenyl)-2-aminoethane C18H21NO4 2-methoxy-4,5-methylenedioxy H 2-甲氧基苯基 125px DOB-NBOMe N-(2-methoxybenzyl)-1-(2,5-dimethoxy-4-bromophenyl)-2-aminopropane 2,5-二甲氧基-4-溴 甲基 2-甲氧基苯基 125px DOI-NBOMe N-(2-methoxybenzyl)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane  2,5-二甲氧基-4-碘 甲基 2-甲氧基苯基 125px MDBZ N-benzyl-1-(3,4-methylenedioxyphenyl)-2-aminopropane C17H19NO2 65033-29-6 3,4-亚甲二氧基 甲基 苯基 125px Clobenzorex N-(2-chlorobenzyl)-1-phenyl-2-aminopropane C16H18ClN 13364-32-4 H 甲基 2-氯苯基 125px 4-EA-NBOMe N-(2-methoxybenzyl)-1-(4-ethylphenyl)-2-aminopropane C19H25NO 2055108-04-6 4-乙基 甲基 2-甲氧基苯基 125px 5-APB-NBOMe N-(2-methoxybenzyl)-1-(benzofuran-5-yl)-2-aminopropane  苯基替换为苯并呋喃-5-基 甲基 2-甲氧基苯基

另见
 苯乙胺衍生物
 2,5-二甲氧基苯乙胺衍生物

 参考文献 

Category:仲胺
Category:苯乙胺类
*