2,2-二氟丁酸

2,2-二氟丁酸是一种有机氟化合物，化学式为C4H6F2O2。它可以为原料，经氯化、消除、氧化制得。Albert L. Henne and W. J. Zimmerschied. Fluorinated Acids. J. Am. Chem. Soc. 1947, 69, 2, 281–283. .它和邻苯二胺在三氟乙酸中于70 °C反应，可以得到2-(1,1-二氟丙基)苯并咪唑。Olivier René, Alexandra Souverneva, Steven R. Magnuson, Benjamin P. Fauber. Efficient syntheses of 2-fluoroalkylbenzimidazoles and -benzothiazoles. Tetrahedron Letters. 2013. 54 (3): 201-204. .它和异烟酸乙酯、过硫酸钾在硝酸银催化下反应，可以得到2-(1,1-二氟丙基)异烟酸乙酯。Guo, Chunfang; Han, Xuliang; Li, Xiangye; Diao, Zhengzhen; Li, Xinjin; Dong, Yunhui. Direct C-H Difluoroalkylation of Heteroarenes with Difluoroalkyl Carboxylic Acids. Asian Journal of Organic Chemistry. 2022. 11 (1). e202100663. .
参考文献

Category:有机氟化合物
Category:羧酸