N-(9-芴甲氧羰基)天门冬氨酸-4-叔丁酯

N-(9-芴甲氧羰基)天门冬氨酸-4-叔丁酯是一种有机化合物，化学式为C23H25NO6。它可由天门冬氨酸-4-叔丁酯和氯甲酸-9-芴甲酯为原料反应得到。Bolin, David R.; Sytwu, Iou Iou; Humiec, Frank; Meienhofer, Johannes. Preparation of oligomer-free Nα-Fmoc and Nα-urethane amino acids. International Journal of Peptide & Protein Research, 1989. 33 (5): 353-359. .它和溴化苄在碳酸铯存在下反应，可以得到N-(9-芴甲氧羰基)天门冬氨酸-1-苄酯-4-叔丁酯，它可进一步被甲酸脱叔丁基后，由甲硼烷二甲硫醚将羧酸还原为醇。Dieuwertje E. Streefkerk; Marcel Schmidt; Johannes H. Ippel; Tilman M. Hackeng; Timo Nuijens; Peter Timmerman; Jan H. van Maarseveen. Synthesis of Constrained Tetracyclic Peptides by Consecutive CEPS, CLIPS, and Oxime Ligation. Org. Lett. 2019, 21, 7, 2095–2100. .
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Category:叔丁酯
Category:9-芴甲氧羰基化合物