2-(3,3-二苯基丙基)咪唑-5-乙胺

2-(3,3-二苯基丙基)咪唑-5-乙胺一类强效且具有选择性的组胺H1受体激动剂的母体化合物Sigurd Elz, Kai Kramer, Christian Leschke, Walter Schunack. Ring-substituted histaprodifen analogues as partial agonists for histamine H1 receptors: synthesis and structure–activity relationships. European Journal of Medicinal Chemistry, 2000. 35 (1): 41-52. .，化学式为C20H23N3，它可以二苯甲烷为原料，经多步反应制得。

它和4-吡啶乙酸盐酸盐在吡啶和CDI的存在下于THF中反应，可以得到N-[2-(3,3-二苯基丙基)咪唑-5-基乙基]-4-吡啶乙酰胺。Sonja Menghin, Heinz H. Pertz, Kai Kramer, Roland Seifert, Walter Schunack, and Sigurd Elz. Nα-Imidazolylalkyl and Pyridylalkyl Derivatives of Histaprodifen: Synthesis and in Vitro Evaluation of Highly Potent Histamine H1-Receptor Agonists. J. Med. Chem. 2003, 46, 25, 5458–5470. .
参考文献

Category:乙胺
Category:咪唑