1-甲基-4-(2-肼基乙基)哌嗪

1-甲基-4-(2-肼基乙基)哌嗪是一种有机化合物，化学式为C7H18N4。它可以从合成过程中Mitsunobu反应的副产物[2-(4-甲基哌嗪基)乙基]肼-1,2-二甲酸二叔丁酯的水解反应制得。J. Gair Ford, Simon M. Pointon, Lyn Powell, Paul S. Siedlecki, John Baum, Richard Chubb, Robin Fieldhouse, James Muxworthy, Alex Nivlet, Rachel Stenson, and Eleanor Warwick. Process Research and Development for the Kilogram Manufacture of the SRC Kinase Inhibitor AZD0530. Org. Process Res. Dev. 2010, 14, 5, 1078–1087. .它和2,4-二氯-N-(2,6-二氯苯基)-5-嘧啶甲酰胺反应，可以得到2-氯-N-(2,6-二氯苯基)-4-{1-[2-(4-甲基哌嗪基)乙基]肼基]5-嘧啶甲酰胺。David J. Kopecky; et al. Identification and optimization of N3,N6-diaryl-1H-pyrazolo[3,4-d]pyrimidine-3,6-diamines as a novel class of ACK1 inhibitors. Bioorganic & Medicinal Chemistry Letters, 2008. 18 (24): 6352-6356. .
参考文献

Category:哌嗪