伏立诺他

{{Drugbox
| Verifiedfields = changed
| Watchedfields = changed
| verifiedrevid = 470631860
| IUPAC_name = N-Hydroxy-''N-phenyloctanediamide
| image = Vorinostat.svg
| width = 275

| pronounce =  
| tradename = Zolinza
| Drugs.com = 
| MedlinePlus = a607050
| licence_US = Vorinostat
| pregnancy_AU = 
| pregnancy_US = D
| pregnancy_category =  
| legal_AU = 
| legal_CA = 
| legal_UK = 
| legal_CN = Unscheduled
| legal_US = Rx-only
| legal_status = Rx-only
| routes_of_administration = 口服（膠囊劑）

| bioavailability = 1.8–11%
| protein_bound = ~71%
| metabolism = 肝脏 和 β-氧化细胞色素P450酶系统不参与代谢
| metabolites = 伏立诺他-O-葡萄糖醛酸化物, 4-苯氨基-4-氧丁酸（均无活性）
| elimination_half-life = 约2小时（伏立诺他 和 O-葡萄糖醛酸化物）11小时（4-苯氨基-4-氧丁酸）
| excretion = 肾脏（可忽略不计的）

| IUPHAR_ligand = 6852
| CAS_number_Ref = 
| CAS_number = 149647-78-9
| ATC_prefix = L01
| ATC_suffix = XH01
| PubChem = 5311
| DrugBank_Ref = 
| DrugBank = DB02546
| ChemSpiderID_Ref = 
| ChemSpiderID = 5120
| UNII_Ref = 
| UNII = 58IFB293JI
| KEGG_Ref = 
| KEGG = D06320
| ChEBI_Ref = 
| ChEBI = 45716
| ChEMBL_Ref = 
| ChEMBL = 98

| C=14 | H=20 | N=2 | O=3 
| smiles = O=C(Nc1ccccc1)CCCCCCC(=O)NO
| StdInChI_Ref = 
| StdInChI = 1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18)
| StdInChIKey_Ref = 
| StdInChIKey = WAEXFXRVDQXREF-UHFFFAOYSA-N
}}'''（rINN：，商品名：Zolinza）是一种含氮有机化合物，分子式C14H20N2O3，是一种组蛋白脱乙酰酶抑制劑，用于治疗（CTCL）患者在接受两次全身治疗期间或之后病情持续、恶化或复发的皮肤表现。

参考文献

外部链接
 Vorinostat bound to proteins  in the PDB

Category:酰替苯胺
Category:抗肿瘤药
Category:组蛋白脱乙酰酶抑制剂
Category:異羥肟酸
Category:罕用药