3,4-二氢-2-喹喔啉酮

3,4-二氢-2-喹喔啉酮是一种有机化合物，化学式为C8H8N2O。它可用于的合成。Robichaud, Albert J.; Lee, Taekyu; Deng, Wei; Mitchell, Ian S.; Yang, Michael G.; Haydar, Simon; Chen, Wenting; McClung, Christopher D.; Calvello, Emilie J.; Zawrotny, David M. Substituted heterocycle fused gamma-carbolines. 2004. US20040220178.

合成与反应
它可由N-(2-硝基苯基)甘氨酸甲酯和连二亚硫酸钠在二甲基亚砜中反应得到，Pankaj Gupta, Surabhi Panday, Amitava Hazra, and Joydev K. Laha. Metal- and Additive-Free Intramolecular Direct Amidation of Ester Functionality within a Nitroarene Framework: Facile Access to Azaheterocycles. ACS Sustainable Chem. Eng. 2023, 11, 48, 17031–17037. .或由邻苯二胺和氯乙酸在氨水中加热制得。Mohammed K. Ibrahim, Ibrahim H. Eissa, Abdallah E. Abdallah, Ahmed M. Metwaly, M.M. Radwan, M.A. ElSohly. Design, synthesis, molecular modeling and anti-hyperglycemic evaluation of novel quinoxaline derivatives as potential PPARγ and SUR agonists. Bioorganic & Medicinal Chemistry. 2017. 25 (4). .

它在乙酸铜催化下可以被氧气氧化为。Shuocheng Wan, Jie Wang, Congde Huo. Copper catalyzed aerobic oxidative amination of 3,4-dihydroquinoxalin-2(1H)-ones. Tetrahedron Letters, 2021. 78. .
参考文献

Category:酮